STAP1 and GRIPAP1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		STAP1	GRIPAP1
Description		signal transducing adaptor family member 1	GRIP1 associated protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Cytosol Nuclear Body Protein-containing Complex	Nucleoplasm Endosome Cytosol Membrane Axon Dendrite Early Endosome Membrane Presynaptic Membrane Cell Projection Neuronal Cell Body Synapse Recycling Endosome Membrane Blood Microparticle Glutamatergic Synapse Extrinsic Component Of Postsynaptic Early Endosome Membrane
	Molecular Function	Phosphotyrosine Residue Binding Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Macrophage Colony-stimulating Factor Receptor Binding Protein Binding Phospholipid Binding Protein Kinase Binding Protein Tyrosine Kinase Activator Activity Protein-macromolecule Adaptor Activity Receptor Tyrosine Kinase Binding Signaling Adaptor Activity	Guanyl-nucleotide Exchange Factor Activity Protein Binding Ionotropic Glutamate Receptor Binding Identical Protein Binding
	Biological Process	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Response To Bacterium Positive Regulation Of Gene Expression Negative Regulation Of Macrophage Chemotaxis Positive Regulation Of B Cell Receptor Signaling Pathway Positive Regulation Of Phagocytosis, Engulfment Cellular Response To Lipopolysaccharide Negative Regulation Of Ruffle Assembly Negative Regulation Of Macrophage Colony-stimulating Factor Signaling Pathway Positive Regulation Of Microglial Cell Activation Negative Regulation Of Microglial Cell Migration Positive Regulation Of Microglial Cell Mediated Cytotoxicity	Protein Transport Regulation Of Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane Regulation Of Recycling Endosome Localization Within Postsynapse Negative Regulation Of Protein Localization Negative Regulation Of Receptor Clustering
Pathways
Drugs
Diseases
GWAS		Regular attendance at a pub or social club ( 29970889)	Eosinophil percentage of white cells ( 32888494)
Interacting Genes		14 interacting genes: AR EGFR ERBB2 ERBB3 ERBB4 GAB1 GRIPAP1 KIT MET PTK2B RETREG3 SH3KBP1 TEC URI1	70 interacting genes: AARD ANKRD11 ARL15 ATG5 BYSL CASP3 CBX8 CCDC185 CCDC187 CCNH CCNT1 CDC37 CEP57L1 CFAP53 CWF19L2 DAXX DISC1 DNAAF19 DRC4 DUSP26 EHHADH ELOA ENKD1 FAM161A FAM50B FAM90A1 FXR1 GRIA1 GRIP1 GRM7 HDAC4 HSPB1 ING4 ING5 LNX1 MAP3K1 MEOX2 MFAP1 MLLT6 NUAK2 PIBF1 PKP2 PPP1R18 PRPF18 PSMB1 RAB4A RCOR3 SMAD2 SMARCE1 SMURF1 SNAPC5 SNW1 SPP1 STAP1 TBC1D30 TCEA2 TEPSIN TES TRAF2 TSGA10IP TSHZ2 TSNAX TTC23 UBC USP2 ZMAT2 ZNF219 ZNF250 ZNF35 ZNF835
Entrez ID		26228	56850
HPRD ID		16053	02325
Ensembl ID		ENSG00000035720	ENSG00000068400
Uniprot IDs		Q9ULZ2	Q4V328
PDB IDs		1X1F 3MAZ
Enriched GO Terms of Interacting Partners?		Protein Tyrosine Kinase Activity Epidermal Growth Factor Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway ERBB Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Programmed Cell Death Enzyme-linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Activity Basal Plasma Membrane Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein Kinase Activity ERBB2 Signaling Pathway Receptor Complex Kinase Activity Regulation Of Programmed Cell Death Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Neuron Differentiation Regulation Of Epithelial Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Regulation Of MAPK Cascade Regulation Of Biological Quality ERBB3:ERBB2 Complex Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Protein Phosphorylation Positive Regulation Of Signal Transduction Positive Regulation Of Phosphorylation Epidermal Growth Factor Receptor Activity Neuregulin Receptor Activity Regulation Of Multicellular Organismal Process Positive Regulation Of Endothelial Cell Migration Cellular Response To Growth Factor Stimulus Regulation Of Signal Transduction Regulation Of Anatomical Structure Morphogenesis Positive Regulation Of Cell Communication Intracellular Signal Transduction Positive Regulation Of Signaling Mast Cell Differentiation Positive Regulation Of Cell Population Proliferation Regulation Of Developmental Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of Cell Migration Positive Regulation Of Phosphate Metabolic Process Cell Migration Response To Growth Factor Positive Regulation Of Cell Motility Positive Regulation Of Locomotion	Nucleoplasm Protein Binding DNA Replication-dependent Chromatin Disassembly
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