KCNE5 and SGTA

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KCNE5	SGTA
Description		potassium voltage-gated channel subfamily E regulatory subunit 5	small glutamine rich tetratricopeptide repeat co-chaperone alpha
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Voltage-gated Potassium Channel Complex Membrane	Nucleus Nucleoplasm Cytoplasm Cytosol Membrane TRC Complex
	Molecular Function	Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Protein Binding Potassium Channel Regulator Activity Transmembrane Transporter Binding Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization	Protein Binding Identical Protein Binding Molecular Adaptor Activity BAT3 Complex Binding
	Biological Process	Monoatomic Ion Transport Regulation Of Heart Contraction Cardiac Muscle Contraction Regulation Of Membrane Repolarization Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Regulation Of Atrial Cardiac Muscle Cell Membrane Repolarization Ventricular Cardiac Muscle Cell Action Potential Membrane Repolarization During Action Potential Atrial Cardiac Muscle Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Potassium Ion Export Across Plasma Membrane Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Potassium Ion Transmembrane Transport Positive Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Potassium Ion Export Across Plasma Membrane	Post-translational Protein Targeting To Endoplasmic Reticulum Membrane ERAD Pathway Tail-anchored Membrane Protein Insertion Into ER Membrane Negative Regulation Of ERAD Pathway Positive Regulation Of ERAD Pathway Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways		Phase 3 - rapid repolarisation Phase 2 - plateau phase	Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Drugs		Enflurane Promethazine Miconazole
Diseases
GWAS			Femur bone mineral density x serum urate levels interaction ( 34046847)
Interacting Genes		7 interacting genes: APP GET3 KCNB1 KCNG4 PGRMC1 SGTA SGTB	182 interacting genes: ADAM21 ADIPOQ ADRM1 AGR2 AGR3 AOC3 BAG6 BCL2L12 BTC C1QA C1QL4 C1QTNF1 C1QTNF5 C1QTNF6 C3orf52 C5orf46 CD79B CD99 CD99L2 CDH15 CDSN CHRNG COL1A2 COL8A2 CREB3L3 CSF1 CST1 CTAG1A CTAG1B CTSL CXCL8 CYB5R1 DEFA6 DEFB131A DKK3 DMKN EDA2R EDAR EFEMP1 EFEMP2 ERP27 ERP29 ETNK1 EVA1B F11R FERD3L FGF21 FIP1L1 FKBP7 FSTL1 FXYD2 FXYD7 FZD7 GABARAPL2 GAL GALP GHR GIP GPX7 GRN GUCA2A GYPA HSP90AA1 HSP90AB1 HSPA13 HSPA4 IER3 IGFBP6 IGL IGLC1 IL6ST IRF3 IRF5 ITPRIPL1 KASH5 KCNA1 KCNA10 KCNE5 KLHL20 KRT6A KTN1 LAIR2 LAT LCN2 LDLRAD4 LSMEM2 MRAP2 MS4A3 MSMB MSTN MYDGF MYOC NAXD NME3 NPVF NR3C1 NRSN2 NXF1 PAGE3 PBXIP1 PCDHA4 PCDHGA4 PFN2 PGLYRP2 PGR PIAS1 PLAAT4 PMEPA1 PODXL PPIB PPIC PPP1R3C PRAP1 PRB4 PRRG2 PSORS1C2 PTN PYY RCN1 RNASE10 RNF144A RNF144B RNF170 RPN1 SDC4 SDF2L1 SERPINE1 SERPINI2 SGCA SGTB SHISA4 SHISA5 SLPI SMAGP SMIM14 SMIM5 SOD3 SPINK9 SPN SPP1 SPPL2A SRGN SRL STMP1 SUOX SYT11 SYT4 TFF3 TFRC TGFA TIAM1 TMEM154 TMEM174 TMEM230 TMEM31 TMEM98 TMPO TMPRSS11D TMUB2 TNFRSF10C TNFRSF13B TNFRSF19 TNFRSF1A TNFRSF21 TNFSF12 TRIM5 TWSG1 TXNDC12 UBL4A UBQLN2 UPK3A USP14 USP5 USP9X VIP WBP1L WFDC12 WFDC13 WFDC5 ZBTB8B ZG16 ZG16B
Entrez ID		23630	6449
HPRD ID		02268	04568
Ensembl ID		ENSG00000176076	ENSG00000104969
Uniprot IDs		Q9UJ90	O43765
PDB IDs			2VYI 4CPG 4GOD 4GOE 4GOF
Enriched GO Terms of Interacting Partners?		TRC Complex Protein Homooligomerization Protein Complex Oligomerization Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Tail-anchored Membrane Protein Insertion Into ER Membrane Localization Within Membrane Dendrite Membrane Protein Insertion Into ER Membrane Establishment Of Protein Localization To Membrane Protein Targeting To ER Establishment Of Protein Localization To Endoplasmic Reticulum Cellular Localization Positive Regulation Of Response To Endoplasmic Reticulum Stress Potassium Channel Regulator Activity Glutamate Receptor Signaling Pathway Positive Regulation Of Establishment Of Protein Localization Voltage-gated Potassium Channel Activity Neuron Projection Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Protein Insertion Into Membrane Potassium Channel Activity Voltage-gated Potassium Channel Complex Protein Targeting To Membrane Cell Body Regulation Of Membrane Potential Regulation Of Protein Transport Regulation Of Response To Endoplasmic Reticulum Stress Associative Learning Protein-folding Chaperone Binding Acetylcholine Receptor Activator Activity Protein-containing Complex Assembly Lipoprotein Particle Positive Regulation Of Protein Import Action Potential PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Establishment Of Protein Localization Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Memory Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization GET Complex	Extracellular Region Extracellular Space Protein Binding Endoplasmic Reticulum Lumen Response To Bacterium Defense Response To Bacterium Collagen Trimer Response To Stress Membrane Response To Other Organism Antimicrobial Humoral Response Endoplasmic Reticulum Immune System Process Regulation Of Immune System Process Humoral Immune Response Peptidase Inhibitor Activity Negative Regulation Of Cell Activation Positive Regulation Of Leukocyte Migration Serine-type Endopeptidase Inhibitor Activity Defense Response Extracellular Exosome Defense Response To Symbiont Negative Regulation Of Proteasomal Protein Catabolic Process Antibacterial Humoral Response Plasma Membrane Immune Response Defense Response To Other Organism Negative Regulation Of Leukocyte Activation Identical Protein Binding Negative Regulation Of Cell Adhesion Positive Regulation Of MAPK Cascade Response To External Biotic Stimulus Tumor Necrosis Factor Receptor Activity Negative Regulation Of Proteolysis Positive Regulation Of Intracellular Signal Transduction Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Positive Regulation Of Immune System Process Hormone Activity Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Glucocorticoid Metabolic Process Growth Factor Activity Fibronectin Binding Macrophage Apoptotic Process BAT3 Complex Regulation Of Cell Adhesion Protein Folding Negative Regulation Of Cell-cell Adhesion Negative Regulation Of Lymphocyte Proliferation Epidermal Growth Factor Receptor Binding Negative Regulation Of Mononuclear Cell Proliferation
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