PRKCE and SLC25A4

Number of citations of the paper that reports this interaction (PMID 12663490)
95

Data Source:
HPRD (in vivo)

		PRKCE	SLC25A4
Gene Name		protein kinase C, epsilon	solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Endoplasmic Reticulum Golgi Apparatus Cytosol Cytoskeleton Plasma Membrane Perinuclear Region Of Cytoplasm Cell Periphery	Nucleus Mitochondrion Mitochondrial Inner Membrane Integral Component Of Plasma Membrane
	Molecular Function	Actin Monomer Binding Protein Serine/threonine Kinase Activity Protein Kinase C Activity Calcium-independent Protein Kinase C Activity Signal Transducer Activity Protein Binding ATP Binding Enzyme Activator Activity Enzyme Binding Receptor Activator Activity Ethanol Binding Metal Ion Binding 14-3-3 Protein Binding	Protein Binding Adenine Transmembrane Transporter Activity
	Biological Process	Macrophage Activation Involved In Immune Response Protein Phosphorylation Apoptotic Process Cell Cycle Cell Adhesion Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Activation Of Phospholipase C Activity Blood Coagulation Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Fibroblast Migration Positive Regulation Of Cell-substrate Adhesion Peptidyl-serine Phosphorylation Platelet Activation Positive Regulation Of Actin Filament Polymerization Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Insulin Secretion Positive Regulation Of Synaptic Transmission, GABAergic Positive Regulation Of Cytokinesis Intracellular Signal Transduction Locomotory Exploration Behavior TRAM-dependent Toll-like Receptor 4 Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Morphine Positive Regulation Of MAPK Cascade Innate Immune Response Neurotrophin TRK Receptor Signaling Pathway Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Lipid Catabolic Process Release Of Sequestered Calcium Ion Into Cytosol Cell Division Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Mucus Secretion Cellular Response To Ethanol Cellular Response To Hypoxia Positive Regulation Of Wound Healing Positive Regulation Of Receptor Activity Negative Regulation Of Sodium Ion Transmembrane Transporter Activity Positive Regulation Of Cellular Glucuronidation	Mitochondrial Genome Maintenance Generation Of Precursor Metabolites And Energy Energy Reserve Metabolic Process Transport Apoptotic Mitochondrial Changes Adenine Transport Viral Process Small Molecule Metabolic Process Regulation Of Insulin Secretion Transmembrane Transport Negative Regulation Of Necroptotic Process
Pathways		G alpha (q) signalling events Signaling by GPCR Signaling by FGFR in disease Phospholipase C-mediated cascade Signaling by EGFRvIII in Cancer Effects of PIP2 hydrolysis PLCG1 events in ERBB2 signaling DAG and IP3 signaling DAP12 signaling Gastrin-CREB signalling pathway via PKC and MAPK Downstream signaling of activated FGFR G alpha (z) signalling events Role of phospholipids in phagocytosis Fcgamma receptor (FCGR) dependent phagocytosis Innate Immune System Signaling by PDGF DAP12 interactions Signalling by NGF Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR EGFR interacts with phospholipase C-gamma G alpha (q) signalling events Signaling by ERBB2 Signaling by EGFR GPCR downstream signaling Downstream signal transduction PLC-gamma1 signalling Signaling by EGFR in Cancer Platelet activation, signaling and aggregation	Integration of energy metabolism Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization HIV Infection Regulation of insulin secretion Host Interactions of HIV factors Mitochondrial protein import Interactions of Vpr with host cellular proteins
Drugs			Adenosine triphosphate Clodronate [3-(Dodecanoylamino)Propyl](Hydroxy)Dimethylammonium Carboxyatractyloside Cardiolipin Di-Stearoyl-3-Sn-Phosphatidylcholine
Diseases
GWAS		Hematocrit ( 19862010) Hematological and biochemical traits ( 20139978) Hemoglobin ( 19862010) Red blood cell count ( 20139978) Red blood cell traits ( 23446634 23222517)
Protein-Protein Interactions		57 interactors: ACTA1 ACTC1 ADAP1 AFAP1 AKAP9 ATF2 BRAF BTK CFTR CHAT CNN1 COPB1 COPB2 DSP ELAVL1 FYN GAD1 GAD2 GJA1 GNA12 GNA13 GNB2L1 GRIN1 GRIN2D GRM5 HIST1H1A HK2 IKBKB ITGB1 ITGB2 KEAP1 KRT1 KRT18 MAP4K4 MAPK1 MAPK3 MARK2 MYH2 NANOG NUMB OPRD1 PDLIM5 PDPK1 PECAM1 PIK3CB PPP1R14A PRKD1 RAF1 RASGRP3 RPS6KB2 SLC25A4 SLC4A3 SNCA SRC TIAM1 TRPV1 VDAC1	7 interactors: AR BAX NFKBIA NR3C1 PPID PPIF PRKCE
Entrez ID		5581	291
HPRD ID		01500	00058
Ensembl ID		ENSG00000171132	ENSG00000151729
Uniprot IDs		L7RTI5 Q02156	P12235
PDB IDs		2WH0
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Component Organization Developmental Process Anatomical Structure Development Apoptotic Process Signaling Programmed Cell Death Cell Differentiation Cell Communication Cell Death Response To Organic Substance Death Positive Regulation Of Protein Metabolic Process Neurotrophin TRK Receptor Signaling Pathway Regulation Of Body Fluid Levels Positive Regulation Of Cellular Protein Metabolic Process Neurotrophin Signaling Pathway Response To Growth Factor Response To Stimulus Positive Regulation Of Protein Phosphorylation Wound Healing Multicellular Organismal Development Cell-cell Signaling Cellular Response To Fibroblast Growth Factor Stimulus Platelet Activation Cell Activation Response To Fibroblast Growth Factor Fc Receptor Signaling Pathway Innate Immune Response Cellular Response To Growth Factor Stimulus Response To Wounding Immune Response-regulating Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of Phosphorylation Synaptic Transmission Positive Regulation Of Phosphorylation Regulation Of Cellular Amino Acid Metabolic Process Defense Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Modification Process Regulation Of Signaling Regulation Of Protein Phosphorylation Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Protein Metabolic Process Blood Coagulation Cell Surface Receptor Signaling Pathway Hemostasis Regulation Of Locomotion Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cellular Component Movement Movement Of Cell Or Subcellular Component	Regulation Of Mitochondrial Membrane Permeability Involved In Programmed Necrotic Cell Death Regulation Of Apoptotic Process Regulation Of Cell Death Apoptotic Process Programmed Cell Death Regulation Of Cellular Localization Cellular Response To Lipid Cell Death Death Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Signal Transduction Intracellular Receptor Signaling Pathway Regulation Of Nitrogen Compound Metabolic Process Regulation Of Establishment Of Protein Localization Positive Regulation Of Release Of Cytochrome C From Mitochondria Positive Regulation Of Transport Regulation Of Signaling Regulation Of Protein Localization Negative Regulation Of Apoptotic Signaling Pathway Regulation Of Mitochondrial Membrane Permeability Regulation Of Membrane Permeability Response To Lipid Lipopolysaccharide-mediated Signaling Pathway Cellular Response To Organic Substance Immune Response-activating Cell Surface Receptor Signaling Pathway Response To Organic Cyclic Compound Negative Regulation Of Transporter Activity Negative Regulation Of Apoptotic Process Programmed Necrotic Cell Death Negative Regulation Of Programmed Cell Death Necrotic Cell Death Negative Regulation Of Cell Death Negative Regulation Of Transmembrane Transport Positive Regulation Of Mitochondrion Organization Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Neuron Apoptotic Process Cellular Response To UV Cellular Response To Stimulus Mitochondrial Membrane Organization Response To Abiotic Stimulus Negative Regulation Of Transport Intracellular Steroid Hormone Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Positive Regulation Of Organelle Organization Apoptotic Mitochondrial Changes Positive Regulation Of Neuron Death
Tagcloud ?		16p11 acgh actually appreciating brwd3 cnv cnvs comorbidity debated disrupt duplication electroclinical epilepsies epileptic grin2a inheritance inherited kcnc3 microdeletions microduplications neurodevelopmental novo prrt2 re res rolandic shank1 speech tspan7	aberrantly af anr atrial autonomic bioinformatics canine copyright dysregulated fgf19 fgf3 fgf4 fibrillation filtering inducibility lentiviruses lncrnas nearby neurogenesis orchestrators pads pipelines prolong reserved rights shorten tcons transcriptomes twofold
Tagcloud (Difference) ?		16p11 acgh actually appreciating brwd3 cnv cnvs comorbidity debated disrupt duplication electroclinical epilepsies epileptic grin2a inheritance inherited kcnc3 microdeletions microduplications neurodevelopmental novo prrt2 re res rolandic shank1 speech tspan7	aberrantly af anr atrial autonomic bioinformatics canine copyright dysregulated fgf19 fgf3 fgf4 fibrillation filtering inducibility lentiviruses lncrnas nearby neurogenesis orchestrators pads pipelines prolong reserved rights shorten tcons transcriptomes twofold
Tagcloud (Intersection) ?