PRKCE and IKBKB

Number of citations of the paper that reports this interaction (PubMedID 23123196)
37

Data Source:
BioGRID (enzymatic study)

		PRKCE	IKBKB
Description		protein kinase C epsilon	inhibitor of nuclear factor kappa B kinase subunit beta
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Endoplasmic Reticulum Golgi Apparatus Cytosol Cytoskeleton Plasma Membrane Membrane Intermediate Filament Cytoskeleton Synapse Perinuclear Region Of Cytoplasm Cell Periphery	Nucleus Cytoplasm Cytosol IkappaB Kinase Complex Cytoplasmic Side Of Plasma Membrane Membrane CD40 Receptor Complex Membrane Raft
	Molecular Function	Nucleotide Binding Actin Monomer Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Diacylglycerol-dependent Serine/threonine Kinase Activity Diacylglycerol-dependent, Calcium-independent Serine/threonine Kinase Activity Protein Binding ATP Binding Enzyme Activator Activity Zinc Ion Binding Kinase Activity Transferase Activity Enzyme Binding Signaling Receptor Activator Activity Ethanol Binding Metal Ion Binding 14-3-3 Protein Binding Protein Serine Kinase Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding IkappaB Kinase Activity Kinase Activity Transferase Activity Protein Kinase Binding Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Scaffold Protein Binding Protein Serine Kinase Activity Transferrin Receptor Binding
	Biological Process	MAPK Cascade Macrophage Activation Involved In Immune Response Immune System Process Apoptotic Process Cell Adhesion Signal Transduction Toxin Catabolic Process Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Fibroblast Migration Positive Regulation Of Cell-substrate Adhesion Regulation Of Metal Ion Transport Peptidyl-serine Phosphorylation Regulation Of Lipid Metabolic Process Insulin Secretion Positive Regulation Of Actin Filament Polymerization Negative Regulation Of Protein Ubiquitination Cell-substrate Adhesion Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Insulin Secretion Positive Regulation Of Synaptic Transmission, GABAergic Positive Regulation Of Cytokinesis Positive Regulation Of Superoxide Anion Generation Intracellular Signal Transduction Locomotory Exploration Behavior TRAM-dependent Toll-like Receptor 4 Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Xenobiotic Catabolic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Response To Morphine Positive Regulation Of MAPK Cascade Positive Regulation Of Lipid Catabolic Process Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Cell Division Establishment Of Localization In Cell Synaptic Transmission, GABAergic Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Mucus Secretion Positive Regulation Of Mucus Secretion Cellular Response To Ethanol Cellular Response To Prostaglandin E Stimulus Cellular Response To Hypoxia Positive Regulation Of Wound Healing Negative Regulation Of Sodium Ion Transmembrane Transport Positive Regulation Of Protein Localization To Plasma Membrane Regulation Of Monoatomic Cation Transmembrane Transport	Protein Polyubiquitination Pattern Recognition Receptor Signaling Pathway Stimulatory C-type Lectin Receptor Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation Inflammatory Response Canonical NF-kappaB Signal Transduction Response To Virus Positive Regulation Of Macromolecule Metabolic Process Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Peptidyl-serine Phosphorylation Signal Transduction Involved In Regulation Of Gene Expression Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Non-canonical NF-kappaB Signal Transduction Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Stress-activated MAPK Cascade Protein Maturation Interleukin-1-mediated Signaling Pathway Cellular Response To Tumor Necrosis Factor Protein Localization To Plasma Membrane Negative Regulation Of Cytokine Production Involved In Inflammatory Response Regulation Of Establishment Of Endothelial Barrier Negative Regulation Of Bicellular Tight Junction Assembly
Pathways		Effects of PIP2 hydrolysis SHC1 events in ERBB2 signaling DAG and IP3 signaling Role of phospholipids in phagocytosis G alpha (z) signalling events	Activation of NF-kappaB in B cells Activation of NF-kappaB in B cells ER-Phagosome pathway NOD1/2 Signaling Pathway TICAM1, RIP1-mediated IKK complex recruitment RIP-mediated NFkB activation via ZBP1 Downstream TCR signaling p75NTR recruits signalling complexes NF-kB is activated and signals survival FCERI mediated NF-kB activation TAK1-dependent IKK and NF-kappa-B activation Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway IKBKB deficiency causes SCID IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) IkBA variant leads to EDA-ID CLEC7A (Dectin-1) signaling MAP3K8 (TPL2)-dependent MAPK1/3 activation Interleukin-1 signaling TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 IRAK1 recruits IKK complex IKK complex recruitment mediated by RIP1 SARS-CoV-2 activates/modulates innate and adaptive immune responses IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation Regulation of NF-kappa B signaling PKR-mediated signaling SLC15A4:TASL-dependent IRF5 activation Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells Modulation of host responses by IFN-stimulated genes
Drugs		Tamoxifen Staurosporine Dequalinium KAI-1455 Benzoyl peroxide Bryostatin 1 Fostamatinib	Mesalazine Acetylsalicylic acid Auranofin Arsenic trioxide MLN0415 Acetylcysteine Ertiprotafib Fostamatinib
Diseases
GWAS		Appendicular lean mass ( 33097823) Body mass index ( 28552196) Carotenoid levels (alpha-carotene) ( 28002826) Cerebral amyloid deposition in APOEe4 non-carriers (PET imaging) ( 26252872) Coronary artery disease ( 33020668 29212778) Corpus callosum posterior volume ( 31530798) Craniofacial microsomia ( 26853712) Diastolic blood pressure ( 30578418 28135244) Diisocyanate-induced asthma ( 25918132) Heel bone mineral density ( 30598549) Hematocrit ( 32888494 29403010 19862010 27863252 28453575 28017375) Hematological and biochemical traits ( 31902109 20139978) Hemoglobin ( 19862010 28453575 32888494 29403010) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 28017375 32327693) High light scatter reticulocyte count ( 27863252 32888494) LDL cholesterol ( 30275531) Metabolite levels ( 23823483) Metabolite levels (X-11787) ( 23934736) Monocyte count ( 32888494) Pathological gambling ( 27315593) Platelet count ( 32888494) Plateletcrit ( 32888494) Premature menopause in childhood cancer survivors ( 29432556) Pulse pressure ( 27841878 30578418 28135244) Red blood cell count ( 32888494 20139978 29403010 28017375 27863252) Red blood cell traits ( 23446634 23222517) Response to zileuton treatment in asthma (FEV1 change interaction) ( 26031901) Reticulocyte count ( 32888494) Suicide risk ( 21041247) Systolic blood pressure ( 30578418) Total cholesterol levels ( 30275531) Triiodothyronine levels ( 30824882) Two-hour glucose in pregnancy (gestational week 30-32) ( 30324795) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683) Weight ( 28552196) White blood cell count ( 32888494)
Interacting Genes		59 interacting genes: ACTA1 ACTC1 ADAP1 AFAP1 AKAP9 ATF2 BRAF BTK CFTR CHAT CNN1 COPB1 COPB2 DSP EGFR ELAVL1 FYN GAD1 GAD2 GJA1 GNA12 GNA13 GRIN1 GRIN2D GRM5 H1-1 HK2 IKBKB ITGB1 ITGB2 KRT1 KRT18 MAP4K4 MAPK1 MAPK3 MAPT MARK2 MYH2 NANOG NUMB OPRD1 PDLIM5 PDPK1 PECAM1 PIK3CB PPP1R14A PRKD1 RACK1 RAD9A RAF1 RASGRP3 RPS6KB2 SLC25A4 SLC4A3 SNCA SRC TIAM1 TRPV1 VDAC1	91 interacting genes: ACVR1 AKT1 AURKA BTRC CASP8 CCAR2 CDC37 CFLAR CHUK COPS3 COPS4 COPS5 CSF2RA CSF2RB CTNNB1 CUEDC2 E2F4 EIF2AK2 EIF2AK3 ELP1 FAF1 FANCA FOXO3 GLI1 HMGCL HSP90AA1 HSP90AB1 HTT IKBKG IRS1 JUN KLHL21 MAP3K1 MAP3K11 MAP3K13 MAP3K14 MAP3K3 MAP3K7 MAVS MTDH MYC NAA20 NCOA3 NEDD4L NFKB1 NFKB2 NFKBIA NFKBIB NR2C2 PEBP1 PELI1 PLK1 PPARG PPM1B PPP2R3C PRKCA PRKCB PRKCD PRKCE PRKCQ PRKCZ PRKDC RELA RICTOR ROCK1 SAMHD1 SASH1 SQSTM1 SRC STAP2 TAB2 TANK TBK1 TFAP2C TGFBR1 TNFAIP3 TNFRSF1A TP53 TP73 TRAF1 TRAF2 TRAF3IP2 TRIM21 TRIM27 TRPC4AP TSC1 TWIST1 UBB UBC VHL YWHAB
Entrez ID		5581	3551
HPRD ID		01500	04462
Ensembl ID		ENSG00000171132	ENSG00000104365
Uniprot IDs		L7RTI5 Q02156	A0A499FJS7 G3V105 O14920
PDB IDs		2WH0 5LIH	3BRT 3BRV 4E3C 4KIK 8OMV
Enriched GO Terms of Interacting Partners?		Regulation Of Biological Quality Intracellular Signaling Cassette Focal Adhesion Cytoplasm Regulation Of Anatomical Structure Morphogenesis Phosphorylation Plasma Membrane Regulation Of Developmental Process Protein Phosphorylation Regulation Of Multicellular Organismal Process Kinase Activity Membrane Raft Regulation Of Membrane Potential Intracellular Signal Transduction ATP Binding Nucleotide Binding Regulation Of Transport Protein Kinase Activity Regulation Of Locomotion Regulation Of Cell Migration Regulation Of Vesicle-mediated Transport Regulation Of Cell Motility Positive Regulation Of Cell Communication Positive Regulation Of Signaling Phospholipase Binding ERBB Signaling Pathway Response To Growth Factor Cell Surface Receptor Signaling Pathway ERBB2 Signaling Pathway Regulation Of Cellular Localization Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Intracellular Signal Transduction Protein Serine Kinase Activity Regulation Of Signal Transduction Regulation Of Cellular Component Organization Phospholipase Activator Activity Positive Regulation Of Cell Migration Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Motility Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Locomotion MAPK Cascade Cell-cell Signaling Chemical Synaptic Transmission Cytoskeleton Organization Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Apoptotic Process Scaffold Protein Binding Positive Regulation Of Signal Transduction	Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Metabolic Process Regulation Of Canonical NF-kappaB Signal Transduction Intracellular Signal Transduction Cytosol Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Regulation Of Metabolic Process Negative Regulation Of Programmed Cell Death Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Signal Transduction Positive Regulation Of Biosynthetic Process Negative Regulation Of Cell Communication Negative Regulation Of Signaling Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Apoptotic Process Regulation Of Protein Metabolic Process Signal Transduction Protein Modification Process Cytoplasm Positive Regulation Of Nucleobase-containing Compound Metabolic Process Non-canonical NF-kappaB Signal Transduction Protein Serine/threonine Kinase Activity Response To Stress Intracellular Signaling Cassette Macromolecule Metabolic Process Protein Kinase Activity Ubiquitin Protein Ligase Binding Enzyme Binding Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Protein Modification Process Protein Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Post-translational Protein Modification Regulation Of Immune Response Regulation Of Gene Expression Positive Regulation Of Catabolic Process Regulation Of Apoptotic Signaling Pathway Regulation Of Immune System Process Cell Surface Receptor Signaling Pathway Protein Serine Kinase Activity
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