HMOX2 and SKA2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		HMOX2	SKA2
Description		heme oxygenase 2	spindle and kinetochore associated complex subunit 2
Image
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Specific Granule Membrane	Chromosome, Centromeric Region Kinetochore Outer Kinetochore Chromosome Cytoplasm Spindle Cytosol Cytoskeleton Microtubule Spindle Microtubule Meiotic Spindle SKA Complex
	Molecular Function	Heme Oxygenase (decyclizing) Activity Protein Binding Oxidoreductase Activity Heme Binding Metal Ion Binding	Protein Binding Microtubule Binding
	Biological Process	Response To Hypoxia Heme Oxidation Response To Oxidative Stress Heme Catabolic Process	Mitotic Sister Chromatid Segregation Mitotic Cell Cycle Spindle Assembly Involved In Female Meiosis Chromosome Segregation Mitotic Metaphase Chromosome Alignment Regulation Of Microtubule Polymerization Or Depolymerization Establishment Of Meiotic Spindle Orientation Cell Division Attachment Of Mitotic Spindle Microtubules To Kinetochore
Pathways		Heme degradation Neutrophil degranulation RHOA GTPase cycle Iron uptake and transport Cytoprotection by HMOX1	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs		NADH Stannsoporfin
Diseases
GWAS		Erectile dysfunction ( 30583798)	Cognitive function ( 25644384) Refractive error ( 32231278) Testicular germ cell tumor ( 23666239)
Interacting Genes		67 interacting genes: A2M APP AQP6 ARL13B ASGR2 ATP5F1B BCL2L13 BIK BLOC1S2 CCR2 CD79A CEBPZ CEP126 COPS6 CRB3 CSNK2A1 EBP EEF1G EIF3C ELOVL4 ERGIC3 F2RL1 FAM209A FAM210B GET1 GIT1 GPR152 GPRASP1 GPX8 HAP1 IMMT INPP5K ITFG1 JADE1 KCNJ6 KCNMA1 LAPTM5 LRIF1 MED31 MGST3 MTNR1A NDUFS2 NKRF NR3C1 PCNT PLXNB2 PTGER4 RBBP4 RETREG3 RNASEK SAR1A SETDB1 SGPL1 SHC1 SKA2 SLC30A8 SMO SNX5 SNX7 SSMEM1 STOM SYT1 TMEM14B TMX2 VMA21 ZFP28 ZNF746	5 interacting genes: HMOX2 IFT57 PRKD3 SKA1 SPC24
Entrez ID		3163	348235
HPRD ID		00783	13306
Ensembl ID		ENSG00000103415	ENSG00000182628
Uniprot IDs		A0A087WT44 B3KSE0 P30519	J3KSP0 Q8WVK7
PDB IDs		2Q32 2QPP 2RGZ 4WMH 5UC8 5UC9 5UCA	4AJ5
Enriched GO Terms of Interacting Partners?		Membrane Protein Binding	Outer Kinetochore Ciliary Basal Body Attachment Of Spindle Microtubules To Kinetochore Regulation Of Mitotic Sister Chromatid Separation Regulation Of Chromosome Separation Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Sister Chromatid Segregation Heme Oxidation Heme Oxygenase (decyclizing) Activity Regulation Of Mitotic Nuclear Division Regulation Of Chromosome Segregation Chromosome Segregation Regulation Of Nuclear Division Chromosome, Centromeric Region Kinetochore SKA Complex Ndc80 Complex Establishment Of Meiotic Spindle Orientation Dendrite Terminus Negative Regulation Of Mitotic Spindle Assembly Checkpoint Signaling Regulation Of Chromosome Organization Microtubule Binding Establishment Of Meiotic Spindle Localization Negative Regulation Of Cell Cycle Process Positive Regulation Of Mitotic Sister Chromatid Segregation Heme Catabolic Process Porphyrin-containing Compound Catabolic Process Spindle Assembly Involved In Female Meiosis Left/right Pattern Formation Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Cell Cycle Meiotic Spindle Assembly Mitotic Spindle Microtubule Diacylglycerol-dependent Serine/threonine Kinase Activity Intraciliary Anterograde Transport Intraciliary Transport Particle B Positive Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Keratinocyte Proliferation Regulation Of Cell Cycle Phase Transition Cell Division Meiotic Spindle Organization Positive Regulation Of Mitotic Sister Chromatid Separation Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Attachment Of Mitotic Spindle Microtubules To Kinetochore Keratinocyte Proliferation Negative Regulation Of Mitotic Metaphase/anaphase Transition Mitotic Spindle Assembly Checkpoint Signaling Regulation Of Mitotic Cell Cycle Positive Regulation Of Microtubule Polymerization Positive Regulation Of Chromosome Separation
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