PRKCE and PIK3CB

Number of citations of the paper that reports this interaction (PubMedID 9822674)
0

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		PRKCE	PIK3CB
Description		protein kinase C epsilon	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Endoplasmic Reticulum Golgi Apparatus Cytosol Cytoskeleton Plasma Membrane Membrane Intermediate Filament Cytoskeleton Synapse Perinuclear Region Of Cytoplasm Cell Periphery	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Plasma Membrane Phosphatidylinositol 3-kinase Complex Phosphatidylinositol 3-kinase Complex, Class IA Midbody
	Molecular Function	Nucleotide Binding Actin Monomer Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Diacylglycerol-dependent Serine/threonine Kinase Activity Diacylglycerol-dependent, Calcium-independent Serine/threonine Kinase Activity Protein Binding ATP Binding Enzyme Activator Activity Zinc Ion Binding Kinase Activity Transferase Activity Enzyme Binding Signaling Receptor Activator Activity Ethanol Binding Metal Ion Binding 14-3-3 Protein Binding Protein Serine Kinase Activity	Nucleotide Binding Protein Binding ATP Binding Kinase Activity 1-phosphatidylinositol-3-kinase Activity Transferase Activity 1-phosphatidylinositol-4-phosphate 3-kinase Activity Insulin Receptor Substrate Binding 1-phosphatidylinositol-4,5-bisphosphate 3-kinase Activity Phosphatidylinositol Kinase Activity Protein Serine Kinase Activity
	Biological Process	MAPK Cascade Macrophage Activation Involved In Immune Response Immune System Process Apoptotic Process Cell Adhesion Signal Transduction Toxin Catabolic Process Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Fibroblast Migration Positive Regulation Of Cell-substrate Adhesion Regulation Of Metal Ion Transport Peptidyl-serine Phosphorylation Regulation Of Lipid Metabolic Process Insulin Secretion Positive Regulation Of Actin Filament Polymerization Negative Regulation Of Protein Ubiquitination Cell-substrate Adhesion Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Insulin Secretion Positive Regulation Of Synaptic Transmission, GABAergic Positive Regulation Of Cytokinesis Positive Regulation Of Superoxide Anion Generation Intracellular Signal Transduction Locomotory Exploration Behavior TRAM-dependent Toll-like Receptor 4 Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Xenobiotic Catabolic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Response To Morphine Positive Regulation Of MAPK Cascade Positive Regulation Of Lipid Catabolic Process Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Cell Division Establishment Of Localization In Cell Synaptic Transmission, GABAergic Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Mucus Secretion Positive Regulation Of Mucus Secretion Cellular Response To Ethanol Cellular Response To Prostaglandin E Stimulus Cellular Response To Hypoxia Positive Regulation Of Wound Healing Negative Regulation Of Sodium Ion Transmembrane Transport Positive Regulation Of Protein Localization To Plasma Membrane Regulation Of Monoatomic Cation Transmembrane Transport	Endothelial Cell Proliferation Regulation Of Cell-matrix Adhesion Leukocyte Mediated Immunity Response To Ischemia Sphingosine-1-phosphate Receptor Signaling Pathway Lipid Metabolic Process Intracellular Calcium Ion Homeostasis Endocytosis Autophagy Chemotaxis Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Autophagy Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression Cell Migration Platelet Activation Positive Regulation Of Neutrophil Apoptotic Process Positive Regulation Of Rac Protein Signal Transduction Phosphatidylinositol-3-phosphate Biosynthetic Process Embryonic Cleavage Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of MAPK Cascade Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Innate Immune Response Positive Regulation Of Nitric Oxide Biosynthetic Process Phosphatidylinositol Phosphate Biosynthetic Process Phosphatidylinositol-mediated Signaling Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Angiogenesis Involved In Wound Healing Platelet Aggregation Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Negative Regulation Of Hypoxia-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Sprouting Angiogenesis Regulation Of Clathrin-dependent Endocytosis
Pathways		Effects of PIP2 hydrolysis SHC1 events in ERBB2 signaling DAG and IP3 signaling Role of phospholipids in phagocytosis G alpha (z) signalling events	PI3K Cascade IRS-mediated signalling GPVI-mediated activation cascade PIP3 activates AKT signaling Synthesis of PIPs at the plasma membrane Downstream signal transduction PI3K/AKT activation Signaling by ALK Downstream TCR signaling Role of phospholipids in phagocytosis Tie2 Signaling Constitutive Signaling by Aberrant PI3K in Cancer DAP12 signaling Role of LAT2/NTAL/LAB on calcium mobilization Nephrin family interactions CD28 dependent PI3K/Akt signaling VEGFA-VEGFR2 Pathway VEGFA-VEGFR2 Pathway Interleukin-3, Interleukin-5 and GM-CSF signaling RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling RET signaling Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Interleukin receptor SHC signaling Regulation of signaling by CBL Regulation of signaling by CBL Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants Signaling by PDGFRA extracellular domain mutants Signaling by CSF1 (M-CSF) in myeloid cells Signaling by ALK fusions and activated point mutants Signaling by LTK in cancer Signaling by LTK High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Co-stimulation by ICOS
Drugs		Tamoxifen Staurosporine Dequalinium KAI-1455 Benzoyl peroxide Bryostatin 1 Fostamatinib	Caffeine XL765
Diseases
GWAS		Appendicular lean mass ( 33097823) Body mass index ( 28552196) Carotenoid levels (alpha-carotene) ( 28002826) Cerebral amyloid deposition in APOEe4 non-carriers (PET imaging) ( 26252872) Coronary artery disease ( 33020668 29212778) Corpus callosum posterior volume ( 31530798) Craniofacial microsomia ( 26853712) Diastolic blood pressure ( 30578418 28135244) Diisocyanate-induced asthma ( 25918132) Heel bone mineral density ( 30598549) Hematocrit ( 32888494 29403010 19862010 27863252 28453575 28017375) Hematological and biochemical traits ( 31902109 20139978) Hemoglobin ( 19862010 28453575 32888494 29403010) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 28017375 32327693) High light scatter reticulocyte count ( 27863252 32888494) LDL cholesterol ( 30275531) Metabolite levels ( 23823483) Metabolite levels (X-11787) ( 23934736) Monocyte count ( 32888494) Pathological gambling ( 27315593) Platelet count ( 32888494) Plateletcrit ( 32888494) Premature menopause in childhood cancer survivors ( 29432556) Pulse pressure ( 27841878 30578418 28135244) Red blood cell count ( 32888494 20139978 29403010 28017375 27863252) Red blood cell traits ( 23446634 23222517) Response to zileuton treatment in asthma (FEV1 change interaction) ( 26031901) Reticulocyte count ( 32888494) Suicide risk ( 21041247) Systolic blood pressure ( 30578418) Total cholesterol levels ( 30275531) Triiodothyronine levels ( 30824882) Two-hour glucose in pregnancy (gestational week 30-32) ( 30324795) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683) Weight ( 28552196) White blood cell count ( 32888494)	Male-pattern baldness ( 28196072) Mean platelet volume ( 32888494)
Interacting Genes		59 interacting genes: ACTA1 ACTC1 ADAP1 AFAP1 AKAP9 ATF2 BRAF BTK CFTR CHAT CNN1 COPB1 COPB2 DSP EGFR ELAVL1 FYN GAD1 GAD2 GJA1 GNA12 GNA13 GRIN1 GRIN2D GRM5 H1-1 HK2 IKBKB ITGB1 ITGB2 KRT1 KRT18 MAP4K4 MAPK1 MAPK3 MAPT MARK2 MYH2 NANOG NUMB OPRD1 PDLIM5 PDPK1 PECAM1 PIK3CB PPP1R14A PRKD1 RACK1 RAD9A RAF1 RASGRP3 RPS6KB2 SLC25A4 SLC4A3 SNCA SRC TIAM1 TRPV1 VDAC1	13 interacting genes: AGTR2 ALAS1 DVL3 HCK HPS6 LRRK2 MME PIK3R1 PIK3R2 PRKCD PRKCE RAB5B YWHAQ
Entrez ID		5581	5291
HPRD ID		01500	04234
Ensembl ID		ENSG00000171132	ENSG00000051382
Uniprot IDs		L7RTI5 Q02156	B4DER4 P42338
PDB IDs		2WH0 5LIH
Enriched GO Terms of Interacting Partners?		Regulation Of Biological Quality Intracellular Signaling Cassette Focal Adhesion Cytoplasm Regulation Of Anatomical Structure Morphogenesis Phosphorylation Plasma Membrane Regulation Of Developmental Process Protein Phosphorylation Regulation Of Multicellular Organismal Process Kinase Activity Membrane Raft Regulation Of Membrane Potential Intracellular Signal Transduction ATP Binding Nucleotide Binding Regulation Of Transport Protein Kinase Activity Regulation Of Locomotion Regulation Of Cell Migration Regulation Of Vesicle-mediated Transport Regulation Of Cell Motility Positive Regulation Of Cell Communication Positive Regulation Of Signaling Phospholipase Binding ERBB Signaling Pathway Response To Growth Factor Cell Surface Receptor Signaling Pathway ERBB2 Signaling Pathway Regulation Of Cellular Localization Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Intracellular Signal Transduction Protein Serine Kinase Activity Regulation Of Signal Transduction Regulation Of Cellular Component Organization Phospholipase Activator Activity Positive Regulation Of Cell Migration Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Motility Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Locomotion MAPK Cascade Cell-cell Signaling Chemical Synaptic Transmission Cytoskeleton Organization Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Apoptotic Process Scaffold Protein Binding Positive Regulation Of Signal Transduction	Intracellular Signaling Cassette Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament-based Process Intracellular Signal Transduction Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Actin Filament Organization Regulation Of Biological Quality Regulation Of Cytoskeleton Organization Exploration Behavior Regulation Of Actin Filament Polymerization Fc-gamma Receptor Signaling Pathway Response To Hormone Cellular Response To Hormone Stimulus Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Positive Regulation Of Protein Import Into Nucleus Diacylglycerol-dependent, Calcium-independent Serine/threonine Kinase Activity Regulation Of Transport Phosphotyrosine Residue Binding Regulation Of Supramolecular Fiber Organization Regulation Of Kidney Size Cellular Response To Peptide Hormone Stimulus 1-phosphatidylinositol-3-kinase Regulator Activity Regulation Of Organelle Organization Fc Receptor Signaling Pathway Regulation Of Protein-containing Complex Assembly Regulation Of Cellular Component Organization Regulation Of Protein Import Into Nucleus Positive Regulation Of Nucleocytoplasmic Transport Establishment Of Protein Localization Phosphatidylinositol 3-kinase Complex, Class IA Phosphatidylinositol 3-kinase Regulatory Subunit Binding Cellular Response To Oxygen-containing Compound Cell Surface Receptor Signaling Pathway Regulation Of Protein Localization Regulation Of Cellular Localization Positive Regulation Of Protein Transport Regulation Of Establishment Of Protein Localization Regulation Of Cellular Component Size Cellular Response To UV Regulation Of Intracellular Transport Positive Regulation Of Intracellular Protein Transport Insulin Receptor Substrate Binding Cellular Response To Insulin Stimulus Positive Regulation Of Protein Localization To Nucleus Locomotory Exploration Behavior Response To Peptide Hormone Cellular Response To Light Stimulus Protein Transport
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