SLPI and PRSS2

Number of citations of the paper that reports this interaction (PubMedID 8573092)
32

Data Source:
HPRD (in vitro)

		SLPI	PRSS2
Description		secretory leukocyte peptidase inhibitor	serine protease 2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Apparatus Extracellular Matrix Specific Granule Lumen Extracellular Exosome	Extracellular Region Extracellular Space Extracellular Matrix Azurophil Granule Lumen
	Molecular Function	DNA Binding MRNA Binding Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Protein Binding Enzyme Binding Peptidase Inhibitor Activity	Metalloendopeptidase Activity Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Metal Ion Binding
	Biological Process	Immune System Process Immune Response Antibacterial Humoral Response Negative Regulation Of Protein Binding Response To Lipopolysaccharide Defense Response To Bacterium Negative Regulation Of Viral Genome Replication Innate Immune Response Host-mediated Perturbation Of Symbiont Process	Proteolysis Digestion Antimicrobial Humoral Response Extracellular Matrix Disassembly Positive Regulation Of Cell Growth Collagen Catabolic Process Positive Regulation Of Cell Adhesion
Pathways		Neutrophil degranulation Developmental Lineage of Mammary Gland Luminal Epithelial Cells Developmental Lineage of Mammary Gland Alveolar Cells	Collagen degradation Alpha-defensins Activation of Matrix Metalloproteinases Neutrophil degranulation Antimicrobial peptides
Drugs			Monoisopropylphosphorylserine O-Benzylsulfonyl-Serine Benzylamine Benzamidine Phosphorylisopropane Phenethylamine 3-Phenylpropylamine
Diseases			Hereditary pancreatitis; Hereditary chronic pancreatitis
GWAS		Bipolar disorder ( 31043756) Blood protein levels ( 30072576) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Malaria ( 31844061)	Pancreatitis ( 23143602)
Interacting Genes		26 interacting genes: CALN1 CIB3 CTSB CTSL CTSS EFEMP1 ELANE FAM9B GRN HOXA1 KLK3 LAT MAPK8IP2 MICOS10-NBL1 MKRN3 MMP14 NBL1 NTAQ1 PIH1D2 PLSCR1 PRSS2 SGTA SGTB SMIM14 UBQLN1 UBQLN2	7 interacting genes: APP BPI CSN1S1 GLP1R MMP9 SERPINA1 SLPI
Entrez ID		6590	5645
HPRD ID		00121	03335
Ensembl ID		ENSG00000124107	ENSG00000275896
Uniprot IDs		P03973	A0A0J9YYC8 A6XMV9 P07478 Q5NV56 Q6PK75
PDB IDs		2Z7F 4DOQ
Enriched GO Terms of Interacting Partners?		Collagen Catabolic Process Endolysosome Lumen Collagen Metabolic Process Cellular Response To Thyroid Hormone Stimulus Extracellular Matrix Disassembly Proteoglycan Binding Extracellular Matrix TRC Complex Positive Regulation Of ERAD Pathway Serine-type Endopeptidase Activity Peptidase Activity Proteolysis Extracellular Space Response To Thyroid Hormone Regulation Of ERAD Pathway Endopeptidase Activity Positive Regulation Of Proteolysis Sequestering Of BMP In Extracellular Matrix Sequestering Of BMP From Receptor Via BMP Binding Protein Metabolic Process Determination Of Dorsal Identity Zymogen Activation Protein Catabolic Process Positive Regulation Of Response To Endoplasmic Reticulum Stress Morphogen Activity Negative Regulation Of Monocyte Chemotaxis Negative Regulation Of Chemotaxis Regulation Of Immune System Process Sequestering Of Extracellular Ligand From Receptor Cysteine-type Endopeptidase Activity Regulation Of Cellular Response To Stress Extracellular Negative Regulation Of Signal Transduction Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Collagen Binding Positive Regulation Of Defense Response To Bacterium Protein Processing Positive Regulation Of Protein Metabolic Process Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides Regulation Of Proteolysis Regulation Of Defense Response To Bacterium Catabolic Process Azurophil Granule Lumen Regulation Of Leukocyte Migration Regulation Of Response To Endoplasmic Reticulum Stress Hydrolase Activity ERAD Pathway Macromolecule Metabolic Process Regulation Of Immune Response Proteolysis Involved In Protein Catabolic Process BMP Binding	Antibacterial Humoral Response Extracellular Space Antimicrobial Humoral Response Humoral Immune Response Heparan Sulfate Binding Defense Response To Bacterium Serine-type Endopeptidase Inhibitor Activity Extracellular Region Defense Response To Gram-negative Bacterium Peptidase Inhibitor Activity Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Response To Bacterium Extracellular Matrix Lipopolysaccharide Binding Extracellular Exosome Innate Immune Response Response To External Biotic Stimulus Negative Regulation Of Blood Pressure Defense Response Amyloid-beta Complex Growth Cone Lamellipodium Defense Response To Symbiont Regulation Of Response To Calcium Ion Platelet Alpha Granule Lumen Defense Response To Other Organism Regulation Of Multicellular Organism Growth Amylin Binding Response To Amyloid-beta Positive Regulation Of Toll Signaling Pathway Specific Granule Lumen Response To Lipopolysaccharide Response To Lipid Response To 11-deoxycorticosterone Zymogen Binding Glucagon-like Peptide 1 Receptor Activity Response To Molecule Of Bacterial Origin Cellular Response To Oxygen-containing Compound Acetylcholine Receptor Activator Activity Lipoprotein Particle Positive Regulation Of Protein Import Pigment Granule Aggregation In Cell Center PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization
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