SLPI and MKRN3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SLPI	MKRN3
Description		secretory leukocyte peptidase inhibitor	makorin ring finger protein 3
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Apparatus Extracellular Matrix Specific Granule Lumen Extracellular Exosome	Nucleus Ribonucleoprotein Complex
	Molecular Function	DNA Binding MRNA Binding Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Protein Binding Enzyme Binding Peptidase Inhibitor Activity	RNA Binding Protein Binding Zinc Ion Binding Transferase Activity Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Immune System Process Immune Response Antibacterial Humoral Response Negative Regulation Of Protein Binding Response To Lipopolysaccharide Defense Response To Bacterium Negative Regulation Of Viral Genome Replication Innate Immune Response Host-mediated Perturbation Of Symbiont Process	Protein Polyubiquitination Protein Ubiquitination
Pathways		Neutrophil degranulation Developmental Lineage of Mammary Gland Luminal Epithelial Cells Developmental Lineage of Mammary Gland Alveolar Cells
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) Blood protein levels ( 30072576) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Malaria ( 31844061)	Height ( 31562340) Menarche (age at onset) ( 25231870) Pre-treatment viral load in HIV-1 infection ( 31219150)
Interacting Genes		26 interacting genes: CALN1 CIB3 CTSB CTSL CTSS EFEMP1 ELANE FAM9B GRN HOXA1 KLK3 LAT MAPK8IP2 MICOS10-NBL1 MKRN3 MMP14 NBL1 NTAQ1 PIH1D2 PLSCR1 PRSS2 SGTA SGTB SMIM14 UBQLN1 UBQLN2	181 interacting genes: ACOT11 ADAMTSL4 ADRA2C ANKRD11 ANTKMT APEX2 AQP1 ARID5A ARMC5 ATOSB AVPI1 BATF2 BCL2L11 BEX2 BLZF1 BPIFA1 C21orf58 CCDC120 CCDC185 CCDC187 CCDC33 CDCA4 CEP70 CERCAM CIMAP1B CRACR2A CYSRT1 DDIT4L ECM1 ECSIT EFEMP1 ENKD1 ERCC1 FAM110A FAM124B FARS2 GADD45GIP1 GATA1 GEM GOLGA6A GRAP2 HCK HGS HOXA1 HOXD12 HSF2BP HSF4 IGF1 IKZF3 INO80B KANK2 KIF1A KIFC3 KLF1 KLHL38 KRT34 KRT75 KRT86 KRTAP19-2 KRTAP19-6 KRTAP19-7 KRTAP21-2 KRTAP6-2 KRTAP7-1 KRTAP8-1 LAGE3 LASP1 LRSAM1 MAGED1 MBD3 MCCD1 MDM2 MDM4 MEOX1 MEOX2 MGAT5B MIF4GD MNAT1 MORN3 MRPL38 MRPS6 MYOZ2 NABP1 NDE1 NDUFB7 NKAPD1 NME4 ODAD4 PABPC4 PEX10 PEX5 PKN1 POLR1C POMC PRKAA2 PRPF31 PRR22 PRR35 PSMA1 PSMB1 PTH1R PTK6 RASD1 RBM41 RBPMS RBPMS2 RIBC1 RNF10 RNF166 RNF32 RNF7 RSPH1 RSPO4 RTP5 SCNM1 SF1 SFN SLPI SMARCD1 SMYD3 SNRPC SORBS3 SPATA8 SPMIP5 STH STMN3 STN1 SYNGAP1 TADA2A TASOR2 TCEA2 TCHP TCL1B TENT5B TFAP2A TFIP11 TLE5 TPRX1 TRAF2 TRIM23 TRIM31 TRIM34 TRIM5 TRIM65 TRIM8 TSG101 TSGA10IP TSPAN4 TTC23 TXNDC11 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2I UBE2K UBE2L3 UBE2N UBE2U UBE2V1 UBE2V2 UBE2W UQCC2 USHBP1 VPS9D1 WDR25 WWOX YPEL3 ZBTB42 ZFC3H1 ZFP57 ZIM2 ZNF34 ZNF414 ZNF587 ZNF688 ZNF835
Entrez ID		6590	7681
HPRD ID		00121	04836
Ensembl ID		ENSG00000124107	ENSG00000179455
Uniprot IDs		P03973	Q13064
PDB IDs		2Z7F 4DOQ
Enriched GO Terms of Interacting Partners?		Collagen Catabolic Process Endolysosome Lumen Collagen Metabolic Process Cellular Response To Thyroid Hormone Stimulus Extracellular Matrix Disassembly Proteoglycan Binding Extracellular Matrix TRC Complex Positive Regulation Of ERAD Pathway Serine-type Endopeptidase Activity Peptidase Activity Proteolysis Extracellular Space Response To Thyroid Hormone Regulation Of ERAD Pathway Endopeptidase Activity Positive Regulation Of Proteolysis Sequestering Of BMP In Extracellular Matrix Sequestering Of BMP From Receptor Via BMP Binding Protein Metabolic Process Determination Of Dorsal Identity Zymogen Activation Protein Catabolic Process Positive Regulation Of Response To Endoplasmic Reticulum Stress Morphogen Activity Negative Regulation Of Monocyte Chemotaxis Negative Regulation Of Chemotaxis Regulation Of Immune System Process Sequestering Of Extracellular Ligand From Receptor Cysteine-type Endopeptidase Activity Regulation Of Cellular Response To Stress Extracellular Negative Regulation Of Signal Transduction Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Collagen Binding Positive Regulation Of Defense Response To Bacterium Protein Processing Positive Regulation Of Protein Metabolic Process Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides Regulation Of Proteolysis Regulation Of Defense Response To Bacterium Catabolic Process Azurophil Granule Lumen Regulation Of Leukocyte Migration Regulation Of Response To Endoplasmic Reticulum Stress Hydrolase Activity ERAD Pathway Macromolecule Metabolic Process Regulation Of Immune Response Proteolysis Involved In Protein Catabolic Process BMP Binding	Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Binding Ubiquitin-protein Transferase Activity Post-translational Protein Modification Protein K63-linked Ubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Modification-dependent Protein Catabolic Process Protein K11-linked Ubiquitination Protein K48-linked Ubiquitination Regulation Of Nucleobase-containing Compound Metabolic Process Proteolysis Involved In Protein Catabolic Process Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription UBC13-MMS2 Complex Regulation Of RNA Biosynthetic Process Ubiquitin Protein Ligase Activity Nucleus Protein Modification Process Ubiquitin Conjugating Enzyme Complex Intermediate Filament Macromolecule Catabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Protein Polyubiquitination Transferase Activity Positive Regulation Of Protein K63-linked Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Autoubiquitination Regulation Of Gene Expression Zinc Ion Binding Error-free Postreplication DNA Repair Regulation Of Macromolecule Biosynthetic Process Protein Metabolic Process Regulation Of Protein Polyubiquitination Regulation Of Transcription By RNA Polymerase II Transcription Coactivator Activity Regulation Of Protein K63-linked Ubiquitination Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Proteasomal Protein Catabolic Process TORC1 Signaling NEDD8 Ligase Activity ISG15 Transferase Activity
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