NCOA6 and ZNF335

Number of citations of the paper that reports this interaction (PMID 12215545)
11

Data Source:
HPRD (in vitro, in vivo)

		NCOA6	ZNF335
Gene Name		nuclear receptor coactivator 6	zinc finger protein 335
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Factor Complex Histone Methyltransferase Complex Intracellular Membrane-bounded Organelle	Nucleus Histone Methyltransferase Complex
	Molecular Function	Chromatin Binding Transcription Coactivator Activity Protein Binding Enzyme Binding Estrogen Receptor Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Retinoid X Receptor Binding Thyroid Hormone Receptor Binding	RNA Polymerase II Core Promoter Sequence-specific DNA Binding Protein Binding Transcription Regulatory Region DNA Binding Metal Ion Binding
	Biological Process	DNA Replication DNA Repair DNA Recombination DNA-templated Transcription, Initiation Transcription Initiation From RNA Polymerase II Promoter Cellular Response To DNA Damage Stimulus Brain Development Heart Development Response To Hormone Myeloid Cell Differentiation Intracellular Estrogen Receptor Signaling Pathway Glucocorticoid Receptor Signaling Pathway Cellular Lipid Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Labyrinthine Layer Blood Vessel Development	In Utero Embryonic Development Positive Regulation Of Neuroblast Proliferation Transcription, DNA-templated Regulation Of Transcription, DNA-templated Brain Development Cerebral Cortex Neuron Differentiation Regulation Of Gene Expression, Epigenetic Neuron Projection Morphogenesis Brain Morphogenesis Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Neurogenesis Regulation Of Histone H3-K4 Methylation Histone H3-K4 Trimethylation
Pathways		PPARA activates gene expression Organelle biogenesis and maintenance Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins REV-ERBA represses gene expression RORA activates circadian gene expression Mitochondrial biogenesis Regulation of cholesterol biosynthesis by SREBP (SREBF) Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Activation of gene expression by SREBF (SREBP) YAP1- and WWTR1 (TAZ)-stimulated gene expression Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Transcriptional activation of mitochondrial biogenesis BMAL1:CLOCK,NPAS2 activates circadian gene expression Orphan transporters
Drugs
Diseases
GWAS
Protein-Protein Interactions		64 interactors: AR ASCC1 ATF2 BCL3 CD40 CEBPA CREBBP E2F1 EP300 ESR1 ESR2 FHOD1 FOS GHR GRIP1 GTF2A1 HIST2H3C HNF4A HSF1 JUN LAMTOR5 MED1 MED23 NCOA1 NCOR2 NFKB1 NR1H2 NR1H3 NR1H4 NR1I2 NR3C1 NUMA1 PARP1 PPARG PPARGC1A PRKDC PRMT2 RANBP9 RARA RB1 RBM14 RBM39 RELA RORB RORC RXRA RXRG SMAD2 SMAD3 SRC SRF TBP TGS1 THRA THRB TOP1 TRA TRB TXNRD2 UBC VDR XRCC5 XRCC6 ZNF335	4 interactors: CCAR2 CDK4 CDK6 NCOA6
Entrez ID		23054	63925
HPRD ID		05599	11709
Ensembl ID		ENSG00000198646	ENSG00000198026
Uniprot IDs		F6M2K2 Q14686	Q8IW09 Q9H4Z2
PDB IDs
Enriched GO Terms of Interacting Partners?		Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated DNA-templated Transcription, Initiation Positive Regulation Of Macromolecule Biosynthetic Process Intracellular Receptor Signaling Pathway Positive Regulation Of Gene Expression Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Response To Lipid Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process RNA Metabolic Process Gene Expression Steroid Hormone Mediated Signaling Pathway Response To Steroid Hormone Cellular Response To Lipid Response To Hormone Cellular Macromolecule Biosynthetic Process Hormone-mediated Signaling Pathway Response To Organic Cyclic Compound Macromolecule Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Cellular Response To Organic Substance Cellular Response To Hormone Stimulus Cellular Response To Organic Cyclic Compound Cellular Response To Steroid Hormone Stimulus Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Heterocycle Metabolic Process Negative Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Response To Organic Substance Regulation Of Metabolic Process Nitrogen Compound Metabolic Process Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter	Positive Regulation Of Fibroblast Proliferation Regulation Of Fibroblast Proliferation Positive Regulation Of DNA Damage Checkpoint Cell Dedifferentiation Regulation Of Cell Cycle G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle Process Mitotic Cell Cycle Phase Transition Cell Cycle Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Rhythmic Process Positive Regulation Of Gene Expression Glucocorticoid Receptor Signaling Pathway Mitochondrial Fragmentation Involved In Apoptotic Process Negative Regulation Of Cellular Senescence Positive Regulation Of Cell Size Positive Regulation Of Cell Cycle Checkpoint Regulation Of Gene Expression Cell Division Regulation Of DNA Damage Checkpoint Negative Regulation Of Cell Cycle Posttranscriptional Regulation Of Gene Expression Hematopoietic Stem Cell Differentiation Negative Regulation Of Cell Aging Regulation Of Cell Cycle Process Dentate Gyrus Development Type B Pancreatic Cell Development Intracellular Estrogen Receptor Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Astrocyte Development Positive Regulation Of Cell Death Type B Pancreatic Cell Differentiation Negative Regulation Of Cell Cycle Arrest Lateral Ventricle Development Enteroendocrine Cell Differentiation Hemopoiesis Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Cellular Senescence Response To Lead Ion Mitochondrial Fission Labyrinthine Layer Blood Vessel Development Response To Hyperoxia Mitotic Cell Cycle Process Glandular Epithelial Cell Development Regulation Of Cellular Response To Heat Immune System Development Response To Testosterone
Tagcloud ?		candidate cardiomyopathy coactivator coding contractile dcm defects delta depletion dilated dilation dysfunction embryonic germline heart humans idcm idiopathic left lethality malfunction nonsynonymous peroxisome ppardelta progressive proliferator sequencing unclear ventricular
Tagcloud (Difference) ?		candidate cardiomyopathy coactivator coding contractile dcm defects delta depletion dilated dilation dysfunction embryonic germline heart humans idcm idiopathic left lethality malfunction nonsynonymous peroxisome ppardelta progressive proliferator sequencing unclear ventricular
Tagcloud (Intersection) ?