PRKCE and ITGB1

Number of citations of the paper that reports this interaction (PMID 15949469)
11

Data Source:
HPRD (in vitro)

		PRKCE	ITGB1
Gene Name		protein kinase C, epsilon	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Endoplasmic Reticulum Golgi Apparatus Cytosol Cytoskeleton Plasma Membrane Perinuclear Region Of Cytoplasm Cell Periphery	Acrosomal Vesicle Ruffle Basement Membrane Cytoplasm Plasma Membrane Focal Adhesion Integrin Complex External Side Of Plasma Membrane Cell Surface Intercalated Disc Membrane Lamellipodium Hemidesmosome Filopodium Neuromuscular Junction Cleavage Furrow Ruffle Membrane Integrin Alpha1-beta1 Complex Integrin Alpha2-beta1 Complex Integrin Alpha3-beta1 Complex Integrin Alpha7-beta1 Complex Integrin Alpha8-beta1 Complex Integrin Alpha9-beta1 Complex Integrin Alpha10-beta1 Complex Integrin Alpha11-beta1 Complex Myelin Sheath Abaxonal Region Sarcolemma Melanosome Dendritic Spine Receptor Complex Membrane Raft Recycling Endosome Extracellular Vesicular Exosome Invadopodium Membrane Synaptic Membrane
	Molecular Function	Actin Monomer Binding Protein Serine/threonine Kinase Activity Protein Kinase C Activity Calcium-independent Protein Kinase C Activity Signal Transducer Activity Protein Binding ATP Binding Enzyme Activator Activity Enzyme Binding Receptor Activator Activity Ethanol Binding Metal Ion Binding 14-3-3 Protein Binding	Virus Receptor Activity Glycoprotein Binding Fibronectin Binding Protease Binding Actin Binding Integrin Binding Protein Binding Protein Kinase Binding Protein Domain Specific Binding Peptide Binding Laminin Binding Metal Ion Binding Protein Heterodimerization Activity Cell Adhesion Molecule Binding Alpha-actinin Binding Collagen Binding Involved In Cell-matrix Adhesion
	Biological Process	Macrophage Activation Involved In Immune Response Protein Phosphorylation Apoptotic Process Cell Cycle Cell Adhesion Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Activation Of Phospholipase C Activity Blood Coagulation Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Fibroblast Migration Positive Regulation Of Cell-substrate Adhesion Peptidyl-serine Phosphorylation Platelet Activation Positive Regulation Of Actin Filament Polymerization Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Insulin Secretion Positive Regulation Of Synaptic Transmission, GABAergic Positive Regulation Of Cytokinesis Intracellular Signal Transduction Locomotory Exploration Behavior TRAM-dependent Toll-like Receptor 4 Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Morphine Positive Regulation Of MAPK Cascade Innate Immune Response Neurotrophin TRK Receptor Signaling Pathway Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Lipid Catabolic Process Release Of Sequestered Calcium Ion Into Cytosol Cell Division Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Mucus Secretion Cellular Response To Ethanol Cellular Response To Hypoxia Positive Regulation Of Wound Healing Positive Regulation Of Receptor Activity Negative Regulation Of Sodium Ion Transmembrane Transporter Activity Positive Regulation Of Cellular Glucuronidation	G1/S Transition Of Mitotic Cell Cycle In Utero Embryonic Development Cell Fate Specification Tissue Homeostasis Cell Migration Involved In Sprouting Angiogenesis Cellular Calcium Ion Homeostasis Cellular Defense Response Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Leukocyte Cell-cell Adhesion Cell-matrix Adhesion Calcium-independent Cell-matrix Adhesion Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Axon Guidance Blood Coagulation Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Germ Cell Migration Visual Learning Response To Virus Regulation Of Collagen Catabolic Process Positive Regulation Of Cell-substrate Adhesion Positive Regulation Of Neuron Projection Development Response To Activity Viral Process Cell Migration Formation Of Radial Glial Scaffolds B Cell Differentiation Extracellular Matrix Organization Positive Regulation Of Cell Migration Negative Regulation Of Cell Projection Organization Cell-substrate Adhesion Protein Transport Within Lipid Bilayer Cell-cell Adhesion Mediated By Integrin Heterotypic Cell-cell Adhesion Cell Junction Assembly Response To Gonadotropin Negative Regulation Of Rho Protein Signal Transduction Response To Drug Positive Regulation Of Apoptotic Process Stress Fiber Assembly Positive Regulation Of MAPK Cascade Sarcomere Organization Negative Regulation Of Neuron Differentiation Positive Regulation Of Endocytosis Mesodermal Cell Differentiation Axon Extension Dendrite Morphogenesis Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Immune Response Leukocyte Migration Leukocyte Tethering Or Rolling Regulation Of Cell Cycle Cardiac Muscle Cell Differentiation Maternal Process Involved In Female Pregnancy Tight Junction Assembly Cellular Response To Mechanical Stimulus Cellular Response To Vitamin D Cellular Response To Ionizing Radiation Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane Negative Regulation Of Anoikis
Pathways		G alpha (q) signalling events Signaling by GPCR Signaling by FGFR in disease Phospholipase C-mediated cascade Signaling by EGFRvIII in Cancer Effects of PIP2 hydrolysis PLCG1 events in ERBB2 signaling DAG and IP3 signaling DAP12 signaling Gastrin-CREB signalling pathway via PKC and MAPK Downstream signaling of activated FGFR G alpha (z) signalling events Role of phospholipids in phagocytosis Fcgamma receptor (FCGR) dependent phagocytosis Innate Immune System Signaling by PDGF DAP12 interactions Signalling by NGF Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR EGFR interacts with phospholipase C-gamma G alpha (q) signalling events Signaling by ERBB2 Signaling by EGFR GPCR downstream signaling Downstream signal transduction PLC-gamma1 signalling Signaling by EGFR in Cancer Platelet activation, signaling and aggregation	Platelet Adhesion to exposed collagen Axon guidance Elastic fibre formation L1CAM interactions Molecules associated with elastic fibres Laminin interactions ECM proteoglycans Fibronectin matrix formation Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Localization of the PINCH-ILK-PARVIN complex to focal adhesions Cell junction organization Signal transduction by L1 Semaphorin interactions Other semaphorin interactions Non-integrin membrane-ECM interactions Basigin interactions Cell surface interactions at the vascular wall Syndecan interactions CHL1 interactions Integrin cell surface interactions Cell-extracellular matrix interactions Adaptive Immune System
Drugs
Diseases
GWAS		Hematocrit ( 19862010) Hematological and biochemical traits ( 20139978) Hemoglobin ( 19862010) Red blood cell count ( 20139978) Red blood cell traits ( 23446634 23222517)	Depression (quantitative trait) ( 20800221)
Protein-Protein Interactions		57 interactors: ACTA1 ACTC1 ADAP1 AFAP1 AKAP9 ATF2 BRAF BTK CFTR CHAT CNN1 COPB1 COPB2 DSP ELAVL1 FYN GAD1 GAD2 GJA1 GNA12 GNA13 GNB2L1 GRIN1 GRIN2D GRM5 HIST1H1A HK2 IKBKB ITGB1 ITGB2 KEAP1 KRT1 KRT18 MAP4K4 MAPK1 MAPK3 MARK2 MYH2 NANOG NUMB OPRD1 PDLIM5 PDPK1 PECAM1 PIK3CB PPP1R14A PRKD1 RAF1 RASGRP3 RPS6KB2 SLC25A4 SLC4A3 SNCA SRC TIAM1 TRPV1 VDAC1	67 interactors: ACAP1 ACTN1 ACTN4 ARHGAP5 CANX CD151 CD36 CD46 CD82 CD9 CRKL DAG1 DOK1 EPS8 FBLN1 FBXO2 FHL2 FLNA FLNB FLT4 FN1 GNB2L1 HSPD1 HSPG2 ICAM4 IGF1R ILK ITGA1 ITGA10 ITGA11 ITGA2 ITGA3 ITGA4 ITGA5 ITGA6 ITGA8 ITGA9 ITGAV ITGB1BP1 ITGB1BP2 LAMA1 LGALS1 LGALS3BP LGALS8 MAP4K4 NCKIPSD NF2 NME1 NMRK2 PDHB PLAUR PRKCA PRKCE PTK2 PXN RAB25 SLC3A2 SPP1 TGM2 TGOLN2 TIMP2 TLN1 TSPAN4 UPF2 VCAM1 VCAN YWHAB
Entrez ID		5581	3688
HPRD ID		01500	00628
Ensembl ID		ENSG00000171132	ENSG00000150093
Uniprot IDs		L7RTI5 Q02156	P05556
PDB IDs		2WH0	1K11 1LHA 3G9W 3T9K 3VI3 3VI4 4DX9
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Component Organization Developmental Process Anatomical Structure Development Apoptotic Process Signaling Programmed Cell Death Cell Differentiation Cell Communication Cell Death Response To Organic Substance Death Positive Regulation Of Protein Metabolic Process Neurotrophin TRK Receptor Signaling Pathway Regulation Of Body Fluid Levels Positive Regulation Of Cellular Protein Metabolic Process Neurotrophin Signaling Pathway Response To Growth Factor Response To Stimulus Positive Regulation Of Protein Phosphorylation Wound Healing Multicellular Organismal Development Cell-cell Signaling Cellular Response To Fibroblast Growth Factor Stimulus Platelet Activation Cell Activation Response To Fibroblast Growth Factor Fc Receptor Signaling Pathway Innate Immune Response Cellular Response To Growth Factor Stimulus Response To Wounding Immune Response-regulating Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of Phosphorylation Synaptic Transmission Positive Regulation Of Phosphorylation Regulation Of Cellular Amino Acid Metabolic Process Defense Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Modification Process Regulation Of Signaling Regulation Of Protein Phosphorylation Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Protein Metabolic Process Blood Coagulation Cell Surface Receptor Signaling Pathway Hemostasis Regulation Of Locomotion Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cellular Component Movement Movement Of Cell Or Subcellular Component	Extracellular Matrix Organization Extracellular Structure Organization Cell Adhesion Integrin-mediated Signaling Pathway Blood Coagulation Hemostasis Cell-matrix Adhesion Cell-substrate Adhesion Wound Healing Response To Wounding Regulation Of Body Fluid Levels Multicellular Organismal Development Movement Of Cell Or Subcellular Component Anatomical Structure Development Locomotion System Development Developmental Process Positive Regulation Of Cell Adhesion Regulation Of Cell Adhesion Cell Differentiation Anatomical Structure Morphogenesis Regulation Of Cellular Component Movement Positive Regulation Of Cellular Component Movement Cell Morphogenesis Involved In Differentiation Cell Migration Leukocyte Migration Cell Motility Signal Transduction Cell Junction Assembly Regulation Of Cell Migration Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Signaling Response To Stimulus Positive Regulation Of Locomotion Regulation Of Cell Motility Cell Communication Cell Activation Regulation Of Locomotion Regulation Of Cell-substrate Adhesion Platelet Activation Cell Surface Receptor Signaling Pathway Immune System Process Regulation Of Phosphorus Metabolic Process Cellular Response To Stimulus Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Regulation Of Cellular Process Cell Morphogenesis Response To Stress
Tagcloud ?		16p11 acgh actually appreciating brwd3 cnv cnvs comorbidity debated disrupt duplication electroclinical epilepsies epileptic grin2a inheritance inherited kcnc3 microdeletions microduplications neurodevelopmental novo prrt2 re res rolandic shank1 speech tspan7	124a aia ameliorated analogue ankle arthritis ccaat destruction freund hind histopathology incomplete injecting killed leucocyte lewis luciferase micrornas mir nfatc1 osteoclasts prerequisites rankl raw264 rheumatoid rnas synoviocyte tartrate utr
Tagcloud (Difference) ?		16p11 acgh actually appreciating brwd3 cnv cnvs comorbidity debated disrupt duplication electroclinical epilepsies epileptic grin2a inheritance inherited kcnc3 microdeletions microduplications neurodevelopmental novo prrt2 re res rolandic shank1 speech tspan7	124a aia ameliorated analogue ankle arthritis ccaat destruction freund hind histopathology incomplete injecting killed leucocyte lewis luciferase micrornas mir nfatc1 osteoclasts prerequisites rankl raw264 rheumatoid rnas synoviocyte tartrate utr
Tagcloud (Intersection) ?