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GRB2 and SHANK3
Number of citations of the paper that reports this interaction (PubMedID
21988832
)
38
Data Source:
BioGRID
(two hybrid)
GRB2
SHANK3
Description
growth factor receptor bound protein 2
SH3 and multiple ankyrin repeat domains 3
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Endosome
Golgi Apparatus
Centrosome
Cytosol
Plasma Membrane
Cell-cell Junction
Cell Cortex
COP9 Signalosome
Vesicle Membrane
Membrane
Extracellular Exosome
Grb2-EGFR Complex
Cytoplasm
Cytosol
Plasma Membrane
Postsynaptic Density
Cell Projection
Neuron Projection
Dendritic Spine
Neuron Spine
Synapse
Postsynaptic Membrane
Ciliary Membrane
Molecular Function
Phosphotyrosine Residue Binding
RNA Binding
Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity
Guanyl-nucleotide Exchange Factor Adaptor Activity
Epidermal Growth Factor Receptor Binding
Neurotrophin TRKA Receptor Binding
Protein Binding
SH3 Domain Binding
Protein Kinase Binding
Protein Phosphatase Binding
Protein Domain Specific Binding
Protein-macromolecule Adaptor Activity
Identical Protein Binding
Insulin Receptor Substrate Binding
Ephrin Receptor Binding
Actin Binding
Protein Binding
Zinc Ion Binding
SH3 Domain Binding
Synaptic Receptor Adaptor Activity
Ionotropic Glutamate Receptor Binding
Scaffold Protein Binding
Biological Process
Signal Transduction
Epidermal Growth Factor Receptor Signaling Pathway
Ras Protein Signal Transduction
Insulin Receptor Signaling Pathway
Fibroblast Growth Factor Receptor Signaling Pathway
Schwann Cell Development
Actin Cytoskeleton Organization
Positive Regulation Of Actin Filament Polymerization
T Cell Costimulation
Receptor Internalization
Endodermal Cell Differentiation
T Cell Activation
Natural Killer Cell Mediated Cytotoxicity
Myelination
Signal Transduction In Response To DNA Damage
Regulation Of MAPK Cascade
Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity
Insulin-like Growth Factor Receptor Signaling Pathway
Anatomical Structure Formation Involved In Morphogenesis
B Cell Receptor Signaling Pathway
Branching Involved In Labyrinthine Layer Morphogenesis
Cellular Response To Ionizing Radiation
Positive Regulation Of Reactive Oxygen Species Metabolic Process
MAPK Cascade
Synapse Assembly
Learning
Memory
Associative Learning
Striatal Medium Spiny Neuron Differentiation
Adult Behavior
Negative Regulation Of Actin Filament Bundle Assembly
Social Behavior
Vocal Learning
Negative Regulation Of Cell Volume
Positive Regulation Of Long-term Neuronal Synaptic Plasticity
Brain Morphogenesis
Synapse Organization
Neuromuscular Process Controlling Balance
Cognition
Positive Regulation Of Synapse Structural Plasticity
Positive Regulation Of Synaptic Transmission, Glutamatergic
Dendritic Spine Morphogenesis
Positive Regulation Of Dendritic Spine Development
Regulation Of Dendritic Spine Morphogenesis
Vocalization Behavior
Postsynaptic Density Assembly
AMPA Glutamate Receptor Clustering
NMDA Glutamate Receptor Clustering
Guanylate Kinase-associated Protein Clustering
Regulation Of Long-term Synaptic Potentiation
Positive Regulation Of Long-term Synaptic Potentiation
Positive Regulation Of Glutamate Receptor Signaling Pathway
Regulation Of Long-term Synaptic Depression
Positive Regulation Of Excitatory Postsynaptic Potential
Pathways
Interleukin-15 signaling
Interleukin-15 signaling
Signaling by CSF3 (G-CSF)
Signaling by CSF3 (G-CSF)
STAT5 activation downstream of FLT3 ITD mutants
Signaling by FLT3 ITD and TKD mutants
Signaling by FLT3 ITD and TKD mutants
Signaling by ALK fusions and activated point mutants
Signaling by LTK
Neurexins and neuroligins
Neurexins and neuroligins
RET signaling
Drugs
Pegademase
4-[(10s,14s,18s)-18-(2-Amino-2-Oxoethyl)-14-(1-Naphthylmethyl)-8,17,20-Trioxo-7,16,19-Triazaspiro[5.14]Icos-11-En-10-Yl]Benzylphosphonic Acid
Diseases
GWAS
Aspartate aminotransferase levels (
33547301
)
Deep white matter hyperintensities (
32517579
)
Multiple sclerosis (
31604244
)
Systemic lupus erythematosus (
26502338
28714469
29848360
)
Systemic sclerosis (
31672989
)
Triglyceride levels (
32203549
)
Waist circumference adjusted for body mass index (
34021172
)
Waist-hip index (
34021172
)
Aspartate aminotransferase levels (
33547301
)
Blood protein levels (
30072576
)
Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) (
31374203
)
Extremely high intelligence (
29520040
)
Fibrinogen (
23969696
)
Fibrinogen levels (
26561523
28107422
)
Intelligence (MTAG) (
29326435
)
Mean platelet volume (
32888494
)
Memory dysfunction in frontotemporal lobe dementia (
29724592
)
Platelet count (
32888494
)
Interacting Genes
397 interacting genes:
A2M
ABI3
ABI3BP
ABL1
ABL2
ACAP1
ADA
ADAM12
ADAM15
ADRB1
ADRB2
AEBP1
AGR2
AGT
AHSG
AJUBA
ALAS2
ALOX5
AMBP
ANKRD13A
ANKRD23
ANXA2
AP4S1
APCS
APOH
APP
AR
ARHGAP17
ARHGAP32
ARHGAP35
ARID5A
ASAP1
ASAP2
AUNIP
AXL
B2M
BCAR1
BCL2A1
BCR
BLNK
BPGM
BTG1
C1orf94
C21orf58
C21orf91
CALD1
CASC3
CASP2
CBL
CBLB
CBLC
CCDC28B
CCL5
CD164
CD19
CD22
CD247
CD28
CD2AP
CD72
CDC42
CDKN1B
CEBPA
CFH
CHRM4
CHRND
CKS2
CLNK
CLU
COPB1
COX6A1
CPSF7
CRBN
CRK
CRKL
CSF1R
CSF3R
CSN2
CTTN
CUTA
DAB2
DAG1
DCTN1
DCTN2
DDIT4L
DDX17
DLGAP1
DNAJA3
DNAJB11
DNM1
DNM2
DOCK4
DPPA4
DRD3
DRD4
DTX1
DTX3
DVL2
E2F2
ECHS1
EFHC2
EGF
EGFR
ELK1
ENO1
EP300
EPHA2
EPHB1
EPHB2
EPHB6
EPOR
EPS15
EPS8
ERBB2
ERBB3
ERBB4
ESD
ESR1
ETV6
FABP1
FASLG
FCGR2A
FCGR2B
FGFR1
FGFR3
FH
FHOD1
FLT1
FLT3
FLT4
FN1
FRS2
FRS3
FTH1
FTL
FYN
GAB1
GAB2
GAB3
GC
GGN
GHR
GIT1
GPANK1
GRAP2
GRB7
GSTK1
H1-0
H2AX
HCLS1
HELZ
HIPK3
HNRNPC
HNRNPK
HOMEZ
HP
HRAS
HTT
IK
IKZF3
IL2RB
INCA1
INPP5D
IRS1
IRS2
IRS4
ITGA2B
ITGA6
ITGB4
ITIH4
ITK
JAK1
JAK2
KDR
KHDRBS1
KHDRBS2
KIAA0408
KIAA1549L
KIF3A
KIT
KPNA2
KPRP
KRT8
LAT
LAT2
LAX1
LCP2
LIME1
LMO2
LNX1
LNX2
LY6G6F
LZTS2
MAP1A
MAP2
MAP4K1
MAP4K5
MAPK1
MAPK12
MAPK14
MAPK9
MED19
MED28
MEI4
MERTK
MET
METTL27
MIA2
MICAL1
MLXIPL
MRE11
MS4A2
MSI2
MST1R
MT-ATP8
MT-ND4
MTA1
MTA3
MUC1
MYG1
MYH11
MYO18A
MYOZ1
NADK
NAP1L5
NCKIPSD
NCL
NEU3
NFYB
NGFR
NIF3L1
NKD2
NPM1
NTRK1
NUTM2F
OCRL
OLIG1
PACRGL
PAG1
PAK1
PAK2
PAK4
PBXIP1
PCDHB5
PDCD6IP
PDE4D
PDE6G
PDGFRB
PHACTR4
PHC2
PHETA1
PIK3AP1
PIK3C2B
PIK3CG
PIK3R1
PIK3R2
PIK3R3
PLCG1
PLEKHA7
PNMA5
PNRC1
POLR1D
POLR2A
POMP
PON2
PPP3CA
PRAP1
PRKAB1
PRKAR1A
PRNP
PRR22
PRR5-ARHGAP8
PRRC2A
PRRG4
PTK2
PTK2B
PTPN1
PTPN11
PTPN12
PTPN22
PTPN6
PTPRA
PTPRC
PTPRE
PXN
RALGPS1
RAPGEF1
RAPSN
RASA1
RBBP6
RBM33
RBP4
REL
REPS1
REPS2
RET
RHOU
RIF1
RNF10
RNF208
RPA1
RPS6KA1
SELL
SF3A2
SF3B4
SH2B1
SH2B2
SH2B3
SH2D1A
SH2D4A
SH3BP2
SH3D19
SH3KBP1
SHANK3
SHB
SHBG
SHC1
SHC2
SHC3
SHC4
SHKBP1
SIGLEC7
SIT1
SKAP1
SLC1A2
SLX1A
SNRNP200
SNTA1
SOCS1
SOCS7
SOS1
SOS2
SPATA2L
SPRY1
SPRY2
SPTBN1
SRC
SS18
STAMBP
STK32C
STRADB
SYK
SYN1
SYNCRIP
SYNJ1
SYNJ2
SYP
TBC1D3B
TBC1D3G
TCEAL8
TCERG1
TEK
TF
TFG
TLE5
TNFRSF1A
TNK2
TOM1L1
TP53BP2
TP63
TRAT1
TRIB3
TRIM27
TSC2
TSPAN2
TUB
TXK
UBA1
UBA52
UBC
UQCC2
USP53
USP6NL
USP8
VAV1
VAV2
VAV3
VIM
VPS37C
WAS
WASF1
WASF2
WASL
WBP11
WDFY3
WDR1
WDR44
WIPF1
WIPF2
YLPM1
ZAP70
ZBTB12
ZBTB7B
ZMAT1
ZNF341
ZNF474
ZNF620
152 interacting genes:
ABCC2
ABI1
ABI2
ACE2
ACTN2
ADGRL1
AGAP7P
ALDOA
ANKRD35
APP
ARHGAP44
ARPC2
ARPC5L
ATN1
BAIAP2
C1QBP
CA10
CALCOCO1
CAMK2B
CCT3
CEP72
CIBAR1
CLTA
CLU
CNKSR2
COPS5
COPS6
COQ5
CPAP
CRELD1
CRKL
CSNK1D
CTTN
CYP51A1
CYTIP
DBNL
DCTN2
DDB1
DLGAP1
DLGAP2
DLGAP3
DLGAP4
DNAJA3
DNM2
EFEMP1
EFEMP2
EID1
ELAVL1
ERI3
FAM13A
FBXO7
FKBP8
FRS3
FRYL
GAPDH
GOT1
GPR162
GRB2
GRN
HAGH
HECW1
HGS
HNRNPK
HOMER3
ICA1
IGSF9
ITGBL1
ITSN1
JAG2
KHDRBS1
KIAA0232
LINGO1
LRRC73
LTBP3
LTBP4
LZTS2
LZTS3
MAPK1
MBIP
MBOAT7
MCRS1
MDH2
MEGF10
MEGF11
MEGF6
MIPOL1
MRM3
MT-CO2
MT-ND6
MYO5B
N4BP3
NCK1
NCKIPSD
NEFL
NGRN
NOTCH1
NOTCH2
NOTCH2NLA
NOTCH3
NR1D1
NRBF2
PAX6
PFKL
PHF12
PHLDB1
PLEKHA4
PPHLN1
PPP1CC
PPP1R13L
PPP1R9B
PPP2R3B
PRMT2
QSOX1
RBM5
RPS6KA1
RTN3
RUNDC3A
SCYL3
SETD2
SH3GL2
SH3GL3
SHANK1
SHARPIN
SIPA1
SLC48A1
SNRPN
SORBS2
SORBS3
SPAG5
SPTAN1
SRSF9
STK32C
SYNGAP1
SYT5
TCF25
TDRD7
TFIP11
THRAP3
TMEM14C
TNIP2
TRAF3
TRIM27
TRIM9
TRIP10
TSG101
TUBA1C
UCHL1
USP8
VIM
VPS18
WWP1
ZCCHC2
Entrez ID
2885
85358
HPRD ID
00150
18979
Ensembl ID
ENSG00000177885
ENSG00000251322
Uniprot IDs
B0LPF3
P62993
Q9BYB0
PDB IDs
1AZE
1BM2
1BMB
1CJ1
1FHS
1FYR
1GCQ
1GFC
1GFD
1GHU
1GRI
1IO6
1JYQ
1JYR
1JYU
1QG1
1TZE
1X0N
1ZFP
2AOA
2AOB
2H46
2H5K
2HUW
2VVK
2VWF
2W0Z
3C7I
3IMD
3IMJ
3IN7
3IN8
3KFJ
3MXC
3MXY
3N7Y
3N84
3N8M
3OV1
3OVE
3S8L
3S8N
3S8O
3WA4
4P9V
4P9Z
5CDW
6ICG
6ICH
6SDF
6VK2
6WM1
6WO2
7MPH
8DGO
6CPK
7C7I
7C7J
Enriched GO Terms of Interacting Partners
?
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Cell Surface Receptor Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Signal Transduction
Protein Tyrosine Kinase Activity
SH3 Domain Binding
Regulation Of Intracellular Signal Transduction
Intracellular Signal Transduction
Regulation Of Signal Transduction
Plasma Membrane
Regulation Of Signaling
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Regulation Of Cell Communication
Phosphotyrosine Residue Binding
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Regulation Of MAPK Cascade
SH2 Domain Binding
Immune Response-activating Cell Surface Receptor Signaling Pathway
Transmembrane Receptor Protein Tyrosine Kinase Activity
Antigen Receptor-mediated Signaling Pathway
Regulation Of Cellular Component Organization
Positive Regulation Of Cellular Component Organization
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Signaling
Positive Regulation Of Signal Transduction
Intracellular Signaling Cassette
Peptidyl-tyrosine Phosphorylation
Regulation Of Immune System Process
Positive Regulation Of Cell Communication
Regulation Of Immune Response
Cytosol
Protein Kinase Activity
T Cell Receptor Signaling Pathway
Immune Response-regulating Signaling Pathway
Positive Regulation Of Immune System Process
Immune System Process
Protein Binding
Immune Response-activating Signaling Pathway
Regulation Of Cell Population Proliferation
Regulation Of Multicellular Organismal Process
Regulation Of Programmed Cell Death
Positive Regulation Of Multicellular Organismal Process
Epidermal Growth Factor Receptor Signaling Pathway
Positive Regulation Of MAPK Cascade
Regulation Of Apoptotic Process
Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity
Cell Migration
Activation Of Immune Response
Response To Growth Factor
Synapse
Glutamatergic Synapse
Postsynaptic Density
Protein Domain Specific Binding
Cytoplasm
Dendritic Spine
Regulation Of Cell Communication
Regulation Of Signaling
Positive Regulation Of Supramolecular Fiber Organization
Organelle Organization
Identical Protein Binding
Regulation Of Cellular Component Organization
Endocytosis
Cytoskeleton
Regulation Of Signal Transduction
Cytoskeleton Organization
SH3 Domain Binding
Positive Regulation Of Cytoskeleton Organization
Cytosol
Cell Projection Morphogenesis
Regulation Of Supramolecular Fiber Organization
Supramolecular Fiber Organization
Postsynaptic Specialization
Neuron Projection
Signal Transduction
Dendrite Development
Endosome
Cell Projection Organization
Regulation Of Actin Filament Organization
Cell Projection
Neuron Projection Morphogenesis
Regulation Of Postsynapse Organization
Positive Regulation Of Cellular Component Organization
Positive Regulation Of Amyloid Fibril Formation
Notch Signaling Pathway
Lamellipodium
Modulation Of Chemical Synaptic Transmission
Plasma Membrane Bounded Cell Projection Organization
Import Into Cell
Vesicle-mediated Transport
Regulation Of Actin Cytoskeleton Organization
Positive Regulation Of Organelle Organization
Regulation Of Synapse Organization
Regulation Of Cytoskeleton Organization
Actin Filament Organization
Neuron Projection Development
Cadherin Binding
Modification Of Postsynaptic Structure
Regulation Of Cell Projection Organization
Postsynaptic Cytoskeleton Organization
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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