HMOX2 and GET1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		HMOX2	GET1
Description		heme oxygenase 2	guided entry of tail-anchored proteins factor 1
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GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Specific Granule Membrane	Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane GET Complex
	Molecular Function	Heme Oxygenase (decyclizing) Activity Protein Binding Oxidoreductase Activity Heme Binding Metal Ion Binding	Protein Binding Protein-membrane Adaptor Activity
	Biological Process	Response To Hypoxia Heme Oxidation Response To Oxidative Stress Heme Catabolic Process	Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Sensory Perception Of Sound Protein Insertion Into ER Membrane Synapse Organization Protein Stabilization Establishment Of Localization In Cell Otic Vesicle Development Tail-anchored Membrane Protein Insertion Into ER Membrane Establishment Of Protein Localization To Membrane
Pathways		Heme degradation Neutrophil degranulation RHOA GTPase cycle Iron uptake and transport Cytoprotection by HMOX1	Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Drugs		NADH Stannsoporfin
Diseases
GWAS		Erectile dysfunction ( 30583798)
Interacting Genes		67 interacting genes: A2M APP AQP6 ARL13B ASGR2 ATP5F1B BCL2L13 BIK BLOC1S2 CCR2 CD79A CEBPZ CEP126 COPS6 CRB3 CSNK2A1 EBP EEF1G EIF3C ELOVL4 ERGIC3 F2RL1 FAM209A FAM210B GET1 GIT1 GPR152 GPRASP1 GPX8 HAP1 IMMT INPP5K ITFG1 JADE1 KCNJ6 KCNMA1 LAPTM5 LRIF1 MED31 MGST3 MTNR1A NDUFS2 NKRF NR3C1 PCNT PLXNB2 PTGER4 RBBP4 RETREG3 RNASEK SAR1A SETDB1 SGPL1 SHC1 SKA2 SLC30A8 SMO SNX5 SNX7 SSMEM1 STOM SYT1 TMEM14B TMX2 VMA21 ZFP28 ZNF746	28 interacting genes: ABHD5 APOA2 APOL2 AQP1 CAMLG CCL4L2 CD302 CD53 CLCN7 COMT COX20 ERG28 HMOX2 HTATIP2 ORMDL3 PLPP4 PTPN9 RASGRP3 RTP2 SERP2 SLC35E3 SLC7A1 SPTSSA STX2 TECR TFRC TM4SF19 TMEM42
Entrez ID		3163	7485
HPRD ID		00783	04224
Ensembl ID		ENSG00000103415	ENSG00000182093
Uniprot IDs		A0A087WT44 B3KSE0 P30519	O00258
PDB IDs		2Q32 2QPP 2RGZ 4WMH 5UC8 5UC9 5UCA	6SO5 8CQZ 8CR1 8CR2
Enriched GO Terms of Interacting Partners?		Membrane Protein Binding	Basolateral Plasma Membrane Membrane Serine Palmitoyltransferase Complex
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