GRB2 and PIK3R1

Number of citations: 0 (PubMedID 16219545)
Data Source: HPRD (in vivo, in vitro)

		GRB2	PIK3R1
Name		growth factor receptor bound protein 2	phosphoinositide-3-kinase regulatory subunit 1
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endosome Golgi Apparatus Centrosome Cytosol Plasma Membrane Cell-cell Junction Cell Cortex COP9 Signalosome Vesicle Membrane Membrane Extracellular Exosome Grb2-EGFR Complex	Nucleus Cytoplasm Cis-Golgi Network Cytosol Plasma Membrane Cell-cell Junction Phosphatidylinositol 3-kinase Complex Phosphatidylinositol 3-kinase Complex, Class IA Membrane Perinuclear Region Of Cytoplasm Perinuclear Endoplasmic Reticulum Membrane
	Molecular Function	Phosphotyrosine Residue Binding RNA Binding Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Guanyl-nucleotide Exchange Factor Adaptor Activity Epidermal Growth Factor Receptor Binding Neurotrophin TRKA Receptor Binding Protein Binding SH3 Domain Binding Protein Kinase Binding Protein Phosphatase Binding Protein Domain Specific Binding Protein-macromolecule Adaptor Activity Identical Protein Binding Insulin Receptor Substrate Binding Ephrin Receptor Binding	Phosphotyrosine Residue Binding Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity GTPase Activator Activity Insulin Receptor Binding Insulin-like Growth Factor Receptor Binding Neurotrophin TRKA Receptor Binding Protein Binding Kinase Regulator Activity Kinase Activator Activity Protein Phosphatase Binding Phosphatidylinositol 3-kinase Regulator Activity Phosphatidylinositol 3-kinase Regulatory Subunit Binding ErbB-3 Class Receptor Binding Phosphatidylinositol 3-kinase Binding Insulin Binding Insulin Receptor Substrate Binding 1-phosphatidylinositol-3-kinase Regulator Activity Protein Heterodimerization Activity Phosphatidylinositol Kinase Activity Enzyme-substrate Adaptor Activity Phosphatidylinositol 3-kinase Activator Activity
	Biological Process	Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Ras Protein Signal Transduction Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Schwann Cell Development Actin Cytoskeleton Organization Positive Regulation Of Actin Filament Polymerization T Cell Costimulation Receptor Internalization Endodermal Cell Differentiation T Cell Activation Natural Killer Cell Mediated Cytotoxicity Myelination Signal Transduction In Response To DNA Damage Regulation Of MAPK Cascade Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Insulin-like Growth Factor Receptor Signaling Pathway Anatomical Structure Formation Involved In Morphogenesis B Cell Receptor Signaling Pathway Branching Involved In Labyrinthine Layer Morphogenesis Cellular Response To Ionizing Radiation Positive Regulation Of Reactive Oxygen Species Metabolic Process	Intracellular Glucose Homeostasis Negative Regulation Of Cell-matrix Adhesion Positive Regulation Of Leukocyte Migration Transcription By RNA Polymerase II Protein Import Into Nucleus Immune Response Negative Regulation Of Cell Adhesion Signal Transduction Insulin Receptor Signaling Pathway Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Lamellipodium Assembly Protein Transport Cytokine-mediated Signaling Pathway B Cell Differentiation T Cell Differentiation Osteoclast Differentiation Positive Regulation Of Tumor Necrosis Factor Production Cellular Response To Insulin Stimulus Positive Regulation Of RNA Splicing Regulation Of Toll-like Receptor 4 Signaling Pathway Substrate Adhesion-dependent Cell Spreading Cellular Response To UV Response To Endoplasmic Reticulum Stress Interleukin-18-mediated Signaling Pathway Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Protein Import Into Nucleus Negative Regulation Of Apoptotic Process Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Osteoclast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of D-glucose Import Phosphatidylinositol Phosphate Biosynthetic Process Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Smooth Muscle Cell Proliferation Protein Stabilization Positive Regulation Of Filopodium Assembly Regulation Of Stress Fiber Assembly Negative Regulation Of Stress Fiber Assembly Growth Hormone Receptor Signaling Pathway T Follicular Helper Cell Differentiation Myeloid Leukocyte Migration Positive Regulation Of Focal Adhesion Disassembly Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Protein Localization To Plasma Membrane
Pathways		Interleukin-15 signaling Interleukin-15 signaling Signaling by CSF3 (G-CSF) Signaling by CSF3 (G-CSF) STAT5 activation downstream of FLT3 ITD mutants Signaling by FLT3 ITD and TKD mutants Signaling by FLT3 ITD and TKD mutants Signaling by ALK fusions and activated point mutants Signaling by LTK	PI3K Cascade IRS-mediated signalling GPVI-mediated activation cascade Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants PI3K events in ERBB4 signaling PIP3 activates AKT signaling Interleukin-7 signaling Interleukin-7 signaling Signaling by SCF-KIT Synthesis of PIPs at the plasma membrane GAB1 signalosome Signaling by cytosolic FGFR1 fusion mutants Downstream signal transduction PI3K events in ERBB2 signaling PI3K/AKT activation Signaling by ALK Downstream TCR signaling Role of phospholipids in phagocytosis Tie2 Signaling Constitutive Signaling by Aberrant PI3K in Cancer DAP12 signaling Role of LAT2/NTAL/LAB on calcium mobilization Nephrin family interactions CD28 dependent PI3K/Akt signaling G alpha (q) signalling events GP1b-IX-V activation signalling VEGFA-VEGFR2 Pathway VEGFA-VEGFR2 Pathway Interleukin-3, Interleukin-5 and GM-CSF signaling Constitutive Signaling by EGFRvIII PI-3K cascade:FGFR1 PI-3K cascade:FGFR2 PI-3K cascade:FGFR3 PI-3K cascade:FGFR4 Signaling by FGFR2 in disease Signaling by FGFR4 in disease Signaling by FGFR1 in disease Signaling by FGFR3 in disease RAF/MAP kinase cascade Interleukin-4 and Interleukin-13 signaling PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling MET activates PI3K/AKT signaling RET signaling RHOA GTPase cycle Extra-nuclear estrogen signaling RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RHOU GTPase cycle RAC3 GTPase cycle RHOV GTPase cycle Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Activated NTRK2 signals through PI3K RHOF GTPase cycle Interleukin receptor SHC signaling Regulation of signaling by CBL Regulation of signaling by CBL Activated NTRK3 signals through PI3K FLT3 Signaling FLT3 Signaling Signaling by ERBB2 KD Mutants Signaling by ERBB2 ECD mutants Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants Signaling by PDGFRA extracellular domain mutants Signaling by CSF1 (M-CSF) in myeloid cells RND3 GTPase cycle RND2 GTPase cycle RND1 GTPase cycle Signaling by FLT3 fusion proteins Signaling by FLT3 fusion proteins Signaling by FLT3 ITD and TKD mutants Signaling by FLT3 ITD and TKD mutants Signaling by ALK fusions and activated point mutants Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Signaling by LTK in cancer Signaling by LTK Co-stimulation by ICOS
Drugs		Pegademase 4-[(10s,14s,18s)-18-(2-Amino-2-Oxoethyl)-14-(1-Naphthylmethyl)-8,17,20-Trioxo-7,16,19-Triazaspiro[5.14]Icos-11-En-10-Yl]Benzylphosphonic Acid	SF1126 Enzastaurin Wortmannin
GWAS		Aspartate aminotransferase levels ( 33547301 ) Deep white matter hyperintensities ( 32517579 ) Multiple sclerosis ( 31604244 ) Systemic lupus erythematosus ( 26502338 28714469 29848360 ) Systemic sclerosis ( 31672989 ) Triglyceride levels ( 32203549 ) Waist circumference adjusted for body mass index ( 34021172 ) Waist-hip index ( 34021172 )	Alzheimer's disease biomarkers ( 23419831 ) Anthropometric traits (multi-trait analysis) ( 30166351 ) Appendicular lean mass ( 33097823 ) Basal cell carcinoma ( 33549134 ) Birth weight ( 31043758 ) Body fat percentage and HDL-C (pairwise) ( 33619380 ) Bone mineral density (hip) ( 26911590 ) Corneal astigmatism ( 30306274 ) Crohn's disease ( 32581322 ) Estimated glomerular filtration rate ( 30604766 31152163 ) Glomerular filtration rate (creatinine) ( 28452372 26831199 ) HDL cholesterol levels ( 32203549 ) Height ( 31562340 ) Hip minimal joint space width ( 27701424 ) Intelligence (MTAG) ( 29326435 ) Leg fat mass (lean adjusted) ( 32719433 ) Leg fat mass and leg lean mass (pleiotropy) ( 32719433 ) Liver enzyme levels (alanine transaminase) ( 33972514 ) Mean corpuscular hemoglobin ( 27863252 32888494 ) Mean corpuscular volume ( 32888494 27863252 ) Mean reticulocyte volume ( 32888494 ) Menarche (age at onset) ( 23599027 ) Offspring birth weight ( 31043758 ) Red cell distribution width ( 32888494 27863252 ) Rosacea symptom severity ( 29771307 ) Triglyceride levels ( 32203549 29083408 ) Type 2 diabetes (adjusted for BMI) ( 30297969 ) Waist circumference adjusted for body mass index ( 34021172 )
Interacting Genes		397 interacting genes: A2M ABI3 ABI3BP ABL1 ABL2 ACAP1 ADA ADAM12 ADAM15 ADRB1 ADRB2 AEBP1 AGR2 AGT AHSG AJUBA ALAS2 ALOX5 AMBP ANKRD13A ANKRD23 ANXA2 AP4S1 APCS APOH APP AR ARHGAP17 ARHGAP32 ARHGAP35 ARID5A ASAP1 ASAP2 AUNIP AXL B2M BCAR1 BCL2A1 BCR BLNK BPGM BTG1 C1orf94 C21orf58 C21orf91 CALD1 CASC3 CASP2 CBL CBLB CBLC CCDC28B CCL5 CD164 CD19 CD22 CD247 CD28 CD2AP CD72 CDC42 CDKN1B CEBPA CFH CHRM4 CHRND CKS2 CLNK CLU COPB1 COX6A1 CPSF7 CRBN CRK CRKL CSF1R CSF3R CSN2 CTTN CUTA DAB2 DAG1 DCTN1 DCTN2 DDIT4L DDX17 DLGAP1 DNAJA3 DNAJB11 DNM1 DNM2 DOCK4 DPPA4 DRD3 DRD4 DTX1 DTX3 DVL2 E2F2 ECHS1 EFHC2 EGF EGFR ELK1 ENO1 EP300 EPHA2 EPHB1 EPHB2 EPHB6 EPOR EPS15 EPS8 ERBB2 ERBB3 ERBB4 ESD ESR1 ETV6 FABP1 FASLG FCGR2A FCGR2B FGFR1 FGFR3 FH FHOD1 FLT1 FLT3 FLT4 FN1 FRS2 FRS3 FTH1 FTL FYN GAB1 GAB2 GAB3 GC GGN GHR GIT1 GPANK1 GRAP2 GRB7 GSTK1 H1-0 H2AX HCLS1 HELZ HIPK3 HNRNPC HNRNPK HOMEZ HP HRAS HTT IK IKZF3 IL2RB INCA1 INPP5D IRS1 IRS2 IRS4 ITGA2B ITGA6 ITGB4 ITIH4 ITK JAK1 JAK2 KDR KHDRBS1 KHDRBS2 KIAA0408 KIAA1549L KIF3A KIT KPNA2 KPRP KRT8 LAT LAT2 LAX1 LCP2 LIME1 LMO2 LNX1 LNX2 LY6G6F LZTS2 MAP1A MAP2 MAP4K1 MAP4K5 MAPK1 MAPK12 MAPK14 MAPK9 MED19 MED28 MEI4 MERTK MET METTL27 MIA2 MICAL1 MLXIPL MRE11 MS4A2 MSI2 MST1R MT-ATP8 MT-ND4 MTA1 MTA3 MUC1 MYG1 MYH11 MYO18A MYOZ1 NADK NAP1L5 NCKIPSD NCL NEU3 NFYB NGFR NIF3L1 NKD2 NPM1 NTRK1 NUTM2F OCRL OLIG1 PACRGL PAG1 PAK1 PAK2 PAK4 PBXIP1 PCDHB5 PDCD6IP PDE4D PDE6G PDGFRB PHACTR4 PHC2 PHETA1 PIK3AP1 PIK3C2B PIK3CG PIK3R1 PIK3R2 PIK3R3 PLCG1 PLEKHA7 PNMA5 PNRC1 POLR1D POLR2A POMP PON2 PPP3CA PRAP1 PRKAB1 PRKAR1A PRNP PRR22 PRR5-ARHGAP8 PRRC2A PRRG4 PTK2 PTK2B PTPN1 PTPN11 PTPN12 PTPN22 PTPN6 PTPRA PTPRC PTPRE PXN RALGPS1 RAPGEF1 RAPSN RASA1 RBBP6 RBM33 RBP4 REL REPS1 REPS2 RET RHOU RIF1 RNF10 RNF208 RPA1 RPS6KA1 SELL SF3A2 SF3B4 SH2B1 SH2B2 SH2B3 SH2D1A SH2D4A SH3BP2 SH3D19 SH3KBP1 SHANK3 SHB SHBG SHC1 SHC2 SHC3 SHC4 SHKBP1 SIGLEC7 SIT1 SKAP1 SLC1A2 SLX1A SNRNP200 SNTA1 SOCS1 SOCS7 SOS1 SOS2 SPATA2L SPRY1 SPRY2 SPTBN1 SRC SS18 STAMBP STK32C STRADB SYK SYN1 SYNCRIP SYNJ1 SYNJ2 SYP TBC1D3B TBC1D3G TCEAL8 TCERG1 TEK TF TFG TLE5 TNFRSF1A TNK2 TOM1L1 TP53BP2 TP63 TRAT1 TRIB3 TRIM27 TSC2 TSPAN2 TUB TXK UBA1 UBA52 UBC UQCC2 USP53 USP6NL USP8 VAV1 VAV2 VAV3 VIM VPS37C WAS WASF1 WASF2 WASL WBP11 WDFY3 WDR1 WDR44 WIPF1 WIPF2 YLPM1 ZAP70 ZBTB12 ZBTB7B ZMAT1 ZNF341 ZNF474 ZNF620	180 interacting genes: ABL1 ADAM12 ADAMTS2 AGAP2 AKT1 ALK ANK3 APPL1 AR ARAF ARHGAP1 ARHGAP17 ARHGAP32 AXL BCAR1 BLK BRCA1 CBL CBLB CCL14 CD19 CD22 CD28 CD2AP CD3E CD4 CD40 CD5 CD7 CDC42 CDH2 CHRNA7 CIP2A CLNK CRK CRKL CSF1R CSF2RA CTLA4 CTNNB1 CXCL2 CYP4A11 DLX2 DNM1 DOK1 EGF EGFR ENKUR EPHA2 EPOR ERAS ERBB2 ERBB3 ERBB4 ESR1 EZR FASLG FBXO21 FCGR2A FER FES FGFR1 FLT1 FYN GAB1 GAB2 GAB3 GHR GP1BA GRB2 GSPT1 GTF2H1 HCK HCST HGS HOXA1 HRAS HTT IFNAR1 IGF1R IKZF3 IL13 IL1R1 IL1RAP IL2RB IL7R INPP4A INSR IRS1 IRS2 IRS4 ITSN1 JAK1 JAK2 JAK3 KBTBD2 KHDRBS1 KIT LAT LCK LNX2 LRRK2 MAPK8 MAPT MET MME MST1R MYO16 NFKBIA NLRP6 NTRK1 NTRK2 NUP85 NYAP1 NYAP2 PASK PDE4D PDGFB PDGFRA PDGFRB PECAM1 PFN1 PIK3AP1 PIK3CA PIK3CB PIK3CD PPM1A PRMT8 PROM1 PSEN1 PSMB5 PTEN PTK2 PTK2B PTPN11 PTPN6 RAC1 RASA1 RASD2 RB1 RET RRAS2 SH3KBP1 SHB SHC1 SLC9A2 SOCS1 SOCS6 SOCS7 SQSTM1 SRC SSTR2 STAT3 SYK SYN1 TEC TEK TGFBR1 TGFBR2 TIE1 TLR2 TNK2 TNS4 TOM1L1 TRAT1 TRIM25 TSHR TTR TUB TUBA1B TUBG1 TXK TYK2 TYRO3 VAV1 VAV3 WAS WASF3 WBP11 YWHAG
Entrez ID		2885	5295
HPRD ID		00150	01381
Ensembl ID		ENSG00000177885	ENSG00000145675
Uniprot IDs		B0LPF3 P62993	A0A2X0SFG1 P27986
PDB IDs		1AZE 1BM2 1BMB 1CJ1 1FHS 1FYR 1GCQ 1GFC 1GFD 1GHU 1GRI 1IO6 1JYQ 1JYR 1JYU 1QG1 1TZE 1X0N 1ZFP 2AOA 2AOB 2H46 2H5K 2HUW 2VVK 2VWF 2W0Z 3C7I 3IMD 3IMJ 3IN7 3IN8 3KFJ 3MXC 3MXY 3N7Y 3N84 3N8M 3OV1 3OVE 3S8L 3S8N 3S8O 3WA4 4P9V 4P9Z 5CDW 6ICG 6ICH 6SDF 6VK2 6WM1 6WO2 7MPH 8DGO	1A0N 1AZG 1H9O 1PBW 1PHT 1PIC 1PKS 1PKT 2IUG 2IUH 2IUI 2RD0 2V1Y 3HHM 3HIZ 3I5R 3I5S 4A55 4JPS 4L1B 4L23 4L2Y 4OVU 4OVV 4WAF 4YKN 4ZOP 5AUL 5FI4 5GJI 5ITD 5M6U 5SW8 5SWG 5SWO 5SWP 5SWR 5SWT 5SX8 5SX9 5SXA 5SXB 5SXC 5SXD 5SXE 5SXF 5SXI 5SXJ 5SXK 5UBT 5UK8 5UKJ 5UL1 5VLR 5XGH 5XGI 5XGJ 6NCT 6PYR 6PYU 7CIO 7LM2 7LQ1 7MYN 7MYO 7PG5 7PG6 7RNS 7TZ7 8AM0 8DCP 8DCX 8DD4 8DD8 8GUB 8H36 8H37 8ILR 8ILS 8ILV 8SBC 8SBJ 8TDU 8TGD 8TS7 8TS8 8TS9 8TSA 8TSB 8TSC 8TSD 8TU6 8V8H 8V8I 8V8J 8V8U 8V8V 8W9A 8W9B
GO Terms Enriched among Interactors		Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Signal Transduction Protein Tyrosine Kinase Activity SH3 Domain Binding Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Regulation Of Signal Transduction Plasma Membrane Regulation Of Signaling Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cell Communication Phosphotyrosine Residue Binding Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of MAPK Cascade SH2 Domain Binding Immune Response-activating Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Activity Antigen Receptor-mediated Signaling Pathway Regulation Of Cellular Component Organization Positive Regulation Of Cellular Component Organization Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signaling Positive Regulation Of Signal Transduction Intracellular Signaling Cassette Peptidyl-tyrosine Phosphorylation Regulation Of Immune System Process Positive Regulation Of Cell Communication Regulation Of Immune Response Cytosol Protein Kinase Activity T Cell Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Positive Regulation Of Immune System Process Immune System Process Protein Binding Immune Response-activating Signaling Pathway Regulation Of Cell Population Proliferation Regulation Of Multicellular Organismal Process Regulation Of Programmed Cell Death Positive Regulation Of Multicellular Organismal Process Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Regulation Of Apoptotic Process Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Cell Migration Activation Of Immune Response Response To Growth Factor	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Signal Transduction Protein Tyrosine Kinase Activity Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Plasma Membrane Regulation Of Signal Transduction Regulation Of Cell Communication Intracellular Signal Transduction Regulation Of Signaling Regulation Of Multicellular Organismal Process Regulation Of Immune System Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Signal Transduction Peptidyl-tyrosine Phosphorylation Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Immune System Process Immune System Process Protein Kinase Activity Regulation Of Immune Response Kinase Activity Positive Regulation Of Multicellular Organismal Process Transmembrane Receptor Protein Tyrosine Kinase Activity Immune Response-activating Cell Surface Receptor Signaling Pathway Phosphorylation Immune Response-regulating Signaling Pathway Regulation Of MAPK Cascade Positive Regulation Of Cell Population Proliferation Protein Phosphorylation Receptor Complex Positive Regulation Of MAPK Cascade Intracellular Signaling Cassette Regulation Of Cell Population Proliferation Regulation Of Cell Activation Antigen Receptor-mediated Signaling Pathway Immune Response-activating Signaling Pathway Non-membrane Spanning Protein Tyrosine Kinase Activity Positive Regulation Of Immune Response Cell Migration Cytokine-mediated Signaling Pathway Protein Autophosphorylation Regulation Of Developmental Process Regulation Of Lymphocyte Activation Positive Regulation Of Cell Migration Activation Of Immune Response