SMC3 and MXD4

Number of citations of the paper that reports this interaction (PMID 9528857)
4

Data Source:
BioGRID (two hybrid, pull down)

		SMC3	MXD4
Gene Name		structural maintenance of chromosomes 3	MAX dimerization protein 4
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Chromosome, Centromeric Region Chromatin Lateral Element Spindle Pole Basement Membrane Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol Cohesin Complex Cohesin Core Heterodimer Nuclear Matrix Meiotic Cohesin Complex Nuclear Meiotic Cohesin Complex	Nucleus
	Molecular Function	Chromatin Binding Microtubule Motor Activity Protein Binding ATP Binding Mediator Complex Binding Dynein Binding Protein Heterodimerization Activity	DNA Binding Transcription Corepressor Activity Protein Binding Protein Dimerization Activity
	Biological Process	Mitotic Cell Cycle Regulation Of DNA Replication DNA Repair Mitotic Spindle Organization Sister Chromatid Cohesion Mitotic Sister Chromatid Cohesion Mitotic Nuclear Division Meiotic Nuclear Division Signal Transduction Stem Cell Maintenance Negative Regulation Of DNA Endoreduplication Cell Division	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Negative Regulation Of Cell Proliferation
Pathways		Establishment of Sister Chromatid Cohesion Mitotic Prometaphase Mitotic Telophase/Cytokinesis Separation of Sister Chromatids Meiotic synapsis Cohesin Loading onto Chromatin Mitotic Anaphase S Phase M Phase Cell Cycle, Mitotic Resolution of Sister Chromatid Cohesion Mitotic Metaphase and Anaphase
Drugs
Diseases
GWAS
Protein-Protein Interactions		14 interactors: APC CEP63 DISC1 FEZ1 FEZ2 KIFAP3 MXD1 MXD3 MXD4 MXI1 RPGR SMC1A SMC1B TRAF3IP1	6 interactors: MAX MLX SHBG SIN3A SMC3 TCP10L
Entrez ID		9126	10608
HPRD ID		05829	10103
Ensembl ID		ENSG00000108055	ENSG00000123933
Uniprot IDs		Q9UQE7	Q14582
PDB IDs
Enriched GO Terms of Interacting Partners?		Microtubule-based Process Movement Of Cell Or Subcellular Component Microtubule-based Transport Cytoskeleton-dependent Intracellular Transport Negative Regulation Of Cellular Metabolic Process Cell Projection Morphogenesis Cell Part Morphogenesis Microtubule Cytoskeleton Organization Sister Chromatid Cohesion Organelle Organization Intraciliary Transport Cell Morphogenesis Cell Cycle Checkpoint Cell Projection Organization Negative Regulation Of Cell Proliferation Positive Regulation Of Calcium-dependent Cell-cell Adhesion Cell Cycle Mitotic Nuclear Division Negative Regulation Of Biosynthetic Process Microtubule-based Movement Regulation Of Cell Proliferation Nervous System Development Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Apoptotic Process Signal Transduction In Response To DNA Damage Canonical Wnt Signaling Pathway Generation Of Neurons Eye Development Cellular Localization Cell Division Neuron Development Neurogenesis Negative Regulation Of Odontogenesis Organelle Assembly Cell Cycle Process Spindle Organization Regulation Of Cell Projection Organization Cell Development Negative Regulation Of DNA Endoreduplication Negative Regulation Of Transcription, DNA-templated Axonogenesis Negative Regulation Of Nucleic Acid-templated Transcription Cytoskeleton Organization Neuron Differentiation Cellular Component Assembly Negative Regulation Of RNA Biosynthetic Process Plus-end-directed Vesicle Transport Along Microtubule Stem Cell Maintenance Positive Regulation Of Wnt Signaling Pathway Metaphase/anaphase Transition Of Mitotic Cell Cycle Axon Development See more	Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Response To Methylglyoxal Primary Spermatocyte Growth Negative Regulation Of Histone H3-K27 Acetylation Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Chromatin Silencing Negative Regulation Of Cellular Metabolic Process Transcription, DNA-templated Negative Regulation Of DNA Endoreduplication RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of DNA Endoreduplication Nitrogen Compound Metabolic Process Mitotic Sister Chromatid Cohesion Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress RNA Metabolic Process Negative Regulation Of Circadian Rhythm Negative Regulation Of Transcription Regulatory Region DNA Binding Positive Regulation Of Defense Response To Virus By Host Cellular Response To Stress Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Gene Expression Negative Regulation Of Histone Acetylation Regulation Of Gene Silencing Negative Regulation Of Peptidyl-lysine Acetylation Regulation Of Cell Cycle Process Cellular Macromolecule Biosynthetic Process Negative Regulation Of Protein Acetylation Regulation Of Transcription Regulatory Region DNA Binding Macromolecule Biosynthetic Process Sister Chromatid Cohesion Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Defense Response To Virus By Host Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Mitotic Spindle Organization Regulation Of Transcription, DNA-templated Negative Regulation Of DNA Binding Response To Wounding Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of DNA Replication See more
Tagcloud ?		12q13 1p36 ankrd11 cdls cleaves cohesin cornelia deeper discriminating encompassing espl1 exome filtering hdac8 intellectual intronic kbg lange merits mosaic multisystem nipbl novo partitioning rad21 recursive separase smc1a undetected	activators argonaute box downregulating elevate enter feed forward implicate interferon interplay irf irf3 mediate mediating micrornas mir mirna mirnas mobility modulating myc networks preventing quiescence quiescent repressor suppresses transition
Tagcloud (Difference) ?		12q13 1p36 ankrd11 cdls cleaves cohesin cornelia deeper discriminating encompassing espl1 exome filtering hdac8 intellectual intronic kbg lange merits mosaic multisystem nipbl novo partitioning rad21 recursive separase smc1a undetected	activators argonaute box downregulating elevate enter feed forward implicate interferon interplay irf irf3 mediate mediating micrornas mir mirna mirnas mobility modulating myc networks preventing quiescence quiescent repressor suppresses transition
Tagcloud (Intersection) ?