NCOA6 and THRA

Number of citations of the paper that reports this interaction (PMID 10866662)
36

Data Source:
BioGRID (pull down)
HPRD (in vitro, two hybrid)

		NCOA6	THRA
Gene Name		nuclear receptor coactivator 6	thyroid hormone receptor, alpha
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Factor Complex Histone Methyltransferase Complex Intracellular Membrane-bounded Organelle	Nucleus Nucleoplasm Cytosol
	Molecular Function	Chromatin Binding Transcription Coactivator Activity Protein Binding Enzyme Binding Estrogen Receptor Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Retinoid X Receptor Binding Thyroid Hormone Receptor Binding	Steroid Receptor RNA Activator RNA Binding Sequence-specific DNA Binding Transcription Factor Activity Steroid Hormone Receptor Activity Thyroid Hormone Receptor Activity Protein Binding Transcription Factor Binding Zinc Ion Binding TBP-class Protein Binding Protein Domain Specific Binding Chromatin DNA Binding Protein Complex Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding Thyroid Hormone Binding
	Biological Process	DNA Replication DNA Repair DNA Recombination DNA-templated Transcription, Initiation Transcription Initiation From RNA Polymerase II Promoter Cellular Response To DNA Damage Stimulus Brain Development Heart Development Response To Hormone Myeloid Cell Differentiation Intracellular Estrogen Receptor Signaling Pathway Glucocorticoid Receptor Signaling Pathway Cellular Lipid Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Labyrinthine Layer Blood Vessel Development	Cartilage Condensation Ossification Regulation Of Thyroid Hormone Mediated Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Learning Or Memory Regulation Of Heart Contraction Female Courtship Behavior Response To Cold Hormone-mediated Signaling Pathway Gene Expression Positive Regulation Of Myotube Differentiation Negative Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly Erythrocyte Differentiation Intracellular Receptor Signaling Pathway Thyroid Gland Development Regulation Of Myeloid Cell Apoptotic Process Cytoplasmic Sequestering Of Transcription Factor Steroid Hormone Mediated Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Female Receptivity Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Lipid Catabolic Process Type I Pneumocyte Differentiation Negative Regulation Of DNA-templated Transcription, Initiation
Pathways		PPARA activates gene expression Organelle biogenesis and maintenance Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins REV-ERBA represses gene expression RORA activates circadian gene expression Mitochondrial biogenesis Regulation of cholesterol biosynthesis by SREBP (SREBF) Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Activation of gene expression by SREBF (SREBP) YAP1- and WWTR1 (TAZ)-stimulated gene expression Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Transcriptional activation of mitochondrial biogenesis BMAL1:CLOCK,NPAS2 activates circadian gene expression Orphan transporters	Generic Transcription Pathway Nuclear Receptor transcription pathway
Drugs			Liothyronine Levothyroxine Dextrothyroxine Liotrix 3,5-Dichloro-4-[(4-Hydroxy-3-Isopropylphenoxy)Phenylacetic Acid
Diseases
GWAS			White blood cell count ( 21738480)
Protein-Protein Interactions		64 interactors: AR ASCC1 ATF2 BCL3 CD40 CEBPA CREBBP E2F1 EP300 ESR1 ESR2 FHOD1 FOS GHR GRIP1 GTF2A1 HIST2H3C HNF4A HSF1 JUN LAMTOR5 MED1 MED23 NCOA1 NCOR2 NFKB1 NR1H2 NR1H3 NR1H4 NR1I2 NR3C1 NUMA1 PARP1 PPARG PPARGC1A PRKDC PRMT2 RANBP9 RARA RB1 RBM14 RBM39 RELA RORB RORC RXRA RXRG SMAD2 SMAD3 SRC SRF TBP TGS1 THRA THRB TOP1 TRA TRB TXNRD2 UBC VDR XRCC5 XRCC6 ZNF335	56 interactors: AKAP13 AMOTL2 ARID5A BTG1 BUB3 C1D CCND1 CDK7 CLIC1 COPS2 CREB1 CREBBP CUL1 DAP3 ESR1 FOXJ1 FUS GRIP1 GTF2B HDAC2 HDAC3 ITGB3BP L3MBTL3 MED1 MED21 MED25 MEF2A NCOA1 NCOA6 NCOR1 NCOR2 NR0B2 NR2F1 NRIP1 NSD1 OASL PML POU2F1 PRKDC PTGES3 RANBP9 RGN RXRA RXRB RXRG SEPP1 SLC16A2 SRC SUV39H1 TBL1X TDG TRIM24 TRIP11 YWHAH YWHAQ ZBTB3
Entrez ID		23054	7067
HPRD ID		05599	07185
Ensembl ID		ENSG00000198646	ENSG00000126351
Uniprot IDs		F6M2K2 Q14686	P10827 Q6FH41
PDB IDs			1NAV 2H77 2H79 3HZF 3ILZ 3JZB
Enriched GO Terms of Interacting Partners?		Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated DNA-templated Transcription, Initiation Positive Regulation Of Macromolecule Biosynthetic Process Intracellular Receptor Signaling Pathway Positive Regulation Of Gene Expression Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Response To Lipid Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process RNA Metabolic Process Gene Expression Steroid Hormone Mediated Signaling Pathway Response To Steroid Hormone Cellular Response To Lipid Response To Hormone Cellular Macromolecule Biosynthetic Process Hormone-mediated Signaling Pathway Response To Organic Cyclic Compound Macromolecule Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Cellular Response To Organic Substance Cellular Response To Hormone Stimulus Cellular Response To Organic Cyclic Compound Cellular Response To Steroid Hormone Stimulus Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Heterocycle Metabolic Process Negative Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Response To Organic Substance Regulation Of Metabolic Process Nitrogen Compound Metabolic Process Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter	Transcription, DNA-templated RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process RNA Metabolic Process Gene Expression Regulation Of Transcription, DNA-templated Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Gene Expression Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Intracellular Receptor Signaling Pathway Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process DNA-templated Transcription, Initiation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Nitrogen Compound Metabolic Process Intracellular Steroid Hormone Receptor Signaling Pathway Rhythmic Process Organ Development Multicellular Organismal Development Regulation Of Cellular Process Anatomical Structure Development Developmental Process Cellular Response To Organic Substance Signal Transduction Chromosome Organization Signaling System Development
Tagcloud ?		candidate cardiomyopathy coactivator coding contractile dcm defects delta depletion dilated dilation dysfunction embryonic germline heart humans idcm idiopathic left lethality malfunction nonsynonymous peroxisome ppardelta progressive proliferator sequencing unclear ventricular	accounts averages bimodality bxd bxh chr counted encode ganglion heritable hoxb idea inbred krt1 lod mapped neuregulin nnc1 opposed qtl qtls retina retinal striking subsidiary surprisingly thyroxine trait vertebrate
Tagcloud (Difference) ?		candidate cardiomyopathy coactivator coding contractile dcm defects delta depletion dilated dilation dysfunction embryonic germline heart humans idcm idiopathic left lethality malfunction nonsynonymous peroxisome ppardelta progressive proliferator sequencing unclear ventricular	accounts averages bimodality bxd bxh chr counted encode ganglion heritable hoxb idea inbred krt1 lod mapped neuregulin nnc1 opposed qtl qtls retina retinal striking subsidiary surprisingly thyroxine trait vertebrate
Tagcloud (Intersection) ?