GRB2 and HRAS

Number of citations of the paper that reports this interaction (PMID 11352655)
0

Data Source:
HPRD (in vivo)

		GRB2	HRAS
Gene Name		growth factor receptor-bound protein 2	Harvey rat sarcoma viral oncogene homolog
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Endosome Golgi Apparatus Cytosol Plasma Membrane Cell-cell Junction COP9 Signalosome Vesicle Membrane Extracellular Vesicular Exosome Grb2-EGFR Complex	Golgi Membrane Nucleus Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Phosphotyrosine Binding SH3/SH2 Adaptor Activity Epidermal Growth Factor Receptor Binding Neurotrophin TRKA Receptor Binding Protein Binding SH3 Domain Binding Protein Kinase Binding Protein Phosphatase Binding Identical Protein Binding Insulin Receptor Substrate Binding Poly(A) RNA Binding Ephrin Receptor Binding	Protein Binding GTP Binding Protein C-terminus Binding
	Biological Process	Epidermal Growth Factor Receptor Signaling Pathway Ras Protein Signal Transduction Cell-cell Signaling Axon Guidance Aging Blood Coagulation Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Signal Transduction Viral Process Platelet Activation Positive Regulation Of Actin Filament Polymerization T Cell Costimulation Receptor Internalization Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Signal Transduction In Response To DNA Damage Regulation Of MAPK Cascade Innate Immune Response Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Anatomical Structure Formation Involved In Morphogenesis Leukocyte Migration Protein Heterooligomerization Branching Involved In Labyrinthine Layer Morphogenesis Cellular Response To Ionizing Radiation Positive Regulation Of Reactive Oxygen Species Metabolic Process	MAPK Cascade Activation Of MAPKK Activity Positive Regulation Of Protein Phosphorylation Endocytosis Chemotaxis Cell Cycle Arrest Mitotic Cell Cycle Checkpoint Signal Transduction Cell Surface Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Ras Protein Signal Transduction Synaptic Transmission Axon Guidance Blood Coagulation Cell Proliferation Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Visual Learning Fibroblast Growth Factor Receptor Signaling Pathway Organ Morphogenesis Negative Regulation Of Gene Expression Actin Cytoskeleton Organization Positive Regulation Of Cell Migration Regulation Of Synaptic Transmission, GABAergic Positive Regulation Of Rac GTPase Activity Negative Regulation Of Rho GTPase Activity Positive Regulation Of Rac Protein Signal Transduction Social Behavior Fc-epsilon Receptor Signaling Pathway Positive Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Negative Regulation Of Neuron Apoptotic Process Innate Immune Response Negative Regulation Of Cell Differentiation Positive Regulation Of DNA Replication Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of JNK Cascade Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Epithelial Cell Proliferation Leukocyte Migration Striated Muscle Cell Differentiation Protein Heterooligomerization Epithelial Tube Branching Involved In Lung Morphogenesis Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Wound Healing Cellular Senescence Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Ruffle Assembly Positive Regulation Of Actin Cytoskeleton Reorganization Positive Regulation Of MiRNA Metabolic Process
Pathways			Signaling by the B Cell Receptor (BCR) Signaling by GPCR Signaling by FGFR in disease SHC-mediated cascade MEK activation FCERI mediated MAPK activation CREB phosphorylation through the activation of Ras Signaling by EGFRvIII in Cancer SHC1 events in ERBB2 signaling Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants Interleukin receptor SHC signaling Gastrin-CREB signalling pathway via PKC and MAPK p38MAPK events EPH-Ephrin signaling SOS-mediated signalling Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell SHC-mediated signalling Signaling by PDGF DAP12 interactions SHC-related events triggered by IGF1R GRB2 events in EGFR signaling Signaling by ERBB4 Signaling by ERBB2 Signaling by EGFR Signaling by Interleukins SHC1 events in ERBB4 signaling Signaling by VEGF Signalling to RAS Downstream signal transduction Signaling by FGFR mutants Signaling by EGFR in Cancer Fc epsilon receptor (FCERI) signaling Interleukin-2 signaling Interleukin-3, 5 and GM-CSF signaling Frs2-mediated activation Transmission across Chemical Synapses Ras activation uopn Ca2+ infux through NMDA receptor Adaptive Immune System Signaling by Leptin Signalling to ERKs Prolonged ERK activation events Axon guidance IRS-mediated signalling IGF1R signaling cascade VEGFA-VEGFR2 Pathway EPHB-mediated forward signaling IRS-related events triggered by IGF1R EGFR Transactivation by Gastrin VEGFR2 mediated cell proliferation GRB2 events in ERBB2 signaling Activation of NMDA receptor upon glutamate binding and postsynaptic events RAF phosphorylates MEK Downstream signaling of activated FGFR NCAM signaling for neurite out-growth RAF/MAP kinase cascade Signalling to p38 via RIT and RIN Post NMDA receptor activation events Innate Immune System Signaling by Insulin receptor Signalling by NGF Insulin receptor signalling cascade SOS-mediated signalling SHC-mediated signalling IRS-related events Cytokine Signaling in Immune system Signaling by Ligand-Responsive EGFR Variants in Cancer SHC-related events NGF signalling via TRKA from the plasma membrane Tie2 Signaling Signaling by Overexpressed Wild-Type EGFR in Cancer Cell surface interactions at the vascular wall Signaling by FGFR ARMS-mediated activation SHC1 events in EGFR signaling RAF activation IRS-mediated signalling FRS2-mediated cascade Activation of RAS in B cells Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Interleukin receptor SHC signaling Constitutive Signaling by EGFRvIII
Drugs		Pegademase bovine 4-[(10s,14s,18s)-18-(2-Amino-2-Oxoethyl)-14-(1-Naphthylmethyl)-8,17,20-Trioxo-7,16,19-Triazaspiro[5.14]Icos-11-En-10-Yl]Benzylphosphonic Acid	Hexane-1,6-Diol Trifluoroethanol Guanosine-5\'-Triphosphate Guanosine-5\'-Diphosphate N,N\'-DIMETHYL-N-(ACETYL)-N\'-(7-NITROBENZ-2-OXA-1,3-DIAZOL-4-YL)ETHYLENEDIAMINE
Diseases
GWAS
Protein-Protein Interactions		347 interactors: A2M ABI3 ABI3BP ABL1 ABL2 ADA ADAM12 ADAM15 ADRB1 ADRB2 AEBP1 AES AGT AHSG AJUBA ALAS2 ALOX5 AMBP ANXA2 AP4S1 APCS APOH APP ARHGAP17 ARHGAP32 ARHGAP9 ARHGEF5 ASAP1 ASAP2 ATP8 AXL B2M BCAR1 BCL2A1 BCR BLNK BPGM C1orf94 C21orf58 C21orf91 CALD1 CASC3 CASP2 CBL CBLB CBLC CCL5 CD164 CD19 CD22 CD247 CD28 CD2AP CD72 CDC42 CDKN1B CFH CHRM4 CHRND CKS2 CLU COPB1 COX6A1 CRK CRKL CSF1R CSF3R CSN2 CTAGE5 CTTN CUTA DAB2 DAG1 DCTN1 DCTN2 DDX17 DLGAP1 DNAJA3 DNAJB11 DNM1 DNM2 DOCK4 DPPA4 DRD3 DRD4 DTX1 ECHS1 EGF EGFR ELK1 ENO1 EP300 EPHA2 EPHB1 EPHB2 EPHB6 EPOR EPS15 EPS8 ERBB2 ERBB3 ERBB4 ERRFI1 ESD ESR1 ETV6 FABP1 FASLG FGFR1 FGFR3 FH FHOD1 FLT1 FLT3 FLT4 FN1 FRS2 FRS3 FTH1 FTL FYN GAB1 GAB2 GAB3 GAREM GC GHR GIT1 GPANK1 GRB7 GSTK1 H1F0 HCLS1 HELZ HIPK3 HNRNPC HNRNPK HOMEZ HP HRAS HSPA5 HTT IK IKZF3 IL2RB INCA1 INPP5D IRS1 IRS2 IRS4 ITGA2B ITGA6 ITGB4 ITIH4 ITK JAK1 JAK2 KDR KHDRBS1 KHDRBS2 KIAA1549L KIF3A KIT KPNA2 KRT8 LAT LAT2 LAX1 LCP2 LIME1 LMO2 LNX1 LY6G6F LZTS2 MAP1A MAP2 MAP3K1 MAP4K1 MAP4K3 MAP4K5 MAPK1 MAPK12 MAPK14 MAPK9 MED28 MERTK MET MICAL1 MLXIPL MS4A2 MSI2 MST1R MTA1 MTA3 MUC1 MYH11 MYH9 MYO18A NADK NAP1L5 NCKIPSD NCL ND4 NEU3 NFYB NGFR NIF3L1 NKD2 NPM1 NTRK1 NUTM2F OCRL PAG1 PAK1 PAK2 PAK4 PBXIP1 PDCD6IP PDE4D PDE6G PDGFRB PHACTR4 PHC2 PIK3AP1 PIK3C2B PIK3CG PIK3R1 PIK3R2 PLCG1 PNMA5 PNRC1 POLR1D POLR2A POMP PON2 PPP3CA PRAP1 PRKAB1 PRKAR1A PRNP PRR22 PRRC2A PTK2 PTK2B PTPN1 PTPN11 PTPN12 PTPN22 PTPN23 PTPN6 PTPRA PTPRC PTPRE PXN RALGPS1 RAPGEF1 RAPSN RASA1 RBBP6 RBM33 RBP4 REL REPS1 REPS2 RET RHOU RIF1 RNF10 RPS6KA1 SELL SF3B4 SH2B1 SH2B2 SH2B3 SH2D1A SH2D4A SH3BP2 SH3D19 SH3KBP1 SHANK3 SHB SHBG SHC1 SHC2 SHC3 SHC4 SHKBP1 SIGLEC7 SIT1 SKAP1 SLC1A2 SLX1A SNRNP200 SNTA1 SOCS1 SOCS7 SOS1 SOS2 SPRY1 SPRY2 SPTBN1 SRC SS18 STAMBP STK32C STRADB SYK SYN1 SYNCRIP SYNJ1 SYNJ2 SYP TCEAL8 TCERG1 TEK TF TFG TNFRSF1A TNK2 TOM1L1 TP53BP2 TP63 TRAT1 TRIM27 TSC2 TUB UBA1 UBA52 USP53 USP6NL USP8 VAV1 VAV2 VAV3 VIM WAS WASF1 WASF2 WASL WBP11 WDR1 WDR44 WIPF1 WIPF2 YLPM1 ZAP70 ZBTB7B	78 interactors: AGTR1 ARAF ARHGEF1 BCL2 BRAF BRAP CAV1 CDC25A CDC25C DEAF1 DGKZ FNTA FNTB FYN GPSM2 GRB2 GRIN1 GRIN2D ICMT IKZF3 IL3 INSR IRAK1 IRAK2 ITSN1 KRT18 LGALS1 MAP2K1 MAPK8 MLLT4 NF1 PDE6D PDGFB PIK3CA PIK3CD PIK3CG PIK3R1 PLCE1 PRKCI PRKCZ RABAC1 RABGEF1 RAF1 RALA RALGDS RAP1B RAP1GDS1 RAPGEF1 RARRES3 RASA1 RASGRF1 RASGRP1 RASGRP4 RASIP1 RASSF1 RASSF2 RASSF5 RGL1 RGL2 RGL4 RGS12 RHOD RIN1 RIT2 RNF115 SHOC2 SNRPE SNX17 SOS1 SOS2 SRC TIAM1 TLR2 TLR9 TP73 TTC1 VAV1 ZBTB12
Entrez ID		2885	3265
HPRD ID		00150	01813
Ensembl ID		ENSG00000177885	ENSG00000174775
Uniprot IDs		B0LPF3 P62993	P01112
PDB IDs		1AZE 1BM2 1BMB 1CJ1 1FHS 1FYR 1GCQ 1GFC 1GFD 1GHU 1GRI 1IO6 1JYQ 1JYR 1JYU 1QG1 1TZE 1X0N 1ZFP 2AOA 2AOB 2H46 2H5K 2HUW 2VVK 2VWF 2W0Z 3C7I 3IMD 3IMJ 3IN7 3IN8 3KFJ 3MXC 3MXY 3N7Y 3N84 3N8M 3OV1 3OVE 3S8L 3S8N 3S8O	121P 1AA9 1AGP 1BKD 1CLU 1CRP 1CRQ 1CRR 1CTQ 1GNP 1GNQ 1GNR 1HE8 1IAQ 1IOZ 1JAH 1JAI 1K8R 1LF0 1LF5 1LFD 1NVU 1NVV 1NVW 1NVX 1P2S 1P2T 1P2U 1P2V 1PLJ 1PLK 1PLL 1Q21 1QRA 1RVD 1WQ1 1XCM 1XD2 1XJ0 1ZVQ 1ZW6 221P 2C5L 2CE2 2CL0 2CL6 2CL7 2CLC 2CLD 2EVW 2GDP 2LCF 2LWI 2Q21 2QUZ 2RGA 2RGB 2RGC 2RGD 2RGE 2RGG 2UZI 2VH5 2X1V 3DDC 3I3S 3K8Y 3K9L 3K9N 3KKM 3KKN 3KUD 3L8Y 3L8Z 3LBH 3LBI 3LBN 3LO5 3OIU 3OIV 3OIW 3RRY 3RRZ 3RS0 3RS2 3RS3 3RS4 3RS5 3RS7 3RSL 3RSO 3TGP 421P 4DLR 4DLS 4DLT 4DLU 4DLV 4DLW 4DLX 4DLY 4DLZ 4DST 4DSU 4EFL 4EFM 4EFN 4G0N 4G3X 4K81 4Q21 521P 5P21 621P 6Q21 721P 821P
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Signaling Signal Transduction Cell Communication Regulation Of Signaling Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Cellular Response To Stimulus Immune System Process Response To Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Intracellular Signal Transduction Regulation Of Catalytic Activity Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Immune Response-regulating Signaling Pathway Regulation Of Kinase Activity Regulation Of Phosphorylation Positive Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Immune Response Regulation Of Phosphorus Metabolic Process Regulation Of Immune System Process Innate Immune Response Fc Receptor Signaling Pathway Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Regulation Of Protein Metabolic Process Response To Stress Immune Response Positive Regulation Of Kinase Activity Defense Response Neurotrophin TRK Receptor Signaling Pathway Movement Of Cell Or Subcellular Component Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Process Neurotrophin Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Catalytic Activity Response To Organic Substance Regulation Of MAPK Cascade Positive Regulation Of Metabolic Process Locomotion Developmental Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Transferase Activity Positive Regulation Of Protein Metabolic Process Response To Growth Factor Cellular Response To Organic Substance	Intracellular Signal Transduction Regulation Of Signaling Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Catalytic Activity Neurotrophin Signaling Pathway Signal Transduction Positive Regulation Of Catalytic Activity Neurotrophin TRK Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Signaling Cell Communication Small GTPase Mediated Signal Transduction Cellular Response To Growth Factor Stimulus Response To Growth Factor Positive Regulation Of Metabolic Process Cellular Response To Stimulus Ras Protein Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Response To Stimulus Positive Regulation Of Intracellular Signal Transduction Regulation Of Ras Protein Signal Transduction Positive Regulation Of Hydrolase Activity Positive Regulation Of Signal Transduction Regulation Of Metabolic Process Cellular Response To Organic Substance Regulation Of GTPase Activity Regulation Of Cellular Process Positive Regulation Of GTPase Activity Response To Organic Substance Positive Regulation Of Ras GTPase Activity Regulation Of Ras GTPase Activity Regulation Of Phosphorylation Platelet Activation Response To Wounding Positive Regulation Of Protein Modification Process Epidermal Growth Factor Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Protein Phosphorylation Regulation Of Immune System Process Cell Activation Regulation Of Phosphorus Metabolic Process Regulation Of Kinase Activity Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Cellular Response To Fibroblast Growth Factor Stimulus
Tagcloud ?		actions adaptor antiapoptotic behavior believed chemotactic converting crkii crkl focused igfs implicated intracellularly ir irs mediates metabolism mitogenic nucleus occur organogenesis outlines promoting shc signalling signals stimulating substrate transmitting	12th arising arose carcinogenic carrying clustered codon contain detectable epithelium find fraction gaa gga gland indirectly mammary measure methylurea mutants nitroso nmu organ origin preexisting sectors transition untreated
Tagcloud (Difference) ?		actions adaptor antiapoptotic behavior believed chemotactic converting crkii crkl focused igfs implicated intracellularly ir irs mediates metabolism mitogenic nucleus occur organogenesis outlines promoting shc signalling signals stimulating substrate transmitting	12th arising arose carcinogenic carrying clustered codon contain detectable epithelium find fraction gaa gga gland indirectly mammary measure methylurea mutants nitroso nmu organ origin preexisting sectors transition untreated
Tagcloud (Intersection) ?