GRB2 and PIK3R2

Number of citations of the paper that reports this interaction (PMID 8662998)
25

Data Source:
HPRD (in vivo)

		GRB2	PIK3R2
Gene Name		growth factor receptor-bound protein 2	phosphoinositide-3-kinase, regulatory subunit 2 (beta)
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Endosome Golgi Apparatus Cytosol Plasma Membrane Cell-cell Junction COP9 Signalosome Vesicle Membrane Extracellular Vesicular Exosome Grb2-EGFR Complex	Nucleus Cytosol Phosphatidylinositol 3-kinase Complex
	Molecular Function	Phosphotyrosine Binding SH3/SH2 Adaptor Activity Epidermal Growth Factor Receptor Binding Neurotrophin TRKA Receptor Binding Protein Binding SH3 Domain Binding Protein Kinase Binding Protein Phosphatase Binding Identical Protein Binding Insulin Receptor Substrate Binding Poly(A) RNA Binding Ephrin Receptor Binding	Protein Binding 1-phosphatidylinositol-3-kinase Activity Protein Phosphatase Binding Receptor Tyrosine Kinase Binding Phosphatidylinositol 3-kinase Regulator Activity
	Biological Process	Epidermal Growth Factor Receptor Signaling Pathway Ras Protein Signal Transduction Cell-cell Signaling Axon Guidance Aging Blood Coagulation Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Signal Transduction Viral Process Platelet Activation Positive Regulation Of Actin Filament Polymerization T Cell Costimulation Receptor Internalization Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Signal Transduction In Response To DNA Damage Regulation Of MAPK Cascade Innate Immune Response Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Anatomical Structure Formation Involved In Morphogenesis Leukocyte Migration Protein Heterooligomerization Branching Involved In Labyrinthine Layer Morphogenesis Cellular Response To Ionizing Radiation Positive Regulation Of Reactive Oxygen Species Metabolic Process	Cellular Glucose Homeostasis Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Epidermal Growth Factor Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Blood Coagulation Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Autophagy Phosphatidylinositol 3-kinase Signaling Cellular Response To Insulin Stimulus Response To Endoplasmic Reticulum Stress Phosphatidylinositol-3-phosphate Biosynthetic Process Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of Transcription Factor Import Into Nucleus Regulation Of Phosphatidylinositol 3-kinase Activity Small Molecule Metabolic Process Innate Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling T Cell Receptor Signaling Pathway Leukocyte Migration Regulation Of Small GTPase Mediated Signal Transduction
Pathways			Signaling by the B Cell Receptor (BCR) Signaling by GPCR Metabolism of lipids and lipoproteins Signaling by FGFR in disease Signaling by EGFRvIII in Cancer Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling PI3K/AKT activation Interleukin receptor SHC signaling PI-3K cascade Gastrin-CREB signalling pathway via PKC and MAPK Interleukin-7 signaling Role of phospholipids in phagocytosis Phospholipid metabolism Fcgamma receptor (FCGR) dependent phagocytosis PI3K Cascade Signaling by PDGF DAP12 interactions GAB1 signalosome G-protein beta:gamma signalling CD28 co-stimulation CD28 dependent PI3K/Akt signaling Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling Signaling by ERBB2 G alpha (q) signalling events Signaling by EGFR GPCR downstream signaling Signaling by Interleukins TCR signaling Signaling by VEGF Signaling by Rho GTPases Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer Nephrin interactions Interleukin-2 signaling PI3K/AKT Signaling in Cancer Platelet activation, signaling and aggregation Interleukin-3, 5 and GM-CSF signaling Adaptive Immune System G alpha (q) signalling events Downstream TCR signaling Costimulation by the CD28 family IRS-mediated signalling PIP3 activates AKT signaling IGF1R signaling cascade VEGFA-VEGFR2 Pathway Rho GTPase cycle Synthesis of PIPs at the plasma membrane IRS-related events triggered by IGF1R G beta:gamma signalling through PI3Kgamma PI3K events in ERBB2 signaling Regulation of signaling by CBL Downstream signaling of activated FGFR G alpha (12/13) signalling events PI Metabolism Innate Immune System Signaling by Insulin receptor Signalling by NGF Insulin receptor signalling cascade IRS-related events Cytokine Signaling in Immune system Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Tie2 Signaling Signaling by Overexpressed Wild-Type EGFR in Cancer Cell surface interactions at the vascular wall Signaling by FGFR IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) GPVI-mediated activation cascade Interleukin receptor SHC signaling PI3K Cascade
Drugs		Pegademase bovine 4-[(10s,14s,18s)-18-(2-Amino-2-Oxoethyl)-14-(1-Naphthylmethyl)-8,17,20-Trioxo-7,16,19-Triazaspiro[5.14]Icos-11-En-10-Yl]Benzylphosphonic Acid
Diseases
GWAS
Protein-Protein Interactions		347 interactors: A2M ABI3 ABI3BP ABL1 ABL2 ADA ADAM12 ADAM15 ADRB1 ADRB2 AEBP1 AES AGT AHSG AJUBA ALAS2 ALOX5 AMBP ANXA2 AP4S1 APCS APOH APP ARHGAP17 ARHGAP32 ARHGAP9 ARHGEF5 ASAP1 ASAP2 ATP8 AXL B2M BCAR1 BCL2A1 BCR BLNK BPGM C1orf94 C21orf58 C21orf91 CALD1 CASC3 CASP2 CBL CBLB CBLC CCL5 CD164 CD19 CD22 CD247 CD28 CD2AP CD72 CDC42 CDKN1B CFH CHRM4 CHRND CKS2 CLU COPB1 COX6A1 CRK CRKL CSF1R CSF3R CSN2 CTAGE5 CTTN CUTA DAB2 DAG1 DCTN1 DCTN2 DDX17 DLGAP1 DNAJA3 DNAJB11 DNM1 DNM2 DOCK4 DPPA4 DRD3 DRD4 DTX1 ECHS1 EGF EGFR ELK1 ENO1 EP300 EPHA2 EPHB1 EPHB2 EPHB6 EPOR EPS15 EPS8 ERBB2 ERBB3 ERBB4 ERRFI1 ESD ESR1 ETV6 FABP1 FASLG FGFR1 FGFR3 FH FHOD1 FLT1 FLT3 FLT4 FN1 FRS2 FRS3 FTH1 FTL FYN GAB1 GAB2 GAB3 GAREM GC GHR GIT1 GPANK1 GRB7 GSTK1 H1F0 HCLS1 HELZ HIPK3 HNRNPC HNRNPK HOMEZ HP HRAS HSPA5 HTT IK IKZF3 IL2RB INCA1 INPP5D IRS1 IRS2 IRS4 ITGA2B ITGA6 ITGB4 ITIH4 ITK JAK1 JAK2 KDR KHDRBS1 KHDRBS2 KIAA1549L KIF3A KIT KPNA2 KRT8 LAT LAT2 LAX1 LCP2 LIME1 LMO2 LNX1 LY6G6F LZTS2 MAP1A MAP2 MAP3K1 MAP4K1 MAP4K3 MAP4K5 MAPK1 MAPK12 MAPK14 MAPK9 MED28 MERTK MET MICAL1 MLXIPL MS4A2 MSI2 MST1R MTA1 MTA3 MUC1 MYH11 MYH9 MYO18A NADK NAP1L5 NCKIPSD NCL ND4 NEU3 NFYB NGFR NIF3L1 NKD2 NPM1 NTRK1 NUTM2F OCRL PAG1 PAK1 PAK2 PAK4 PBXIP1 PDCD6IP PDE4D PDE6G PDGFRB PHACTR4 PHC2 PIK3AP1 PIK3C2B PIK3CG PIK3R1 PIK3R2 PLCG1 PNMA5 PNRC1 POLR1D POLR2A POMP PON2 PPP3CA PRAP1 PRKAB1 PRKAR1A PRNP PRR22 PRRC2A PTK2 PTK2B PTPN1 PTPN11 PTPN12 PTPN22 PTPN23 PTPN6 PTPRA PTPRC PTPRE PXN RALGPS1 RAPGEF1 RAPSN RASA1 RBBP6 RBM33 RBP4 REL REPS1 REPS2 RET RHOU RIF1 RNF10 RPS6KA1 SELL SF3B4 SH2B1 SH2B2 SH2B3 SH2D1A SH2D4A SH3BP2 SH3D19 SH3KBP1 SHANK3 SHB SHBG SHC1 SHC2 SHC3 SHC4 SHKBP1 SIGLEC7 SIT1 SKAP1 SLC1A2 SLX1A SNRNP200 SNTA1 SOCS1 SOCS7 SOS1 SOS2 SPRY1 SPRY2 SPTBN1 SRC SS18 STAMBP STK32C STRADB SYK SYN1 SYNCRIP SYNJ1 SYNJ2 SYP TCEAL8 TCERG1 TEK TF TFG TNFRSF1A TNK2 TOM1L1 TP53BP2 TP63 TRAT1 TRIM27 TSC2 TUB UBA1 UBA52 USP53 USP6NL USP8 VAV1 VAV2 VAV3 VIM WAS WASF1 WASF2 WASL WBP11 WDR1 WDR44 WIPF1 WIPF2 YLPM1 ZAP70 ZBTB7B	51 interactors: APP ARRB1 AXL CBL CD28 CRKL CSF1 CSF1R DYDC1 EGF EGFR EPHA2 ERBB2 ERBB3 ERBB4 FBXL2 FGFR1 FYN GOLGA2 GRB2 GRN HCK IGF1R IKZF3 IRS1 IRS2 KIT KRAS KRT15 KRT20 KRT38 LAMB2 LTBP3 MRFAP1L1 PDGFRB PIK3CD RINT1 SEPT2 SHC1 SOCS1 SOCS6 SOCS7 SOS1 STAB1 SYK TEC TGFBR1 TGFBR2 TRIM23 WASF3 YWHAB
Entrez ID		2885	5296
HPRD ID		00150	04404
Ensembl ID		ENSG00000177885	ENSG00000105647
Uniprot IDs		B0LPF3 P62993	O00459
PDB IDs		1AZE 1BM2 1BMB 1CJ1 1FHS 1FYR 1GCQ 1GFC 1GFD 1GHU 1GRI 1IO6 1JYQ 1JYR 1JYU 1QG1 1TZE 1X0N 1ZFP 2AOA 2AOB 2H46 2H5K 2HUW 2VVK 2VWF 2W0Z 3C7I 3IMD 3IMJ 3IN7 3IN8 3KFJ 3MXC 3MXY 3N7Y 3N84 3N8M 3OV1 3OVE 3S8L 3S8N 3S8O	2KT1 2XS6 3MTT 3O5Z
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Signaling Signal Transduction Cell Communication Regulation Of Signaling Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Cellular Response To Stimulus Immune System Process Response To Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Intracellular Signal Transduction Regulation Of Catalytic Activity Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Immune Response-regulating Signaling Pathway Regulation Of Kinase Activity Regulation Of Phosphorylation Positive Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Immune Response Regulation Of Phosphorus Metabolic Process Regulation Of Immune System Process Innate Immune Response Fc Receptor Signaling Pathway Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Regulation Of Protein Metabolic Process Response To Stress Immune Response Positive Regulation Of Kinase Activity Defense Response Neurotrophin TRK Receptor Signaling Pathway Movement Of Cell Or Subcellular Component Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Process Neurotrophin Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Catalytic Activity Response To Organic Substance Regulation Of MAPK Cascade Positive Regulation Of Metabolic Process Locomotion Developmental Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Transferase Activity Positive Regulation Of Protein Metabolic Process Response To Growth Factor Cellular Response To Organic Substance	Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fc Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Fc-epsilon Receptor Signaling Pathway Response To Fibroblast Growth Factor Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Response To Growth Factor Innate Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Phosphatidylinositol-mediated Signaling Immune Response-regulating Signaling Pathway Regulation Of Kinase Activity Intracellular Signal Transduction Cellular Response To Organic Substance Defense Response Regulation Of Intracellular Signal Transduction Cell Surface Receptor Signaling Pathway Immune System Process Immune Response Regulation Of Immune System Process Regulation Of Phosphorylation Peptidyl-tyrosine Phosphorylation Positive Regulation Of Intracellular Signal Transduction Response To Organic Substance Regulation Of Phosphorus Metabolic Process Regulation Of Signal Transduction Regulation Of Signaling Positive Regulation Of Cell Proliferation Positive Regulation Of Signal Transduction Response To Stress Regulation Of Protein Kinase Activity Regulation Of Immune Response Regulation Of Cell Proliferation Regulation Of Protein Phosphorylation Positive Regulation Of Kinase Activity Developmental Process Positive Regulation Of Transferase Activity Regulation Of Catalytic Activity Signal Transduction Signaling Anatomical Structure Development Positive Regulation Of Phosphorylation Regulation Of MAPK Cascade Cell Communication
Tagcloud ?		actions adaptor antiapoptotic behavior believed chemotactic converting crkii crkl focused igfs implicated intracellularly ir irs mediates metabolism mitogenic nucleus occur organogenesis outlines promoting shc signalling signals stimulating substrate transmitting	acetylated acetylations chip contrary deacetylase deacetylases distally dysregulated encompassing facilitates featured h2a h3k9 hexokinase hk2 irs2 l6 lysines myotubes p85beta pharmacologically responsive reverted template treatable trichostatin tsa tss z
Tagcloud (Difference) ?		actions adaptor antiapoptotic behavior believed chemotactic converting crkii crkl focused igfs implicated intracellularly ir irs mediates metabolism mitogenic nucleus occur organogenesis outlines promoting shc signalling signals stimulating substrate transmitting	acetylated acetylations chip contrary deacetylase deacetylases distally dysregulated encompassing facilitates featured h2a h3k9 hexokinase hk2 irs2 l6 lysines myotubes p85beta pharmacologically responsive reverted template treatable trichostatin tsa tss z
Tagcloud (Intersection) ?