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ANXA5 and PPP2R1B
Number of citations of the paper that reports this interaction (PMID
17540176
)
59
Data Source:
HPRD
(in vivo)
ANXA5
PPP2R1B
Gene Name
annexin A5
protein phosphatase 2, regulatory subunit A, beta
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Intracellular
Cytoplasm
Focal Adhesion
External Side Of Plasma Membrane
Membrane
Extracellular Vesicular Exosome
Endothelial Microparticle
Membrane Raft
Extracellular Vesicular Exosome
Molecular Function
Phospholipase Inhibitor Activity
Calcium Ion Binding
Phospholipid Binding
Calcium-dependent Phospholipid Binding
Protein Binding
Biological Process
Signal Transduction
Blood Coagulation
Response To Organic Substance
Negative Regulation Of Apoptotic Process
Negative Regulation Of Catalytic Activity
Negative Regulation Of Coagulation
Apoptotic Process Involved In Morphogenesis
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways
Signaling by GPCR
Integration of energy metabolism
Mitotic Prophase
misspliced GSK3beta mutants stabilize beta-catenin
T41 mutants of beta-catenin aren't phosphorylated
ERKs are inactivated
truncated APC mutants destabilize the destruction complex
TCF7L2 mutants don't bind CTBP
Glycolysis
Signaling by Wnt
Glucose metabolism
Toll Like Receptor TLR1:TLR2 Cascade
Degradation of beta-catenin by the destruction complex
Toll Like Receptor 5 (TLR5) Cascade
RNF mutants show enhanced WNT signaling and proliferation
Myoclonic epilepsy of Lafora
S33 mutants of beta-catenin aren't phosphorylated
AXIN mutants destabilize the destruction complex, activating WNT signaling
G1/S Transition
Glycogen storage diseases
MyD88 dependent cascade initiated on endosome
Toll Like Receptor 9 (TLR9) Cascade
Beta-catenin phosphorylation cascade
Mitotic G1-G1/S phases
ERK/MAPK targets
truncations of AMER1 destabilize the destruction complex
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
TRIF-mediated TLR3/TLR4 signaling
Opioid Signalling
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
AXIN missense mutants destabilize the destruction complex
S45 mutants of beta-catenin aren't phosphorylated
Toll Like Receptor 2 (TLR2) Cascade
Platelet homeostasis
deletions in the AMER1 gene destabilize the destruction complex
Platelet sensitization by LDL
AMER1 mutants destabilize the destruction complex
Resolution of Sister Chromatid Cohesion
Toll Like Receptor 3 (TLR3) Cascade
Toll Like Receptor 4 (TLR4) Cascade
Metabolism of carbohydrates
Mitotic G2-G2/M phases
Mitotic Metaphase and Anaphase
Adaptive Immune System
PP2A-mediated dephosphorylation of key metabolic factors
MASTL Facilitates Mitotic Progression
Mitotic Prometaphase
Costimulation by the CD28 family
Separation of Sister Chromatids
APC truncation mutants have impaired AXIN binding
Toll Like Receptor 7/8 (TLR7/8) Cascade
G2/M Transition
Mitotic Anaphase
Toll Like Receptor TLR6:TLR2 Cascade
M Phase
APC truncation mutants are not K63 polyubiquitinated
disassembly of the destruction complex and recruitment of AXIN to the membrane
Activated TLR4 signalling
S37 mutants of beta-catenin aren't phosphorylated
MyD88 cascade initiated on plasma membrane
Cyclin A/B1 associated events during G2/M transition
XAV939 inhibits tankyrase, stabilizing AXIN
DARPP-32 events
MyD88:Mal cascade initiated on plasma membrane
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
Innate Immune System
E2F mediated regulation of DNA replication
ERKs are inactivated
Signalling by NGF
MAP kinase activation in TLR cascade
CTLA4 inhibitory signaling
G1 Phase
NGF signalling via TRKA from the plasma membrane
MyD88-independent cascade
Cell Cycle, Mitotic
Toll-Like Receptors Cascades
Cyclin D associated events in G1
Toll Like Receptor 10 (TLR10) Cascade
TCF dependent signaling in response to WNT
ERK/MAPK targets
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
MAPK targets/ Nuclear events mediated by MAP kinases
Signaling by WNT in cancer
Inhibition of replication initiation of damaged DNA by RB1/E2F1
Nuclear Events (kinase and transcription factor activation)
Drugs
Diseases
GWAS
Chronic obstructive pulmonary disease (
21685187
)
Protein-Protein Interactions
17 interactors:
ACTG1
APP
COL10A1
COL2A1
EED
EIF4G1
FDFT1
IFNGR2
ITGB5
KDR
LAMC3
PPP2R1B
SUPT4H1
TERF1
TERF2
TERF2IP
TINF2
31 interactors:
AKAP9
ANXA5
BSG
CDK1
CDK4
CFTR
EEF2
FGFR1OP
HDAC1
HSPD1
JAK2
MCM3
PARK7
PPP2CA
PPP2R2A
PPP2R3B
PPP2R5C
PPP2R5D
PPP2R5E
PRDX1
PRDX2
RAB11A
RAB18
RAB7A
RALA
RELA
SET
SGOL1
SGOL2
STRN
STRN3
Entrez ID
308
5519
HPRD ID
00568
04384
Ensembl ID
ENSG00000164111
ENSG00000137713
Uniprot IDs
P08758
P30154
PDB IDs
1ANW
1ANX
1AVH
1AVR
1HAK
1HVD
1HVE
1HVF
1HVG
1SAV
2XO2
2XO3
Enriched GO Terms of Interacting Partners
?
Negative Regulation Of Telomere Maintenance
Regulation Of Telomere Maintenance
Protein Localization To Chromosome, Telomeric Region
Telomere Maintenance Via Telomere Lengthening
Telomere Maintenance Via Telomerase
Extracellular Matrix Organization
Extracellular Structure Organization
Telomere Maintenance
Regulation Of Chromosome Organization
Negative Regulation Of Chromosome Organization
RNA-dependent DNA Replication
Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication
Negative Regulation Of DNA Metabolic Process
Protein Localization To Chromosome
Telomeric Loop Formation
Age-dependent Telomere Shortening
Homeostatic Process
Telomere Maintenance Via Telomere Shortening
Protection From Non-homologous End Joining At Telomere
Telomere Capping
Negative Regulation Of DNA Replication
Negative Regulation Of Telomere Maintenance Via Telomerase
Replicative Cell Aging
Regulation Of Nuclear Cell Cycle DNA Replication
Positive Regulation Of Telomere Maintenance
Regulation Of Telomere Maintenance Via Telomerase
Chromosome Organization
Regulation Of DNA Replication
Anatomical Structure Morphogenesis
Positive Regulation Of Organelle Organization
Tissue Homeostasis
Regulation Of Organelle Organization
Negative Regulation Of Cellular Metabolic Process
Endochondral Ossification
Multicellular Organismal Homeostasis
Organelle Organization
Chromatin Modification
Negative Regulation Of Protein ADP-ribosylation
Negative Regulation Of DNA Recombination At Telomere
DNA Replication
Collagen Catabolic Process
Cell Development
Cell Aging
Chromatin Organization
Cell Morphogenesis Involved In Differentiation
Collagen Metabolic Process
Regulation Of Protein ADP-ribosylation
Synaptic Growth At Neuromuscular Junction
Developmental Process
MRNA 3'-end Processing
Mitotic Cell Cycle
Cell Cycle
Cell Cycle Process
Mitotic Cell Cycle Process
Response To Organic Substance
Mitotic Cell Cycle Phase Transition
Cell Cycle Phase Transition
Organelle Organization
Cellular Response To Stimulus
Cellular Response To Oxidative Stress
Cellular Response To Reactive Oxygen Species
Ras Protein Signal Transduction
Signal Transduction
Regulation Of Catalytic Activity
Response To Stimulus
Signaling
Negative Regulation Of Apoptotic Process
Negative Regulation Of Programmed Cell Death
Response To Inorganic Substance
Cell Communication
Regulation Of Cellular Process
MyD88-dependent Toll-like Receptor Signaling Pathway
Negative Regulation Of Cell Death
Response To Reactive Oxygen Species
Regulation Of Schwann Cell Differentiation
Neurotrophin TRK Receptor Signaling Pathway
Regulation Of Apoptotic Process
Neurotrophin Signaling Pathway
Regulation Of Cellular Amino Acid Metabolic Process
Response To Organic Cyclic Compound
Intracellular Signal Transduction
Hydrogen Peroxide Metabolic Process
Toll-like Receptor Signaling Pathway
Response To Oxidative Stress
Regulation Of Cell Death
Cell Division
Regulation Of Innate Immune Response
Positive Regulation Of Protein Metabolic Process
Endomembrane System Organization
G2/M Transition Of Mitotic Cell Cycle
Response To CAMP
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
Regulation Of Metabolic Process
Chromosome Organization
Activation Of Innate Immune Response
Regulation Of Cellular Ketone Metabolic Process
Reproduction
Response To Organophosphorus
Tagcloud
?
a2
alkaline
altered
annexin
annexins
anxa2
bglap
col1a1
else
fibrinolysis
generate
ibsp
knock
knockdown
mineralizing
osteoblasts
osteogenesis
osteogenic
osteoprogenitor
programming
psiren
rafts
responsiveness
runx2
shrna
si
stat6
vesicles
Tagcloud (Difference)
?
a2
alkaline
altered
annexin
annexins
anxa2
bglap
col1a1
else
fibrinolysis
generate
ibsp
knock
knockdown
mineralizing
osteoblasts
osteogenesis
osteogenic
osteoprogenitor
programming
psiren
rafts
responsiveness
runx2
shrna
si
stat6
vesicles
Tagcloud (Intersection)
?