PRKCE and ITGB1

Number of citations of the paper that reports this interaction (PubMedID 15949469)
0

Data Source:
HPRD (in vitro)

		PRKCE	ITGB1
Description		protein kinase C epsilon	integrin subunit beta 1
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Endoplasmic Reticulum Golgi Apparatus Cytosol Cytoskeleton Plasma Membrane Membrane Intermediate Filament Cytoskeleton Synapse Perinuclear Region Of Cytoplasm Cell Periphery	Ruffle Cytoplasm Endosome Plasma Membrane Focal Adhesion Integrin Complex External Side Of Plasma Membrane Cell Surface Endosome Membrane Intercalated Disc Membrane Lamellipodium Filopodium Cytoplasmic Vesicle Neuromuscular Junction Cleavage Furrow Ruffle Membrane Integrin Alpha1-beta1 Complex Integrin Alpha2-beta1 Complex Integrin Alpha3-beta1 Complex Integrin Alpha4-beta1 Complex Integrin Alpha5-beta1 Complex Integrin Alpha6-beta1 Complex Integrin Alpha7-beta1 Complex Integrin Alpha8-beta1 Complex Integrin Alpha9-beta1 Complex Integrin Alpha10-beta1 Complex Integrin Alpha11-beta1 Complex Integrin Alphav-beta1 Complex Myelin Sheath Abaxonal Region Sarcolemma Melanosome Cell Projection Dendritic Spine Receptor Complex Membrane Raft Synapse Perinuclear Region Of Cytoplasm Recycling Endosome Extracellular Exosome Anchoring Junction Synaptic Membrane Glial Cell Projection Schaffer Collateral - CA1 Synapse Glutamatergic Synapse Cerebellar Climbing Fiber To Purkinje Cell Synapse
	Molecular Function	Nucleotide Binding Actin Monomer Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Diacylglycerol-dependent Serine/threonine Kinase Activity Diacylglycerol-dependent, Calcium-independent Serine/threonine Kinase Activity Protein Binding ATP Binding Enzyme Activator Activity Zinc Ion Binding Kinase Activity Transferase Activity Enzyme Binding Signaling Receptor Activator Activity Ethanol Binding Metal Ion Binding 14-3-3 Protein Binding Protein Serine Kinase Activity	Magnesium Ion Binding Virus Receptor Activity Fibronectin Binding Protease Binding Actin Binding Integrin Binding Calcium Ion Binding Protein Binding Coreceptor Activity Protein Kinase Binding C-X3-C Chemokine Binding Signaling Receptor Activity Laminin Binding Protein-containing Complex Binding Cadherin Binding Metal Ion Binding Protein Heterodimerization Activity Cell Adhesion Molecule Binding Collagen Binding Involved In Cell-matrix Adhesion Integrin Binding Involved In Cell-matrix Adhesion Protein Tyrosine Kinase Binding
	Biological Process	MAPK Cascade Macrophage Activation Involved In Immune Response Immune System Process Apoptotic Process Cell Adhesion Signal Transduction Toxin Catabolic Process Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Fibroblast Migration Positive Regulation Of Cell-substrate Adhesion Regulation Of Metal Ion Transport Peptidyl-serine Phosphorylation Regulation Of Lipid Metabolic Process Insulin Secretion Positive Regulation Of Actin Filament Polymerization Negative Regulation Of Protein Ubiquitination Cell-substrate Adhesion Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Insulin Secretion Positive Regulation Of Synaptic Transmission, GABAergic Positive Regulation Of Cytokinesis Positive Regulation Of Superoxide Anion Generation Intracellular Signal Transduction Locomotory Exploration Behavior TRAM-dependent Toll-like Receptor 4 Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Xenobiotic Catabolic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Response To Morphine Positive Regulation Of MAPK Cascade Positive Regulation Of Lipid Catabolic Process Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Cell Division Establishment Of Localization In Cell Synaptic Transmission, GABAergic Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Mucus Secretion Positive Regulation Of Mucus Secretion Cellular Response To Ethanol Cellular Response To Prostaglandin E Stimulus Cellular Response To Hypoxia Positive Regulation Of Wound Healing Negative Regulation Of Sodium Ion Transmembrane Transport Positive Regulation Of Protein Localization To Plasma Membrane Regulation Of Monoatomic Cation Transmembrane Transport	G1/S Transition Of Mitotic Cell Cycle Establishment Of Mitotic Spindle Orientation Angiogenesis In Utero Embryonic Development Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Neuroblast Proliferation Phagocytosis Cellular Defense Response Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Leukocyte Cell-cell Adhesion Cell-matrix Adhesion Calcium-independent Cell-matrix Adhesion Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Neuroblast Proliferation Muscle Organ Development Myoblast Fusion Cell Population Proliferation Germ Cell Migration Visual Learning Regulation Of Collagen Catabolic Process Positive Regulation Of Fibroblast Migration Response To Muscle Activity Cell Migration Formation Of Radial Glial Scaffolds Central Nervous System Neuron Differentiation CD40 Signaling Pathway Cell Projection Organization Lamellipodium Assembly B Cell Differentiation Extracellular Matrix Organization Positive Regulation Of Cell Migration Neuron Projection Development Cell-substrate Adhesion Receptor Internalization Cell Adhesion Mediated By Integrin Cell-cell Adhesion Mediated By Integrin Heterotypic Cell-cell Adhesion Negative Regulation Of Rho Protein Signal Transduction Wound Healing, Spreading Of Epidermal Cells Maintenance Of Blood-brain Barrier Positive Regulation Of Apoptotic Process Stress Fiber Assembly Positive Regulation Of GTPase Activity Sarcomere Organization Myoblast Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Angiogenesis Negative Regulation Of Vasoconstriction Symbiont Entry Into Host Cell Mesodermal Cell Differentiation Myoblast Fate Specification Axon Extension Dendrite Morphogenesis Regulation Of Developmental Process Modulation Of Chemical Synaptic Transmission Leukocyte Tethering Or Rolling Regulation Of Cell Cycle Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Glutamate Uptake Involved In Transmission Of Nerve Impulse Cardiac Muscle Cell Differentiation Cardiac Muscle Cell Myoblast Differentiation Cardiac Cell Fate Specification Regulation Of Biological Quality Cellular Response To Low-density Lipoprotein Particle Stimulus Basement Membrane Organization Positive Regulation Of Wound Healing Cell-cell Adhesion Regulation Of Spontaneous Synaptic Transmission Reactive Gliosis Positive Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Protein Localization To Plasma Membrane Regulation Of Synapse Pruning Negative Regulation Of Anoikis
Pathways		Effects of PIP2 hydrolysis SHC1 events in ERBB2 signaling DAG and IP3 signaling Role of phospholipids in phagocytosis G alpha (z) signalling events	Elastic fibre formation Fibronectin matrix formation Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Cell surface interactions at the vascular wall Basigin interactions Molecules associated with elastic fibres Integrin cell surface interactions Integrin cell surface interactions TGF-beta receptor signaling activates SMADs Laminin interactions Laminin interactions Syndecan interactions ECM proteoglycans Other semaphorin interactions Signal transduction by L1 Localization of the PINCH-ILK-PARVIN complex to focal adhesions CHL1 interactions RHO GTPases Activate Formins Interleukin-4 and Interleukin-13 signaling Platelet Adhesion to exposed collagen MET activates PTK2 signaling MET interacts with TNS proteins RAC1 GTPase cycle RAC2 GTPase cycle RHOG GTPase cycle RAC3 GTPase cycle HCMV Early Events GPER1 signaling Potential therapeutics for SARS Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin Formation of the ureteric bud Mechanical load activates signaling by PIEZO1 and integrins in osteocytes Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells Developmental Lineage of Mammary Gland Luminal Epithelial Cells Developmental Lineage of Mammary Gland Myoepithelial Cells Developmental Lineage of Mammary Stem Cells
Drugs		Tamoxifen Staurosporine Dequalinium KAI-1455 Benzoyl peroxide Bryostatin 1 Fostamatinib	Antithymocyte immunoglobulin (rabbit) MK-0668 PLN-74809
Diseases
GWAS		Appendicular lean mass ( 33097823) Body mass index ( 28552196) Carotenoid levels (alpha-carotene) ( 28002826) Cerebral amyloid deposition in APOEe4 non-carriers (PET imaging) ( 26252872) Coronary artery disease ( 33020668 29212778) Corpus callosum posterior volume ( 31530798) Craniofacial microsomia ( 26853712) Diastolic blood pressure ( 30578418 28135244) Diisocyanate-induced asthma ( 25918132) Heel bone mineral density ( 30598549) Hematocrit ( 32888494 29403010 19862010 27863252 28453575 28017375) Hematological and biochemical traits ( 31902109 20139978) Hemoglobin ( 19862010 28453575 32888494 29403010) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 28017375 32327693) High light scatter reticulocyte count ( 27863252 32888494) LDL cholesterol ( 30275531) Metabolite levels ( 23823483) Metabolite levels (X-11787) ( 23934736) Monocyte count ( 32888494) Pathological gambling ( 27315593) Platelet count ( 32888494) Plateletcrit ( 32888494) Premature menopause in childhood cancer survivors ( 29432556) Pulse pressure ( 27841878 30578418 28135244) Red blood cell count ( 32888494 20139978 29403010 28017375 27863252) Red blood cell traits ( 23446634 23222517) Response to zileuton treatment in asthma (FEV1 change interaction) ( 26031901) Reticulocyte count ( 32888494) Suicide risk ( 21041247) Systolic blood pressure ( 30578418) Total cholesterol levels ( 30275531) Triiodothyronine levels ( 30824882) Two-hour glucose in pregnancy (gestational week 30-32) ( 30324795) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683) Weight ( 28552196) White blood cell count ( 32888494)	Depression (quantitative trait) ( 20800221) Suicide in bipolar disorder ( 25917933)
Interacting Genes		59 interacting genes: ACTA1 ACTC1 ADAP1 AFAP1 AKAP9 ATF2 BRAF BTK CFTR CHAT CNN1 COPB1 COPB2 DSP EGFR ELAVL1 FYN GAD1 GAD2 GJA1 GNA12 GNA13 GRIN1 GRIN2D GRM5 H1-1 HK2 IKBKB ITGB1 ITGB2 KRT1 KRT18 MAP4K4 MAPK1 MAPK3 MAPT MARK2 MYH2 NANOG NUMB OPRD1 PDLIM5 PDPK1 PECAM1 PIK3CB PPP1R14A PRKD1 RACK1 RAD9A RAF1 RASGRP3 RPS6KB2 SLC25A4 SLC4A3 SNCA SRC TIAM1 TRPV1 VDAC1	80 interacting genes: ACAP1 ACTN1 ACTN4 ARHGAP5 CANX CD151 CD274 CD36 CD46 CD82 CD9 CD93 COL18A1 CRKL DAG1 DOK1 EGFR ENO1 EPS8 FBLN1 FBXO2 FERMT1 FERMT2 FERMT3 FHL2 FLNA FLNB FLT4 FN1 HSPD1 HSPG2 ICAM4 IGF1R ILK ITGA1 ITGA10 ITGA11 ITGA2 ITGA3 ITGA4 ITGA5 ITGA6 ITGA8 ITGA9 ITGAV ITGB1BP1 ITGB1BP2 LAMA1 LAMTOR5 LGALS1 LGALS3BP LGALS8 MAP4K4 MET NCKIPSD NF2 NGF NME1 NMRK2 PDHB PIP5K1C PLAUR PRKCA PRKCE PTK2 PXN RAB25 RACK1 SLC3A2 SPP1 TGM2 TGOLN2 TIMP2 TLN1 TSPAN4 TSPAN7 UPF2 VCAM1 VCAN YWHAB
Entrez ID		5581	3688
HPRD ID		01500	00628
Ensembl ID		ENSG00000171132	ENSG00000150093
Uniprot IDs		L7RTI5 Q02156	P05556
PDB IDs		2WH0 5LIH	3G9W 3T9K 3VI3 3VI4 4DX9 4WJK 4WK0 4WK2 4WK4 7CEB 7CEC 7NWL 7NXD 8RPQ 8W30 9B9J 9B9K 9CKV
Enriched GO Terms of Interacting Partners?		Regulation Of Biological Quality Intracellular Signaling Cassette Focal Adhesion Cytoplasm Regulation Of Anatomical Structure Morphogenesis Phosphorylation Plasma Membrane Regulation Of Developmental Process Protein Phosphorylation Regulation Of Multicellular Organismal Process Kinase Activity Membrane Raft Regulation Of Membrane Potential Intracellular Signal Transduction ATP Binding Nucleotide Binding Regulation Of Transport Protein Kinase Activity Regulation Of Locomotion Regulation Of Cell Migration Regulation Of Vesicle-mediated Transport Regulation Of Cell Motility Positive Regulation Of Cell Communication Positive Regulation Of Signaling Phospholipase Binding ERBB Signaling Pathway Response To Growth Factor Cell Surface Receptor Signaling Pathway ERBB2 Signaling Pathway Regulation Of Cellular Localization Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Intracellular Signal Transduction Protein Serine Kinase Activity Regulation Of Signal Transduction Regulation Of Cellular Component Organization Phospholipase Activator Activity Positive Regulation Of Cell Migration Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Motility Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Locomotion MAPK Cascade Cell-cell Signaling Chemical Synaptic Transmission Cytoskeleton Organization Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Apoptotic Process Scaffold Protein Binding Positive Regulation Of Signal Transduction	Integrin Binding Focal Adhesion Cell Adhesion Integrin-mediated Signaling Pathway Cell-matrix Adhesion Cell-substrate Adhesion Regulation Of Cell Adhesion Positive Regulation Of Cell Adhesion Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Regulation Of Cell Migration Integrin Complex Regulation Of Cell Motility Regulation Of Locomotion Cell Surface Regulation Of Cell-substrate Adhesion Plasma Membrane Cell Migration Positive Regulation Of Cell-substrate Adhesion Cell-cell Adhesion Cell Surface Receptor Signaling Pathway Cell Motility Signal Transduction Regulation Of Cell Population Proliferation Regulation Of Cell Communication Regulation Of Signal Transduction Positive Regulation Of Cell Population Proliferation Anchoring Junction Regulation Of Signaling Regulation Of Intracellular Signal Transduction Regulation Of Programmed Cell Death Regulation Of Multicellular Organismal Process Extracellular Exosome Signaling Receptor Activity Substrate Adhesion-dependent Cell Spreading Regulation Of Apoptotic Process Membrane Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Cell Communication Cell-substrate Junction Assembly Anatomical Structure Morphogenesis Cell-substrate Junction Organization Integrin Activation Positive Regulation Of Signal Transduction Ruffle Membrane Regulation Of Cellular Component Organization Collagen Binding Involved In Cell-matrix Adhesion Positive Regulation Of Signaling Positive Regulation Of Cellular Component Organization
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