NCOA6 and RORC

Number of citations of the paper that reports this interaction (PMID 15604093)
36

Data Source:
HPRD (two hybrid)

		NCOA6	RORC
Gene Name		nuclear receptor coactivator 6	RAR-related orphan receptor C
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Factor Complex Histone Methyltransferase Complex Intracellular Membrane-bounded Organelle	Nucleus Nucleoplasm
	Molecular Function	Chromatin Binding Transcription Coactivator Activity Protein Binding Enzyme Binding Estrogen Receptor Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Retinoid X Receptor Binding Thyroid Hormone Receptor Binding	Transcription Coactivator Binding DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Steroid Hormone Receptor Activity Ligand-activated Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Protein Binding Oxysterol Binding Zinc Ion Binding Sequence-specific DNA Binding Direct Ligand Regulated Sequence-specific DNA Binding Transcription Factor Activity
	Biological Process	DNA Replication DNA Repair DNA Recombination DNA-templated Transcription, Initiation Transcription Initiation From RNA Polymerase II Promoter Cellular Response To DNA Damage Stimulus Brain Development Heart Development Response To Hormone Myeloid Cell Differentiation Intracellular Estrogen Receptor Signaling Pathway Glucocorticoid Receptor Signaling Pathway Cellular Lipid Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Labyrinthine Layer Blood Vessel Development	Transcription Initiation From RNA Polymerase II Promoter Protein Phosphorylation Xenobiotic Metabolic Process Gene Expression Regulation Of Glucose Metabolic Process Regulation Of Steroid Metabolic Process Intracellular Receptor Signaling Pathway Circadian Regulation Of Gene Expression T Cell Differentiation In Thymus Cellular Response To Sterol T-helper Cell Differentiation Positive Regulation Of Circadian Rhythm Steroid Hormone Mediated Signaling Pathway Regulation Of Gamma-delta T Cell Differentiation Regulation Of Fat Cell Differentiation Positive Regulation Of Transcription, DNA-templated Lymph Node Development Peyer's Patch Development Adipose Tissue Development Regulation Of Transcription Involved In Cell Fate Commitment Negative Regulation Of Thymocyte Apoptotic Process T-helper 17 Cell Differentiation
Pathways		PPARA activates gene expression Organelle biogenesis and maintenance Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins REV-ERBA represses gene expression RORA activates circadian gene expression Mitochondrial biogenesis Regulation of cholesterol biosynthesis by SREBP (SREBF) Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Activation of gene expression by SREBF (SREBP) YAP1- and WWTR1 (TAZ)-stimulated gene expression Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Transcriptional activation of mitochondrial biogenesis BMAL1:CLOCK,NPAS2 activates circadian gene expression Orphan transporters	Generic Transcription Pathway Nuclear Receptor transcription pathway
Drugs
Diseases
GWAS			Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		64 interactors: AR ASCC1 ATF2 BCL3 CD40 CEBPA CREBBP E2F1 EP300 ESR1 ESR2 FHOD1 FOS GHR GRIP1 GTF2A1 HIST2H3C HNF4A HSF1 JUN LAMTOR5 MED1 MED23 NCOA1 NCOR2 NFKB1 NR1H2 NR1H3 NR1H4 NR1I2 NR3C1 NUMA1 PARP1 PPARG PPARGC1A PRKDC PRMT2 RANBP9 RARA RB1 RBM14 RBM39 RELA RORB RORC RXRA RXRG SMAD2 SMAD3 SRC SRF TBP TGS1 THRA THRB TOP1 TRA TRB TXNRD2 UBC VDR XRCC5 XRCC6 ZNF335	5 interactors: CHD4 EIF3I EIF4EBP1 EVI2A NCOA6
Entrez ID		23054	6097
HPRD ID		05599	04250
Ensembl ID		ENSG00000198646	ENSG00000143365
Uniprot IDs		F6M2K2 Q14686	B6ZGS6 F1D8P6 H7BYJ4 P51449 Q6I9R9
PDB IDs			3B0W 3KYT 3L0J 3L0L
Enriched GO Terms of Interacting Partners?		Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated DNA-templated Transcription, Initiation Positive Regulation Of Macromolecule Biosynthetic Process Intracellular Receptor Signaling Pathway Positive Regulation Of Gene Expression Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Response To Lipid Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process RNA Metabolic Process Gene Expression Steroid Hormone Mediated Signaling Pathway Response To Steroid Hormone Cellular Response To Lipid Response To Hormone Cellular Macromolecule Biosynthetic Process Hormone-mediated Signaling Pathway Response To Organic Cyclic Compound Macromolecule Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Cellular Response To Organic Substance Cellular Response To Hormone Stimulus Cellular Response To Organic Cyclic Compound Cellular Response To Steroid Hormone Stimulus Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Heterocycle Metabolic Process Negative Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Response To Organic Substance Regulation Of Metabolic Process Nitrogen Compound Metabolic Process Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter	Regulation Of Translational Initiation Translational Initiation IRES-dependent Translational Initiation Cap-independent Translational Initiation Regulation Of Translation Glucocorticoid Receptor Signaling Pathway Gene Expression Cytoplasmic Translational Initiation Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Cytoplasmic Translation Posttranscriptional Regulation Of Gene Expression Intracellular Estrogen Receptor Signaling Pathway Negative Regulation Of Translational Initiation Formation Of Translation Preinitiation Complex TOR Signaling Labyrinthine Layer Blood Vessel Development Response To Ischemia Biosynthetic Process Translation Regulation Of Gene Expression
Tagcloud ?		candidate cardiomyopathy coactivator coding contractile dcm defects delta depletion dilated dilation dysfunction embryonic germline heart humans idcm idiopathic left lethality malfunction nonsynonymous peroxisome ppardelta progressive proliferator sequencing unclear ventricular	1q21 3f2 approved chromosomal consists corresponds exon exons finger gamma genomic hgmw introns kb mapped mror orphan p1 polyadenylation rzr spanning splice steroid subfamily superfamily symbol syntenic tr3
Tagcloud (Difference) ?		candidate cardiomyopathy coactivator coding contractile dcm defects delta depletion dilated dilation dysfunction embryonic germline heart humans idcm idiopathic left lethality malfunction nonsynonymous peroxisome ppardelta progressive proliferator sequencing unclear ventricular	1q21 3f2 approved chromosomal consists corresponds exon exons finger gamma genomic hgmw introns kb mapped mror orphan p1 polyadenylation rzr spanning splice steroid subfamily superfamily symbol syntenic tr3
Tagcloud (Intersection) ?