PRKCE and COPB2

Number of citations of the paper that reports this interaction (PMID 9360998)
50

Data Source:
HPRD (in vitro)

		PRKCE	COPB2
Gene Name		protein kinase C, epsilon	coatomer protein complex, subunit beta 2 (beta prime)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Endoplasmic Reticulum Golgi Apparatus Cytosol Cytoskeleton Plasma Membrane Perinuclear Region Of Cytoplasm Cell Periphery	Cytosol COPI Vesicle Coat
	Molecular Function	Actin Monomer Binding Protein Serine/threonine Kinase Activity Protein Kinase C Activity Calcium-independent Protein Kinase C Activity Signal Transducer Activity Protein Binding ATP Binding Enzyme Activator Activity Enzyme Binding Receptor Activator Activity Ethanol Binding Metal Ion Binding 14-3-3 Protein Binding	Structural Molecule Activity
	Biological Process	Macrophage Activation Involved In Immune Response Protein Phosphorylation Apoptotic Process Cell Cycle Cell Adhesion Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Activation Of Phospholipase C Activity Blood Coagulation Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Fibroblast Migration Positive Regulation Of Cell-substrate Adhesion Peptidyl-serine Phosphorylation Platelet Activation Positive Regulation Of Actin Filament Polymerization Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Insulin Secretion Positive Regulation Of Synaptic Transmission, GABAergic Positive Regulation Of Cytokinesis Intracellular Signal Transduction Locomotory Exploration Behavior TRAM-dependent Toll-like Receptor 4 Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Morphine Positive Regulation Of MAPK Cascade Innate Immune Response Neurotrophin TRK Receptor Signaling Pathway Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Lipid Catabolic Process Release Of Sequestered Calcium Ion Into Cytosol Cell Division Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Mucus Secretion Cellular Response To Ethanol Cellular Response To Hypoxia Positive Regulation Of Wound Healing Positive Regulation Of Receptor Activity Negative Regulation Of Sodium Ion Transmembrane Transporter Activity Positive Regulation Of Cellular Glucuronidation	Intracellular Protein Transport Retrograde Vesicle-mediated Transport, Golgi To ER Intra-Golgi Vesicle-mediated Transport COPI Coating Of Golgi Vesicle Membrane Organization
Pathways		G alpha (q) signalling events Signaling by GPCR Signaling by FGFR in disease Phospholipase C-mediated cascade Signaling by EGFRvIII in Cancer Effects of PIP2 hydrolysis PLCG1 events in ERBB2 signaling DAG and IP3 signaling DAP12 signaling Gastrin-CREB signalling pathway via PKC and MAPK Downstream signaling of activated FGFR G alpha (z) signalling events Role of phospholipids in phagocytosis Fcgamma receptor (FCGR) dependent phagocytosis Innate Immune System Signaling by PDGF DAP12 interactions Signalling by NGF Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR EGFR interacts with phospholipase C-gamma G alpha (q) signalling events Signaling by ERBB2 Signaling by EGFR GPCR downstream signaling Downstream signal transduction PLC-gamma1 signalling Signaling by EGFR in Cancer Platelet activation, signaling and aggregation	COPI Mediated Transport Golgi to ER Retrograde Transport
Drugs
Diseases
GWAS		Hematocrit ( 19862010) Hematological and biochemical traits ( 20139978) Hemoglobin ( 19862010) Red blood cell count ( 20139978) Red blood cell traits ( 23446634 23222517)	Kawasaki disease ( 22446961)
Protein-Protein Interactions		57 interactors: ACTA1 ACTC1 ADAP1 AFAP1 AKAP9 ATF2 BRAF BTK CFTR CHAT CNN1 COPB1 COPB2 DSP ELAVL1 FYN GAD1 GAD2 GJA1 GNA12 GNA13 GNB2L1 GRIN1 GRIN2D GRM5 HIST1H1A HK2 IKBKB ITGB1 ITGB2 KEAP1 KRT1 KRT18 MAP4K4 MAPK1 MAPK3 MARK2 MYH2 NANOG NUMB OPRD1 PDLIM5 PDPK1 PECAM1 PIK3CB PPP1R14A PRKD1 RAF1 RASGRP3 RPS6KB2 SLC25A4 SLC4A3 SNCA SRC TIAM1 TRPV1 VDAC1	10 interactors: ARCN1 COPA COPE NDRG1 NFKB1 PRKCE RGS2 RGS4 SACM1L TMED10
Entrez ID		5581	9276
HPRD ID		01500	06103
Ensembl ID		ENSG00000171132	ENSG00000184432
Uniprot IDs		L7RTI5 Q02156	P35606
PDB IDs		2WH0
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Component Organization Developmental Process Anatomical Structure Development Apoptotic Process Signaling Programmed Cell Death Cell Differentiation Cell Communication Cell Death Response To Organic Substance Death Positive Regulation Of Protein Metabolic Process Neurotrophin TRK Receptor Signaling Pathway Regulation Of Body Fluid Levels Positive Regulation Of Cellular Protein Metabolic Process Neurotrophin Signaling Pathway Response To Growth Factor Response To Stimulus Positive Regulation Of Protein Phosphorylation Wound Healing Multicellular Organismal Development Cell-cell Signaling Cellular Response To Fibroblast Growth Factor Stimulus Platelet Activation Cell Activation Response To Fibroblast Growth Factor Fc Receptor Signaling Pathway Innate Immune Response Cellular Response To Growth Factor Stimulus Response To Wounding Immune Response-regulating Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of Phosphorylation Synaptic Transmission Positive Regulation Of Phosphorylation Regulation Of Cellular Amino Acid Metabolic Process Defense Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Modification Process Regulation Of Signaling Regulation Of Protein Phosphorylation Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Protein Metabolic Process Blood Coagulation Cell Surface Receptor Signaling Pathway Hemostasis Regulation Of Locomotion Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cellular Component Movement Movement Of Cell Or Subcellular Component	COPI-coated Vesicle Budding COPI Coating Of Golgi Vesicle Golgi Vesicle Budding Vesicle Targeting, To, From Or Within Golgi Retrograde Vesicle-mediated Transport, Golgi To ER Localization Within Membrane Vesicle Targeting Membrane Budding Establishment Of Vesicle Localization Vesicle Organization Vesicle Localization Golgi Vesicle Transport Establishment Of Organelle Localization Membrane Organization Organelle Localization Response To Alkaloid Vesicle-mediated Transport Intracellular Transport Termination Of G-protein Coupled Receptor Signaling Pathway Termination Of Signal Transduction MyD88-independent Toll-like Receptor Signaling Pathway Positive Regulation Of Cellular Glucuronidation Cerebellar Purkinje Cell Layer Maturation Negative Regulation Of Interleukin-12 Biosynthetic Process Toll-like Receptor 4 Signaling Pathway Negative Regulation Of MAP Kinase Activity Regulation Of Phospholipase Activity Establishment Of Localization In Cell Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels ER To Golgi Vesicle-mediated Transport TRAM-dependent Toll-like Receptor 4 Signaling Pathway Toll-like Receptor Signaling Pathway Cellular Response To Oxygen Levels Regulation Of Protein Metabolic Process Positive Regulation Of Protein Polymerization Negative Regulation Of Calcidiol 1-monooxygenase Activity Positive Regulation Of Hyaluronan Biosynthetic Process Cerebellum Maturation Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Negative Regulation Of Protein Serine/threonine Kinase Activity Activation Of Innate Immune Response Cellular Localization Regulation Of Carbohydrate Metabolic Process Regulation Of MAPK Cascade Cellular Response To Lipopolysaccharide Protein Transport Negative Regulation Of MAPK Cascade
Tagcloud ?		16p11 acgh actually appreciating brwd3 cnv cnvs comorbidity debated disrupt duplication electroclinical epilepsies epileptic grin2a inheritance inherited kcnc3 microdeletions microduplications neurodevelopmental novo prrt2 re res rolandic shank1 speech tspan7	addiction axonogenesis bnip4 camk1gammab candidates classes cns dao dendritogenesis deregulation differentially dopaminergic glutamatergic grb2 great grik indicative magi1b morphine mu neurotransmission opioid otpb patterning serotonergic sox19b whose wls zebrafish
Tagcloud (Difference) ?		16p11 acgh actually appreciating brwd3 cnv cnvs comorbidity debated disrupt duplication electroclinical epilepsies epileptic grin2a inheritance inherited kcnc3 microdeletions microduplications neurodevelopmental novo prrt2 re res rolandic shank1 speech tspan7	addiction axonogenesis bnip4 camk1gammab candidates classes cns dao dendritogenesis deregulation differentially dopaminergic glutamatergic grb2 great grik indicative magi1b morphine mu neurotransmission opioid otpb patterning serotonergic sox19b whose wls zebrafish
Tagcloud (Intersection) ?