ANXA5 and FDFT1

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ANXA5	FDFT1
Gene Name		annexin A5	farnesyl-diphosphate farnesyltransferase 1
Image
Gene Ontology Annotations	Cellular Component	Intracellular Cytoplasm Focal Adhesion External Side Of Plasma Membrane Membrane Extracellular Vesicular Exosome Endothelial Microparticle	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane
	Molecular Function	Phospholipase Inhibitor Activity Calcium Ion Binding Phospholipid Binding Calcium-dependent Phospholipid Binding	Farnesyl-diphosphate Farnesyltransferase Activity Oxidoreductase Activity Squalene Synthase Activity
	Biological Process	Signal Transduction Blood Coagulation Response To Organic Substance Negative Regulation Of Apoptotic Process Negative Regulation Of Catalytic Activity Negative Regulation Of Coagulation	Steroid Biosynthetic Process Cholesterol Biosynthetic Process Isoprenoid Biosynthetic Process Cellular Lipid Metabolic Process Small Molecule Metabolic Process Farnesyl Diphosphate Metabolic Process Oxidation-reduction Process
Pathways			Regulation of cholesterol biosynthesis by SREBP (SREBF) PPARA activates gene expression Cholesterol biosynthesis Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Activation of gene expression by SREBF (SREBP) Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Drugs
Diseases
GWAS		Chronic obstructive pulmonary disease ( 21685187)	Non-alcoholic fatty liver disease histology (lobular) ( 20708005) Non-alcoholic fatty liver disease histology (other) ( 20708005)
Protein-Protein Interactions		17 interactors: ACTG1 APP COL10A1 COL2A1 EED EIF4G1 FDFT1 IFNGR2 ITGB5 KDR LAMC3 PPP2R1B SUPT4H1 TERF1 TERF2 TERF2IP TINF2	6 interactors: ANXA5 ARL6IP1 FAM101A RUVBL2 SHPRH TMEM43
Entrez ID		308	2222
HPRD ID		00568	01694
Ensembl ID		ENSG00000164111	ENSG00000079459
Uniprot IDs		P08758	B4DT56 B4DWP0 B7Z1J3 P37268 Q6IAX1
PDB IDs		1ANW 1ANX 1AVH 1AVR 1HAK 1HVD 1HVE 1HVF 1HVG 1SAV 2XO2 2XO3	1EZF 3ASX 3LEE 3Q2Z 3Q30 3V66 3VJ8 3VJ9 3VJA 3VJB 3VJC
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Protein Localization To Chromosome, Telomeric Region Telomere Maintenance Via Telomere Lengthening Telomere Maintenance Via Telomerase Extracellular Matrix Organization Extracellular Structure Organization Telomere Maintenance Regulation Of Chromosome Organization Negative Regulation Of Chromosome Organization RNA-dependent DNA Replication Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Negative Regulation Of DNA Metabolic Process Protein Localization To Chromosome Telomeric Loop Formation Age-dependent Telomere Shortening Homeostatic Process Telomere Maintenance Via Telomere Shortening Protection From Non-homologous End Joining At Telomere Telomere Capping Negative Regulation Of DNA Replication Negative Regulation Of Telomere Maintenance Via Telomerase Replicative Cell Aging Regulation Of Nuclear Cell Cycle DNA Replication Positive Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Chromosome Organization Regulation Of DNA Replication Anatomical Structure Morphogenesis Positive Regulation Of Organelle Organization Tissue Homeostasis Regulation Of Organelle Organization Negative Regulation Of Cellular Metabolic Process Endochondral Ossification Multicellular Organismal Homeostasis Organelle Organization Chromatin Modification Negative Regulation Of Protein ADP-ribosylation Negative Regulation Of DNA Recombination At Telomere DNA Replication Collagen Catabolic Process Cell Development Cell Aging Chromatin Organization Cell Morphogenesis Involved In Differentiation Collagen Metabolic Process Regulation Of Protein ADP-ribosylation Synaptic Growth At Neuromuscular Junction Developmental Process MRNA 3'-end Processing	Negative Regulation Of Estrogen Receptor Binding Transcriptional Activation By Promoter-enhancer Looping Nuclear Membrane Organization Establishment Of Protein Localization To Chromatin DNA Conformation Change Negative Regulation Of Receptor Binding Protein Localization To Chromatin Histone H2A Acetylation
Tagcloud ?		a2 alkaline altered annexin annexins anxa2 bglap col1a1 else fibrinolysis generate ibsp knock knockdown mineralizing osteoblasts osteogenesis osteogenic osteoprogenitor programming psiren rafts responsiveness runx2 shrna si stat6 vesicles	abca1 biosynthesis brains cassette cholesterol debated extensively fdps genetically idi1 ldr lipids microarray mvd mvk notably nsdhl oligomeric oligomers plaques principal qpcr sc4mol steroid steroids toxic unexpected unresolved verified
Tagcloud (Difference) ?		a2 alkaline altered annexin annexins anxa2 bglap col1a1 else fibrinolysis generate ibsp knock knockdown mineralizing osteoblasts osteogenesis osteogenic osteoprogenitor programming psiren rafts responsiveness runx2 shrna si stat6 vesicles	abca1 biosynthesis brains cassette cholesterol debated extensively fdps genetically idi1 ldr lipids microarray mvd mvk notably nsdhl oligomeric oligomers plaques principal qpcr sc4mol steroid steroids toxic unexpected unresolved verified
Tagcloud (Intersection) ?