NCOA6 and TRA

Number of citations of the paper that reports this interaction (PubMedID 10866662)
63

Data Source:
BioGRID (pull down)

		NCOA6	TRA
Description		nuclear receptor coactivator 6	T cell receptor alpha locus
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Regulator Complex Cytosol Histone Methyltransferase Complex MLL3/4 Complex	Plasma Membrane Membrane T Cell Receptor Complex Alpha-beta T Cell Receptor Complex
	Molecular Function	Chromatin Binding Transcription Coactivator Activity Protein Binding Enzyme Binding Nuclear Estrogen Receptor Binding Nuclear Retinoid X Receptor Binding Nuclear Thyroid Hormone Receptor Binding	Signaling Receptor Activity
	Biological Process	DNA-templated Transcription Initiation DNA Damage Response Brain Development Heart Development Response To Hormone Myeloid Cell Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II	Adaptive Immune Response Detection Of Tumor Cell Immune System Process T Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Response To Bacterium
Pathways		BMAL1:CLOCK,NPAS2 activates circadian expression PPARA activates gene expression PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis Activation of gene expression by SREBF (SREBP) Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by PPARalpha Activation of anterior HOX genes in hindbrain development during early embryogenesis Cytoprotection by HMOX1 Heme signaling Formation of WDR5-containing histone-modifying complexes Epigenetic regulation of gene expression by MLL3 and MLL4 complexes MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Expression of BMAL (ARNTL), CLOCK, and NPAS2 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Bipolar disorder ( 31043756) Coronary artery disease ( 29212778) Estimated glomerular filtration rate in non-diabetics ( 31451708) Feeling nervous ( 29500382) Fish- and plant-related diet ( 32066663) Height ( 28552196) Hip circumference adjusted for BMI ( 25673412 34021172) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Urate levels ( 31578528) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) ( 23648065) Narcolepsy ( 24204295) Periodontal disease-related phenotype (Socransky) ( 26962152)
Interacting Genes		63 interacting genes: AR ASCC1 ATF2 CD40 CEBPA CREBBP E2F1 EP300 ESR1 ESR2 FHOD1 FOS GHR GRIP1 GTF2A1 H3C14 HNF4A HSF1 JUN LAMTOR5 MED1 MED23 NCOR2 NFKB1 NR1H2 NR1H3 NR1H4 NR1I2 NR3C1 NUMA1 PARP1 PPARG PPARGC1A PRKDC PRMT2 RANBP9 RARA RB1 RBM14 RBM39 RELA RORB RORC RXRA RXRG SMAD2 SMAD3 SRC SRF TBP TGS1 THRA THRB TOP1 TRA TRB TXNRD2 UBC VDR XIAP XRCC5 XRCC6 ZNF335	16 interacting genes: CANX CD247 CD3D CD3G EDEM3 HLA-A HLA-B HLA-DRB1 HSPA5 LEF1 NCOA6 SNTA1 TMUB1 TRAT1 TRB TRD
Entrez ID		23054	6955
HPRD ID		05599	01736
Ensembl ID		ENSG00000198646
Uniprot IDs		F6M2K2 F6M2K3 Q14686
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Chromatin Nuclear Receptor Activity Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Nucleoplasm Positive Regulation Of Biosynthetic Process Intracellular Receptor Signaling Pathway Sequence-specific DNA Binding Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process DNA-templated Transcription DNA Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Regulator Complex Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Nucleobase-containing Compound Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II RNA Metabolic Process Chromatin DNA Binding Hormone-mediated Signaling Pathway Transcription Cis-regulatory Region Binding Chromatin Binding Intracellular Signal Transduction RNA Polymerase II-specific DNA-binding Transcription Factor Binding Response To Lipid Regulation Of Primary Metabolic Process Nuclear Receptor-mediated Signaling Pathway Nucleic Acid Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process RNA Polymerase II Transcription Regulator Complex Response To Hormone Negative Regulation Of Biosynthetic Process	Alpha-beta T Cell Receptor Complex Adaptive Immune Response T Cell Receptor Complex Lumenal Side Of Endoplasmic Reticulum Membrane Detection Of Biotic Stimulus Alpha-beta T Cell Activation T Cell Receptor Signaling Pathway Detection Of Bacterium T Cell Receptor Binding Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Immune Response Positive Regulation Of Immune System Process ERAD Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Gamma-delta T Cell Receptor Complex Antigen Processing And Presentation Of Endogenous Antigen TAP Binding T Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response Positive Regulation Of T Cell Mediated Cytotoxicity Peptide Antigen Binding T Cell Activation Regulation Of T Cell Mediated Cytotoxicity Regulation Of Immune Response External Side Of Plasma Membrane Immune System Process Protection From Natural Killer Cell Mediated Cytotoxicity Immune Response-activating Signaling Pathway Immune Response To Tumor Cell ER To Golgi Transport Vesicle Membrane Immune Response-regulating Signaling Pathway Antigen Processing And Presentation Of Peptide Antigen MHC Class I Protein Complex Positive Regulation Of Leukocyte Mediated Cytotoxicity Activation Of Immune Response Clathrin-coated Endocytic Vesicle Membrane Regulation Of Immune System Process Positive Regulation Of Cell Killing Positive Regulation Of T Cell Mediated Immunity Lymphocyte Activation Protein Folding In Endoplasmic Reticulum Positive Thymic T Cell Selection Response To Endoplasmic Reticulum Stress Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Detection Of Stimulus Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Positive T Cell Selection Regulation Of Leukocyte Mediated Cytotoxicity Antigen Processing And Presentation
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