ANXA5 and SUPT4H1

Number of citations: 0 (PubMedID 16169070)
Data Source: HPRD (two hybrid)

		ANXA5	SUPT4H1
Name		annexin A5	SPT4 homolog, DSIF elongation factor subunit
Structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Cytosol Focal Adhesion External Side Of Plasma Membrane Vesicle Membrane Membrane Extracellular Matrix Sarcolemma Extracellular Exosome Endothelial Microparticle	Nucleus Nucleoplasm DSIF Complex
	Molecular Function	Phosphatidylserine Binding Phospholipase Inhibitor Activity Calcium Ion Binding Protein Binding Phospholipid Binding Calcium-dependent Phospholipid Binding	RNA Polymerase II Complex Binding Protein Binding Zinc Ion Binding Metal Ion Binding Protein Heterodimerization Activity
	Biological Process	Signal Transduction Blood Coagulation Hemostasis Negative Regulation Of Apoptotic Process Negative Regulation Of Coagulation	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Transcription Elongation By RNA Polymerase II Negative Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of DNA-templated Transcription, Elongation Regulation Of Transcription Elongation By RNA Polymerase II Negative Regulation Of Transcription Elongation By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Transcription Elongation-coupled Chromatin Remodeling
Pathways		Platelet degranulation	Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Abortive elongation of HIV-1 transcript in the absence of Tat Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes RNA polymerase II transcribes snRNA genes RNA Polymerase II Transcription Elongation
Drugs		Fluocinolone acetonide L-Alpha-Glycerophosphorylserine L-thioproline K201 free base sn-glycero-3-phosphoethanolamine 1,4-Dideoxy-O2-Sulfo-Glucuronic Acid N,O6-Disulfo-Glucosamine 1,4-Dideoxy-5-Dehydro-O2-Sulfo-Glucuronic Acid Copper	None
GWAS		A body shape index ( 34021172 ) Age at smoking initiation in chronic obstructive pulmonary disease ( 21685187 ) Age-related cognitive decline (language) (slope of z-scores) ( 30954325 ) Resting-state electroencephalogram vigilance ( 29703947 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )	Eosinophil percentage of white cells ( 32888494 ) Mental health study participation (completed survey) ( 31263887 ) Refractive error ( 32231278 )
Novel Interactors		2 novel interactors: BBS7 MAD1L1	None recorded
Interacting Genes		20 interacting genes: ACTG1 APP CEBPA COL10A1 COL2A1 EED EIF4G1 FDFT1 GSC2 IFNGR2 ITGB5 KDR LAMC3 LINC01554 PPP2R1B SUPT4H1 TERF1 TERF2 TERF2IP TINF2	12 interacting genes: ANXA5 APP EWSR1 HTATSF1 LRIF1 LRRK2 MFHAS1 NSG2 PDLIM1 SMARCA2 SUPT5H XRCC5
Entrez ID		308	6827
HPRD ID		00568	16026
Ensembl ID		ENSG00000164111	ENSG00000213246
Uniprot IDs		P08758 V9HWE0	P63272
PDB IDs		1ANW 1ANX 1AVH 1AVR 1HAK 1HVD 1HVE 1HVF 1HVG 1SAV 2XO2 2XO3 6K22 6K25 8GYC 8H0J 8H9Z	3H7H 5OIK 6GMH 6GML 6TED 7OKY 7UND 7YCX 8A3Y 8P4C 8P4D 8P4F 8UHA 8UHD 8W8E 8W8F 9EGX 9EGY 9EGZ 9EH0 9EH1 9EH2 9J0N 9J0O 9J0P
GO Terms Enriched among Interactors		Shelterin Complex Nuclear Telomere Cap Complex Telomere Capping Telomeric DNA Binding Negative Regulation Of Chromosome Organization Negative Regulation Of Telomere Maintenance Positive Regulation Of Chromosome Organization G-rich Strand Telomeric DNA Binding Protein Localization To Chromosome, Telomeric Region Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Negative Regulation Of DNA Recombination At Telomere Positive Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Via Telomerase RNA-templated DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Telomere Maintenance Negative Regulation Of DNA Biosynthetic Process Regulation Of Telomere Maintenance Regulation Of Chromosome Organization Telomere Organization Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of DNA Metabolic Process Positive Regulation Of Organelle Organization Telomerase Activity Protection From Non-homologous End Joining At Telomere Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Cellular Component Organization Telomeric D-loop Disassembly Double-stranded Telomeric DNA Binding Chromosome Organization Chromosome, Telomeric Region Telomeric Loop Disassembly Telomere Maintenance In Response To DNA Damage Chromosome Regulation Of DNA Biosynthetic Process DNA Biosynthetic Process Multicellular Organismal-level Homeostasis Regulation Of Cell Junction Assembly Telomere Maintenance Via Telomerase Protein Localization To Chromosome Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA Metabolic Process Epithelial Cell Maturation Regulation Of Organelle Organization Regulation Of Presynapse Organization Regulation Of Presynapse Assembly Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Mitotic Cell Cycle Negative Regulation Of Macromolecule Metabolic Process	Golgi-associated Vesicle Cellular Response To Catecholamine Stimulus Cellular Response To Manganese Ion Response To Catecholamine Response To Manganese Ion Positive Regulation Of Defense Response ATP-dependent Activity, Acting On DNA Negative Regulation Of Protein Localization To Nucleus Positive Regulation Of Immune System Process Amyloid-beta Complex Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Growth Cone Lamellipodium Regulation Of Toll-like Receptor Signaling Pathway Regulation Of Response To Calcium Ion Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Lysosome Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of CAMP/PKA Signal Transduction Modulation Of Excitatory Postsynaptic Potential Regulation Of Macrophage Activation Cellular Response To Curcumin Caveola Neck GTP-dependent Protein Kinase Activity Wnt Signalosome Assembly Regulation Of Cell Activation Epigenetic Regulation Of Gene Expression Endothelial Microparticle Acetylcholine Receptor Activator Activity PTB Domain Binding Regulation Of Defense Response Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Protein-containing Complex Organization Chromatin Organization Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Negative Regulation Of Macromolecule Biosynthetic Process Growth Cone Filopodium Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Calcium-mediated Signaling Protein-containing Complex Assembly Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization DSIF Complex Small-subunit Processome Assembly DNA End Binding