SLPI and CTSL

Number of citations of the paper that reports this interaction (PubMedID 11435427)
0

Data Source:
HPRD (in vitro)

		SLPI	CTSL
Description		secretory leukocyte peptidase inhibitor	cathepsin L
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Apparatus Extracellular Matrix Specific Granule Lumen Extracellular Exosome	Extracellular Region Extracellular Space Nucleus Lysosome Multivesicular Body Golgi Apparatus Plasma Membrane Membrane Apical Plasma Membrane Extracellular Matrix Cytoplasmic Vesicle Endolysosome Lumen Chromaffin Granule Lysosomal Lumen Extracellular Exosome Endocytic Vesicle Lumen
	Molecular Function	DNA Binding MRNA Binding Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Protein Binding Enzyme Binding Peptidase Inhibitor Activity	Fibronectin Binding Cysteine-type Endopeptidase Activity Protein Binding Collagen Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Histone Binding Proteoglycan Binding Serpin Family Protein Binding
	Biological Process	Immune System Process Immune Response Antibacterial Humoral Response Negative Regulation Of Protein Binding Response To Lipopolysaccharide Defense Response To Bacterium Negative Regulation Of Viral Genome Replication Innate Immune Response Host-mediated Perturbation Of Symbiont Process	Adaptive Immune Response Proteolysis Protein Autoprocessing Fusion Of Virus Membrane With Host Plasma Membrane Receptor-mediated Endocytosis Of Virus By Host Cell Antigen Processing And Presentation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Collagen Catabolic Process Zymogen Activation Enkephalin Processing Fusion Of Virus Membrane With Host Endosome Membrane CD4-positive, Alpha-beta T Cell Lineage Commitment Symbiont Entry Into Host Cell Antigen Processing And Presentation Of Peptide Antigen Proteolysis Involved In Protein Catabolic Process Elastin Catabolic Process Macrophage Apoptotic Process Cellular Response To Thyroid Hormone Stimulus
Pathways		Neutrophil degranulation Developmental Lineage of Mammary Gland Luminal Epithelial Cells Developmental Lineage of Mammary Gland Alveolar Cells	Endosomal/Vacuolar pathway Collagen degradation Degradation of the extracellular matrix Trafficking and processing of endosomal TLR Assembly of collagen fibrils and other multimeric structures HS-GAG degradation MHC class II antigen presentation RUNX1 regulates transcription of genes involved in differentiation of keratinocytes Attachment and Entry Attachment and Entry Degradation of CDH1
Drugs			L-cysteic acid Felbinac Fostamatinib
Diseases
GWAS		Bipolar disorder ( 31043756) Blood protein levels ( 30072576) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Malaria ( 31844061)
Interacting Genes		26 interacting genes: CALN1 CIB3 CTSB CTSL CTSS EFEMP1 ELANE FAM9B GRN HOXA1 KLK3 LAT MAPK8IP2 MICOS10-NBL1 MKRN3 MMP14 NBL1 NTAQ1 PIH1D2 PLSCR1 PRSS2 SGTA SGTB SMIM14 UBQLN1 UBQLN2	29 interacting genes: ARSA BAG6 BTN3A3 CD7 CD74 COL18A1 CST3 CST7 CSTA CSTB CTSC CUX1 CXCL8 EED GCG GEM IGFBP3 KNG1 MCPH1 PLAU PPP1CC RELB RSPH1 RXRA SERPINB13 SERPINB3 SGTA SLPI TG
Entrez ID		6590	1514
HPRD ID		00121	00293
Ensembl ID		ENSG00000124107	ENSG00000135047
Uniprot IDs		P03973	P07711 Q5T8F0 Q9HBQ7
PDB IDs		2Z7F 4DOQ	1CJL 1CS8 1ICF 1MHW 2NQD 2VHS 2XU1 2XU3 2XU4 2XU5 2YJ2 2YJ8 2YJ9 2YJB 2YJC 3BC3 3H89 3H8B 3H8C 3HHA 3HWN 3IV2 3K24 3KSE 3OF8 3OF9 4AXL 4AXM 5F02 5I4H 5MAE 5MAJ 5MQY 6EZP 6EZX 6F06 6JD0 6JD8 7QKB 7QKC 7QKD 7W33 7W34 7Z3T 7Z58 7ZS7 7ZVF 7ZXA 8A4U 8A4V 8A4W 8A4X 8A5B 8AHV 8B4F 8C77 8GX2 8HET 8HFV 8OFA 8OZA 8PRX 8QKB 8UAC
Enriched GO Terms of Interacting Partners?		Collagen Catabolic Process Endolysosome Lumen Collagen Metabolic Process Cellular Response To Thyroid Hormone Stimulus Extracellular Matrix Disassembly Proteoglycan Binding Extracellular Matrix TRC Complex Positive Regulation Of ERAD Pathway Serine-type Endopeptidase Activity Peptidase Activity Proteolysis Extracellular Space Response To Thyroid Hormone Regulation Of ERAD Pathway Endopeptidase Activity Positive Regulation Of Proteolysis Sequestering Of BMP In Extracellular Matrix Sequestering Of BMP From Receptor Via BMP Binding Protein Metabolic Process Determination Of Dorsal Identity Zymogen Activation Protein Catabolic Process Positive Regulation Of Response To Endoplasmic Reticulum Stress Morphogen Activity Negative Regulation Of Monocyte Chemotaxis Negative Regulation Of Chemotaxis Regulation Of Immune System Process Sequestering Of Extracellular Ligand From Receptor Cysteine-type Endopeptidase Activity Regulation Of Cellular Response To Stress Extracellular Negative Regulation Of Signal Transduction Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Collagen Binding Positive Regulation Of Defense Response To Bacterium Protein Processing Positive Regulation Of Protein Metabolic Process Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides Regulation Of Proteolysis Regulation Of Defense Response To Bacterium Catabolic Process Azurophil Granule Lumen Regulation Of Leukocyte Migration Regulation Of Response To Endoplasmic Reticulum Stress Hydrolase Activity ERAD Pathway Macromolecule Metabolic Process Regulation Of Immune Response Proteolysis Involved In Protein Catabolic Process BMP Binding	Cysteine-type Endopeptidase Inhibitor Activity Endopeptidase Inhibitor Activity Negative Regulation Of Proteolysis Peptidase Inhibitor Activity Regulation Of Proteolysis Extracellular Space Protease Binding Negative Regulation Of Protein Metabolic Process Extracellular Region Endoplasmic Reticulum Lumen Negative Regulation Of Macromolecule Metabolic Process Regulation Of Multicellular Organismal Process Negative Regulation Of Metabolic Process Immune Response Regulation Of Protein Metabolic Process Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Identical Protein Binding Immune System Process Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Regulation Of Primary Metabolic Process Regulation Of Myelination Extracellular Exosome Regulation Of Macrophage Activation Adaptive Immune Response Negative Regulation Of Endopeptidase Activity Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Positive Regulation Of Multicellular Organismal Process Negative Regulation Of Peptidase Activity Regulation Of Developmental Process Tail-anchored Membrane Protein Insertion Into ER Membrane Regulation Of Multicellular Organismal Development Positive Regulation Of Proteolysis Regulation Of Microglial Cell Activation Regulation Of Endopeptidase Activity Serine-type Endopeptidase Inhibitor Activity Positive Regulation Of ERAD Pathway Azurophil Granule Lumen Lysosomal Lumen Extracellular Matrix Regulation Of Antigen Processing And Presentation Positive Regulation Of Neutrophil Chemotaxis Regulation Of Nervous System Development Regulation Of ERAD Pathway Regulation Of Viral Life Cycle Positive Regulation Of Granulocyte Chemotaxis Hormone Activity Lymphocyte Mediated Immunity Protein Targeting To ER Negative Regulation Of Protein Catabolic Process
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