HMOX2 and ZNF746

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		HMOX2	ZNF746
Description		heme oxygenase 2	zinc finger protein 746
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Specific Granule Membrane	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Heme Oxygenase (decyclizing) Activity Protein Binding Oxidoreductase Activity Heme Binding Metal Ion Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Response To Hypoxia Heme Oxidation Response To Oxidative Stress Heme Catabolic Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Protein Homooligomerization Protein Heterooligomerization
Pathways		Heme degradation Neutrophil degranulation RHOA GTPase cycle Iron uptake and transport Cytoprotection by HMOX1	Generic Transcription Pathway
Drugs		NADH Stannsoporfin
Diseases
GWAS		Erectile dysfunction ( 30583798)	Amyotrophic lateral sclerosis ( 19451621) Multiple sclerosis ( 21833088)
Interacting Genes		67 interacting genes: A2M APP AQP6 ARL13B ASGR2 ATP5F1B BCL2L13 BIK BLOC1S2 CCR2 CD79A CEBPZ CEP126 COPS6 CRB3 CSNK2A1 EBP EEF1G EIF3C ELOVL4 ERGIC3 F2RL1 FAM209A FAM210B GET1 GIT1 GPR152 GPRASP1 GPX8 HAP1 IMMT INPP5K ITFG1 JADE1 KCNJ6 KCNMA1 LAPTM5 LRIF1 MED31 MGST3 MTNR1A NDUFS2 NKRF NR3C1 PCNT PLXNB2 PTGER4 RBBP4 RETREG3 RNASEK SAR1A SETDB1 SGPL1 SHC1 SKA2 SLC30A8 SMO SNX5 SNX7 SSMEM1 STOM SYT1 TMEM14B TMX2 VMA21 ZFP28 ZNF746	15 interacting genes: DIABLO DUSP23 EPHA8 FAM118B FES GSK3B HMOX2 ILK MAP3K20 MAP3K7 PRKN PRKRA RPS6KA6 UBE2E3 ZNF777
Entrez ID		3163	155061
HPRD ID		00783	08099
Ensembl ID		ENSG00000103415	ENSG00000181220
Uniprot IDs		A0A087WT44 B3KSE0 P30519	A0A2R8YDQ5 A0A8J9FQ52 Q6NUN9
PDB IDs		2Q32 2QPP 2RGZ 4WMH 5UC8 5UC9 5UCA
Enriched GO Terms of Interacting Partners?		Membrane Protein Binding	Protein Kinase Activity ATP Binding Kinase Activity Protein Serine/threonine Kinase Activity Nucleotide Binding Positive Regulation Of Intracellular Signal Transduction Transferase Activity Magnesium Ion Binding Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Protein Phosphorylation Protein Autophosphorylation Protein Serine Kinase Activity P38MAPK Cascade Stress-activated MAPK Cascade MAP Kinase Kinase Kinase Activity Stress-activated Protein Kinase Signaling Cascade Negative Regulation Of Gene Expression Phosphorylation Signal Transduction In Response To DNA Damage Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Autophagy Protein Kinase Binding Protein K11-linked Ubiquitination Protein Kinase Activator Activity Regulation Of Microtubule Anchoring At Centrosome Negative Regulation Of Spontaneous Neurotransmitter Secretion Positive Regulation Of Mitotic DNA Damage Checkpoint Positive Regulation Of Canonical NF-kappaB Signal Transduction Protein Modification Process Cytosol Regulation Of Canonical Wnt Signaling Pathway Cellular Response To Stress Superior Temporal Gyrus Development Negative Regulation Of Type B Pancreatic Cell Development SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Mesenchymal Stem Cell Differentiation Negative Regulation Of Biosynthetic Process Negative Regulation Of Glycogen (starch) Synthase Activity Scaffold Protein Binding Heme Oxidation Heme Oxygenase (decyclizing) Activity Positive Regulation Of Retrograde Transport, Endosome To Golgi Protein Monoubiquitination Negative Regulation Of Intralumenal Vesicle Formation
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