GRB2 and TSC2

Number of citations of the paper that reports this interaction (PubMedID 18624398)
0

Data Source:
BioGRID (two hybrid)

		GRB2	TSC2
Description		growth factor receptor bound protein 2	TSC complex subunit 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endosome Golgi Apparatus Centrosome Cytosol Plasma Membrane Cell-cell Junction Cell Cortex COP9 Signalosome Vesicle Membrane Membrane Extracellular Exosome Grb2-EGFR Complex	Nucleus Cytoplasm Lysosome Lysosomal Membrane Golgi Apparatus Cytosol Postsynaptic Density Membrane TSC1-TSC2 Complex Synapse Perinuclear Region Of Cytoplasm
	Molecular Function	Phosphotyrosine Residue Binding RNA Binding Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Guanyl-nucleotide Exchange Factor Adaptor Activity Epidermal Growth Factor Receptor Binding Neurotrophin TRKA Receptor Binding Protein Binding SH3 Domain Binding Protein Kinase Binding Protein Phosphatase Binding Protein Domain Specific Binding Protein-macromolecule Adaptor Activity Identical Protein Binding Insulin Receptor Substrate Binding Ephrin Receptor Binding	GTPase Activator Activity Protein Binding Phosphatase Binding Small GTPase Binding Protein Homodimerization Activity Hsp90 Protein Binding
	Biological Process	Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Ras Protein Signal Transduction Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Schwann Cell Development Actin Cytoskeleton Organization Positive Regulation Of Actin Filament Polymerization T Cell Costimulation Receptor Internalization Endodermal Cell Differentiation T Cell Activation Natural Killer Cell Mediated Cytotoxicity Myelination Signal Transduction In Response To DNA Damage Regulation Of MAPK Cascade Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Insulin-like Growth Factor Receptor Signaling Pathway Anatomical Structure Formation Involved In Morphogenesis B Cell Receptor Signaling Pathway Branching Involved In Labyrinthine Layer Morphogenesis Cellular Response To Ionizing Radiation Positive Regulation Of Reactive Oxygen Species Metabolic Process	Neural Tube Closure Cytoplasmic Translation Protein Import Into Nucleus Endocytosis Heart Development Intracellular Protein Localization Negative Regulation Of Cell Population Proliferation Cellular Response To Starvation Vesicle-mediated Transport Positive Regulation Of Macroautophagy Regulation Of Macroautophagy Regulation Of Endocytosis Negative Regulation Of Wnt Signaling Pathway Cellular Response To Nutrient Levels Negative Regulation Of TOR Signaling TORC1 Signaling Anoikis Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Insulin Receptor Signaling Pathway Positive Chemotaxis Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Cell Cycle Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Mitophagy Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling
Pathways		Interleukin-15 signaling Interleukin-15 signaling Signaling by CSF3 (G-CSF) Signaling by CSF3 (G-CSF) STAT5 activation downstream of FLT3 ITD mutants Signaling by FLT3 ITD and TKD mutants Signaling by FLT3 ITD and TKD mutants Signaling by ALK fusions and activated point mutants Signaling by LTK	Macroautophagy Inhibition of TSC complex formation by PKB AKT phosphorylates targets in the cytosol Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Constitutive Signaling by AKT1 E17K in Cancer TBC/RABGAPs
Drugs		Pegademase 4-[(10s,14s,18s)-18-(2-Amino-2-Oxoethyl)-14-(1-Naphthylmethyl)-8,17,20-Trioxo-7,16,19-Triazaspiro[5.14]Icos-11-En-10-Yl]Benzylphosphonic Acid
Diseases			Lymphangioleiomyomatosis (LAM) Tuberous sclerosis complex (TSC); Bourneville-Pringle disease
GWAS		Aspartate aminotransferase levels ( 33547301) Deep white matter hyperintensities ( 32517579) Multiple sclerosis ( 31604244) Systemic lupus erythematosus ( 26502338 28714469 29848360) Systemic sclerosis ( 31672989) Triglyceride levels ( 32203549) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172)	Major depressive disorder ( 29317602) Obesity-related traits ( 23251661) White blood cell count ( 32888494)
Interacting Genes		397 interacting genes: A2M ABI3 ABI3BP ABL1 ABL2 ACAP1 ADA ADAM12 ADAM15 ADRB1 ADRB2 AEBP1 AGR2 AGT AHSG AJUBA ALAS2 ALOX5 AMBP ANKRD13A ANKRD23 ANXA2 AP4S1 APCS APOH APP AR ARHGAP17 ARHGAP32 ARHGAP35 ARID5A ASAP1 ASAP2 AUNIP AXL B2M BCAR1 BCL2A1 BCR BLNK BPGM BTG1 C1orf94 C21orf58 C21orf91 CALD1 CASC3 CASP2 CBL CBLB CBLC CCDC28B CCL5 CD164 CD19 CD22 CD247 CD28 CD2AP CD72 CDC42 CDKN1B CEBPA CFH CHRM4 CHRND CKS2 CLNK CLU COPB1 COX6A1 CPSF7 CRBN CRK CRKL CSF1R CSF3R CSN2 CTTN CUTA DAB2 DAG1 DCTN1 DCTN2 DDIT4L DDX17 DLGAP1 DNAJA3 DNAJB11 DNM1 DNM2 DOCK4 DPPA4 DRD3 DRD4 DTX1 DTX3 DVL2 E2F2 ECHS1 EFHC2 EGF EGFR ELK1 ENO1 EP300 EPHA2 EPHB1 EPHB2 EPHB6 EPOR EPS15 EPS8 ERBB2 ERBB3 ERBB4 ESD ESR1 ETV6 FABP1 FASLG FCGR2A FCGR2B FGFR1 FGFR3 FH FHOD1 FLT1 FLT3 FLT4 FN1 FRS2 FRS3 FTH1 FTL FYN GAB1 GAB2 GAB3 GC GGN GHR GIT1 GPANK1 GRAP2 GRB7 GSTK1 H1-0 H2AX HCLS1 HELZ HIPK3 HNRNPC HNRNPK HOMEZ HP HRAS HTT IK IKZF3 IL2RB INCA1 INPP5D IRS1 IRS2 IRS4 ITGA2B ITGA6 ITGB4 ITIH4 ITK JAK1 JAK2 KDR KHDRBS1 KHDRBS2 KIAA0408 KIAA1549L KIF3A KIT KPNA2 KPRP KRT8 LAT LAT2 LAX1 LCP2 LIME1 LMO2 LNX1 LNX2 LY6G6F LZTS2 MAP1A MAP2 MAP4K1 MAP4K5 MAPK1 MAPK12 MAPK14 MAPK9 MED19 MED28 MEI4 MERTK MET METTL27 MIA2 MICAL1 MLXIPL MRE11 MS4A2 MSI2 MST1R MT-ATP8 MT-ND4 MTA1 MTA3 MUC1 MYG1 MYH11 MYO18A MYOZ1 NADK NAP1L5 NCKIPSD NCL NEU3 NFYB NGFR NIF3L1 NKD2 NPM1 NTRK1 NUTM2F OCRL OLIG1 PACRGL PAG1 PAK1 PAK2 PAK4 PBXIP1 PCDHB5 PDCD6IP PDE4D PDE6G PDGFRB PHACTR4 PHC2 PHETA1 PIK3AP1 PIK3C2B PIK3CG PIK3R1 PIK3R2 PIK3R3 PLCG1 PLEKHA7 PNMA5 PNRC1 POLR1D POLR2A POMP PON2 PPP3CA PRAP1 PRKAB1 PRKAR1A PRNP PRR22 PRR5-ARHGAP8 PRRC2A PRRG4 PTK2 PTK2B PTPN1 PTPN11 PTPN12 PTPN22 PTPN6 PTPRA PTPRC PTPRE PXN RALGPS1 RAPGEF1 RAPSN RASA1 RBBP6 RBM33 RBP4 REL REPS1 REPS2 RET RHOU RIF1 RNF10 RNF208 RPA1 RPS6KA1 SELL SF3A2 SF3B4 SH2B1 SH2B2 SH2B3 SH2D1A SH2D4A SH3BP2 SH3D19 SH3KBP1 SHANK3 SHB SHBG SHC1 SHC2 SHC3 SHC4 SHKBP1 SIGLEC7 SIT1 SKAP1 SLC1A2 SLX1A SNRNP200 SNTA1 SOCS1 SOCS7 SOS1 SOS2 SPATA2L SPRY1 SPRY2 SPTBN1 SRC SS18 STAMBP STK32C STRADB SYK SYN1 SYNCRIP SYNJ1 SYNJ2 SYP TBC1D3B TBC1D3G TCEAL8 TCERG1 TEK TF TFG TLE5 TNFRSF1A TNK2 TOM1L1 TP53BP2 TP63 TRAT1 TRIB3 TRIM27 TSC2 TSPAN2 TUB TXK UBA1 UBA52 UBC UQCC2 USP53 USP6NL USP8 VAV1 VAV2 VAV3 VIM VPS37C WAS WASF1 WASF2 WASL WBP11 WDFY3 WDR1 WDR44 WIPF1 WIPF2 YLPM1 ZAP70 ZBTB12 ZBTB7B ZMAT1 ZNF341 ZNF474 ZNF620	61 interacting genes: ACTN2 AKT1 AKT2 AKT3 ANKRD35 BTG3 CALM1 CBY2 CCND1 CDKN1B EEF1A1 ESR1 FBXL6 FBXW5 GAPDH GRB2 GSK3B LNX1 MAPK1 MAPK3 MAPKAPK2 MDFI MKRN1 MRPL21 NEK1 PAM PHLDB1 PICK1 PIN1 PLK2 PPP1CA PPP2CA PRKAA1 PTK2 PTPN11 RAB5A RABEP1 RHEB RPL4 RPS6KA1 RPSA SEPTIN4 SERPINI1 SFN SLC13A3 SMAD2 SMAD3 SSC4D SUPT6H TK1 TRIM55 TRIM63 TSC1 UBE3A USPL1 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ
Entrez ID		2885	7249
HPRD ID		00150	01850
Ensembl ID		ENSG00000177885	ENSG00000103197
Uniprot IDs		B0LPF3 P62993	A0A2R8Y6C9 A0A2R8YDZ2 B3KWH7 H3BMQ0 P49815 Q5HYF7 X5D2U8 X5D7Q2
PDB IDs		1AZE 1BM2 1BMB 1CJ1 1FHS 1FYR 1GCQ 1GFC 1GFD 1GHU 1GRI 1IO6 1JYQ 1JYR 1JYU 1QG1 1TZE 1X0N 1ZFP 2AOA 2AOB 2H46 2H5K 2HUW 2VVK 2VWF 2W0Z 3C7I 3IMD 3IMJ 3IN7 3IN8 3KFJ 3MXC 3MXY 3N7Y 3N84 3N8M 3OV1 3OVE 3S8L 3S8N 3S8O 3WA4 4P9V 4P9Z 5CDW 6ICG 6ICH 6SDF 6VK2 6WM1 6WO2 7MPH 8DGO	7DL2 9CE3
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Signal Transduction Protein Tyrosine Kinase Activity SH3 Domain Binding Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Regulation Of Signal Transduction Plasma Membrane Regulation Of Signaling Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cell Communication Phosphotyrosine Residue Binding Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of MAPK Cascade SH2 Domain Binding Immune Response-activating Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Activity Antigen Receptor-mediated Signaling Pathway Regulation Of Cellular Component Organization Positive Regulation Of Cellular Component Organization Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signaling Positive Regulation Of Signal Transduction Intracellular Signaling Cassette Peptidyl-tyrosine Phosphorylation Regulation Of Immune System Process Positive Regulation Of Cell Communication Regulation Of Immune Response Cytosol Protein Kinase Activity T Cell Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Positive Regulation Of Immune System Process Immune System Process Protein Binding Immune Response-activating Signaling Pathway Regulation Of Cell Population Proliferation Regulation Of Multicellular Organismal Process Regulation Of Programmed Cell Death Positive Regulation Of Multicellular Organismal Process Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Regulation Of Apoptotic Process Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Cell Migration Activation Of Immune Response Response To Growth Factor	Intracellular Signal Transduction Protein Modification Process Protein Metabolic Process Phosphoserine Residue Binding Regulation Of TOR Signaling Cytosol TOR Signaling Negative Regulation Of TOR Signaling Protein Kinase Binding Cytoplasm TORC1 Signaling Regulation Of Intracellular Signal Transduction Regulation Of Biological Quality Intracellular Signaling Cassette Regulation Of Cell Communication Regulation Of Signaling Regulation Of TORC1 Signaling Negative Regulation Of TORC1 Signaling Regulation Of Signal Transduction Protein Domain Specific Binding Macromolecule Metabolic Process Cellular Response To Stress Protein Sequestering Activity Ciliary Basal Body Identical Protein Binding Insulin Receptor Signaling Pathway Signal Transduction Protein Kinase Activity Cellular Response To Nutrient Levels Positive Regulation Of TOR Signaling Kinase Activity Protein Phosphorylation Protein Serine Kinase Activity Regulation Of Synaptic Plasticity SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Signal Transduction Regulation Of Protein Stability Negative Regulation Of Catabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Organelle Organization Epidermal Growth Factor Receptor Signaling Pathway Phosphorylation Negative Regulation Of Signaling Positive Regulation Of TORC1 Signaling Negative Regulation Of Cell Communication Nucleus Regulation Of Immune Response Regulation Of Protein Metabolic Process Protein Serine/threonine Kinase Activity
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