NCOA6 and TGS1

Number of citations of the paper that reports this interaction (PMID 11517327)
27

Data Source:
HPRD (in vivo, in vitro)

		NCOA6	TGS1
Gene Name		nuclear receptor coactivator 6	trimethylguanosine synthase 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Factor Complex Histone Methyltransferase Complex Intracellular Membrane-bounded Organelle	Extracellular Space Nucleus Nucleoplasm Cytoplasm Cytosol Cajal Body Small Nuclear Ribonucleoprotein Complex
	Molecular Function	Chromatin Binding Transcription Coactivator Activity Protein Binding Enzyme Binding Estrogen Receptor Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Retinoid X Receptor Binding Thyroid Hormone Receptor Binding	Protein Binding RNA Trimethylguanosine Synthase Activity
	Biological Process	DNA Replication DNA Repair DNA Recombination DNA-templated Transcription, Initiation Transcription Initiation From RNA Polymerase II Promoter Cellular Response To DNA Damage Stimulus Brain Development Heart Development Response To Hormone Myeloid Cell Differentiation Intracellular Estrogen Receptor Signaling Pathway Glucocorticoid Receptor Signaling Pathway Cellular Lipid Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Labyrinthine Layer Blood Vessel Development	Spliceosomal SnRNP Assembly Transcription, DNA-templated Regulation Of Transcription, DNA-templated 7-methylguanosine RNA Capping Gene Expression Ribonucleoprotein Complex Biogenesis NcRNA Metabolic Process 7-methylguanosine Cap Hypermethylation Cellular Lipid Metabolic Process Small Molecule Metabolic Process Ribonucleoprotein Complex Import Into Nucleus
Pathways		PPARA activates gene expression Organelle biogenesis and maintenance Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins REV-ERBA represses gene expression RORA activates circadian gene expression Mitochondrial biogenesis Regulation of cholesterol biosynthesis by SREBP (SREBF) Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Activation of gene expression by SREBF (SREBP) YAP1- and WWTR1 (TAZ)-stimulated gene expression Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Transcriptional activation of mitochondrial biogenesis BMAL1:CLOCK,NPAS2 activates circadian gene expression Orphan transporters	PPARA activates gene expression Organelle biogenesis and maintenance Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Metabolism of non-coding RNA REV-ERBA represses gene expression RORA activates circadian gene expression Mitochondrial biogenesis Regulation of cholesterol biosynthesis by SREBP (SREBF) Generic Transcription Pathway snRNP Assembly Transcriptional regulation of white adipocyte differentiation YAP1- and WWTR1 (TAZ)-stimulated gene expression Activation of gene expression by SREBF (SREBP) Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Transcriptional activation of mitochondrial biogenesis BMAL1:CLOCK,NPAS2 activates circadian gene expression Orphan transporters
Drugs
Diseases
GWAS			Height ( 18391951)
Protein-Protein Interactions		64 interactors: AR ASCC1 ATF2 BCL3 CD40 CEBPA CREBBP E2F1 EP300 ESR1 ESR2 FHOD1 FOS GHR GRIP1 GTF2A1 HIST2H3C HNF4A HSF1 JUN LAMTOR5 MED1 MED23 NCOA1 NCOR2 NFKB1 NR1H2 NR1H3 NR1H4 NR1I2 NR3C1 NUMA1 PARP1 PPARG PPARGC1A PRKDC PRMT2 RANBP9 RARA RB1 RBM14 RBM39 RELA RORB RORC RXRA RXRG SMAD2 SMAD3 SRC SRF TBP TGS1 THRA THRB TOP1 TRA TRB TXNRD2 UBC VDR XRCC5 XRCC6 ZNF335	6 interactors: COIL CREBBP EED EP300 HNF4A NCOA6
Entrez ID		23054	96764
HPRD ID		05599	07567
Ensembl ID		ENSG00000198646	ENSG00000137574
Uniprot IDs		F6M2K2 Q14686	Q96RS0
PDB IDs			3EGI 3GDH
Enriched GO Terms of Interacting Partners?		Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated DNA-templated Transcription, Initiation Positive Regulation Of Macromolecule Biosynthetic Process Intracellular Receptor Signaling Pathway Positive Regulation Of Gene Expression Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Response To Lipid Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process RNA Metabolic Process Gene Expression Steroid Hormone Mediated Signaling Pathway Response To Steroid Hormone Cellular Response To Lipid Response To Hormone Cellular Macromolecule Biosynthetic Process Hormone-mediated Signaling Pathway Response To Organic Cyclic Compound Macromolecule Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Cellular Response To Organic Substance Cellular Response To Hormone Stimulus Cellular Response To Organic Cyclic Compound Cellular Response To Steroid Hormone Stimulus Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Heterocycle Metabolic Process Negative Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Response To Organic Substance Regulation Of Metabolic Process Nitrogen Compound Metabolic Process Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter	N-terminal Peptidyl-lysine Acetylation N-terminal Protein Amino Acid Acetylation Transcription Initiation From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia RNA Biosynthetic Process N-terminal Protein Amino Acid Modification Regulation Of Cellular Response To Heat Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Histone Modification Positive Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress RNA Metabolic Process Regulation Of DNA-templated Transcription In Response To Stress Positive Regulation Of Metabolic Process Gene Expression Cellular Response To Heat Positive Regulation Of Macromolecule Biosynthetic Process Cellular Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Type I Interferon Production Chromatin Modification Cellular Response To Hypoxia Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Decreased Oxygen Levels Regulation Of Type I Interferon Production Regulation Of Transcription, DNA-templated Histone H2B Acetylation Regulation Of Nucleic Acid-templated Transcription Cellular Response To Oxygen Levels Regulation Of RNA Biosynthetic Process Response To Heat Histone Acetylation Regulation Of RNA Metabolic Process Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Chromatin Organization Internal Protein Amino Acid Acetylation Nucleobase-containing Compound Metabolic Process Protein Acetylation Notch Signaling Pathway Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process
Tagcloud ?		candidate cardiomyopathy coactivator coding contractile dcm defects delta depletion dilated dilation dysfunction embryonic germline heart humans idcm idiopathic left lethality malfunction nonsynonymous peroxisome ppardelta progressive proliferator sequencing unclear ventricular	accumulate accumulates billion dormancy dosr drastic droplet droplets fatty filled granuloma hspx hypoxic icl1 imports incorporates inside isoniazid latently lipid lipy loaded mtb radiolabeled sequestered tag taqman triacylglycerol utilizes
Tagcloud (Difference) ?		candidate cardiomyopathy coactivator coding contractile dcm defects delta depletion dilated dilation dysfunction embryonic germline heart humans idcm idiopathic left lethality malfunction nonsynonymous peroxisome ppardelta progressive proliferator sequencing unclear ventricular	accumulate accumulates billion dormancy dosr drastic droplet droplets fatty filled granuloma hspx hypoxic icl1 imports incorporates inside isoniazid latently lipid lipy loaded mtb radiolabeled sequestered tag taqman triacylglycerol utilizes
Tagcloud (Intersection) ?