GRB2 and CDC42

Number of citations of the paper that reports this interaction (PubMedID 31478661)
0

Data Source:
BioGRID (pull down, two hybrid)

		GRB2	CDC42
Description		growth factor receptor bound protein 2	cell division cycle 42
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endosome Golgi Apparatus Centrosome Cytosol Plasma Membrane Cell-cell Junction Cell Cortex COP9 Signalosome Vesicle Membrane Membrane Extracellular Exosome Grb2-EGFR Complex	Golgi Membrane Storage Vacuole Cytoplasm Endoplasmic Reticulum Membrane Centrosome Spindle Cytosol Cytoskeleton Plasma Membrane Cell-cell Junction Focal Adhesion Membrane Golgi Transport Complex Filopodium Dendrite Midbody Cell Leading Edge Leading Edge Membrane Protein-containing Complex Cytoplasmic Ribonucleoprotein Granule Cell Projection Neuron Projection Neuronal Cell Body Apical Part Of Cell Phagocytic Vesicle Spindle Midzone Extracellular Exosome Cell Periphery Mitotic Spindle Postsynapse Glutamatergic Synapse
	Molecular Function	Phosphotyrosine Residue Binding RNA Binding Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Guanyl-nucleotide Exchange Factor Adaptor Activity Epidermal Growth Factor Receptor Binding Neurotrophin TRKA Receptor Binding Protein Binding SH3 Domain Binding Protein Kinase Binding Protein Phosphatase Binding Protein Domain Specific Binding Protein-macromolecule Adaptor Activity Identical Protein Binding Insulin Receptor Substrate Binding Ephrin Receptor Binding	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity Protein Kinase Binding GTP-dependent Protein Binding Thioesterase Binding GBD Domain Binding Apolipoprotein A-I Receptor Binding Identical Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Ras Protein Signal Transduction Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Schwann Cell Development Actin Cytoskeleton Organization Positive Regulation Of Actin Filament Polymerization T Cell Costimulation Receptor Internalization Endodermal Cell Differentiation T Cell Activation Natural Killer Cell Mediated Cytotoxicity Myelination Signal Transduction In Response To DNA Damage Regulation Of MAPK Cascade Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Insulin-like Growth Factor Receptor Signaling Pathway Anatomical Structure Formation Involved In Morphogenesis B Cell Receptor Signaling Pathway Branching Involved In Labyrinthine Layer Morphogenesis Cellular Response To Ionizing Radiation Positive Regulation Of Reactive Oxygen Species Metabolic Process	Heart Process Cardiac Conduction System Development Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Endocytosis Phagocytosis, Engulfment Actin Filament Organization Golgi Organization Regulation Of Mitotic Nuclear Division Nuclear Migration Establishment Or Maintenance Of Cell Polarity Signal Transduction Integrin-mediated Signaling Pathway Small GTPase-mediated Signal Transduction Nervous System Development Intracellular Protein Localization Anatomical Structure Morphogenesis Regulation Of Lamellipodium Assembly Positive Regulation Of Lamellipodium Assembly Substantia Nigra Development Establishment Of Cell Polarity Actin Cytoskeleton Organization Cell Differentiation Macrophage Differentiation Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Positive Regulation Of Pseudopodium Assembly Negative Regulation Of Protein-containing Complex Assembly Positive Regulation Of Cytokinesis Regulation Of Actin Cytoskeleton Organization Cell Junction Assembly Adherens Junction Organization Embryonic Heart Tube Development Establishment Or Maintenance Of Apical/basal Cell Polarity Dendritic Cell Migration Neuropilin Signaling Pathway Positive Regulation Of MAPK Cascade Host-mediated Perturbation Of Viral Process Establishment Of Epithelial Cell Apical/basal Polarity Filopodium Assembly Positive Regulation Of Pinocytosis Neuron Fate Determination Positive Regulation Of Cellular Component Organization Regulation Of Filopodium Assembly Positive Regulation Of Filopodium Assembly Regulation Of Stress Fiber Assembly Positive Regulation Of Stress Fiber Assembly Nucleus Localization Establishment Of Localization In Cell Establishment Of Golgi Localization Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Attachment Of Spindle Microtubules To Kinetochore Heart Contraction Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Dendritic Spine Morphogenesis Cellular Response To Type II Interferon Organelle Transport Along Microtubule Endothelin Receptor Signaling Pathway Involved In Heart Process Regulation Of Postsynapse Organization Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Pathways		Interleukin-15 signaling Interleukin-15 signaling Signaling by CSF3 (G-CSF) Signaling by CSF3 (G-CSF) STAT5 activation downstream of FLT3 ITD mutants Signaling by FLT3 ITD and TKD mutants Signaling by FLT3 ITD and TKD mutants Signaling by ALK fusions and activated point mutants Signaling by LTK	GPVI-mediated activation cascade EGFR downregulation Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation CD28 dependent Vav1 pathway EPHB-mediated forward signaling EPHB-mediated forward signaling DCC mediated attractive signaling Inactivation of CDC42 and RAC1 VEGFA-VEGFR2 Pathway Myogenesis Myogenesis RHO GTPases activate KTN1 RHO GTPases activate IQGAPs RHO GTPases activate PAKs RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate Formins RHO GTPases Activate Formins MAPK6/MAPK4 signaling Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation G beta:gamma signalling through CDC42 CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOQ GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RHOU GTPase cycle RAC3 GTPase cycle RHOV GTPase cycle FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis Factors involved in megakaryocyte development and platelet production
Drugs		Pegademase 4-[(10s,14s,18s)-18-(2-Amino-2-Oxoethyl)-14-(1-Naphthylmethyl)-8,17,20-Trioxo-7,16,19-Triazaspiro[5.14]Icos-11-En-10-Yl]Benzylphosphonic Acid	Aminophosphonic acid-guanylate ester Guanosine-5'-Diphosphate
Diseases
GWAS		Aspartate aminotransferase levels ( 33547301) Deep white matter hyperintensities ( 32517579) Multiple sclerosis ( 31604244) Systemic lupus erythematosus ( 26502338 28714469 29848360) Systemic sclerosis ( 31672989) Triglyceride levels ( 32203549) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172)	Colorectal cancer ( 25990418) Daytime sleep phenotypes ( 27126917) Extremely high intelligence ( 29520040) Gestational age at birth (maternal effect) ( 28877031) Gynecologic disease ( 31488892) Gynecologic disease (multivariate analysis) ( 31488892) Hip circumference adjusted for BMI ( 34021172) Immune response to smallpox vaccine (IL-6) ( 22610502) Liver enzyme levels (alkaline phosphatase) ( 33972514) Metabolite levels ( 23823483) Uterine fibroids ( 30194396 31249589 31488892 31649266) Uterine fibroids (MTAG) ( 31488892)
Interacting Genes		397 interacting genes: A2M ABI3 ABI3BP ABL1 ABL2 ACAP1 ADA ADAM12 ADAM15 ADRB1 ADRB2 AEBP1 AGR2 AGT AHSG AJUBA ALAS2 ALOX5 AMBP ANKRD13A ANKRD23 ANXA2 AP4S1 APCS APOH APP AR ARHGAP17 ARHGAP32 ARHGAP35 ARID5A ASAP1 ASAP2 AUNIP AXL B2M BCAR1 BCL2A1 BCR BLNK BPGM BTG1 C1orf94 C21orf58 C21orf91 CALD1 CASC3 CASP2 CBL CBLB CBLC CCDC28B CCL5 CD164 CD19 CD22 CD247 CD28 CD2AP CD72 CDC42 CDKN1B CEBPA CFH CHRM4 CHRND CKS2 CLNK CLU COPB1 COX6A1 CPSF7 CRBN CRK CRKL CSF1R CSF3R CSN2 CTTN CUTA DAB2 DAG1 DCTN1 DCTN2 DDIT4L DDX17 DLGAP1 DNAJA3 DNAJB11 DNM1 DNM2 DOCK4 DPPA4 DRD3 DRD4 DTX1 DTX3 DVL2 E2F2 ECHS1 EFHC2 EGF EGFR ELK1 ENO1 EP300 EPHA2 EPHB1 EPHB2 EPHB6 EPOR EPS15 EPS8 ERBB2 ERBB3 ERBB4 ESD ESR1 ETV6 FABP1 FASLG FCGR2A FCGR2B FGFR1 FGFR3 FH FHOD1 FLT1 FLT3 FLT4 FN1 FRS2 FRS3 FTH1 FTL FYN GAB1 GAB2 GAB3 GC GGN GHR GIT1 GPANK1 GRAP2 GRB7 GSTK1 H1-0 H2AX HCLS1 HELZ HIPK3 HNRNPC HNRNPK HOMEZ HP HRAS HTT IK IKZF3 IL2RB INCA1 INPP5D IRS1 IRS2 IRS4 ITGA2B ITGA6 ITGB4 ITIH4 ITK JAK1 JAK2 KDR KHDRBS1 KHDRBS2 KIAA0408 KIAA1549L KIF3A KIT KPNA2 KPRP KRT8 LAT LAT2 LAX1 LCP2 LIME1 LMO2 LNX1 LNX2 LY6G6F LZTS2 MAP1A MAP2 MAP4K1 MAP4K5 MAPK1 MAPK12 MAPK14 MAPK9 MED19 MED28 MEI4 MERTK MET METTL27 MIA2 MICAL1 MLXIPL MRE11 MS4A2 MSI2 MST1R MT-ATP8 MT-ND4 MTA1 MTA3 MUC1 MYG1 MYH11 MYO18A MYOZ1 NADK NAP1L5 NCKIPSD NCL NEU3 NFYB NGFR NIF3L1 NKD2 NPM1 NTRK1 NUTM2F OCRL OLIG1 PACRGL PAG1 PAK1 PAK2 PAK4 PBXIP1 PCDHB5 PDCD6IP PDE4D PDE6G PDGFRB PHACTR4 PHC2 PHETA1 PIK3AP1 PIK3C2B PIK3CG PIK3R1 PIK3R2 PIK3R3 PLCG1 PLEKHA7 PNMA5 PNRC1 POLR1D POLR2A POMP PON2 PPP3CA PRAP1 PRKAB1 PRKAR1A PRNP PRR22 PRR5-ARHGAP8 PRRC2A PRRG4 PTK2 PTK2B PTPN1 PTPN11 PTPN12 PTPN22 PTPN6 PTPRA PTPRC PTPRE PXN RALGPS1 RAPGEF1 RAPSN RASA1 RBBP6 RBM33 RBP4 REL REPS1 REPS2 RET RHOU RIF1 RNF10 RNF208 RPA1 RPS6KA1 SELL SF3A2 SF3B4 SH2B1 SH2B2 SH2B3 SH2D1A SH2D4A SH3BP2 SH3D19 SH3KBP1 SHANK3 SHB SHBG SHC1 SHC2 SHC3 SHC4 SHKBP1 SIGLEC7 SIT1 SKAP1 SLC1A2 SLX1A SNRNP200 SNTA1 SOCS1 SOCS7 SOS1 SOS2 SPATA2L SPRY1 SPRY2 SPTBN1 SRC SS18 STAMBP STK32C STRADB SYK SYN1 SYNCRIP SYNJ1 SYNJ2 SYP TBC1D3B TBC1D3G TCEAL8 TCERG1 TEK TF TFG TLE5 TNFRSF1A TNK2 TOM1L1 TP53BP2 TP63 TRAT1 TRIB3 TRIM27 TSC2 TSPAN2 TUB TXK UBA1 UBA52 UBC UQCC2 USP53 USP6NL USP8 VAV1 VAV2 VAV3 VIM VPS37C WAS WASF1 WASF2 WASL WBP11 WDFY3 WDR1 WDR44 WIPF1 WIPF2 YLPM1 ZAP70 ZBTB12 ZBTB7B ZMAT1 ZNF341 ZNF474 ZNF620	383 interacting genes: A2M AARS1 ACADM ACO1 ACO2 ACOT7 ACTR3 ADRM1 AGAP1 AGAP2 AHSG AKR1B1 ALDH18A1 ANAPC13 ANXA11 ANXA2 AP3D1 APEX1 APOH ARAP1 ARAP2 ARG1 ARHGAP1 ARHGAP10 ARHGAP11B ARHGAP17 ARHGAP20 ARHGAP22 ARHGAP26 ARHGAP27 ARHGAP31 ARHGAP32 ARHGAP35 ARHGAP39 ARHGAP40 ARHGAP44 ARHGDIA ARHGDIB ARHGDIG ARHGEF10 ARHGEF11 ARHGEF15 ARHGEF25 ARHGEF26 ARHGEF4 ARHGEF6 ARHGEF7 ARHGEF9 ARRB1 ARRB2 ATP5F1C ATP5IF1 ATP5MF ATP5PD ATP6V1A BAIAP2 BCAP31 BCCIP BCL2L13 BCR BIRC2 BLMH BNIP2 BRD10 BTF3 BZW2 CALML5 CAPNS1 CAPZB CARHSP1 CASP14 CASP3 CASP7 CBLL1 CBX3 CCN1 CDC42BPA CDC42BPB CDC42BPG CDC42EP1 CDC42EP2 CDC42EP3 CDC42EP4 CDC42EP5 CDC42SE1 CDC5L CDH1 CDKN2A CEBPA CFHR4 CGN CMPK1 CNBP CNOT1 COL1A1 COMT COPA COPE COPG1 CPN1 CRIP2 CSE1L CSN2 CSPG4 CTNNA1 DEF6 DEK DHFR DIAPH1 DIAPH2 DIAPH3 DNMBP DOCK7 DOCK8 DOCK9 DPYSL2 DSG1 DSP ECHS1 EDC4 EDF1 EEF1E1 EEF1G EHD2 EHD4 EIF2AK2 EIF3D EIF3F EIF5 EIF5B EPHA2 EPRS1 ERCC3 ERG28 ERICH6 ERRFI1 ETFA FAM13B FGD1 FGD2 FGD3 FGD4 FKBP10 FKBP1A FKBP3 FLNA FLNC FMN2 FMNL2 FNBP1 FNBP1L FNDC3B FTH1 G6PD GALNT2 GART GDI1 GIT2 GLS GMIP GNB1 GRB2 GRWD1 GSR GSTM5 H1-10 H1-5 H2BC13 HADH HADHB HDAC7 HDLBP HERC2 HLA-G HMGN1 HNRNPAB HNRNPUL2 HSD17B10 HYOU1 IARS1 IGF2BP1 IPO5 IQGAP1 IQGAP2 ITSN1 JPT2 KARS1 KAT5 KHDRBS1 KPNA2 KTN1 KYNU LARS1 LCK LGALS1 LGALS7 LONP1 LRIF1 LRP2 LYZ MAP2K3 MAP3K10 MAP3K11 MAP3K19 MAP3K4 MAP4 MAPRE1 MARCKSL1 MARK4 MASTL MATR3 MCF2L MCM3AP MCM6 MCM7 MDH1 MDK METAP2 MRM1 MRPL49 MSH2 MT-CO1 MTDH MUC12 MYO1C MYO6 MYO9A NAA15 NASP NCAPD2 NCF2 NEK6 NIBAN2 NOP2 NPLOC4 NQO1 NUDT21 NUP155 OCRL OLA1 OPHN1 P3H1 PABPC4 PAK1 PAK2 PAK3 PAK4 PAK5 PAK6 PALLD PARD3 PARD6A PARD6B PARD6G PAXX PCM1 PCNP PDCD5 PDE6C PDE6D PGD PGGT1B PHAX PHB2 PHPT1 PICALM PIK3R1 PLD1 PLEKHG1 PLEKHG2 PLEKHG3 PLEKHG4 PLEKHG4B PMS1 PPP2R1A PRDX3 PREX2 PRKCA PRKCG PRKCI PRKCZ PSAT1 PSIP1 PSMB1 PSMC5 PSMC6 PSMD11 PSMD12 PSMD3 PSME3 PXDN RAC2 RAP1GDS1 RARS1 RASGRF2 RBM8A RHOJ RIOK3 RO60 RPL22 RPL23 RPS15 RPS21 RPS6KB1 RRM1 S100A9 SDHA SEPTIN2 SERPINB1 SERPINB2 SERPINB3 SF1 SF3A2 SH3BGRL3 SH3D19 SLC16A3 SMC2 SNCA SNRNP70 SPATA13 SRGAP1 SRM SRP72 SRSF1 SSB SSX2IP ST13 STARD8 STAT1 STAU1 STMN2 SYNE1 TBC1D3F TBCA TCEAL3 TIAM1 TMED10 TMED9 TMOD3 TMX1 TNFRSF10B TNK2 TOR1AIP1 TP53 TPD52L2 TPM1 TRAF2 TRIM28 TRIM45 TRIM60 TRIO TRIP10 TRRAP TSFM TTC12 TUBB3 TXNL1 TYMS U2AF2 UBC UBE2L3 UBR1 UGDH UNC119 USP6 VARS1 VASP VAV1 VRK2 WAS WASF1 WASF2 WASL WIPF1 XIAP XPO1 YARS1 YWHAH ZNF175 ZNF234 ZNF415 ZNF420 ZNF622
Entrez ID		2885	998
HPRD ID		00150	00309
Ensembl ID		ENSG00000177885	ENSG00000070831
Uniprot IDs		B0LPF3 P62993	P60953
PDB IDs		1AZE 1BM2 1BMB 1CJ1 1FHS 1FYR 1GCQ 1GFC 1GFD 1GHU 1GRI 1IO6 1JYQ 1JYR 1JYU 1QG1 1TZE 1X0N 1ZFP 2AOA 2AOB 2H46 2H5K 2HUW 2VVK 2VWF 2W0Z 3C7I 3IMD 3IMJ 3IN7 3IN8 3KFJ 3MXC 3MXY 3N7Y 3N84 3N8M 3OV1 3OVE 3S8L 3S8N 3S8O 3WA4 4P9V 4P9Z 5CDW 6ICG 6ICH 6SDF 6VK2 6WM1 6WO2 7MPH 8DGO	1A4R 1AJE 1AM4 1AN0 1CEE 1CF4 1DOA 1E0A 1EES 1GRN 1GZS 1KI1 1KZ7 1KZG 1NF3 2ASE 2DFK 2KB0 2NGR 2ODB 2QRZ 2WM9 2WMN 2WMO 3GCG 3QBV 3VHL 4DID 4ITR 4JS0 4YC7 4YDH 5CJP 5FI1 5HZK 5UPK 5UPL 6AJ4 6AJL 6SIU 6SUP 6TKY 6TKZ 7S0Y 8I5F
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Signal Transduction Protein Tyrosine Kinase Activity SH3 Domain Binding Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Regulation Of Signal Transduction Plasma Membrane Regulation Of Signaling Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cell Communication Phosphotyrosine Residue Binding Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of MAPK Cascade SH2 Domain Binding Immune Response-activating Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Activity Antigen Receptor-mediated Signaling Pathway Regulation Of Cellular Component Organization Positive Regulation Of Cellular Component Organization Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signaling Positive Regulation Of Signal Transduction Intracellular Signaling Cassette Peptidyl-tyrosine Phosphorylation Regulation Of Immune System Process Positive Regulation Of Cell Communication Regulation Of Immune Response Cytosol Protein Kinase Activity T Cell Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Positive Regulation Of Immune System Process Immune System Process Protein Binding Immune Response-activating Signaling Pathway Regulation Of Cell Population Proliferation Regulation Of Multicellular Organismal Process Regulation Of Programmed Cell Death Positive Regulation Of Multicellular Organismal Process Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Regulation Of Apoptotic Process Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Cell Migration Activation Of Immune Response Response To Growth Factor	Cytosol Cytoplasm Regulation Of Small GTPase Mediated Signal Transduction GTPase Activator Activity Regulation Of Intracellular Signal Transduction Small GTPase Binding Guanyl-nucleotide Exchange Factor Activity Actin Filament-based Process Small GTPase-mediated Signal Transduction Actin Cytoskeleton Organization Intracellular Signaling Cassette Lamellipodium Intracellular Signal Transduction Regulation Of Signal Transduction Cytoskeleton Organization RNA Binding Regulation Of Signaling Regulation Of Cell Communication Rho Protein Signal Transduction Extracellular Exosome Organelle Organization Cadherin Binding Cell-cell Junction Regulation Of Actin Cytoskeleton Organization Cell Projection Organization Cell Cortex PAR Polarity Complex Biological_process Regulation Of Actin Filament-based Process Ruffle Actin Filament Organization Regulation Of Cytoskeleton Organization Regulation Of Cell Shape Regulation Of Cellular Component Organization Protein Serine Kinase Activity Supramolecular Fiber Organization Anchoring Junction Regulation Of Protein Metabolic Process Actin Cytoskeleton Cellular Component Assembly Regulation Of Programmed Cell Death Regulation Of Actin Filament Organization Actin Binding Cytoskeleton Positive Regulation Of Cellular Component Organization Regulation Of Supramolecular Fiber Organization Regulation Of Cell Morphogenesis Actin Filament Protein Serine/threonine Kinase Activity Regulation Of Rho Protein Signal Transduction
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