DLGAP4 and FKBP6

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		DLGAP4	FKBP6
Name		DLG associated protein 4	FKBP prolyl isomerase family member 6 (inactive)
Structure		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Neuromuscular Junction Synapse Glutamatergic Synapse Cholinergic Synapse Postsynaptic Specialization	Synaptonemal Complex Fibrillar Center Nucleus Cytoplasm Cytosol Microtubule Cytoskeleton Intercellular Bridge
	Molecular Function	Protein Binding Molecular Adaptor Activity	Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding FK506 Binding Identical Protein Binding Hsp90 Protein Binding
	Biological Process	Signaling Modulation Of Chemical Synaptic Transmission Regulation Of Synapse Maturation Modification Of Postsynaptic Structure	Protein Folding Spermatogenesis Cell Differentiation Regulatory NcRNA-mediated Gene Silencing PiRNA Processing Positive Regulation Of Viral Genome Replication Meiotic Cell Cycle Transposable Element Silencing By PiRNA-mediated DNA Methylation
Pathways		Neurexins and neuroligins Neurexins and neuroligins	Meiotic synapsis PIWI-interacting RNA (piRNA) biogenesis
GWAS		Low density lipoprotein cholesterol levels ( 32154731 ) Neuroblastoma or malignant cutaneous melanoma ( 31605138 )	Height ( 31562340 ) Immune reponse to smallpox (secreted IL-12p40) ( 22610502 )
Novel Interactors		1 novel interactors: NKX2-2	None recorded
Interacting Genes		32 interacting genes: ABI2 ALDH16A1 ATPAF2 BIN1 DLG1 DLG3 DLG4 EXOC4 FHL3 FHL5 FKBP6 FYN GRIN1 GRIN2D MAGEA6 MPP7 MTUS2 NCK1 NCK2 NHERF1 NHERF2 PALS1 PLP2 PPP1R1B SH3GL2 SH3RF1 SHANK2 SHANK3 SORBS2 SYNGAP1 UBASH3A UBC	38 interacting genes: ACD ALDH3A1 CCDC198 CCNK CDK5RAP3 CFP CFTR CRACR2A DDIT4L DLGAP4 ECM1 EEF1D ENKD1 FAM107A GAPDH GSC2 HSP90AA1 IHO1 KANK2 KRT75 LZTS2 MAP3K1 MEI4 MEOX2 NME7 NTAQ1 PIAS2 PICK1 RAB11FIP2 RNF4 SAXO4 SUMO1P1 TEPSIN TINF2 TMEM9B TRIM55 TRIM63 ZNF655
Entrez ID		22839	8468
HPRD ID		16826	05326
Ensembl ID		ENSG00000080845	ENSG00000077800
Uniprot IDs		A0A0B4J2C2 Q9Y2H0	O75344
PDB IDs		Not available	3B7X
GO Terms Enriched among Interactors		Ionotropic Glutamate Receptor Binding Postsynaptic Density Learning Receptor Clustering Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Protein Localization To Membrane Regulation Of Neuronal Synaptic Plasticity Cytoskeletal Anchor Activity Positive Regulation Of Excitatory Postsynaptic Potential Localization Within Membrane Establishment Or Maintenance Of Cell Polarity Learning Or Memory Associative Learning Adherens Junction Postsynaptic Density Membrane Cognition Positive Regulation Of Actin Filament Polymerization Regulation Of Synaptic Plasticity Modulation Of Excitatory Postsynaptic Potential Glutamate Receptor Signaling Pathway Neuron Projection Phosphatase Binding Response To Glycine Type 2 Metabotropic Glutamate Receptor Binding Postsynaptic Density Organization Synapse Regulation Of Cellular Component Size Glutamatergic Synapse Positive Regulation Of Synaptic Transmission Vocalization Behavior Dendritic Spine Regulation Of Actin Filament Organization Scaffold Protein Binding Type 3 Metabotropic Glutamate Receptor Binding Postsynaptic Specialization Organization Signaling Adaptor Activity Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Protein Polymerization Lateral Loop Protein Localization To Cell Junction Regulation Of Translation Initiation In Response To Endoplasmic Reticulum Stress Synaptic Receptor Adaptor Activity Positive Regulation Of Cytoskeleton Organization Chemical Synaptic Transmission Ionotropic Glutamate Receptor Signaling Pathway Regulation Of Biological Quality Plasma Membrane MPP7-DLG1-LIN7 Complex	Shelterin Complex Telomere Assembly Meiotic DNA Double-strand Break Formation Protein Binding Regulation Of Telomere Maintenance Via Telomerase Nuclear Telomere Cap Complex Regulation Of Telomere Maintenance Via Telomere Lengthening Protein Localization To Chromosome, Telomeric Region