GRB2 and B2M

Number of citations of the paper that reports this interaction (PMID 18624398)
4

Data Source:
BioGRID (two hybrid)

		GRB2	B2M
Gene Name		growth factor receptor-bound protein 2	beta-2-microglobulin
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Endosome Golgi Apparatus Cytosol Plasma Membrane Cell-cell Junction COP9 Signalosome Vesicle Membrane Extracellular Vesicular Exosome Grb2-EGFR Complex	Golgi Membrane Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Lumen Golgi Apparatus Plasma Membrane Focal Adhesion External Side Of Plasma Membrane ER To Golgi Transport Vesicle Membrane Membrane Phagocytic Vesicle Membrane Early Endosome Membrane Early Endosome Lumen MHC Class I Protein Complex Extracellular Vesicular Exosome
	Molecular Function	Phosphotyrosine Binding SH3/SH2 Adaptor Activity Epidermal Growth Factor Receptor Binding Neurotrophin TRKA Receptor Binding Protein Binding SH3 Domain Binding Protein Kinase Binding Protein Phosphatase Binding Identical Protein Binding Insulin Receptor Substrate Binding Poly(A) RNA Binding Ephrin Receptor Binding	Protein Binding Identical Protein Binding
	Biological Process	Epidermal Growth Factor Receptor Signaling Pathway Ras Protein Signal Transduction Cell-cell Signaling Axon Guidance Aging Blood Coagulation Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Signal Transduction Viral Process Platelet Activation Positive Regulation Of Actin Filament Polymerization T Cell Costimulation Receptor Internalization Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Signal Transduction In Response To DNA Damage Regulation Of MAPK Cascade Innate Immune Response Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Anatomical Structure Formation Involved In Morphogenesis Leukocyte Migration Protein Heterooligomerization Branching Involved In Labyrinthine Layer Morphogenesis Cellular Response To Ionizing Radiation Positive Regulation Of Reactive Oxygen Species Metabolic Process	Retina Homeostasis Positive Regulation Of T Cell Mediated Cytotoxicity Response To Molecule Of Bacterial Origin Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent Antigen Processing And Presentation Of Exogenous Protein Antigen Via MHC Class Ib, TAP-dependent Viral Process Cytokine-mediated Signaling Pathway T Cell Differentiation In Thymus Protein Refolding Response To Drug Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Innate Immune Response Response To Cadmium Ion Regulation Of Defense Response To Virus By Virus Regulation Of Immune Response Iron Ion Homeostasis Interferon-gamma-mediated Signaling Pathway
Pathways			DAP12 interactions Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters HIV Infection Host Interactions of HIV factors Interferon Signaling The role of Nef in HIV-1 replication and disease pathogenesis Cytokine Signaling in Immune system Nef mediated downregulation of MHC class I complex cell surface expression Antigen Presentation: Folding, assembly and peptide loading of class I MHC Interferon gamma signaling Amyloids DAP12 signaling Endosomal/Vacuolar pathway Class I MHC mediated antigen processing & presentation Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Antigen processing-Cross presentation ER-Phagosome pathway Innate Immune System Adaptive Immune System
Drugs		Pegademase bovine 4-[(10s,14s,18s)-18-(2-Amino-2-Oxoethyl)-14-(1-Naphthylmethyl)-8,17,20-Trioxo-7,16,19-Triazaspiro[5.14]Icos-11-En-10-Yl]Benzylphosphonic Acid
Diseases
GWAS
Protein-Protein Interactions		347 interactors: A2M ABI3 ABI3BP ABL1 ABL2 ADA ADAM12 ADAM15 ADRB1 ADRB2 AEBP1 AES AGT AHSG AJUBA ALAS2 ALOX5 AMBP ANXA2 AP4S1 APCS APOH APP ARHGAP17 ARHGAP32 ARHGAP9 ARHGEF5 ASAP1 ASAP2 ATP8 AXL B2M BCAR1 BCL2A1 BCR BLNK BPGM C1orf94 C21orf58 C21orf91 CALD1 CASC3 CASP2 CBL CBLB CBLC CCL5 CD164 CD19 CD22 CD247 CD28 CD2AP CD72 CDC42 CDKN1B CFH CHRM4 CHRND CKS2 CLU COPB1 COX6A1 CRK CRKL CSF1R CSF3R CSN2 CTAGE5 CTTN CUTA DAB2 DAG1 DCTN1 DCTN2 DDX17 DLGAP1 DNAJA3 DNAJB11 DNM1 DNM2 DOCK4 DPPA4 DRD3 DRD4 DTX1 ECHS1 EGF EGFR ELK1 ENO1 EP300 EPHA2 EPHB1 EPHB2 EPHB6 EPOR EPS15 EPS8 ERBB2 ERBB3 ERBB4 ERRFI1 ESD ESR1 ETV6 FABP1 FASLG FGFR1 FGFR3 FH FHOD1 FLT1 FLT3 FLT4 FN1 FRS2 FRS3 FTH1 FTL FYN GAB1 GAB2 GAB3 GAREM GC GHR GIT1 GPANK1 GRB7 GSTK1 H1F0 HCLS1 HELZ HIPK3 HNRNPC HNRNPK HOMEZ HP HRAS HSPA5 HTT IK IKZF3 IL2RB INCA1 INPP5D IRS1 IRS2 IRS4 ITGA2B ITGA6 ITGB4 ITIH4 ITK JAK1 JAK2 KDR KHDRBS1 KHDRBS2 KIAA1549L KIF3A KIT KPNA2 KRT8 LAT LAT2 LAX1 LCP2 LIME1 LMO2 LNX1 LY6G6F LZTS2 MAP1A MAP2 MAP3K1 MAP4K1 MAP4K3 MAP4K5 MAPK1 MAPK12 MAPK14 MAPK9 MED28 MERTK MET MICAL1 MLXIPL MS4A2 MSI2 MST1R MTA1 MTA3 MUC1 MYH11 MYH9 MYO18A NADK NAP1L5 NCKIPSD NCL ND4 NEU3 NFYB NGFR NIF3L1 NKD2 NPM1 NTRK1 NUTM2F OCRL PAG1 PAK1 PAK2 PAK4 PBXIP1 PDCD6IP PDE4D PDE6G PDGFRB PHACTR4 PHC2 PIK3AP1 PIK3C2B PIK3CG PIK3R1 PIK3R2 PLCG1 PNMA5 PNRC1 POLR1D POLR2A POMP PON2 PPP3CA PRAP1 PRKAB1 PRKAR1A PRNP PRR22 PRRC2A PTK2 PTK2B PTPN1 PTPN11 PTPN12 PTPN22 PTPN23 PTPN6 PTPRA PTPRC PTPRE PXN RALGPS1 RAPGEF1 RAPSN RASA1 RBBP6 RBM33 RBP4 REL REPS1 REPS2 RET RHOU RIF1 RNF10 RPS6KA1 SELL SF3B4 SH2B1 SH2B2 SH2B3 SH2D1A SH2D4A SH3BP2 SH3D19 SH3KBP1 SHANK3 SHB SHBG SHC1 SHC2 SHC3 SHC4 SHKBP1 SIGLEC7 SIT1 SKAP1 SLC1A2 SLX1A SNRNP200 SNTA1 SOCS1 SOCS7 SOS1 SOS2 SPRY1 SPRY2 SPTBN1 SRC SS18 STAMBP STK32C STRADB SYK SYN1 SYNCRIP SYNJ1 SYNJ2 SYP TCEAL8 TCERG1 TEK TF TFG TNFRSF1A TNK2 TOM1L1 TP53BP2 TP63 TRAT1 TRIM27 TSC2 TUB UBA1 UBA52 USP53 USP6NL USP8 VAV1 VAV2 VAV3 VIM WAS WASF1 WASF2 WASL WBP11 WDR1 WDR44 WIPF1 WIPF2 YLPM1 ZAP70 ZBTB7B	20 interactors: A2M BAG6 CALR CD1A CD1B CD1D CD1E CD8A CRYAB FCGRT GRB2 HFE HLA-A HLA-B HLA-C HLA-E HLA-F HLA-G LILRB1 PRSS23
Entrez ID		2885	567
HPRD ID		00150	00189
Ensembl ID		ENSG00000177885
Uniprot IDs		B0LPF3 P62993	F5H6I0 P61769
PDB IDs		1AZE 1BM2 1BMB 1CJ1 1FHS 1FYR 1GCQ 1GFC 1GFD 1GHU 1GRI 1IO6 1JYQ 1JYR 1JYU 1QG1 1TZE 1X0N 1ZFP 2AOA 2AOB 2H46 2H5K 2HUW 2VVK 2VWF 2W0Z 3C7I 3IMD 3IMJ 3IN7 3IN8 3KFJ 3MXC 3MXY 3N7Y 3N84 3N8M 3OV1 3OVE 3S8L 3S8N 3S8O	1A1M 1A1N 1A1O 1A6Z 1A9B 1A9E 1AGB 1AGC 1AGD 1AGE 1AGF 1AKJ 1AO7 1B0G 1B0R 1BD2 1C16 1CE6 1CG9 1DE4 1DUY 1DUZ 1E27 1E28 1EEY 1EEZ 1EFX 1EXU 1GZP 1GZQ 1HHG 1HHH 1HHI 1HHJ 1HHK 1HLA 1HSA 1HSB 1I1F 1I1Y 1I4F 1I7R 1I7T 1I7U 1IM3 1IM9 1JF1 1JGD 1JGE 1JHT 1JNJ 1K5N 1KPR 1KTL 1LDS 1LP9 1M05 1M6O 1MHE 1MI5 1N2R 1OF2 1OGA 1OGT 1ONQ 1P7Q 1PY4 1Q94 1QEW 1QLF 1QQD 1QR1 1QRN 1QSE 1QSF 1QVO 1R3H 1S8D 1S9W 1S9X 1S9Y 1SYS 1SYV 1T1W 1T1X 1T1Y 1T1Z 1T20 1T21 1T22 1TMC 1TVB 1TVH 1UQS 1UR7 1UXS 1UXW 1VGK 1W0V 1W0W 1W72 1X7Q 1XH3 1XR8 1XR9 1XZ0 1YDP 1YPZ 1ZHK 1ZHL 1ZS8 1ZSD 1ZT4 1ZVS 2A83 2AK4 2AV1 2AV7 2AXF 2AXG 2BCK 2BNQ 2BNR 2BSR 2BSS 2BST 2BVO 2BVP 2BVQ 2C7U 2CII 2CIK 2CLR 2D31 2D4D 2D4F 2DYP 2E8D 2ESV 2F53 2F54 2F74 2F8O 2FYY 2FZ3 2GIT 2GJ6 2GT9 2GTW 2GTZ 2GUO 2H26 2H6P 2HJK 2HJL 2HLA 2HN7 2J8U 2JCC 2NW3 2NX5 2P5E 2P5W 2PO6 2PYE 2RFX 2UWE 2V2W 2V2X 2VB5 2VLJ 2VLK 2VLL 2VLR 2X4N 2X4O 2X4P 2X4Q 2X4R 2X4S 2X4T 2X4U 2X70 2X89 2XKS 2XKU 2XPG 2YPK 2YPL 2YXF 2Z9T 3AM8 3B3I 3B6S 3BGM 3BH8 3BH9 3BHB 3BO8 3BP4 3BP7 3BVN 3BW9 3BWA 3BXN 3BZE 3BZF 3C9N 3CDG 3CII 3CIQ 3CZF 3D18 3D25 3D2U 3D39 3D3V 3DBX 3DHJ 3DHM 3DTX 3DX6 3DX7 3DX8 3DXA 3EKC 3FFC 3FQN 3FQR 3FQT 3FQU 3FQW 3FQX 3FT2 3FT3 3FT4 3GIV 3GJF 3GSN 3GSO 3GSQ 3GSR 3GSU 3GSV 3GSW 3GSX 3H7B 3H9H 3H9S 3HAE 3HCV 3HG1 3HLA 3HPJ 3HUJ 3I6G 3I6K 3I6L 3IB4 3IXA 3JTS 3KLA 3KPL 3KPM 3KPN 3KPO 3KPP 3KPQ 3KPR 3KPS 3KWW 3KXF 3KYN 3KYO 3L3D 3L3G 3L3I 3L3J 3L3K 3LKN 3LKO 3LKP 3LKQ 3LKR 3LKS 3LN4 3LN5 3LOW 3LOZ 3LV3 3M17 3M1B 3MGO 3MGT 3MR9 3MRB 3MRC 3MRD 3MRE 3MRF 3MRG 3MRH 3MRI 3MRJ 3MRK 3MRL 3MRM 3MRN 3MRO 3MRP 3MRQ 3MRR 3MV7 3MV8 3MV9 3MYJ 3MYZ 3MZT 3NA4 3NFN 3O3A 3O3B 3O3D 3O3E 3O4L 3OV6 3OX8 3OXR 3OXS 3PWJ 3PWL 3PWN 3PWP 3QDA 3QDG 3QDJ 3QDM 3QEQ 3QFD 3QFJ 3QZW 3REW 3RL1 3RL2 3RWJ 3S6C 3SDX 3SJV 3SKM 3SKO 3SPV 3T8X 3TID 3TIE 3TLR 3TM6 3TO2 3TZV 3U0P 3UPR 3UTQ 3UTS 3UTT 3V5D 3V5H 3V5K 3VCL 3VFM 3VFN 3VFO 3VFP 3VFR 3VFS 3VFT 3VFU 3VFV 3VFW 3VH8 3VRI 3VRJ 3VWJ 3VWK 3W39 4E0K 4E0L 4E5X 4EN3 4EUP 4EUQ 4F7M 4F7P 4F7T 4FTV 4FXL 4G8G 4G8I 4G9D 4G9F 4GKN 4GKS 4GUP 4HKJ 4HX1 4I48 4I4W 4JFD 4JFE 4JFF 4JFO 4JFP 4JFQ 4JQV 4JQX 4JRX 4JRY 4K7F 4KDT 4L4T 4L4V 4LCW
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Signaling Signal Transduction Cell Communication Regulation Of Signaling Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Cellular Response To Stimulus Immune System Process Response To Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Intracellular Signal Transduction Regulation Of Catalytic Activity Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Immune Response-regulating Signaling Pathway Regulation Of Kinase Activity Regulation Of Phosphorylation Positive Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Immune Response Regulation Of Phosphorus Metabolic Process Regulation Of Immune System Process Innate Immune Response Fc Receptor Signaling Pathway Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Regulation Of Protein Metabolic Process Response To Stress Immune Response Positive Regulation Of Kinase Activity Defense Response Neurotrophin TRK Receptor Signaling Pathway Movement Of Cell Or Subcellular Component Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Process Neurotrophin Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Catalytic Activity Response To Organic Substance Regulation Of MAPK Cascade Positive Regulation Of Metabolic Process Locomotion Developmental Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Transferase Activity Positive Regulation Of Protein Metabolic Process Response To Growth Factor Cellular Response To Organic Substance	Antigen Processing And Presentation Regulation Of T Cell Mediated Cytotoxicity Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of T Cell Mediated Cytotoxicity Immune Response Positive Regulation Of Leukocyte Mediated Cytotoxicity Immune System Process Positive Regulation Of T Cell Mediated Immunity Positive Regulation Of Cell Killing Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Regulation Of Immune Response Regulation Of Immune System Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Regulation Of Adaptive Immune Response Antigen Processing And Presentation Of Endogenous Antigen Positive Regulation Of Adaptive Immune Response Antigen Processing And Presentation Of Peptide Antigen Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Response To Type I Interferon Antigen Processing And Presentation, Exogenous Lipid Antigen Via MHC Class Ib Positive Regulation Of Immune Response Positive Regulation Of Immune System Process Interferon-gamma-mediated Signaling Pathway Negative Regulation Of Innate Immune Response Cellular Response To Interferon-gamma Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Protection From Natural Killer Cell Mediated Cytotoxicity Response To Interferon-gamma Response To Stress Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Natural Killer Cell Mediated Immunity Response To Stimulus Defense Response Regulation Of Dendritic Cell Differentiation Regulation Of Innate Immune Response Negative Regulation Of Immune Response Innate Immune Response Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Positive Regulation Of Cell Adhesion Negative Regulation Of Immune System Process Cytokine-mediated Signaling Pathway Positive Regulation Of T Cell Activation Detection Of Bacterium Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Cell-cell Adhesion Detection Of Biotic Stimulus
Tagcloud ?		actions adaptor antiapoptotic behavior believed chemotactic converting crkii crkl focused igfs implicated intracellularly ir irs mediates metabolism mitogenic nucleus occur organogenesis outlines promoting shc signalling signals stimulating substrate transmitting	a1m abnormality acetyl albumin albuminuria apparently competition excretion fractional gfr glomerular glucosaminidase histologically imply lmw microglobulin nag necessarily nephritic nephritis nephrotic proteinuria rbp reabsorption retinol ssns steroid tubular up1
Tagcloud (Difference) ?		actions adaptor antiapoptotic behavior believed chemotactic converting crkii crkl focused igfs implicated intracellularly ir irs mediates metabolism mitogenic nucleus occur organogenesis outlines promoting shc signalling signals stimulating substrate transmitting	a1m abnormality acetyl albumin albuminuria apparently competition excretion fractional gfr glomerular glucosaminidase histologically imply lmw microglobulin nag necessarily nephritic nephritis nephrotic proteinuria rbp reabsorption retinol ssns steroid tubular up1
Tagcloud (Intersection) ?