SMC3 and FEZ1

Number of citations of the paper that reports this interaction (PMID 16484223)
14

Data Source:
HPRD (in vitro, two hybrid)

		SMC3	FEZ1
Gene Name		structural maintenance of chromosomes 3	fasciculation and elongation protein zeta 1 (zygin I)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Chromosome, Centromeric Region Chromatin Lateral Element Spindle Pole Basement Membrane Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol Cohesin Complex Cohesin Core Heterodimer Nuclear Matrix Meiotic Cohesin Complex Nuclear Meiotic Cohesin Complex	Cytoplasm Mitochondrion Centrosome Microtubule Plasma Membrane Microtubule Cytoskeleton Axon Dendrite
	Molecular Function	Chromatin Binding Microtubule Motor Activity Protein Binding ATP Binding Mediator Complex Binding Dynein Binding Protein Heterodimerization Activity	Protein Kinase C Binding Protein Binding Gamma-tubulin Binding Protein N-terminus Binding
	Biological Process	Mitotic Cell Cycle Regulation Of DNA Replication DNA Repair Mitotic Spindle Organization Sister Chromatid Cohesion Mitotic Sister Chromatid Cohesion Mitotic Nuclear Division Meiotic Nuclear Division Signal Transduction Stem Cell Maintenance Negative Regulation Of DNA Endoreduplication Cell Division	Transport Cell Adhesion Nervous System Development Axon Guidance Positive Regulation Of Neuron Projection Development Establishment Of Mitochondrion Localization Cellular Response To Growth Factor Stimulus
Pathways		Establishment of Sister Chromatid Cohesion Mitotic Prometaphase Mitotic Telophase/Cytokinesis Separation of Sister Chromatids Meiotic synapsis Cohesin Loading onto Chromatin Mitotic Anaphase S Phase M Phase Cell Cycle, Mitotic Resolution of Sister Chromatid Cohesion Mitotic Metaphase and Anaphase
Drugs
Diseases
GWAS			Schizophrenia ( 22688191 23894747)
Protein-Protein Interactions		14 interactors: APC CEP63 DISC1 FEZ1 FEZ2 KIFAP3 MXD1 MXD3 MXD4 MXI1 RPGR SMC1A SMC1B TRAF3IP1	57 interactors: BARD1 BORA BRD1 C16orf59 C8orf33 CCL7 CIB1 CLASP2 COL9A2 CSTF2 DIS3L2 DISC1 DNAAF5 DRAP1 FEZ2 GEMIN7 GTF2F1 HAP1 HTATSF1 HTT IMMT KIAA1377 LRIF1 MEST NBR1 NDUFB9 NEK1 OLFML3 P4HB PAM16 PDCD7 PRKCZ PTH PTN PTPRS RAB3GAP1 RAB3GAP2 RAI14 RIF1 SAP30L SCOC SERPINH1 SMARCD1 SMC3 SMEK2 STAR TAC3 TAF1D TAF9 TBC1D25 TLK2 TOMM20 TTR TXNDC9 UBE4B WWC1 ZNF251
Entrez ID		9126	9638
HPRD ID		05829	09212
Ensembl ID		ENSG00000108055	ENSG00000149557
Uniprot IDs		Q9UQE7	Q99689
PDB IDs
Enriched GO Terms of Interacting Partners?		Microtubule-based Process Movement Of Cell Or Subcellular Component Microtubule-based Transport Cytoskeleton-dependent Intracellular Transport Negative Regulation Of Cellular Metabolic Process Cell Projection Morphogenesis Cell Part Morphogenesis Microtubule Cytoskeleton Organization Sister Chromatid Cohesion Organelle Organization Intraciliary Transport Cell Morphogenesis Cell Cycle Checkpoint Cell Projection Organization Negative Regulation Of Cell Proliferation Positive Regulation Of Calcium-dependent Cell-cell Adhesion Cell Cycle Mitotic Nuclear Division Negative Regulation Of Biosynthetic Process Microtubule-based Movement Regulation Of Cell Proliferation Nervous System Development Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Apoptotic Process Signal Transduction In Response To DNA Damage Canonical Wnt Signaling Pathway Generation Of Neurons Eye Development Cellular Localization Cell Division Neuron Development Neurogenesis Negative Regulation Of Odontogenesis Organelle Assembly Cell Cycle Process Spindle Organization Regulation Of Cell Projection Organization Cell Development Negative Regulation Of DNA Endoreduplication Negative Regulation Of Transcription, DNA-templated Axonogenesis Negative Regulation Of Nucleic Acid-templated Transcription Cytoskeleton Organization Neuron Differentiation Cellular Component Assembly Negative Regulation Of RNA Biosynthetic Process Plus-end-directed Vesicle Transport Along Microtubule Stem Cell Maintenance Positive Regulation Of Wnt Signaling Pathway Metaphase/anaphase Transition Of Mitotic Cell Cycle Axon Development	Positive Regulation Of Endoplasmic Reticulum Tubular Network Organization Organelle Organization Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Establishment Of Protein Localization To Endoplasmic Reticulum Membrane Regulation Of Cellular Process Vesicle Transport Along Microtubule Cell Cycle Mitotic Cell Cycle Microtubule-based Process Microtubule Cytoskeleton Organization Regulation Of Metabolic Process Response To Radiation Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Heterocycle Metabolic Process Cellular Process Cellular Homeostasis Organelle Transport Along Microtubule Positive Regulation Of Metabolic Process Response To Ionizing Radiation Response To Stimulus Movement Of Cell Or Subcellular Component Cell Division Regulation Of Intracellular Signal Transduction Cell Cycle Process Regulation Of Synaptic Plasticity Nucleobase-containing Compound Metabolic Process Cellular Response To DNA Damage Stimulus Regulation Of Synaptic Transmission Regulation Of Microtubule-based Process Response To Abiotic Stimulus Cellular Nitrogen Compound Metabolic Process Establishment Or Maintenance Of Cell Polarity Cellular Metabolic Process Mitotic Nuclear Division Mitotic Cell Cycle Process Homeostatic Process Regulation Of Signal Transduction Regulation Of Signaling Mitochondrial Calcium Ion Homeostasis Regulation Of Organelle Organization Cellular Aromatic Compound Metabolic Process Regulation Of Cellular Component Organization Nitrogen Compound Metabolic Process DNA-templated Transcription, Elongation Establishment Of Protein Localization To Organelle Anatomical Structure Development Nervous System Development RNA Metabolic Process Diencephalon Development Transcription, DNA-templated
Tagcloud ?		12q13 1p36 ankrd11 cdls cleaves cohesin cornelia deeper discriminating encompassing espl1 exome filtering hdac8 intellectual intronic kbg lange merits mosaic multisystem nipbl novo partitioning rad21 recursive separase smc1a undetected	atf5 burden credible disc1 disordered endophenotypes highlighting intriguing intrinsically lis maf missense nde1 ndel1 neuropsychiatric partners pde4b psychiatric reside schizophrenia striking swedish synonymous sz traf3ip1 unexplored variants ywhae znf365
Tagcloud (Difference) ?		12q13 1p36 ankrd11 cdls cleaves cohesin cornelia deeper discriminating encompassing espl1 exome filtering hdac8 intellectual intronic kbg lange merits mosaic multisystem nipbl novo partitioning rad21 recursive separase smc1a undetected	atf5 burden credible disc1 disordered endophenotypes highlighting intriguing intrinsically lis maf missense nde1 ndel1 neuropsychiatric partners pde4b psychiatric reside schizophrenia striking swedish synonymous sz traf3ip1 unexplored variants ywhae znf365
Tagcloud (Intersection) ?