PRKCE and PECAM1

Number of citations of the paper that reports this interaction (PMID 10801826)
16

Data Source:
HPRD (in vitro)

		PRKCE	PECAM1
Gene Name		protein kinase C, epsilon	platelet/endothelial cell adhesion molecule 1
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Endoplasmic Reticulum Golgi Apparatus Cytosol Cytoskeleton Plasma Membrane Perinuclear Region Of Cytoplasm Cell Periphery	Extracellular Space Plasma Membrane Integral Component Of Membrane Cell Junction Platelet Alpha Granule Membrane Extracellular Vesicular Exosome
	Molecular Function	Actin Monomer Binding Protein Serine/threonine Kinase Activity Protein Kinase C Activity Calcium-independent Protein Kinase C Activity Signal Transducer Activity Protein Binding ATP Binding Enzyme Activator Activity Enzyme Binding Receptor Activator Activity Ethanol Binding Metal Ion Binding 14-3-3 Protein Binding	Protein Binding
	Biological Process	Macrophage Activation Involved In Immune Response Protein Phosphorylation Apoptotic Process Cell Cycle Cell Adhesion Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Activation Of Phospholipase C Activity Blood Coagulation Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Fibroblast Migration Positive Regulation Of Cell-substrate Adhesion Peptidyl-serine Phosphorylation Platelet Activation Positive Regulation Of Actin Filament Polymerization Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Insulin Secretion Positive Regulation Of Synaptic Transmission, GABAergic Positive Regulation Of Cytokinesis Intracellular Signal Transduction Locomotory Exploration Behavior TRAM-dependent Toll-like Receptor 4 Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Morphine Positive Regulation Of MAPK Cascade Innate Immune Response Neurotrophin TRK Receptor Signaling Pathway Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Lipid Catabolic Process Release Of Sequestered Calcium Ion Into Cytosol Cell Division Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Mucus Secretion Cellular Response To Ethanol Cellular Response To Hypoxia Positive Regulation Of Wound Healing Positive Regulation Of Receptor Activity Negative Regulation Of Sodium Ion Transmembrane Transporter Activity Positive Regulation Of Cellular Glucuronidation	Platelet Degranulation Phagocytosis Cell Adhesion Signal Transduction Blood Coagulation Cell Recognition Platelet Activation Extracellular Matrix Organization Leukocyte Migration Diapedesis Glomerular Endothelium Development
Pathways		G alpha (q) signalling events Signaling by GPCR Signaling by FGFR in disease Phospholipase C-mediated cascade Signaling by EGFRvIII in Cancer Effects of PIP2 hydrolysis PLCG1 events in ERBB2 signaling DAG and IP3 signaling DAP12 signaling Gastrin-CREB signalling pathway via PKC and MAPK Downstream signaling of activated FGFR G alpha (z) signalling events Role of phospholipids in phagocytosis Fcgamma receptor (FCGR) dependent phagocytosis Innate Immune System Signaling by PDGF DAP12 interactions Signalling by NGF Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR EGFR interacts with phospholipase C-gamma G alpha (q) signalling events Signaling by ERBB2 Signaling by EGFR GPCR downstream signaling Downstream signal transduction PLC-gamma1 signalling Signaling by EGFR in Cancer Platelet activation, signaling and aggregation	Platelet homeostasis Platelet sensitization by LDL Response to elevated platelet cytosolic Ca2+ Platelet degranulation Integrin cell surface interactions Platelet activation, signaling and aggregation Cell surface interactions at the vascular wall PECAM1 interactions
Drugs
Diseases
GWAS		Hematocrit ( 19862010) Hematological and biochemical traits ( 20139978) Hemoglobin ( 19862010) Red blood cell count ( 20139978) Red blood cell traits ( 23446634 23222517)
Protein-Protein Interactions		57 interactors: ACTA1 ACTC1 ADAP1 AFAP1 AKAP9 ATF2 BRAF BTK CFTR CHAT CNN1 COPB1 COPB2 DSP ELAVL1 FYN GAD1 GAD2 GJA1 GNA12 GNA13 GNB2L1 GRIN1 GRIN2D GRM5 HIST1H1A HK2 IKBKB ITGB1 ITGB2 KEAP1 KRT1 KRT18 MAP4K4 MAPK1 MAPK3 MARK2 MYH2 NANOG NUMB OPRD1 PDLIM5 PDPK1 PECAM1 PIK3CB PPP1R14A PRKD1 RAF1 RASGRP3 RPS6KB2 SLC25A4 SLC4A3 SNCA SRC TIAM1 TRPV1 VDAC1	22 interactors: CD38 CSK CTNNB1 DSP EFNB2 FYN HCK INPP5D ITGA5 ITGB3 JUP LCK LYN PIK3R1 PLCG1 PRKCE PRPF40A PTPN11 PTPN6 SRC XRCC6 YES1
Entrez ID		5581	5175
HPRD ID		01500	01425
Ensembl ID		ENSG00000171132
Uniprot IDs		L7RTI5 Q02156	P16284
PDB IDs		2WH0	2KY5
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Component Organization Developmental Process Anatomical Structure Development Apoptotic Process Signaling Programmed Cell Death Cell Differentiation Cell Communication Cell Death Response To Organic Substance Death Positive Regulation Of Protein Metabolic Process Neurotrophin TRK Receptor Signaling Pathway Regulation Of Body Fluid Levels Positive Regulation Of Cellular Protein Metabolic Process Neurotrophin Signaling Pathway Response To Growth Factor Response To Stimulus Positive Regulation Of Protein Phosphorylation Wound Healing Multicellular Organismal Development Cell-cell Signaling Cellular Response To Fibroblast Growth Factor Stimulus Platelet Activation Cell Activation Response To Fibroblast Growth Factor Fc Receptor Signaling Pathway Innate Immune Response Cellular Response To Growth Factor Stimulus Response To Wounding Immune Response-regulating Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of Phosphorylation Synaptic Transmission Positive Regulation Of Phosphorylation Regulation Of Cellular Amino Acid Metabolic Process Defense Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Modification Process Regulation Of Signaling Regulation Of Protein Phosphorylation Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Protein Metabolic Process Blood Coagulation Cell Surface Receptor Signaling Pathway Hemostasis Regulation Of Locomotion Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cellular Component Movement Movement Of Cell Or Subcellular Component	Cell Migration Cell Motility Leukocyte Migration Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Locomotion Blood Coagulation Hemostasis Wound Healing Immune Response-regulating Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Movement Of Cell Or Subcellular Component Response To Wounding Regulation Of Body Fluid Levels T Cell Costimulation Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Lymphocyte Activation Cellular Response To Peptide Hormone Stimulus Innate Immune Response Positive Regulation Of Cell Activation Immune System Process Cellular Response To Peptide Cellular Response To Organonitrogen Compound Positive Regulation Of Immune Response Regulation Of Cell Activation Regulation Of Immune Response Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Immune System Process Peptidyl-tyrosine Autophosphorylation Positive Regulation Of Cell Adhesion Regulation Of Immune System Process Immune Response Fc Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Response To Organonitrogen Compound Regulation Of T Cell Activation Regulation Of Cell Adhesion Response To Peptide Hormone Platelet Activation Response To Peptide Positive Regulation Of T Cell Activation Response To Stress Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Signal Transduction Regulation Of Cell-cell Adhesion Positive Regulation Of Cell-cell Adhesion Viral Process Defense Response Cellular Response To Hormone Stimulus Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Tagcloud ?		16p11 acgh actually appreciating brwd3 cnv cnvs comorbidity debated disrupt duplication electroclinical epilepsies epileptic grin2a inheritance inherited kcnc3 microdeletions microduplications neurodevelopmental novo prrt2 re res rolandic shank1 speech tspan7	alox15 ccl5 chd consisted cx37 cyp1a1 fcgr2a gpx1 harvested indian meta odd ppard rest retrieved rs1042522 rs1050450 rs1131012 rs12953 rs1764391 rs1801274 rs2016520 rs2107538 rs2228315 rs34210653 rs4646903 rs668 selplg variants
Tagcloud (Difference) ?		16p11 acgh actually appreciating brwd3 cnv cnvs comorbidity debated disrupt duplication electroclinical epilepsies epileptic grin2a inheritance inherited kcnc3 microdeletions microduplications neurodevelopmental novo prrt2 re res rolandic shank1 speech tspan7	alox15 ccl5 chd consisted cx37 cyp1a1 fcgr2a gpx1 harvested indian meta odd ppard rest retrieved rs1042522 rs1050450 rs1131012 rs12953 rs1764391 rs1801274 rs2016520 rs2107538 rs2228315 rs34210653 rs4646903 rs668 selplg variants
Tagcloud (Intersection) ?