STAP1 and TEC

Number of citations of the paper that reports this interaction (PubMedID 10518561)
44

Data Source:
HPRD (in vitro, in vivo)

		STAP1	TEC
Description		signal transducing adaptor family member 1	tec protein tyrosine kinase
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Cytosol Nuclear Body Protein-containing Complex	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Membrane
	Molecular Function	Phosphotyrosine Residue Binding Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Macrophage Colony-stimulating Factor Receptor Binding Protein Binding Phospholipid Binding Protein Kinase Binding Protein Tyrosine Kinase Activator Activity Protein-macromolecule Adaptor Activity Receptor Tyrosine Kinase Binding Signaling Adaptor Activity	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Phospholipid Binding Zinc Ion Binding Lipid Binding Kinase Activity Transferase Activity Metal Ion Binding
	Biological Process	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Response To Bacterium Positive Regulation Of Gene Expression Negative Regulation Of Macrophage Chemotaxis Positive Regulation Of B Cell Receptor Signaling Pathway Positive Regulation Of Phagocytosis, Engulfment Cellular Response To Lipopolysaccharide Negative Regulation Of Ruffle Assembly Negative Regulation Of Macrophage Colony-stimulating Factor Signaling Pathway Positive Regulation Of Microglial Cell Activation Negative Regulation Of Microglial Cell Migration Positive Regulation Of Microglial Cell Mediated Cytotoxicity	Adaptive Immune Response Immune System Process Protein Phosphorylation Integrin-mediated Signaling Pathway Regulation Of Platelet Activation Intracellular Signal Transduction Tissue Regeneration T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway
Pathways			Signaling by SCF-KIT FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization Interleukin-3, Interleukin-5 and GM-CSF signaling
Drugs			Fostamatinib Zanubrutinib
Diseases
GWAS		Regular attendance at a pub or social club ( 29970889)	Crohn's disease ( 23128233) Metabolite levels ( 23823483) Pulse pressure ( 27841878) Rheumatoid arthritis ( 24390342 30423114) Systolic blood pressure ( 27841878)
Interacting Genes		14 interacting genes: AR EGFR ERBB2 ERBB3 ERBB4 GAB1 GRIPAP1 KIT MET PTK2B RETREG3 SH3KBP1 TEC URI1	37 interacting genes: ARHGEF12 BMX BTK DOK1 EGFR ERBB2 ERBB3 ERBB4 FASLG FBXO7 GAB1 GNA12 IKBKG JAK1 JAK2 KIT LRRK1 LYN MET PIK3R1 PIK3R2 PIK3R3 PIP4K2A PIP5K1A PLCG1 PLCG2 PLK4 PRLR PRRG4 PTPN18 PTPN21 SHC1 SOCS1 STAP1 TP53 VAV1 WAS
Entrez ID		26228	7006
HPRD ID		16053	02786
Ensembl ID		ENSG00000035720	ENSG00000135605
Uniprot IDs		Q9ULZ2	P42680
PDB IDs		1X1F 3MAZ	2LUL
Enriched GO Terms of Interacting Partners?		Protein Tyrosine Kinase Activity Epidermal Growth Factor Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway ERBB Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Programmed Cell Death Enzyme-linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Activity Basal Plasma Membrane Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein Kinase Activity ERBB2 Signaling Pathway Receptor Complex Kinase Activity Regulation Of Programmed Cell Death Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Neuron Differentiation Regulation Of Epithelial Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Regulation Of MAPK Cascade Regulation Of Biological Quality ERBB3:ERBB2 Complex Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Protein Phosphorylation Positive Regulation Of Signal Transduction Positive Regulation Of Phosphorylation Epidermal Growth Factor Receptor Activity Neuregulin Receptor Activity Regulation Of Multicellular Organismal Process Positive Regulation Of Endothelial Cell Migration Cellular Response To Growth Factor Stimulus Regulation Of Signal Transduction Regulation Of Anatomical Structure Morphogenesis Positive Regulation Of Cell Communication Intracellular Signal Transduction Positive Regulation Of Signaling Mast Cell Differentiation Positive Regulation Of Cell Population Proliferation Regulation Of Developmental Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of Cell Migration Positive Regulation Of Phosphate Metabolic Process Cell Migration Response To Growth Factor Positive Regulation Of Cell Motility Positive Regulation Of Locomotion	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein Tyrosine Kinase Activity Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Intracellular Signal Transduction Signal Transduction Regulation Of Signal Transduction Kinase Activity Regulation Of Cell Communication Regulation Of Signaling Regulation Of Intracellular Signal Transduction Intracellular Signaling Cassette Protein Kinase Activity Phosphotyrosine Residue Binding Positive Regulation Of Intracellular Signal Transduction Lymphocyte Activation Cellular Developmental Process Phosphate-containing Compound Metabolic Process Positive Regulation Of Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Mononuclear Cell Differentiation Regulation Of Programmed Cell Death Cytosol Protein Phosphorylation Leukocyte Activation ERBB Signaling Pathway Non-membrane Spanning Protein Tyrosine Kinase Activity Receptor Complex Positive Regulation Of Cell Communication Positive Regulation Of Signaling Leukocyte Differentiation Phosphorylation Negative Regulation Of Programmed Cell Death Peptidyl-tyrosine Phosphorylation Fc-epsilon Receptor Signaling Pathway Cell Activation Developmental Process Fc Receptor Signaling Pathway Lymphocyte Differentiation Regulation Of Immune System Process Regulation Of Locomotion Immune System Process B Cell Activation Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Differentiation Regulation Of Immune Response Phosphatidylinositol Metabolic Process T Cell Activation ATP Binding Positive Regulation Of Immune System Process
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