STAP1 and TEC

Number of citations of the paper that reports this interaction (PMID 10518561)
3

Data Source:
HPRD (in vivo, in vitro)

		STAP1	TEC
Gene Name		signal transducing adaptor family member 1	tec protein tyrosine kinase
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Protein Complex	Cytosol Cytoskeleton Cell-cell Junction Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
	Molecular Function	SH3/SH2 Adaptor Activity Protein Binding	Non-membrane Spanning Protein Tyrosine Kinase Activity Receptor Binding Protein Binding ATP Binding Lipid Binding Metal Ion Binding
	Biological Process	Intracellular Protein Transport Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Signal Transduction Membrane Fusion	Adaptive Immune Response Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Integrin-mediated Signaling Pathway Regulation Of Platelet Activation Cell Differentiation Intracellular Signal Transduction Peptidyl-tyrosine Autophosphorylation Fc-epsilon Receptor Signaling Pathway Regulation Of Cell Proliferation Tissue Regeneration Innate Immune Response T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway
Pathways			Signaling by SCF-KIT Signaling by Interleukins Fc epsilon receptor (FCERI) signaling Cytokine Signaling in Immune system FCERI mediated Ca+2 mobilization Interleukin-3, 5 and GM-CSF signaling Innate Immune System
Drugs
Diseases
GWAS			Crohn's disease ( 23128233)
Protein-Protein Interactions		6 interactors: FAM134C KIT PTK2B SH3KBP1 TEC URI1	30 interactors: ARHGEF12 BMX BTK DOK1 ERBB2 FASLG GNA12 IKBKG JAK1 JAK2 KIT LYN PIK3R1 PIK3R2 PIK3R3 PIP4K2A PIP5K1A PLCG1 PLCG2 PLK4 PRLR PTPN18 PTPN21 RHOA SHC1 SOCS1 STAP1 TP53 VAV1 WAS
Entrez ID		26228	7006
HPRD ID		16053	02786
Ensembl ID		ENSG00000035720	ENSG00000135605
Uniprot IDs		Q9ULZ2	P42680
PDB IDs		1X1F 3MAZ	2LUL
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Shape Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Protein Autophosphorylation Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase Activity Negative Regulation Of Programmed Cell Death Response To Hormone Negative Regulation Of Cell Death Peptidyl-tyrosine Phosphorylation Peptidyl-tyrosine Autophosphorylation Locomotion Regulation Of Phosphatidylinositol 3-kinase Activity Regulation Of Lipid Kinase Activity Cellular Response To Lipid Positive Regulation Of JAK-STAT Cascade Movement Of Cell Or Subcellular Component Regulation Of Cell Morphogenesis Regulation Of Cell Death Regulation Of JAK-STAT Cascade Cellular Response To Hormone Stimulus Epithelial Cell Migration Response To External Stimulus Epithelium Migration B Cell Differentiation Cellular Response To Organic Substance Mast Cell Cytokine Production Melanocyte Adhesion Dendritic Cell Cytokine Production Mast Cell Proliferation Regulation Of Cellular Component Organization Response To Hydrogen Peroxide Integrin-mediated Signaling Pathway Innate Immune Response Regulation Of CGMP-mediated Signaling Marginal Zone B Cell Differentiation Positive Regulation Of B Cell Chemotaxis Kit Signaling Pathway Erythropoietin-mediated Signaling Pathway Leukocyte Activation Involved In Immune Response Cell Migration B Cell Activation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Response To Lipid Regulation Of Synaptic Plasticity Response To Organic Cyclic Compound Cell Motility Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Apoptotic Process	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Intracellular Signal Transduction Innate Immune Response Fc Receptor Signaling Pathway Immune Response Fc-epsilon Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune System Process Regulation Of Immune Response Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Signal Transduction Wound Healing Immune Response-regulating Signaling Pathway Response To Organic Substance Signaling Defense Response Response To Wounding Cell Communication Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Phosphate-containing Compound Metabolic Process Neurotrophin TRK Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Neurotrophin Signaling Pathway Cellular Response To Organic Substance Regulation Of Immune System Process Cell Activation Regulation Of Signaling Regulation Of Catalytic Activity Cellular Response To Stimulus Peptidyl-tyrosine Phosphorylation Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Kinase Activity Response To Growth Factor Cell Differentiation Cellular Response To Peptide Hormone Stimulus Growth Hormone Receptor Signaling Pathway Cellular Response To Peptide Cellular Response To Growth Hormone Stimulus Movement Of Cell Or Subcellular Component Phagocytosis Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Fc-gamma Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Phosphorylation
Tagcloud ?		4p13 abbreviation adaptor adh apolipoprotein asp207asn associate convertase exome fh4 fourth glu97asp hypercholesterolemia ile71thr kexin leu69ser lipoprotein mapped missense nonaffected parametric probands proprotein relatives sanger subtilisin suffer thereafter transducing
Tagcloud (Difference) ?		4p13 abbreviation adaptor adh apolipoprotein asp207asn associate convertase exome fh4 fourth glu97asp hypercholesterolemia ile71thr kexin leu69ser lipoprotein mapped missense nonaffected parametric probands proprotein relatives sanger subtilisin suffer thereafter transducing
Tagcloud (Intersection) ?