DLGAP4 and PALS1

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		DLGAP4	PALS1
Name		DLG associated protein 4	protein associated with LIN7 1, MAGUK p55 family member
Structure		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Neuromuscular Junction Synapse Glutamatergic Synapse Cholinergic Synapse Postsynaptic Specialization	Cytoplasm Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Plasma Membrane Adherens Junction Bicellular Tight Junction Endomembrane System Membrane Apical Plasma Membrane Axon Protein-containing Complex Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Myelin Sheath Adaxonal Region Cell Projection Perikaryon Lateral Loop Schmidt-Lanterman Incisure Apical Junction Complex Apical Part Of Cell Extracellular Exosome Anchoring Junction
	Molecular Function	Protein Binding Molecular Adaptor Activity	Nucleotide Binding Protein Binding ATP Binding Protein Domain Specific Binding Identical Protein Binding
	Biological Process	Signaling Modulation Of Chemical Synaptic Transmission Regulation Of Synapse Maturation Modification Of Postsynaptic Structure	Morphogenesis Of An Epithelial Sheet Plasma Membrane Organization Intracellular Protein Localization Gene Expression Establishment Or Maintenance Of Polarity Of Embryonic Epithelium Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Central Nervous System Neuron Development Cerebral Cortex Development Peripheral Nervous System Myelin Maintenance Myelin Assembly Protein Localization To Myelin Sheath Abaxonal Region Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Generation Of Neurons Protein Localization To Plasma Membrane
Pathways		Neurexins and neuroligins Neurexins and neuroligins	Tight junction interactions SARS-CoV-1 targets PDZ proteins in cell-cell junction SARS-CoV-2 targets PDZ proteins in cell-cell junction SARS-CoV-2 targets PDZ proteins in cell-cell junction
GWAS		Low density lipoprotein cholesterol levels ( 32154731 ) Neuroblastoma or malignant cutaneous melanoma ( 31605138 )	No GWAS studies recorded
Novel Interactors		1 novel interactors: NKX2-2	1 novel interactors: NEK9
Interacting Genes		32 interacting genes: ABI2 ALDH16A1 ATPAF2 BIN1 DLG1 DLG3 DLG4 EXOC4 FHL3 FHL5 FKBP6 FYN GRIN1 GRIN2D MAGEA6 MPP7 MTUS2 NCK1 NCK2 NHERF1 NHERF2 PALS1 PLP2 PPP1R1B SH3GL2 SH3RF1 SHANK2 SHANK3 SORBS2 SYNGAP1 UBASH3A UBC	14 interacting genes: ARF6 CRB3 DLGAP4 FTCD GPRASP3 LIN7A MPP4 NUMB PARD6B PATJ SNTG2 SOCS4 SRGAP2B TRAF2
Entrez ID		22839	64398
HPRD ID		16826	09508
Ensembl ID		ENSG00000080845	ENSG00000072415
Uniprot IDs		A0A0B4J2C2 Q9Y2H0	Q8N3R9
PDB IDs		Not available	1Y76 3UIT 4UU5 4UU6 4WSI 7M4R 7NTJ 7NTK 7QCS
GO Terms Enriched among Interactors		Ionotropic Glutamate Receptor Binding Postsynaptic Density Learning Receptor Clustering Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Protein Localization To Membrane Regulation Of Neuronal Synaptic Plasticity Cytoskeletal Anchor Activity Positive Regulation Of Excitatory Postsynaptic Potential Localization Within Membrane Establishment Or Maintenance Of Cell Polarity Learning Or Memory Associative Learning Adherens Junction Postsynaptic Density Membrane Cognition Positive Regulation Of Actin Filament Polymerization Regulation Of Synaptic Plasticity Modulation Of Excitatory Postsynaptic Potential Glutamate Receptor Signaling Pathway Neuron Projection Phosphatase Binding Response To Glycine Type 2 Metabotropic Glutamate Receptor Binding Postsynaptic Density Organization Synapse Regulation Of Cellular Component Size Glutamatergic Synapse Positive Regulation Of Synaptic Transmission Vocalization Behavior Dendritic Spine Regulation Of Actin Filament Organization Scaffold Protein Binding Type 3 Metabotropic Glutamate Receptor Binding Postsynaptic Specialization Organization Signaling Adaptor Activity Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Protein Polymerization Lateral Loop Protein Localization To Cell Junction Regulation Of Translation Initiation In Response To Endoplasmic Reticulum Stress Synaptic Receptor Adaptor Activity Positive Regulation Of Cytoskeleton Organization Chemical Synaptic Transmission Ionotropic Glutamate Receptor Signaling Pathway Regulation Of Biological Quality Plasma Membrane MPP7-DLG1-LIN7 Complex	Apical Part Of Cell Regulation Of Cell Junction Assembly Regulation Of Synapse Organization Bicellular Tight Junction Regulation Of Synapse Assembly Establishment Or Maintenance Of Cell Polarity Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Thioesterase Binding Cell Junction Organization Regulation Of Cellular Component Organization Apical Junction Complex Anchoring Junction Cell Cortex Cell-cell Junction Organization Tight Junction Cell Division Cell Junction Positive Regulation Of Cellular Component Biogenesis Erythrocyte Apoptotic Process TORC2 Complex Disassembly Glutamate Formimidoyltransferase Activity Formimidoyltetrahydrofolate Cyclodeaminase Activity Extracellular Exosome Regulation Of Dendritic Spine Development Glutamatergic Synapse Plasma Membrane TRAF2-GSTP1 Complex TORC1 Complex Assembly CD40 Receptor Binding L-histidine Catabolic Process To Glutamate And Formate L-histidine Catabolic Process To Glutamate And Formamide Signaling Adaptor Activity Protein Localization To Cleavage Furrow Neuroblast Division In Subventricular Zone L27 Domain Binding Subapical Complex