ANXA5

Name	annexin A5
Structure
Novel Interactors	2 novel interactors: BBS7 MAD1L1
Interactors	20 interactors: ACTG1 APP CEBPA COL10A1 COL2A1 EED EIF4G1 FDFT1 GSC2 IFNGR2 ITGB5 KDR LAMC3 LINC01554 PPP2R1B SUPT4H1 TERF1 TERF2 TERF2IP TINF2
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Cytosol Focal Adhesion External Side Of Plasma Membrane Vesicle Membrane Membrane Extracellular Matrix Sarcolemma Extracellular Exosome Endothelial Microparticle
	Molecular Function	Phosphatidylserine Binding Phospholipase Inhibitor Activity Calcium Ion Binding Protein Binding Phospholipid Binding Calcium-dependent Phospholipid Binding
	Biological Process	Signal Transduction Blood Coagulation Hemostasis Negative Regulation Of Apoptotic Process Negative Regulation Of Coagulation
Pathways	Platelet degranulation
Drugs	Fluocinolone acetonide L-Alpha-Glycerophosphorylserine L-thioproline K201 free base sn-glycero-3-phosphoethanolamine 1,4-Dideoxy-O2-Sulfo-Glucuronic Acid N,O6-Disulfo-Glucosamine 1,4-Dideoxy-5-Dehydro-O2-Sulfo-Glucuronic Acid Copper
GWAS	A body shape index ( 34021172 ) Age at smoking initiation in chronic obstructive pulmonary disease ( 21685187 ) Age-related cognitive decline (language) (slope of z-scores) ( 30954325 ) Resting-state electroencephalogram vigilance ( 29703947 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )
Entrez ID	308
HPRD ID	00568
Ensembl ID	ENSG00000164111
Uniprot IDs	P08758 V9HWE0
PDB IDs	1ANW 1ANX 1AVH 1AVR 1HAK 1HVD 1HVE 1HVF 1HVG 1SAV 2XO2 2XO3 6K22 6K25 8GYC 8H0J 8H9Z
GO Terms Enriched among Interactors ?	Shelterin Complex Nuclear Telomere Cap Complex Telomere Capping Telomeric DNA Binding Negative Regulation Of Chromosome Organization Negative Regulation Of Telomere Maintenance Positive Regulation Of Chromosome Organization G-rich Strand Telomeric DNA Binding Protein Localization To Chromosome, Telomeric Region Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Negative Regulation Of DNA Recombination At Telomere Positive Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Via Telomerase RNA-templated DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Telomere Maintenance Negative Regulation Of DNA Biosynthetic Process Regulation Of Telomere Maintenance Regulation Of Chromosome Organization Telomere Organization Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of DNA Metabolic Process Positive Regulation Of Organelle Organization Telomerase Activity Protection From Non-homologous End Joining At Telomere Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Cellular Component Organization Telomeric D-loop Disassembly Double-stranded Telomeric DNA Binding Chromosome Organization Chromosome, Telomeric Region Telomeric Loop Disassembly Telomere Maintenance In Response To DNA Damage Chromosome Regulation Of DNA Biosynthetic Process DNA Biosynthetic Process Multicellular Organismal-level Homeostasis Regulation Of Cell Junction Assembly Telomere Maintenance Via Telomerase Protein Localization To Chromosome Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA Metabolic Process Epithelial Cell Maturation Regulation Of Organelle Organization Regulation Of Presynapse Organization Regulation Of Presynapse Assembly Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Mitotic Cell Cycle Negative Regulation Of Macromolecule Metabolic Process