GRIN2D and SYNGAP1

Number of citations of the paper that reports this interaction (PMID 10862698)
203

Data Source:
HPRD (in vivo)

		GRIN2D	SYNGAP1
Gene Name		glutamate receptor, ionotropic, N-methyl D-aspartate 2D	synaptic Ras GTPase activating protein 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane N-methyl-D-aspartate Selective Glutamate Receptor Complex Cell Junction Dendrite Postsynaptic Membrane	Cytoplasm Intrinsic Component Of The Cytoplasmic Side Of The Plasma Membrane Dendritic Shaft
	Molecular Function	N-methyl-D-aspartate Selective Glutamate Receptor Activity Extracellular-glutamate-gated Ion Channel Activity Protein Binding	Rab GTPase Activator Activity Ras GTPase Activator Activity SH3 Domain Binding
	Biological Process	Startle Response Signal Transduction Synaptic Transmission Adult Locomotory Behavior Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Regulation Of Sensory Perception Of Pain	Ras Protein Signal Transduction Pattern Specification Process Visual Learning Dendrite Development Positive Regulation Of Ras GTPase Activity Positive Regulation Of Rab GTPase Activity Receptor Clustering Regulation Of MAPK Cascade Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Ras Protein Signal Transduction Regulation Of Synaptic Plasticity Regulation Of Long-term Neuronal Synaptic Plasticity Negative Regulation Of Axonogenesis Regulation Of Synapse Structure Or Activity
Pathways		Activation of NMDA receptor upon glutamate binding and postsynaptic events CREB phosphorylation through the activation of CaMKII CREB phosphorylation through the activation of Ras Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Unblocking of NMDA receptor, glutamate binding and activation Ras activation uopn Ca2+ infux through NMDA receptor Post NMDA receptor activation events Transmission across Chemical Synapses
Drugs		L-Glutamic Acid Meperidine Orphenadrine Tenocyclidine
Diseases
GWAS
Protein-Protein Interactions		33 interactors: ABL1 CDH2 CIT CLTC CTNNB1 DLG2 DLG4 DLGAP4 DNM1 DUSP4 FUS GRIN1 HNRNPU HRAS HSPA1A IL16 INA INADL MAP2 MAP2K2 NANOS1 NF1 PPP2R1A PPP2R2A PRKCB PRKCE PRKCG RAP2A RPS6KA3 SPTAN1 SYNGAP1 TJP1 TRAF3	13 interactors: CAMK2A DLG3 DLG4 DLGAP4 GRIN1 GRIN2B GRIN2D KDR MPDZ PDGFRB TRIP6 ULK1 ULK2
Entrez ID		2906	8831
HPRD ID		04095	16018
Ensembl ID		ENSG00000105464	ENSG00000197283
Uniprot IDs		O15399 Q59G17	Q96PV0
PDB IDs
Enriched GO Terms of Interacting Partners?		Nervous System Development Regulation Of MAPK Cascade Regulation Of Long-term Neuronal Synaptic Plasticity Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Neurogenesis Cell Development Locomotion Generation Of Neurons Intracellular Signal Transduction Neuron Projection Development Cell Differentiation Regulation Of Cellular Component Organization Regulation Of Neuronal Synaptic Plasticity Cellular Response To Stimulus Neuron Differentiation Enzyme Linked Receptor Protein Signaling Pathway Cell Projection Organization Signaling Cell Morphogenesis Involved In Differentiation Axonogenesis MyD88-independent Toll-like Receptor Signaling Pathway Neuron Development Cell Communication Apoptotic Process Response To Organic Substance Signal Transduction Axon Guidance Axon Development Programmed Cell Death Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Cell Death Toll-like Receptor 4 Signaling Pathway Death Regulation Of Neuron Death Developmental Process Neuron Projection Morphogenesis Response To Ammonium Ion Immune Response-regulating Signaling Pathway Regulation Of Metabolic Process Response To Stimulus Response To Morphine Regulation Of Intracellular Signal Transduction Cell-cell Signaling Regulation Of Phosphorus Metabolic Process Movement Of Cell Or Subcellular Component Multicellular Organismal Development Response To External Stimulus Toll-like Receptor Signaling Pathway Regulation Of Protein Metabolic Process	Protein Autophosphorylation Cell-cell Signaling Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Synaptic Transmission Signaling Startle Response Cell Communication Neuron Projection Morphogenesis Neuromuscular Process Cell Development Cell Morphogenesis Involved In Differentiation Response To External Stimulus Locomotion Regulation Of Synaptic Plasticity Synaptic Transmission, Glutamatergic Ionotropic Glutamate Receptor Signaling Pathway Neuron Projection Development Cell Projection Morphogenesis Signal Transduction Cell Part Morphogenesis Regulation Of Neuronal Synaptic Plasticity Movement Of Cell Or Subcellular Component Glutamate Receptor Signaling Pathway Negative Regulation Of Collateral Sprouting Neuron Development Neuron-neuron Synaptic Transmission Receptor Localization To Synapse Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Postsynaptic Membrane Potential Anatomical Structure Morphogenesis Cell Morphogenesis Chemotaxis Neuron Differentiation Cell Projection Organization Regulation Of Synaptic Transmission Phosphorylation Membrane Depolarization Cellular Response To Stimulus Protein Localization To Synapse Axon Guidance Learning System Development Regulation Of Signaling Suckling Behavior Nervous System Development Regulation Of Axonogenesis Single-organism Behavior Generation Of Neurons
Tagcloud ?		6j 6jxm atg autosomes backcross codon crosses dispersed egr epsilon espilon exons f1xc57bl flanking grinl interspecific mapping nucleas polyadenylation primer s1 spans spl spretus termination zeta	asah1 atypical broadening canada care4rare causal definitive descriptions encephalopathy epilepsy exome families folr1 forge grin2a kcnq2 nation projects rare recognizable retrospect scn8a segregating seizures suited synj1 translating unrevealing wes
Tagcloud (Difference) ?		6j 6jxm atg autosomes backcross codon crosses dispersed egr epsilon espilon exons f1xc57bl flanking grinl interspecific mapping nucleas polyadenylation primer s1 spans spl spretus termination zeta	asah1 atypical broadening canada care4rare causal definitive descriptions encephalopathy epilepsy exome families folr1 forge kcnq2 nation projects rare recognizable retrospect scn8a segregating seizures suited synj1 translating unrevealing wes
Tagcloud (Intersection) ?		grin2a