SMC3 and TRAF3IP1

Number of citations of the paper that reports this interaction (PMID 17043677)
96

Data Source:
BioGRID (two hybrid)

		SMC3	TRAF3IP1
Gene Name		structural maintenance of chromosomes 3	TNF receptor-associated factor 3 interacting protein 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Chromosome, Centromeric Region Chromatin Lateral Element Spindle Pole Basement Membrane Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol Cohesin Complex Cohesin Core Heterodimer Nuclear Matrix Meiotic Cohesin Complex Nuclear Meiotic Cohesin Complex	Centrosome Cilium Axoneme Intraciliary Transport Particle B Ciliary Basal Body Primary Cilium Ciliary Tip
	Molecular Function	Chromatin Binding Microtubule Motor Activity Protein Binding ATP Binding Mediator Complex Binding Dynein Binding Protein Heterodimerization Activity	Protein Binding Microtubule Binding
	Biological Process	Mitotic Cell Cycle Regulation Of DNA Replication DNA Repair Mitotic Spindle Organization Sister Chromatid Cohesion Mitotic Sister Chromatid Cohesion Mitotic Nuclear Division Meiotic Nuclear Division Signal Transduction Stem Cell Maintenance Negative Regulation Of DNA Endoreduplication Cell Division	Organelle Organization Neural Tube Patterning Embryonic Camera-type Eye Development Negative Regulation Of Interferon-beta Production Embryonic Heart Tube Development Post-anal Tail Morphogenesis Intraciliary Transport Cilium Assembly Embryonic Digit Morphogenesis Negative Regulation Of Defense Response To Virus Negative Regulation Of Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning
Pathways		Establishment of Sister Chromatid Cohesion Mitotic Prometaphase Mitotic Telophase/Cytokinesis Separation of Sister Chromatids Meiotic synapsis Cohesin Loading onto Chromatin Mitotic Anaphase S Phase M Phase Cell Cycle, Mitotic Resolution of Sister Chromatid Cohesion Mitotic Metaphase and Anaphase	Organelle biogenesis and maintenance Assembly of the primary cilium Intraflagellar transport
Drugs
Diseases
GWAS			Iris characteristics ( 21835309)
Protein-Protein Interactions		14 interactors: APC CEP63 DISC1 FEZ1 FEZ2 KIFAP3 MXD1 MXD3 MXD4 MXI1 RPGR SMC1A SMC1B TRAF3IP1	27 interactors: ABI2 APP CCDC93 CCNA2 CDC5L DISC1 DMD DST DTNBP1 EXOC1 FRMD4A GOLGA4 IL13RA1 IMMT MACF1 OLFM1 SFR1 SMC2 SMC3 SMC4 SNAP91 SPTBN1 TAB2 TRAF3 TRAF6 TRAK1 WAC
Entrez ID		9126	26146
HPRD ID		05829	09571
Ensembl ID		ENSG00000108055	ENSG00000204104
Uniprot IDs		Q9UQE7	Q8TDR0
PDB IDs			2EQO
Enriched GO Terms of Interacting Partners?		Microtubule-based Process Movement Of Cell Or Subcellular Component Microtubule-based Transport Cytoskeleton-dependent Intracellular Transport Negative Regulation Of Cellular Metabolic Process Cell Projection Morphogenesis Cell Part Morphogenesis Microtubule Cytoskeleton Organization Sister Chromatid Cohesion Organelle Organization Intraciliary Transport Cell Morphogenesis Cell Cycle Checkpoint Cell Projection Organization Negative Regulation Of Cell Proliferation Positive Regulation Of Calcium-dependent Cell-cell Adhesion Cell Cycle Mitotic Nuclear Division Negative Regulation Of Biosynthetic Process Microtubule-based Movement Regulation Of Cell Proliferation Nervous System Development Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Apoptotic Process Signal Transduction In Response To DNA Damage Canonical Wnt Signaling Pathway Generation Of Neurons Eye Development Cellular Localization Cell Division Neuron Development Neurogenesis Negative Regulation Of Odontogenesis Organelle Assembly Cell Cycle Process Spindle Organization Regulation Of Cell Projection Organization Cell Development Negative Regulation Of DNA Endoreduplication Negative Regulation Of Transcription, DNA-templated Axonogenesis Negative Regulation Of Nucleic Acid-templated Transcription Cytoskeleton Organization Neuron Differentiation Cellular Component Assembly Negative Regulation Of RNA Biosynthetic Process Plus-end-directed Vesicle Transport Along Microtubule Stem Cell Maintenance Positive Regulation Of Wnt Signaling Pathway Metaphase/anaphase Transition Of Mitotic Cell Cycle Axon Development	Post-Golgi Vesicle-mediated Transport Golgi To Plasma Membrane Transport Cell Cycle Process Golgi To Plasma Membrane Protein Transport Meiotic Chromosome Condensation Cell Cycle Golgi Vesicle Transport Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Response To Stress Generation Of Neurons TRIF-dependent Toll-like Receptor Signaling Pathway Neurogenesis Organelle Organization MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Signaling Cell Communication Mitotic Sister Chromatid Segregation Cell Division Establishment Of Protein Localization To Plasma Membrane Regulation Of Neurogenesis Toll-like Receptor 4 Signaling Pathway Nervous System Development Negative Regulation Of Cell Cycle Vesicle-mediated Transport Sister Chromatid Segregation Movement Of Cell Or Subcellular Component Cellular Localization Mitochondrial Calcium Ion Homeostasis Regulation Of Cell Differentiation Toll-like Receptor Signaling Pathway Membrane Organization Regulation Of Cell Development Regulation Of Neuron Differentiation Kinetochore Organization Mitotic Nuclear Division Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Regulation Of Protein Metabolic Process Mitotic Chromosome Condensation Pattern Recognition Receptor Signaling Pathway Regulation Of Cell Cycle Innate Immune Response-activating Signal Transduction Cellular Response To Stimulus Response To Stimulus Activation Of Innate Immune Response Signal Transduction Cell Differentiation Protein Localization To Plasma Membrane DNA Damage Checkpoint Regulation Of Neuron Projection Development
Tagcloud ?		12q13 1p36 ankrd11 cdls cleaves cohesin cornelia deeper discriminating encompassing espl1 exome filtering hdac8 intellectual intronic kbg lange merits mosaic multisystem nipbl novo partitioning rad21 recursive separase smc1a undetected	13r1 arches chlamydomonas cilia ciliary ciliogenesis cilium connections cytoskeletal disc1 dyf elipsa enlarged evolutionarily hedgehog homologs ift54 localizes microtubules mipt3 patterning pharyngeal polydactyly raises sequestration stat6 tnfr ventral
Tagcloud (Difference) ?		12q13 1p36 ankrd11 cdls cleaves cohesin cornelia deeper discriminating encompassing espl1 exome filtering hdac8 intellectual intronic kbg lange merits mosaic multisystem nipbl novo partitioning rad21 recursive separase smc1a undetected	13r1 arches chlamydomonas cilia ciliary ciliogenesis cilium connections cytoskeletal disc1 dyf elipsa enlarged evolutionarily hedgehog homologs ift54 localizes microtubules mipt3 patterning pharyngeal polydactyly raises sequestration stat6 tnfr ventral
Tagcloud (Intersection) ?