ANXA5 and KDR

Number of citations of the paper that reports this interaction (PubMedID 10329451)
0

Data Source:
HPRD (two hybrid)

		ANXA5	KDR
Description		annexin A5	kinase insert domain receptor
Image
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Cytosol Focal Adhesion External Side Of Plasma Membrane Vesicle Membrane Membrane Extracellular Matrix Sarcolemma Extracellular Exosome Endothelial Microparticle	Extracellular Region Nucleus Cytoplasm Endosome Early Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Cell Junction Cytoplasmic Vesicle Receptor Complex Membrane Raft Anchoring Junction Cell Periphery Sorting Endosome
	Molecular Function	Phosphatidylserine Binding Phospholipase Inhibitor Activity Calcium Ion Binding Protein Binding Phospholipid Binding Calcium-dependent Phospholipid Binding	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Vascular Endothelial Growth Factor Receptor Activity Integrin Binding Protein Binding ATP Binding Coreceptor Activity Kinase Activity Transferase Activity Growth Factor Binding Vascular Endothelial Growth Factor Binding Identical Protein Binding Cadherin Binding Hsp90 Protein Binding
	Biological Process	Signal Transduction Blood Coagulation Hemostasis Negative Regulation Of Apoptotic Process Negative Regulation Of Coagulation	Angiogenesis Ovarian Follicle Development Branching Involved In Blood Vessel Morphogenesis Vasculogenesis Positive Regulation Of Protein Phosphorylation Positive Regulation Of Endothelial Cell Proliferation Vasculature Development Lymph Vessel Development Positive Regulation Of Mesenchymal Cell Proliferation Epithelial Cell Maturation Endocardium Development Endothelium Development Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cell Population Proliferation Regulation Of Cell Shape Mesenchymal Cell Proliferation Positive Regulation Of Endothelial Cell Migration Negative Regulation Of Gene Expression Positive Regulation Of Macroautophagy Cell Migration Peptidyl-tyrosine Phosphorylation Hemopoiesis Cell Differentiation Lung Development Positive Regulation Of Cell Migration Positive Regulation Of BMP Signaling Pathway Embryonic Hemopoiesis Cellular Response To Vascular Endothelial Growth Factor Stimulus Vascular Endothelial Growth Factor Receptor-2 Signaling Pathway Vascular Endothelial Growth Factor Signaling Pathway Negative Regulation Of Apoptotic Process Surfactant Homeostasis Regulation Of MAPK Cascade Positive Regulation Of MAPK Cascade Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration Cell Fate Commitment Endothelial Cell Differentiation Positive Regulation Of Angiogenesis Protein Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Lung Alveolus Development Post-embryonic Camera-type Eye Morphogenesis Branching Morphogenesis Of An Epithelial Tube Epithelial Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Positive Chemotaxis Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Mitochondrial Depolarization Calcium Ion Homeostasis Epithelial Tube Morphogenesis Blood Vessel Endothelial Cell Differentiation Vascular Wound Healing Positive Regulation Of ERK1 And ERK2 Cascade Semaphorin-plexin Signaling Pathway Stem Cell Proliferation Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Mitochondrial Fission Positive Regulation Of Nitric Oxide-cGMP Mediated Signal Transduction Regulation Of Hematopoietic Progenitor Cell Differentiation Regulation Of Bone Development Cellular Response To Hydrogen Sulfide Negative Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Stem Cell Proliferation Positive Regulation Of Endothelial Cell Chemotaxis Positive Regulation Of Vasculogenesis
Pathways		Platelet degranulation	Neurophilin interactions with VEGF and VEGFR VEGF binds to VEGFR leading to receptor dimerization Integrin cell surface interactions VEGFA-VEGFR2 Pathway VEGFA-VEGFR2 Pathway VEGFR2 mediated cell proliferation Signaling by membrane-tethered fusions of PDGFRA or PDGFRB High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Drugs		Fluocinolone acetonide L-Alpha-Glycerophosphorylserine L-thioproline K201 free base sn-glycero-3-phosphoethanolamine 1,4-Dideoxy-O2-Sulfo-Glucuronic Acid N,O6-Disulfo-Glucosamine 1,4-Dideoxy-5-Dehydro-O2-Sulfo-Glucuronic Acid Copper	Sorafenib Sunitinib 1-{4-[4-Amino-6-(4-methoxyphenyl)furo[2,3-d]pyrimidin-5-yl]phenyl}-3-[2-fluoro-5-(trifluoromethyl)phenyl]urea Cediranib Vatalanib XL999 TG-100801 XL820 CYC116 Ramucirumab Pegdinetanib RAF-265 Linifanib IMC-1C11 Semaxanib Pazopanib Midostaurin Axitinib 4-[[2-[[4-chloro-3-(trifluoromethyl)phenyl]amino]-3H-benzimidazol-5-yl]oxy]-N-methyl-pyridine-2-carboxamide N-(4-phenoxyphenyl)-2-[(pyridin-4-ylmethyl)amino]nicotinamide N-cyclopropyl-6-[(6,7-dimethoxyquinolin-4-yl)oxy]naphthalene-1-carboxamide 6-chloro-N-pyrimidin-5-yl-3-{[3-(trifluoromethyl)phenyl]amino}-1,2-benzisoxazole-7-carboxamide N-(CYCLOPROPYLMETHYL)-4-(METHYLOXY)-3-({5-[3-(3-PYRIDINYL)PHENYL]-1,3-OXAZOL-2-YL}AMINO)BENZENESULFONAMIDE N-[5-(ETHYLSULFONYL)-2-METHOXYPHENYL]-5-[3-(2-PYRIDINYL)PHENYL]-1,3-OXAZOL-2-AMINE 3-(2-aminoquinazolin-6-yl)-1-(3,3-dimethylindolin-6-yl)-4-methylpyridin-2(1H)-one 3-(2-aminoquinazolin-6-yl)-4-methyl-1-[3-(trifluoromethyl)phenyl]pyridin-2(1H)-one N'-(6-aminopyridin-3-yl)-N-(2-cyclopentylethyl)-4-methyl-benzene-1,3-dicarboxamide N~4~-methyl-N~4~-(3-methyl-1H-indazol-6-yl)-N~2~-(3,4,5-trimethoxyphenyl)pyrimidine-2,4-diamine N~4~-(3-methyl-1H-indazol-6-yl)-N~2~-(3,4,5-trimethoxyphenyl)pyrimidine-2,4-diamine Cabozantinib Regorafenib Ponatinib Lenvatinib Nintedanib Tivozanib Fostamatinib Erdafitinib Foretinib Ripretinib Pralsetinib Olinvacimab
Diseases
GWAS		A body shape index ( 34021172) Age at smoking initiation in chronic obstructive pulmonary disease ( 21685187) Age-related cognitive decline (language) (slope of z-scores) ( 30954325) Resting-state electroencephalogram vigilance ( 29703947) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Blood protein levels ( 30072576) Endometriosis ( 28537267) FEV1 ( 30804560) Heel bone mineral density ( 30598549) Lung function (FVC) ( 30804560) Mosquito bite size ( 28199695) Peak expiratory flow ( 30804560) Serum VEGFR2 concentration ( 25411163) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		20 interacting genes: ACTG1 APP CEBPA COL10A1 COL2A1 EED EIF4G1 FDFT1 GSC2 IFNGR2 ITGB5 KDR LAMC3 LINC01554 PPP2R1B SUPT4H1 TERF1 TERF2 TERF2IP TINF2	63 interacting genes: ACP1 AIMP2 ANXA5 ATR BMX BTRC CAV1 CBL CCDC88A CDH5 COL18A1 CRK CSF2RB CSNK1D CTNNB1 DNM2 DUSP19 FBXO25 FBXW11 FLT1 FLT4 FRS2 FYN GABARAP GNA11 GNAQ GRB10 GRB2 HSP90AA1 ILKAP IQGAP1 ITGB3 KPNA4 MAPK1 NCK1 NRP1 P2RY2 PDCL3 PLCG1 PLCG2 PPM1A PPM1B PTPN11 PTPN12 PTPN6 PTPRR RASA1 SERPINF1 SH2D2A SHB SHC1 SHC2 SNCA SRC STAT1 STYX SYNGAP1 TIMP3 USP7 VEGFA VEGFC VEGFD YES1
Entrez ID		308	3791
HPRD ID		00568	01867
Ensembl ID		ENSG00000164111	ENSG00000128052
Uniprot IDs		P08758 V9HWE0	P35968
PDB IDs		1ANW 1ANX 1AVH 1AVR 1HAK 1HVD 1HVE 1HVF 1HVG 1SAV 2XO2 2XO3 6K22 6K25 8GYC 8H0J 8H9Z	1VR2 1Y6A 1Y6B 1YWN 2M59 2MET 2MEU 2OH4 2P2H 2P2I 2QU5 2QU6 2RL5 2X1W 2X1X 2XIR 3B8Q 3B8R 3BE2 3C7Q 3CJF 3CJG 3CP9 3CPB 3CPC 3DTW 3EFL 3EWH 3KVQ 3S35 3S36 3S37 3U6J 3V2A 3V6B 3VHE 3VHK 3VID 3VNT 3VO3 3WZD 3WZE 4AG8 4AGC 4AGD 4ASD 4ASE 5EW3 5OYJ 6GQO 6GQP 6GQQ 6XVJ 6XVK
Enriched GO Terms of Interacting Partners?		Shelterin Complex Nuclear Telomere Cap Complex Telomere Capping Telomeric DNA Binding Negative Regulation Of Chromosome Organization Negative Regulation Of Telomere Maintenance Positive Regulation Of Chromosome Organization G-rich Strand Telomeric DNA Binding Protein Localization To Chromosome, Telomeric Region Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Negative Regulation Of DNA Recombination At Telomere Positive Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Via Telomerase RNA-templated DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Telomere Maintenance Negative Regulation Of DNA Biosynthetic Process Regulation Of Telomere Maintenance Regulation Of Chromosome Organization Telomere Organization Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of DNA Metabolic Process Positive Regulation Of Organelle Organization Telomerase Activity Protection From Non-homologous End Joining At Telomere Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Cellular Component Organization Telomeric D-loop Disassembly Double-stranded Telomeric DNA Binding Chromosome Organization Chromosome, Telomeric Region Telomeric Loop Disassembly Telomere Maintenance In Response To DNA Damage Chromosome Regulation Of DNA Biosynthetic Process DNA Biosynthetic Process Multicellular Organismal-level Homeostasis Regulation Of Cell Junction Assembly Telomere Maintenance Via Telomerase Protein Localization To Chromosome Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA Metabolic Process Epithelial Cell Maturation Regulation Of Organelle Organization Regulation Of Presynapse Organization Regulation Of Presynapse Assembly Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Mitotic Cell Cycle Negative Regulation Of Macromolecule Metabolic Process	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Response To Growth Factor Cellular Response To Growth Factor Stimulus Phosphotyrosine Residue Binding Regulation Of Intracellular Signal Transduction Signal Transduction Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of MAPK Cascade Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Anatomical Structure Formation Involved In Morphogenesis Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Anatomical Structure Morphogenesis Regulation Of Multicellular Organismal Process Positive Regulation Of Multicellular Organismal Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Ephrin Receptor Binding Immune Response-activating Cell Surface Receptor Signaling Pathway Angiogenesis ERBB Signaling Pathway Cell Migration Positive Regulation Of MAPK Cascade Regulation Of Angiogenesis Cytoplasm Regulation Of Vasculature Development Vascular Endothelial Growth Factor Signaling Pathway Vascular Endothelial Growth Factor Receptor 2 Binding Epidermal Growth Factor Receptor Signaling Pathway Cellular Response To Platelet-derived Growth Factor Stimulus Regulation Of Programmed Cell Death Response To Platelet-derived Growth Factor T Cell Costimulation Antigen Receptor-mediated Signaling Pathway Regulation Of Cell Population Proliferation Cell Motility SH3 Domain Binding Developmental Process Immune Response-regulating Signaling Pathway Activation Of Immune Response Cytosol Ephrin Receptor Signaling Pathway Focal Adhesion Immune Response-activating Signaling Pathway Protein Dephosphorylation
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