DLGAP4 and NHERF2

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		DLGAP4	NHERF2
Name		DLG associated protein 4	NHERF family PDZ scaffold protein 2
Structure		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Neuromuscular Junction Synapse Glutamatergic Synapse Cholinergic Synapse Postsynaptic Specialization	Nucleus Plasma Membrane Focal Adhesion Endomembrane System Membrane Apical Plasma Membrane Extracellular Exosome
	Molecular Function	Protein Binding Molecular Adaptor Activity	Signaling Receptor Binding Protein Binding Beta-catenin Binding Phosphatase Binding Type 2 Metabotropic Glutamate Receptor Binding Type 3 Metabotropic Glutamate Receptor Binding Identical Protein Binding Protein-membrane Adaptor Activity Cadherin Binding Molecular Adaptor Activity
	Biological Process	Signaling Modulation Of Chemical Synaptic Transmission Regulation Of Synapse Maturation Modification Of Postsynaptic Structure	Protein-containing Complex Assembly Protein Localization To Plasma Membrane
Pathways		Neurexins and neuroligins Neurexins and neuroligins	None
GWAS		Low density lipoprotein cholesterol levels ( 32154731 ) Neuroblastoma or malignant cutaneous melanoma ( 31605138 )	No GWAS studies recorded
Novel Interactors		1 novel interactors: NKX2-2	1 novel interactors: IFT140
Interacting Genes		32 interacting genes: ABI2 ALDH16A1 ATPAF2 BIN1 DLG1 DLG3 DLG4 EXOC4 FHL3 FHL5 FKBP6 FYN GRIN1 GRIN2D MAGEA6 MPP7 MTUS2 NCK1 NCK2 NHERF1 NHERF2 PALS1 PLP2 PPP1R1B SH3GL2 SH3RF1 SHANK2 SHANK3 SORBS2 SYNGAP1 UBASH3A UBC	46 interacting genes: ABCC4 ACE2 ACTN4 ACVR2B ADORA2B ADRB2 ATP2B2 BRSK2 CFTR DLGAP4 EZR KCNJ1 LPAR1 LPAR2 P2RY1 PDGFRB PDPK1 PDZK1 PLCB3 PODXL PRKACA PRKCA PTEN PTH1R RDX RPS6KA1 SGK1 SGK3 SIAH1 SLC13A1 SLC22A4 SLC22A5 SLC22A9 SLC26A3 SLC34A1 SLC9A3 SLCO1A2 SLCO3A1 SRY TAFAZZIN TBC1D10A TCF7 TRAF4 UBC WWP2 WWTR1
Entrez ID		22839	9351
HPRD ID		16826	05946
Ensembl ID		ENSG00000080845	ENSG00000065054
Uniprot IDs		A0A0B4J2C2 Q9Y2H0	H3BQS0 Q15599
PDB IDs		Not available	2D11 2HE4 2OCS 4P0C
GO Terms Enriched among Interactors		Ionotropic Glutamate Receptor Binding Postsynaptic Density Learning Receptor Clustering Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Protein Localization To Membrane Regulation Of Neuronal Synaptic Plasticity Cytoskeletal Anchor Activity Positive Regulation Of Excitatory Postsynaptic Potential Localization Within Membrane Establishment Or Maintenance Of Cell Polarity Learning Or Memory Associative Learning Adherens Junction Postsynaptic Density Membrane Cognition Positive Regulation Of Actin Filament Polymerization Regulation Of Synaptic Plasticity Modulation Of Excitatory Postsynaptic Potential Glutamate Receptor Signaling Pathway Neuron Projection Phosphatase Binding Response To Glycine Type 2 Metabotropic Glutamate Receptor Binding Postsynaptic Density Organization Synapse Regulation Of Cellular Component Size Glutamatergic Synapse Positive Regulation Of Synaptic Transmission Vocalization Behavior Dendritic Spine Regulation Of Actin Filament Organization Scaffold Protein Binding Type 3 Metabotropic Glutamate Receptor Binding Postsynaptic Specialization Organization Signaling Adaptor Activity Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Protein Polymerization Lateral Loop Protein Localization To Cell Junction Regulation Of Translation Initiation In Response To Endoplasmic Reticulum Stress Synaptic Receptor Adaptor Activity Positive Regulation Of Cytoskeleton Organization Chemical Synaptic Transmission Ionotropic Glutamate Receptor Signaling Pathway Regulation Of Biological Quality Plasma Membrane MPP7-DLG1-LIN7 Complex	Apical Plasma Membrane PDZ Domain Binding Plasma Membrane Monoatomic Ion Transport Regulation Of Transport Brush Border Membrane Basolateral Plasma Membrane Regulation Of Cell Communication Regulation Of Signaling Sodium Ion Transport Regulation Of Biological Quality Membrane Regulation Of Monoatomic Ion Transport Transmembrane Transport Regulation Of Signal Transduction Positive Regulation Of Transport Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway ATP Binding Regulation Of Intracellular Signal Transduction Chloride Channel Regulator Activity Carnitine Transmembrane Transport Carnitine Transport System Process Protein Serine/threonine/tyrosine Kinase Activity Positive Regulation Of Intracellular Signal Transduction Sodium-independent Organic Anion Transport Sodium-independent Organic Anion Transmembrane Transporter Activity Circulatory System Process Amino-acid Betaine Transport Metal Ion Transport Organic Cation Transport Organic Anion Transport Protein Phosphorylation Quaternary Ammonium Group Transport Xenobiotic Transport Carboxylic Acid Transport Organic Acid Transport Nucleotide Binding Protein Kinase Activity Vascular Process In Circulatory System Phosphorylation Regulation Of MAPK Cascade Positive Regulation Of Cell Communication Positive Regulation Of Signaling Intracellular Chemical Homeostasis Protein Serine/threonine Kinase Activity Intracellular Monoatomic Cation Homeostasis Positive Regulation Of Signal Transduction Intracellular Monoatomic Ion Homeostasis