SMC3 and TRAF3IP1

Number of citations of the paper that reports this interaction (PubMedID 17043677)
0

Data Source:
BioGRID (two hybrid)

		SMC3	TRAF3IP1
Description		structural maintenance of chromosomes 3	TRAF3 interacting protein 1
Image
GO Annotations	Cellular Component	Chromosome, Centromeric Region Chromatin Lateral Element Nucleus Nucleoplasm Chromosome Cytosol Cohesin Complex Nuclear Matrix Mitotic Cohesin Complex Meiotic Cohesin Complex Nuclear Lumen Mitotic Spindle Pole	Fibrillar Center Nucleoplasm Cytoplasm Centrosome Cytoskeleton Cilium Axoneme Nuclear Body Intraciliary Transport Particle B Ciliary Transition Zone Ciliary Basal Body Cell Projection Ciliary Tip Ciliary Base
	Molecular Function	Nucleotide Binding Cis-regulatory Region Sequence-specific DNA Binding Chromatin Binding Double-stranded DNA Binding Microtubule Motor Activity Protein Binding ATP Binding ATP Hydrolysis Activity Mediator Complex Binding Protein Heterodimerization Activity Beta-tubulin Binding Dynein Complex Binding	Protein Binding Microtubule Binding
	Biological Process	Mitotic Cell Cycle Regulation Of DNA Replication DNA Repair DNA Damage Response Sister Chromatid Cohesion Mitotic Sister Chromatid Cohesion Stem Cell Population Maintenance Establishment Of Mitotic Sister Chromatid Cohesion Establishment Of Meiotic Sister Chromatid Cohesion Chromosome Organization Cell Division Meiotic Cell Cycle Mitotic Spindle Assembly	Morphogenesis Of A Polarized Epithelium Kidney Development Negative Regulation Of Protein Phosphorylation Neural Tube Patterning Cell Projection Organization Embryonic Camera-type Eye Development Negative Regulation Of Protein-containing Complex Assembly Negative Regulation Of Type I Interferon Production Negative Regulation Of Interferon-beta Production Embryonic Heart Tube Development Intraciliary Anterograde Transport Post-anal Tail Morphogenesis Intraciliary Transport Embryonic Digit Morphogenesis Negative Regulation Of Smoothened Signaling Pathway Animal Organ Development System Development Negative Regulation Of Defense Response To Virus Defense Response To Virus Cilium Assembly Regulation Of Microtubule Cytoskeleton Organization
Pathways		Meiotic synapsis Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion Cohesin Loading onto Chromatin Resolution of Sister Chromatid Cohesion SUMOylation of DNA damage response and repair proteins Estrogen-dependent gene expression	Intraflagellar transport Intraflagellar transport
Drugs
Diseases		Cornelia de Lange syndrome (CdLS)
GWAS		Acute respiratory distress syndrome in sepsis ( 31982041) Lumbar spine bone mineral density (integral) ( 27476799) Metabolite levels ( 23823483)	Chronotype ( 30696823) FEV1 ( 30804560) Intraocular pressure ( 29617998 29785010 30054594) Iris characteristics ( 21835309) Lung function (FEV1/FVC) ( 28166213 30804560) Metabolite levels ( 23823483) Morning person ( 30696823) Refractive astigmatism ( 30306274) Refractive error ( 32231278) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		19 interacting genes: APC CEBPA CEP63 DISC1 ESCO2 ESR1 FEZ1 FEZ2 KIFAP3 MTNR1B MXD1 MXD3 MXD4 MXI1 RPGR SMC1A SMC1B SUMO2 TRAF3IP1	31 interacting genes: ABI2 APP CCDC93 CCNA2 CDC5L DISC1 DMD DST DTNBP1 EXOC1 FRMD4A GOLGA4 IL13RA1 IMMT ITSN1 MACF1 OLFM1 PCNT SFR1 SGF29 SMC2 SMC3 SMC4 SNAP91 SPTBN1 TAB2 TRAF3 TRAF6 TRAK1 UBXN10 WAC
Entrez ID		9126	26146
HPRD ID		05829	09571
Ensembl ID		ENSG00000108055	ENSG00000204104
Uniprot IDs		Q9UQE7	Q8TDR0
PDB IDs		6WG3 6WG4 6WG6 6WGE 7W1M 8P0A 8PQ5 8ROH 8ROI 8ROJ 8ROK 8ROL	2EQO 8KCQ
Enriched GO Terms of Interacting Partners?		Centrosome Ciliary Basal Body Cohesin Complex Meiotic Cohesin Complex Sister Chromatid Cohesion Condensed Nuclear Chromosome Protein Dimerization Activity Negative Regulation Of Metabolic Process Negative Regulation Of Autophagosome Assembly Chromatin Mitotic Sister Chromatid Cohesion Organelle Organization Microtubule-based Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Metabolic Process Positive Regulation Of Catabolic Process Cilium Organization Plasma Membrane Bounded Cell Projection Organization Nucleoplasm RNA Polymerase II Transcription Regulator Complex Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Ciliary Transition Zone Developmental Process Regulation Of Ubiquitin-dependent Protein Catabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Calcidiol 1-monooxygenase Activity Secalciferol 1-monooxygenase Activity Photoreceptor Connecting Cilium Transport Along Microtubule Cell Projection Organization Organelle Assembly Negative Regulation Of Macroautophagy Positive Regulation Of Anterograde Axonal Transport Of Mitochondrion Regulation Of Neuroblast Proliferation Kinesin Binding Positive Regulation Of Calcium-dependent Cell-cell Adhesion Ciliary Base Negative Regulation Of Macromolecule Metabolic Process Kinesin Complex Ciliary Tip Intraciliary Transport Regulation Of Autophagosome Assembly Cytoskeleton-dependent Intracellular Transport Regulation Of Microtubule-based Movement Positive Regulation Of Proteolysis DNA Binding Protein Localization To Chromatin	Golgi To Plasma Membrane Transport Post-Golgi Vesicle-mediated Transport Positive Regulation Of Cellular Component Organization Vesicle-mediated Transport To The Plasma Membrane Regulation Of Postsynapse Organization Organelle Organization Regulation Of Neuron Projection Development Positive Regulation Of Axonogenesis Axo-dendritic Transport Regulation Of Axon Extension Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Regulation Of Cellular Component Organization Positive Regulation Of Cell Projection Organization Golgi To Plasma Membrane Protein Transport Cytoskeleton Organization Positive Regulation Of Axon Extension Meiotic Chromosome Condensation Establishment Of Protein Localization Condensin Complex Positive Regulation Of Chromosome Condensation Cilium Assembly Positive Regulation Of Cell Differentiation Regulation Of Axonogenesis Golgi Vesicle Transport Regulation Of Dendritic Spine Development Dendritic Spine Establishment Of Protein Localization To Plasma Membrane Vesicle-mediated Transport Cilium Organization CD40 Receptor Complex TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Synapse Organization Axon Cytoplasm Axonal Transport Cellular Localization Organelle Assembly Regulation Of Developmental Growth Transport Along Microtubule Clathrin-coated Pit MyD88-independent Toll-like Receptor Signaling Pathway Meiotic Chromosome Segregation Regulation Of Chromosome Condensation Endosome Molecular Adaptor Activity Cytoskeleton-dependent Intracellular Transport Positive Regulation Of Developmental Process Plasma Membrane Bounded Cell Projection Assembly Signaling Adaptor Activity Mitotic Chromosome Condensation
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