HMOX2 and KCNMA1

Number of citations of the paper that reports this interaction (PubMedID 15528406)
0

Data Source:
HPRD (in vitro)

		HMOX2	KCNMA1
Description		heme oxygenase 2	potassium calcium-activated channel subfamily M alpha 1
Image
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Specific Granule Membrane	Plasma Membrane Caveola Voltage-gated Potassium Channel Complex Membrane Apical Plasma Membrane Monoatomic Ion Channel Complex Postsynaptic Membrane
	Molecular Function	Heme Oxygenase (decyclizing) Activity Protein Binding Oxidoreductase Activity Heme Binding Metal Ion Binding	Actin Binding Monoatomic Ion Channel Activity Voltage-gated Potassium Channel Activity Potassium Channel Activity Protein Binding Calcium-activated Potassium Channel Activity Identical Protein Binding Metal Ion Binding Large Conductance Calcium-activated Potassium Channel Activity
	Biological Process	Response To Hypoxia Heme Oxidation Response To Oxidative Stress Heme Catabolic Process	Response To Hypoxia Monoatomic Ion Transport Potassium Ion Transport Response To Osmotic Stress Intracellular Potassium Ion Homeostasis Monoatomic Ion Transmembrane Transport Response To Carbon Monoxide Vasodilation Regulation Of Membrane Potential Positive Regulation Of Apoptotic Process Negative Regulation Of Cell Volume Response To Calcium Ion Transmembrane Transport Micturition Smooth Muscle Contraction Involved In Micturition Potassium Ion Transmembrane Transport
Pathways		Heme degradation Neutrophil degranulation RHOA GTPase cycle Iron uptake and transport Cytoprotection by HMOX1	Ca2+ activated K+ channels cGMP effects Sensory processing of sound by inner hair cells of the cochlea Acetylcholine inhibits contraction of outer hair cells
Drugs		NADH Stannsoporfin	Chlorzoxazone Bendroflumethiazide Procaine Hydroflumethiazide Ritodrine Hydrochlorothiazide Nitrendipine Miconazole Diazoxide Halothane Colforsin Dequalinium Trimebutine
Diseases
GWAS		Erectile dysfunction ( 30583798)	3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Bell's palsy ( 33602968) Blood pressure ( 24954895) Bone mineral density (spine) ( 26911590) Educational attainment ( 25201988) Estimated glomerular filtration rate ( 31015462 31152163) Femur bone mineral density x serum urate levels interaction ( 34046847) Glucocorticoid-induced osteonecrosis ( 26265699) Gut microbiota relative abundance (Faecalibacterium) ( 33208821) Heel bone mineral density ( 28869591 30598549) Hypospadias ( 25108383) Initial pursuit acceleration ( 29064472) Intraocular pressure ( 31959993) Lean body mass ( 28552196) Lumbar spine bone mineral density ( 29499414 22504420) Male-pattern baldness ( 28196072) Mortality in heart failure ( 20400778) Myopia ( 27182965) Obesity ( 21708048) Refractive error ( 32231278) Response to ranibizumab in age-related macular degeneration (exudative) ( 30054556) Schizophrenia ( 33169155) Smoking cessation in chronic obstructive pulmonary disease ( 29631575) Spherical equivalent or myopia (age of diagnosis) ( 29808027)
Interacting Genes		67 interacting genes: A2M APP AQP6 ARL13B ASGR2 ATP5F1B BCL2L13 BIK BLOC1S2 CCR2 CD79A CEBPZ CEP126 COPS6 CRB3 CSNK2A1 EBP EEF1G EIF3C ELOVL4 ERGIC3 F2RL1 FAM209A FAM210B GET1 GIT1 GPR152 GPRASP1 GPX8 HAP1 IMMT INPP5K ITFG1 JADE1 KCNJ6 KCNMA1 LAPTM5 LRIF1 MED31 MGST3 MTNR1A NDUFS2 NKRF NR3C1 PCNT PLXNB2 PTGER4 RBBP4 RETREG3 RNASEK SAR1A SETDB1 SGPL1 SHC1 SKA2 SLC30A8 SMO SNX5 SNX7 SSMEM1 STOM SYT1 TMEM14B TMX2 VMA21 ZFP28 ZNF746	6 interacting genes: CACNA1H GGT1 HMOX2 KCNMB1 MAP1A PTK2
Entrez ID		3163	3778
HPRD ID		00783	15967
Ensembl ID		ENSG00000103415	ENSG00000156113
Uniprot IDs		A0A087WT44 B3KSE0 P30519	A0A087WZL8 A0A1W2PNQ3 A0A1W2PNW6 A0A1W2PP94 A0A1W2PPY5 A0A1W2PQ61 A0A1W2PQA0 A0A1W2PQK5 A0A1W2PQU4 A0A1W2PR56 A0A1W2PR62 A0A1W2PRB0 A0A1W2PRN5 A0A1W2PSD3 B7ZMF5 D5MRH1 Q12791 Q59FH2 Q5SVJ7 Q5SVJ8 Q5SVJ9 S4R453
PDB IDs		2Q32 2QPP 2RGZ 4WMH 5UC8 5UC9 5UCA	2K44 3MT5 3NAF 6ND0 6V22 6V35 6V38 6V3G 6V5A 7YNZ 7YO0 7YO1 7YO2 7YO3 7YO4 7YO5 8GH9 8GHF 8GHG 8V60 8V63 8V64 8VAV 8VAZ 8Z3S 9CZH 9CZJ 9CZK 9CZM 9CZO 9CZQ 9D18 9D19 9JO3 9JO4
Enriched GO Terms of Interacting Partners?		Membrane Protein Binding
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