KCNE5 and PGRMC1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KCNE5	PGRMC1
Description		potassium voltage-gated channel subfamily E regulatory subunit 5	progesterone receptor membrane component 1
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Voltage-gated Potassium Channel Complex Membrane	Extracellular Region Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Plasma Membrane Endomembrane System Membrane Smooth Endoplasmic Reticulum Membrane Specific Granule Membrane Neuron Projection Neuronal Cell Body Cell Body Synapse
	Molecular Function	Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Protein Binding Potassium Channel Regulator Activity Transmembrane Transporter Binding Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization	Amyloid-beta Binding Steroid Binding Protein Binding Lipid Binding Heme Binding Protein Homodimerization Activity Metal Ion Binding
	Biological Process	Monoatomic Ion Transport Regulation Of Heart Contraction Cardiac Muscle Contraction Regulation Of Membrane Repolarization Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Regulation Of Atrial Cardiac Muscle Cell Membrane Repolarization Ventricular Cardiac Muscle Cell Action Potential Membrane Repolarization During Action Potential Atrial Cardiac Muscle Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Potassium Ion Export Across Plasma Membrane Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Potassium Ion Transmembrane Transport Positive Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Potassium Ion Export Across Plasma Membrane	Heme Biosynthetic Process Axon Guidance Memory Associative Learning Modification Of Synaptic Structure Positive Regulation Of Lipoprotein Transport Positive Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of Synapse Organization
Pathways		Phase 3 - rapid repolarisation Phase 2 - plateau phase	Neutrophil degranulation
Drugs		Enflurane Promethazine Miconazole	Dextromethorphan Nortriptyline Sertraline
Diseases
GWAS			Hodgkin's lymphoma ( 34216518)
Interacting Genes		7 interacting genes: APP GET3 KCNB1 KCNG4 PGRMC1 SGTA SGTB	20 interacting genes: BIK CAMLG CCDC134 CENPU CIAO1 CREB3L1 DEFB124 EVI2B GET3 GLP1R GOLM1 KASH5 KCNE5 LINC00632 MTNR1A PAM16 SCAP SGTB TMEM213 ZNF71
Entrez ID		23630	10857
HPRD ID		02268	02338
Ensembl ID		ENSG00000176076	ENSG00000101856
Uniprot IDs		Q9UJ90	O00264 Q6IB11
PDB IDs			4X8Y
Enriched GO Terms of Interacting Partners?		TRC Complex Protein Homooligomerization Protein Complex Oligomerization Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Tail-anchored Membrane Protein Insertion Into ER Membrane Localization Within Membrane Dendrite Membrane Protein Insertion Into ER Membrane Establishment Of Protein Localization To Membrane Protein Targeting To ER Establishment Of Protein Localization To Endoplasmic Reticulum Cellular Localization Positive Regulation Of Response To Endoplasmic Reticulum Stress Potassium Channel Regulator Activity Glutamate Receptor Signaling Pathway Positive Regulation Of Establishment Of Protein Localization Voltage-gated Potassium Channel Activity Neuron Projection Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Protein Insertion Into Membrane Potassium Channel Activity Voltage-gated Potassium Channel Complex Protein Targeting To Membrane Cell Body Regulation Of Membrane Potential Regulation Of Protein Transport Regulation Of Response To Endoplasmic Reticulum Stress Associative Learning Protein-folding Chaperone Binding Acetylcholine Receptor Activator Activity Protein-containing Complex Assembly Lipoprotein Particle Positive Regulation Of Protein Import Action Potential PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Establishment Of Protein Localization Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Memory Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization GET Complex	GET Complex
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