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SLPI
Description
secretory leukocyte peptidase inhibitor
Image
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Golgi Apparatus
Extracellular Matrix
Specific Granule Lumen
Extracellular Exosome
Molecular Function
DNA Binding
MRNA Binding
Endopeptidase Inhibitor Activity
Serine-type Endopeptidase Inhibitor Activity
Protein Binding
Enzyme Binding
Peptidase Inhibitor Activity
Biological Process
Immune System Process
Immune Response
Antibacterial Humoral Response
Negative Regulation Of Protein Binding
Response To Lipopolysaccharide
Defense Response To Bacterium
Negative Regulation Of Viral Genome Replication
Innate Immune Response
Host-mediated Perturbation Of Symbiont Process
Pathways
Neutrophil degranulation
Developmental Lineage of Mammary Gland Luminal Epithelial Cells
Developmental Lineage of Mammary Gland Alveolar Cells
Drugs
Diseases
GWAS
Bipolar disorder (
31043756
)
Blood protein levels (
30072576
)
Gut microbiota (bacterial taxa, hurdle binary method) (
32572223
)
Malaria (
31844061
)
Interacting Genes
26 interacting genes:
CALN1
CIB3
CTSB
CTSL
CTSS
EFEMP1
ELANE
FAM9B
GRN
HOXA1
KLK3
LAT
MAPK8IP2
MICOS10-NBL1
MKRN3
MMP14
NBL1
NTAQ1
PIH1D2
PLSCR1
PRSS2
SGTA
SGTB
SMIM14
UBQLN1
UBQLN2
Entrez ID
6590
HPRD ID
00121
Ensembl ID
ENSG00000124107
Uniprot IDs
P03973
PDB IDs
2Z7F
4DOQ
Enriched GO Terms of Interacting Partners
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Collagen Catabolic Process
Endolysosome Lumen
Collagen Metabolic Process
Cellular Response To Thyroid Hormone Stimulus
Extracellular Matrix Disassembly
Proteoglycan Binding
Extracellular Matrix
TRC Complex
Positive Regulation Of ERAD Pathway
Serine-type Endopeptidase Activity
Peptidase Activity
Proteolysis
Extracellular Space
Response To Thyroid Hormone
Regulation Of ERAD Pathway
Endopeptidase Activity
Positive Regulation Of Proteolysis
Sequestering Of BMP In Extracellular Matrix
Sequestering Of BMP From Receptor Via BMP Binding
Protein Metabolic Process
Determination Of Dorsal Identity
Zymogen Activation
Protein Catabolic Process
Positive Regulation Of Response To Endoplasmic Reticulum Stress
Morphogen Activity
Negative Regulation Of Monocyte Chemotaxis
Negative Regulation Of Chemotaxis
Regulation Of Immune System Process
Sequestering Of Extracellular Ligand From Receptor
Cysteine-type Endopeptidase Activity
Regulation Of Cellular Response To Stress
Extracellular Negative Regulation Of Signal Transduction
Post-translational Protein Targeting To Endoplasmic Reticulum Membrane
Collagen Binding
Positive Regulation Of Defense Response To Bacterium
Protein Processing
Positive Regulation Of Protein Metabolic Process
Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides
Regulation Of Proteolysis
Regulation Of Defense Response To Bacterium
Catabolic Process
Azurophil Granule Lumen
Regulation Of Leukocyte Migration
Regulation Of Response To Endoplasmic Reticulum Stress
Hydrolase Activity
ERAD Pathway
Macromolecule Metabolic Process
Regulation Of Immune Response
Proteolysis Involved In Protein Catabolic Process
BMP Binding
Tagcloud
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