SMC3 and SMC1B

Number of citations of the paper that reports this interaction (PubMedID 11564881)
69

Data Source:
HPRD (in vitro, in vivo)

		SMC3	SMC1B
Description		structural maintenance of chromosomes 3	structural maintenance of chromosomes 1B
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Chromatin Lateral Element Nucleus Nucleoplasm Chromosome Cytosol Cohesin Complex Nuclear Matrix Mitotic Cohesin Complex Meiotic Cohesin Complex Nuclear Lumen Mitotic Spindle Pole	Chromosome, Centromeric Region Condensed Nuclear Chromosome Synaptonemal Complex Lateral Element Nucleus Nucleoplasm Chromosome Cytosol Cohesin Complex Meiotic Cohesin Complex
	Molecular Function	Nucleotide Binding Cis-regulatory Region Sequence-specific DNA Binding Chromatin Binding Double-stranded DNA Binding Microtubule Motor Activity Protein Binding ATP Binding ATP Hydrolysis Activity Mediator Complex Binding Protein Heterodimerization Activity Beta-tubulin Binding Dynein Complex Binding	Nucleotide Binding DNA Binding ATP Binding ATP Hydrolysis Activity
	Biological Process	Mitotic Cell Cycle Regulation Of DNA Replication DNA Repair DNA Damage Response Sister Chromatid Cohesion Mitotic Sister Chromatid Cohesion Stem Cell Population Maintenance Establishment Of Mitotic Sister Chromatid Cohesion Establishment Of Meiotic Sister Chromatid Cohesion Chromosome Organization Cell Division Meiotic Cell Cycle Mitotic Spindle Assembly	Sister Chromatid Cohesion Chromosome Organization Meiotic Cell Cycle
Pathways		Meiotic synapsis Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion Cohesin Loading onto Chromatin Resolution of Sister Chromatid Cohesion SUMOylation of DNA damage response and repair proteins Estrogen-dependent gene expression	Meiotic synapsis
Drugs
Diseases		Cornelia de Lange syndrome (CdLS)
GWAS		Acute respiratory distress syndrome in sepsis ( 31982041) Lumbar spine bone mineral density (integral) ( 27476799) Metabolite levels ( 23823483)	Height ( 28552196) Peanut allergy (maternal genetic effects) ( 29489655)
Interacting Genes		19 interacting genes: APC CEBPA CEP63 DISC1 ESCO2 ESR1 FEZ1 FEZ2 KIFAP3 MTNR1B MXD1 MXD3 MXD4 MXI1 RPGR SMC1A SMC1B SUMO2 TRAF3IP1	1 interacting genes: SMC3
Entrez ID		9126	27127
HPRD ID		05829	10564
Ensembl ID		ENSG00000108055	ENSG00000077935
Uniprot IDs		Q9UQE7	Q8NDV3
PDB IDs		6WG3 6WG4 6WG6 6WGE 7W1M 8P0A 8PQ5 8ROH 8ROI 8ROJ 8ROK 8ROL
Enriched GO Terms of Interacting Partners?		Centrosome Ciliary Basal Body Cohesin Complex Meiotic Cohesin Complex Sister Chromatid Cohesion Condensed Nuclear Chromosome Protein Dimerization Activity Negative Regulation Of Metabolic Process Negative Regulation Of Autophagosome Assembly Chromatin Mitotic Sister Chromatid Cohesion Organelle Organization Microtubule-based Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Metabolic Process Positive Regulation Of Catabolic Process Cilium Organization Plasma Membrane Bounded Cell Projection Organization Nucleoplasm RNA Polymerase II Transcription Regulator Complex Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Ciliary Transition Zone Developmental Process Regulation Of Ubiquitin-dependent Protein Catabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Calcidiol 1-monooxygenase Activity Secalciferol 1-monooxygenase Activity Photoreceptor Connecting Cilium Transport Along Microtubule Cell Projection Organization Organelle Assembly Negative Regulation Of Macroautophagy Positive Regulation Of Anterograde Axonal Transport Of Mitochondrion Regulation Of Neuroblast Proliferation Kinesin Binding Positive Regulation Of Calcium-dependent Cell-cell Adhesion Ciliary Base Negative Regulation Of Macromolecule Metabolic Process Kinesin Complex Ciliary Tip Intraciliary Transport Regulation Of Autophagosome Assembly Cytoskeleton-dependent Intracellular Transport Regulation Of Microtubule-based Movement Positive Regulation Of Proteolysis DNA Binding Protein Localization To Chromatin	Cohesin Complex Establishment Of Mitotic Sister Chromatid Cohesion Mitotic Cohesin Complex Establishment Of Sister Chromatid Cohesion Mitotic Spindle Pole Sister Chromatid Cohesion Mitotic Spindle Assembly Mitotic Spindle Organization Spindle Assembly Nuclear Matrix Microtubule Cytoskeleton Organization Involved In Mitosis Spindle Organization Chromosome, Centromeric Region Membraneless Organelle Assembly Establishment Of Meiotic Sister Chromatid Cohesion Chromosome Organization Meiotic Cohesin Complex Mediator Complex Binding Microtubule Cytoskeleton Organization Cell Division Chromatin Binding Lateral Element Chromosome Organelle Assembly Mitotic Sister Chromatid Cohesion Microtubule-based Process Dynein Complex Binding Cytoskeleton Organization Chromatin Nuclear Lumen Beta-tubulin Binding Microtubule Motor Activity Cis-regulatory Region Sequence-specific DNA Binding Meiotic Cell Cycle Stem Cell Population Maintenance Maintenance Of Cell Number Regulation Of DNA Replication Double-stranded DNA Binding Mitotic Cell Cycle Chromosome Segregation Cellular Component Assembly Organelle Organization
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