SLPI and MICOS10-NBL1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SLPI	MICOS10-NBL1
Description		secretory leukocyte peptidase inhibitor	MICOS10-NBL1 readthrough
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Apparatus Extracellular Matrix Specific Granule Lumen Extracellular Exosome	Extracellular Region Extracellular Space
	Molecular Function	DNA Binding MRNA Binding Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Protein Binding Enzyme Binding Peptidase Inhibitor Activity	Protein Binding Morphogen Activity BMP Binding Identical Protein Binding Receptor Ligand Activity
	Biological Process	Immune System Process Immune Response Antibacterial Humoral Response Negative Regulation Of Protein Binding Response To Lipopolysaccharide Defense Response To Bacterium Negative Regulation Of Viral Genome Replication Innate Immune Response Host-mediated Perturbation Of Symbiont Process	Signal Transduction Nervous System Development Neuron Differentiation Negative Regulation Of BMP Signaling Pathway Sequestering Of Extracellular Ligand From Receptor Sequestering Of BMP In Extracellular Matrix Sequestering Of BMP From Receptor Via BMP Binding Positive Regulation Of Neuron Differentiation Determination Of Dorsal Identity Neuron Projection Morphogenesis Negative Regulation Of Monocyte Chemotaxis
Pathways		Neutrophil degranulation Developmental Lineage of Mammary Gland Luminal Epithelial Cells Developmental Lineage of Mammary Gland Alveolar Cells
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) Blood protein levels ( 30072576) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Malaria ( 31844061)
Interacting Genes		26 interacting genes: CALN1 CIB3 CTSB CTSL CTSS EFEMP1 ELANE FAM9B GRN HOXA1 KLK3 LAT MAPK8IP2 MICOS10-NBL1 MKRN3 MMP14 NBL1 NTAQ1 PIH1D2 PLSCR1 PRSS2 SGTA SGTB SMIM14 UBQLN1 UBQLN2	11 interacting genes: DPEP2NB HPCAL1 KRTAP11-1 LRIG1 MEOX2 MRPL12 NCALD PLA2G2F SLPI UBQLN1 UBQLN2
Entrez ID		6590	100532736
HPRD ID		00121
Ensembl ID		ENSG00000124107	ENSG00000158747
Uniprot IDs		P03973	P41271
PDB IDs		2Z7F 4DOQ	4X1J 4YU8
Enriched GO Terms of Interacting Partners?		Collagen Catabolic Process Endolysosome Lumen Collagen Metabolic Process Cellular Response To Thyroid Hormone Stimulus Extracellular Matrix Disassembly Proteoglycan Binding Extracellular Matrix TRC Complex Positive Regulation Of ERAD Pathway Serine-type Endopeptidase Activity Peptidase Activity Proteolysis Extracellular Space Response To Thyroid Hormone Regulation Of ERAD Pathway Endopeptidase Activity Positive Regulation Of Proteolysis Sequestering Of BMP In Extracellular Matrix Sequestering Of BMP From Receptor Via BMP Binding Protein Metabolic Process Determination Of Dorsal Identity Zymogen Activation Protein Catabolic Process Positive Regulation Of Response To Endoplasmic Reticulum Stress Morphogen Activity Negative Regulation Of Monocyte Chemotaxis Negative Regulation Of Chemotaxis Regulation Of Immune System Process Sequestering Of Extracellular Ligand From Receptor Cysteine-type Endopeptidase Activity Regulation Of Cellular Response To Stress Extracellular Negative Regulation Of Signal Transduction Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Collagen Binding Positive Regulation Of Defense Response To Bacterium Protein Processing Positive Regulation Of Protein Metabolic Process Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides Regulation Of Proteolysis Regulation Of Defense Response To Bacterium Catabolic Process Azurophil Granule Lumen Regulation Of Leukocyte Migration Regulation Of Response To Endoplasmic Reticulum Stress Hydrolase Activity ERAD Pathway Macromolecule Metabolic Process Regulation Of Immune Response Proteolysis Involved In Protein Catabolic Process BMP Binding	Positive Regulation Of ERAD Pathway Regulation Of ERAD Pathway Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Response To Endoplasmic Reticulum Stress
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?