DLGAP4 and GRIN2D

Number of citations of the paper that reports this interaction (PMID 10862698)
203

Data Source:
HPRD (in vivo)

		DLGAP4	GRIN2D
Gene Name		discs, large (Drosophila) homolog-associated protein 4	glutamate receptor, ionotropic, N-methyl D-aspartate 2D
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Membrane Synapse	Plasma Membrane N-methyl-D-aspartate Selective Glutamate Receptor Complex Cell Junction Dendrite Postsynaptic Membrane
	Molecular Function	Protein Binding	N-methyl-D-aspartate Selective Glutamate Receptor Activity Extracellular-glutamate-gated Ion Channel Activity Protein Binding
	Biological Process	Cell-cell Signaling	Startle Response Signal Transduction Synaptic Transmission Adult Locomotory Behavior Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Regulation Of Sensory Perception Of Pain
Pathways			Activation of NMDA receptor upon glutamate binding and postsynaptic events CREB phosphorylation through the activation of CaMKII CREB phosphorylation through the activation of Ras Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Unblocking of NMDA receptor, glutamate binding and activation Ras activation uopn Ca2+ infux through NMDA receptor Post NMDA receptor activation events Transmission across Chemical Synapses
Drugs			L-Glutamic Acid Meperidine Orphenadrine Tenocyclidine
Diseases
GWAS
Protein-Protein Interactions		15 interactors: BIN1 DLG1 DLG3 DLG4 EXOC4 GRIN1 GRIN2D PLP2 PPP1R1B SH3GL2 SHANK2 SHANK3 SORBS2 SYNGAP1 UBC	33 interactors: ABL1 CDH2 CIT CLTC CTNNB1 DLG2 DLG4 DLGAP4 DNM1 DUSP4 FUS GRIN1 HNRNPU HRAS HSPA1A IL16 INA INADL MAP2 MAP2K2 NANOS1 NF1 PPP2R1A PPP2R2A PRKCB PRKCE PRKCG RAP2A RPS6KA3 SPTAN1 SYNGAP1 TJP1 TRAF3
Entrez ID		22839	2906
HPRD ID		16826	04095
Ensembl ID		ENSG00000080845	ENSG00000105464
Uniprot IDs		Q9Y2H0	O15399 Q59G17
PDB IDs
Enriched GO Terms of Interacting Partners?		Receptor Clustering Learning Regulation Of Long-term Neuronal Synaptic Plasticity Single-organism Behavior Social Behavior Learning Or Memory Receptor Localization To Synapse Membrane Organization Cognition Synaptic Transmission Behavior Regulation Of Neuronal Synaptic Plasticity Regulation Of Synaptic Plasticity Vocalization Behavior Protein Localization To Synapse Neuron Projection Development Cell-cell Signaling Establishment Or Maintenance Of Apical/basal Cell Polarity Neuron Development Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Synaptic Transmission Positive Regulation Of Excitatory Postsynaptic Membrane Potential Chemotaxis Generation Of Neurons Neuron Projection Morphogenesis Nervous System Development Protein Localization To Membrane Positive Regulation Of Membrane Potential Neurogenesis Neuron Differentiation Cell Projection Organization Neurological System Process Cell Morphogenesis Involved In Differentiation Axon Guidance Adult Behavior Response To External Stimulus Locomotion Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Clustering Nucleotide Phosphorylation Cell Projection Morphogenesis Visual Learning Cell Part Morphogenesis Visual Behavior Regulation Of Excitatory Postsynaptic Membrane Potential Axonogenesis Regulation Of Postsynaptic Membrane Potential Synapse Assembly Axon Development Associative Learning Regulation Of Membrane Potential	Nervous System Development Regulation Of MAPK Cascade Regulation Of Long-term Neuronal Synaptic Plasticity Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Neurogenesis Cell Development Locomotion Generation Of Neurons Intracellular Signal Transduction Neuron Projection Development Cell Differentiation Regulation Of Cellular Component Organization Regulation Of Neuronal Synaptic Plasticity Cellular Response To Stimulus Neuron Differentiation Enzyme Linked Receptor Protein Signaling Pathway Cell Projection Organization Signaling Cell Morphogenesis Involved In Differentiation Axonogenesis MyD88-independent Toll-like Receptor Signaling Pathway Neuron Development Cell Communication Apoptotic Process Response To Organic Substance Signal Transduction Axon Guidance Axon Development Programmed Cell Death Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Cell Death Toll-like Receptor 4 Signaling Pathway Death Regulation Of Neuron Death Developmental Process Neuron Projection Morphogenesis Response To Ammonium Ion Immune Response-regulating Signaling Pathway Regulation Of Metabolic Process Response To Stimulus Response To Morphine Regulation Of Intracellular Signal Transduction Cell-cell Signaling Regulation Of Phosphorus Metabolic Process Movement Of Cell Or Subcellular Component Multicellular Organismal Development Response To External Stimulus Toll-like Receptor Signaling Pathway Regulation Of Protein Metabolic Process
Tagcloud ?			6j 6jxm atg autosomes backcross codon crosses dispersed egr epsilon espilon exons f1xc57bl flanking grinl interspecific mapping nucleas polyadenylation primer s1 spans spl spretus termination zeta
Tagcloud (Difference) ?			6j 6jxm atg autosomes backcross codon crosses dispersed egr epsilon espilon exons f1xc57bl flanking grinl interspecific mapping nucleas polyadenylation primer s1 spans spl spretus termination zeta
Tagcloud (Intersection) ?