SMC3 and FEZ2

Number of citations of the paper that reports this interaction (PubMedID 16484223)
0

Data Source:
BioGRID (two hybrid)

		SMC3	FEZ2
Description		structural maintenance of chromosomes 3	fasciculation and elongation protein zeta 2
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Chromatin Lateral Element Nucleus Nucleoplasm Chromosome Cytosol Cohesin Complex Nuclear Matrix Mitotic Cohesin Complex Meiotic Cohesin Complex Nuclear Lumen Mitotic Spindle Pole	Cytoplasm Axon
	Molecular Function	Nucleotide Binding Cis-regulatory Region Sequence-specific DNA Binding Chromatin Binding Double-stranded DNA Binding Microtubule Motor Activity Protein Binding ATP Binding ATP Hydrolysis Activity Mediator Complex Binding Protein Heterodimerization Activity Beta-tubulin Binding Dynein Complex Binding	Protein Binding
	Biological Process	Mitotic Cell Cycle Regulation Of DNA Replication DNA Repair DNA Damage Response Sister Chromatid Cohesion Mitotic Sister Chromatid Cohesion Stem Cell Population Maintenance Establishment Of Mitotic Sister Chromatid Cohesion Establishment Of Meiotic Sister Chromatid Cohesion Chromosome Organization Cell Division Meiotic Cell Cycle Mitotic Spindle Assembly	Signal Transduction Nervous System Development Axon Guidance Negative Regulation Of Autophagosome Assembly
Pathways		Meiotic synapsis Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion Cohesin Loading onto Chromatin Resolution of Sister Chromatid Cohesion SUMOylation of DNA damage response and repair proteins Estrogen-dependent gene expression
Drugs
Diseases		Cornelia de Lange syndrome (CdLS)
GWAS		Acute respiratory distress syndrome in sepsis ( 31982041) Lumbar spine bone mineral density (integral) ( 27476799) Metabolite levels ( 23823483)	Apolipoprotein A1 levels ( 32203549) Haemorrhoidal disease ( 33888516) Hip circumference adjusted for BMI ( 34021172) Intraocular pressure ( 29617998) Metabolite levels ( 23823483) Offspring birth weight ( 31043758) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		19 interacting genes: APC CEBPA CEP63 DISC1 ESCO2 ESR1 FEZ1 FEZ2 KIFAP3 MTNR1B MXD1 MXD3 MXD4 MXI1 RPGR SMC1A SMC1B SUMO2 TRAF3IP1	18 interacting genes: BRD1 CLASP2 DRAP1 FEZ1 KPNA2 NEK1 PDCD7 PRKCZ RAB3GAP1 RAI14 SAP30L SMC3 STIP1 TBC1D25 TEDC2 TLK2 WWC1 ZNF251
Entrez ID		9126	9637
HPRD ID		05829	09213
Ensembl ID		ENSG00000108055	ENSG00000171055
Uniprot IDs		Q9UQE7	Q9UHY8
PDB IDs		6WG3 6WG4 6WG6 6WGE 7W1M 8P0A 8PQ5 8ROH 8ROI 8ROJ 8ROK 8ROL
Enriched GO Terms of Interacting Partners?		Centrosome Ciliary Basal Body Cohesin Complex Meiotic Cohesin Complex Sister Chromatid Cohesion Condensed Nuclear Chromosome Protein Dimerization Activity Negative Regulation Of Metabolic Process Negative Regulation Of Autophagosome Assembly Chromatin Mitotic Sister Chromatid Cohesion Organelle Organization Microtubule-based Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Metabolic Process Positive Regulation Of Catabolic Process Cilium Organization Plasma Membrane Bounded Cell Projection Organization Nucleoplasm RNA Polymerase II Transcription Regulator Complex Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Ciliary Transition Zone Developmental Process Regulation Of Ubiquitin-dependent Protein Catabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Calcidiol 1-monooxygenase Activity Secalciferol 1-monooxygenase Activity Photoreceptor Connecting Cilium Transport Along Microtubule Cell Projection Organization Organelle Assembly Negative Regulation Of Macroautophagy Positive Regulation Of Anterograde Axonal Transport Of Mitochondrion Regulation Of Neuroblast Proliferation Kinesin Binding Positive Regulation Of Calcium-dependent Cell-cell Adhesion Ciliary Base Negative Regulation Of Macromolecule Metabolic Process Kinesin Complex Ciliary Tip Intraciliary Transport Regulation Of Autophagosome Assembly Cytoskeleton-dependent Intracellular Transport Regulation Of Microtubule-based Movement Positive Regulation Of Proteolysis DNA Binding Protein Localization To Chromatin	Establishment Or Maintenance Of Cell Polarity Establishment Of Cell Polarity
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