INO80E and KPNA2

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		INO80E	KPNA2
Gene Name		INO80 complex subunit E	karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Ino80 Complex	Nucleoplasm Cytoplasm Cytosol Membrane
	Molecular Function	Protein Binding	Protein Binding Nuclear Localization Sequence Binding Protein Transporter Activity Histone Deacetylase Binding Poly(A) RNA Binding
	Biological Process	DNA Replication DNA Repair DNA Recombination Transcription, DNA-templated Regulation Of Transcription, DNA-templated	Regulation Of DNA Recombination DNA Metabolic Process NLS-bearing Protein Import Into Nucleus Viral Process Cytokine-mediated Signaling Pathway
Pathways			ISG15 antiviral mechanism Interferon Signaling Cytokine Signaling in Immune system Antiviral mechanism by IFN-stimulated genes
Drugs
Diseases
GWAS
Protein-Protein Interactions		11 interactors: FAM124A GEM IKBKG KPNA2 MORN4 NHLH1 PRKAA1 PSMA1 SDCBP TBRG1 TNFAIP8	104 interactors: ACTN1 ACTN4 ANKIB1 AP2B1 APOBEC1 APP ARL4A ARL5A BRCA1 BTBD2 CASP2 CCDC107 CDA CDK5RAP3 CHD3 CHEK2 CORO1B CREB3L3 CREBBP CSE1L CSNK1A1 CUL4B DCTN2 DDIT3 EP300 EPB41 FEZ2 FN1 FTH1 GART GMCL1 GRB2 H1F0 HAP1 HMG20A HNRNPC HOMER2 HOMEZ HSPA4 IFT20 IMMT INO80E ITK JUN KLC4 KPNB1 KRT18 KRT40 KRT8 LAMB2 LEF1 LZTS2 MAGED1 MAGEH1 MDFI MLH1 MORC3 MVP MYC NECAB2 NFKBIB NMNAT1 NR3C1 NUP153 NUP50 NUP62 NUTM1 PAX5 PLAG1 PNMA5 PRKD3 PTMA RAG1 RAN RANBP2 RBM48 RBPMS RECQL RELA RELB RGL2 RILP RNMT SART3 SERTAD3 SGK1 SLC2A2 SPRY1 SRPK1 TADA2A TAF3 TAF8 TANK TBPL2 TP53 TRAF1 TRIM54 TSC22D4 TXNIP UBR5 USHBP1 ZBTB7B ZC3H12A ZNF131
Entrez ID		283899	3838
HPRD ID		08816	02818
Ensembl ID		ENSG00000169592	ENSG00000182481
Uniprot IDs		J3KNE2 Q6Y2K3 Q8NBZ0	P52292 Q7Z726
PDB IDs			1EFX 1QGK 1QGR 3FEX 3FEY 4E4V
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Death Cell Cycle Process Negative Regulation Of Glucosylceramide Biosynthetic Process Cold Acclimation Establishment Of Localization In Cell Positive Regulation Of MAPK Cascade Negative Regulation Of Cell Cycle Regulation Of Metabolic Process Positive Regulation Of Signal Transduction Viral Process Cellular Localization Positive Regulation Of Transferase Activity Cell Cycle Negative Regulation Of Glucose Import In Response To Insulin Stimulus Nucleolus To Nucleoplasm Transport Activation Of MAPK Activity Positive Regulation Of Cellular Metabolic Process Regulation Of MAPK Cascade Cell Cycle Arrest Regulation Of Apoptotic Process Response To Camptothecin Positive Regulation Of Extracellular Vesicular Exosome Assembly Regulation Of Cell Death Regulation Of Cellular Process Regulation Of Extracellular Vesicular Exosome Assembly Negative Regulation Of Sphingolipid Biosynthetic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of MAP Kinase Activity Regulation Of Ceramide Biosynthetic Process Cell Surface Receptor Signaling Pathway Response To External Stimulus Positive Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Phosphorylation Intracellular Signal Transduction Positive Regulation Of Cholesterol Metabolic Process Cellular Response To Ethanol Positive Regulation Of Protein Modification Process Cellular Nitrogen Compound Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Cycle Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Negative Regulation Of Glucose Import Nuclear Transport Activation Of Protein Kinase Activity Substrate-dependent Cell Migration, Cell Extension Regulation Of Energy Homeostasis Positive Regulation Of Protein Serine/threonine Kinase Activity	Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process Regulation Of Cellular Process RNA Biosynthetic Process Gene Expression Response To Stimulus Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Cellular Response To Stimulus Cell Death Death Apoptotic Process Transcription, DNA-templated Regulation Of RNA Metabolic Process Programmed Cell Death Viral Process Organelle Organization Regulation Of Nucleic Acid-templated Transcription Signal Transduction Regulation Of Gene Expression Regulation Of RNA Biosynthetic Process Developmental Process Regulation Of Transcription, DNA-templated Signaling Positive Regulation Of Transcription, DNA-templated Protein Localization To Nucleus Macromolecule Biosynthetic Process Cellular Localization Cell Cycle Negative Regulation Of Biosynthetic Process Cell Communication Negative Regulation Of Nucleic Acid-templated Transcription Cellular Process Negative Regulation Of RNA Biosynthetic Process Cell Cycle Process Response To Stress Positive Regulation Of Gene Expression Nucleocytoplasmic Transport Negative Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Response To Abiotic Stimulus Negative Regulation Of Transcription, DNA-templated Nuclear Transport Positive Regulation Of Macromolecule Biosynthetic Process Multicellular Organismal Development
Tagcloud ?		apobec3 ash2l cbx1 cbx3 cbx5 cbx6 cbx7 chd3 chd4 dek dnmt3b hdac7 kat1 kdm1b kdm2b kdm5c kdm7 modifiers ncoa4 ontogenic ontogeny prmt1 prmt7 setd8 smarca2 smarca4 smarcb1 suv420h2 unveils	aggressive aggressiveness assembled attempt carcinomas curable diagnostics disregarding eic emgd endometrial entities figo immunoreactivity interplay introducing malignancy mediator mfe microarrays nucleocytoplasmic precancerous regimens surgically tmas trp53 tumour untreatable uterus
Tagcloud (Difference) ?		apobec3 ash2l cbx1 cbx3 cbx5 cbx6 cbx7 chd3 chd4 dek dnmt3b hdac7 kat1 kdm1b kdm2b kdm5c kdm7 modifiers ncoa4 ontogenic ontogeny prmt1 prmt7 setd8 smarca2 smarca4 smarcb1 suv420h2 unveils	aggressive aggressiveness assembled attempt carcinomas curable diagnostics disregarding eic emgd endometrial entities figo immunoreactivity interplay introducing malignancy mediator mfe microarrays nucleocytoplasmic precancerous regimens surgically tmas trp53 tumour untreatable uterus
Tagcloud (Intersection) ?