SMC3 and MXI1

Number of citations of the paper that reports this interaction (PMID 9528857)
4

Data Source:
HPRD (in vitro)

		SMC3	MXI1
Gene Name		structural maintenance of chromosomes 3	MAX interactor 1, dimerization protein
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Chromosome, Centromeric Region Chromatin Lateral Element Spindle Pole Basement Membrane Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol Cohesin Complex Cohesin Core Heterodimer Nuclear Matrix Meiotic Cohesin Complex Nuclear Meiotic Cohesin Complex	Nucleus Nucleolus Cytoplasm
	Molecular Function	Chromatin Binding Microtubule Motor Activity Protein Binding ATP Binding Mediator Complex Binding Dynein Binding Protein Heterodimerization Activity	DNA Binding Transcription Corepressor Activity Protein Dimerization Activity
	Biological Process	Mitotic Cell Cycle Regulation Of DNA Replication DNA Repair Mitotic Spindle Organization Sister Chromatid Cohesion Mitotic Sister Chromatid Cohesion Mitotic Nuclear Division Meiotic Nuclear Division Signal Transduction Stem Cell Maintenance Negative Regulation Of DNA Endoreduplication Cell Division	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Negative Regulation Of Cell Proliferation Cytoplasmic Sequestering Of Transcription Factor
Pathways		Establishment of Sister Chromatid Cohesion Mitotic Prometaphase Mitotic Telophase/Cytokinesis Separation of Sister Chromatids Meiotic synapsis Cohesin Loading onto Chromatin Mitotic Anaphase S Phase M Phase Cell Cycle, Mitotic Resolution of Sister Chromatid Cohesion Mitotic Metaphase and Anaphase
Drugs
Diseases
GWAS			Normalized brain volume ( 19010793)
Protein-Protein Interactions		14 interactors: APC CEP63 DISC1 FEZ1 FEZ2 KIFAP3 MXD1 MXD3 MXD4 MXI1 RPGR SMC1A SMC1B TRAF3IP1	16 interactors: APP CALCOCO2 ENTPD5 KRT40 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 MAX MYC NOTCH2NL RPL23AP32 SIN3A SIN3B SMC3
Entrez ID		9126	4601
HPRD ID		05829	02486
Ensembl ID		ENSG00000108055	ENSG00000119950
Uniprot IDs		Q9UQE7	B1ANN8 P50539
PDB IDs
Enriched GO Terms of Interacting Partners?		Microtubule-based Process Movement Of Cell Or Subcellular Component Microtubule-based Transport Cytoskeleton-dependent Intracellular Transport Negative Regulation Of Cellular Metabolic Process Cell Projection Morphogenesis Cell Part Morphogenesis Microtubule Cytoskeleton Organization Sister Chromatid Cohesion Organelle Organization Intraciliary Transport Cell Morphogenesis Cell Cycle Checkpoint Cell Projection Organization Negative Regulation Of Cell Proliferation Positive Regulation Of Calcium-dependent Cell-cell Adhesion Cell Cycle Mitotic Nuclear Division Negative Regulation Of Biosynthetic Process Microtubule-based Movement Regulation Of Cell Proliferation Nervous System Development Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Apoptotic Process Signal Transduction In Response To DNA Damage Canonical Wnt Signaling Pathway Generation Of Neurons Eye Development Cellular Localization Cell Division Neuron Development Neurogenesis Negative Regulation Of Odontogenesis Organelle Assembly Cell Cycle Process Spindle Organization Regulation Of Cell Projection Organization Cell Development Negative Regulation Of DNA Endoreduplication Negative Regulation Of Transcription, DNA-templated Axonogenesis Negative Regulation Of Nucleic Acid-templated Transcription Cytoskeleton Organization Neuron Differentiation Cellular Component Assembly Negative Regulation Of RNA Biosynthetic Process Plus-end-directed Vesicle Transport Along Microtubule Stem Cell Maintenance Positive Regulation Of Wnt Signaling Pathway Metaphase/anaphase Transition Of Mitotic Cell Cycle Axon Development	Notch Signaling Pathway Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Phase Transition Transcription From RNA Polymerase II Promoter Neuron Apoptotic Process Regulation Of Cell Cycle Nucleobase-containing Compound Metabolic Process Histone Deacetylation Neuron Death Protein Deacetylation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Chromosome Organization Response To Methylglyoxal Positive Regulation Of Metanephric Cap Mesenchymal Cell Proliferation Negative Regulation Of Histone H3-K27 Acetylation Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Response To Stress Regulation Of Cell Cycle Process Synaptic Growth At Neuromuscular Junction Fibroblast Apoptotic Process Positive Regulation Of Mitotic Cell Cycle Developmental Process Nitrogen Compound Metabolic Process Cellular Chemical Homeostasis Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Collateral Sprouting In Absence Of Injury Positive Regulation Of Chromatin Silencing Chromatin Modification Positive Regulation Of Peptidase Activity Cell Growth Transition Metal Ion Homeostasis Cellular Response To Stress Cellular Homeostasis Collateral Sprouting Axon Midline Choice Point Recognition Negative Regulation Of DNA Endoreduplication Response To Wounding Chromatin Organization Negative Regulation Of Cell Differentiation Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Monocyte Differentiation Axon Choice Point Recognition Positive Regulation Of Cell Proliferation Involved In Kidney Development
Tagcloud ?		12q13 1p36 ankrd11 cdls cleaves cohesin cornelia deeper discriminating encompassing espl1 exome filtering hdac8 intellectual intronic kbg lange merits mosaic multisystem nipbl novo partitioning rad21 recursive separase smc1a undetected	acting antagonizes b1 believed cdc2 cdk2 classic declined dramatically g2 glomerulonephritis gradually interactor inversely ki67 max mentioned mesangial myc nephritis obvious opposite percentage plasmid proliferation proliferative sirna thy1 transfection
Tagcloud (Difference) ?		12q13 1p36 ankrd11 cdls cleaves cohesin cornelia deeper discriminating encompassing espl1 exome filtering hdac8 intellectual intronic kbg lange merits mosaic multisystem nipbl novo partitioning rad21 recursive separase smc1a undetected	acting antagonizes b1 believed cdc2 cdk2 classic declined dramatically g2 glomerulonephritis gradually interactor inversely ki67 max mentioned mesangial myc nephritis obvious opposite percentage plasmid proliferation proliferative sirna thy1 transfection
Tagcloud (Intersection) ?