STAP1 and RETREG3

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid)

		STAP1	RETREG3
Description		signal transducing adaptor family member 1	reticulophagy regulator family member 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Cytosol Nuclear Body Protein-containing Complex	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Protein-containing Complex Endoplasmic Reticulum Tubular Network
	Molecular Function	Phosphotyrosine Residue Binding Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Macrophage Colony-stimulating Factor Receptor Binding Protein Binding Phospholipid Binding Protein Kinase Binding Protein Tyrosine Kinase Activator Activity Protein-macromolecule Adaptor Activity Receptor Tyrosine Kinase Binding Signaling Adaptor Activity	Protein Binding Endoplasmic Reticulum-autophagosome Adaptor Activity
	Biological Process	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Response To Bacterium Positive Regulation Of Gene Expression Negative Regulation Of Macrophage Chemotaxis Positive Regulation Of B Cell Receptor Signaling Pathway Positive Regulation Of Phagocytosis, Engulfment Cellular Response To Lipopolysaccharide Negative Regulation Of Ruffle Assembly Negative Regulation Of Macrophage Colony-stimulating Factor Signaling Pathway Positive Regulation Of Microglial Cell Activation Negative Regulation Of Microglial Cell Migration Positive Regulation Of Microglial Cell Mediated Cytotoxicity	Autophagy Endoplasmic Reticulum Organization Positive Regulation Of Neuron Projection Development Collagen Catabolic Process Reticulophagy Substrate Localization To Autophagosome Endoplasmic Reticulum Tubular Network Organization
Pathways
Drugs
Diseases
GWAS		Regular attendance at a pub or social club ( 29970889)	Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)
Interacting Genes		14 interacting genes: AR EGFR ERBB2 ERBB3 ERBB4 GAB1 GRIPAP1 KIT MET PTK2B RETREG3 SH3KBP1 TEC URI1	107 interacting genes: ABHD16A ACSL5 AGPAT4 AGTRAP ANKRD46 ARL6IP1 ARLN ARPC3 ATP6V0C BET1 BNIP1 C16orf92 C1GALT1 CCDC167 CCL4L2 CDIPT CDS1 CLCA4 CMTM3 CMTM5 CMTM7 CSGALNACT2 CYB5B CYP4F2 DERL1 DHRSX ERG28 FAXDC2 FKBP8 FUNDC2 GABARAPL1 GABARAPL2 GIMAP5 GOSR2 HMOX2 HTATIP2 JAGN1 LEMD1 LPAR3 LPCAT2 LRCH4 MAL2 MALL MAP1LC3A MCRS1 MFF MOB2 MOSPD3 NRM ORMDL2 ORMDL3 OTULINL PKMYT1 PLP2 PLPP6 PNLIPRP1 PRAF2 RABAC1 RUSF1 SCD SEC22A SENP2 SERP2 SFT2D1 SFXN3 SLC30A3 SLC39A6 SMCO4 SMIM1 STAP1 STX5 STX7 STX8 SYNGR1 TBRG4 TCEA2 TECR TMEM100 TMEM11 TMEM120B TMEM128 TMEM176A TMEM18 TMEM203 TMEM218 TMEM222 TMEM237 TMEM239 TMEM243 TMEM254 TMEM31 TMEM42 TMEM60 TMEM65 TMPPE TPRG1 TSNARE1 TSPO2 UBIAD1 VAMP1 VAMP3 VAMP4 VAMP5 VAPA VAPB YIPF1 YIPF6
Entrez ID		26228	162427
HPRD ID		16053	14108
Ensembl ID		ENSG00000035720	ENSG00000141699
Uniprot IDs		Q9ULZ2	K7EQI9 Q86VR2
PDB IDs		1X1F 3MAZ
Enriched GO Terms of Interacting Partners?		Protein Tyrosine Kinase Activity Epidermal Growth Factor Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway ERBB Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Programmed Cell Death Enzyme-linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Activity Basal Plasma Membrane Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein Kinase Activity ERBB2 Signaling Pathway Receptor Complex Kinase Activity Regulation Of Programmed Cell Death Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Neuron Differentiation Regulation Of Epithelial Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Regulation Of MAPK Cascade Regulation Of Biological Quality ERBB3:ERBB2 Complex Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Protein Phosphorylation Positive Regulation Of Signal Transduction Positive Regulation Of Phosphorylation Epidermal Growth Factor Receptor Activity Neuregulin Receptor Activity Regulation Of Multicellular Organismal Process Positive Regulation Of Endothelial Cell Migration Cellular Response To Growth Factor Stimulus Regulation Of Signal Transduction Regulation Of Anatomical Structure Morphogenesis Positive Regulation Of Cell Communication Intracellular Signal Transduction Positive Regulation Of Signaling Mast Cell Differentiation Positive Regulation Of Cell Population Proliferation Regulation Of Developmental Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of Cell Migration Positive Regulation Of Phosphate Metabolic Process Cell Migration Response To Growth Factor Positive Regulation Of Cell Motility Positive Regulation Of Locomotion	Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum SNAP Receptor Activity SNARE Complex Membrane Fusion Endomembrane System Organelle Fusion Organelle Membrane Fusion Membrane Organization Golgi Vesicle Transport Vesicle Fusion Protein Binding Organelle Localization By Membrane Tethering Vesicle Organization Lipid Biosynthetic Process Membrane Docking SNARE Binding Golgi Membrane Vesicle-mediated Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Cellular Response To Nitrogen Starvation Endoplasmic Reticulum Organization Vesicle Docking CDP-diacylglycerol Metabolic Process Transport Vesicle SNARE Complex Assembly Mitochondrial Outer Membrane Phosphatidylethanolamine Binding FFAT Motif Binding Endoplasmic Reticulum Membrane Organization Organelle Membrane Bounding Membrane Of Organelle Synaptic Vesicle Phospholipid Metabolic Process Azurophil Granule Membrane COPII-coated Vesicle Budding Endoplasmic Reticulum-plasma Membrane Tethering Intracellular Sphingolipid Homeostasis Negative Regulation Of Ceramide Biosynthetic Process Phospholipid Biosynthetic Process Lipid Metabolic Process Establishment Of Protein Localization Late Endosome Menaquinone Metabolic Process Negative Regulation Of Sphingolipid Biosynthetic Process Chloride Channel Inhibitor Activity Endoplasmic Reticulum Localization Serine Palmitoyltransferase Complex Positive Regulation Of B Cell Receptor Signaling Pathway
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