SF3B1 and TOP1

Number of citations of the paper that reports this interaction (PubMedID 15848144)
0

Data Source:
BioGRID (affinity chromatography technology, unspecified method)

		SF3B1	TOP1
Description		splicing factor 3b subunit 1	DNA topoisomerase I
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Spliceosomal Complex U2-type Spliceosomal Complex U2 SnRNP U12-type Spliceosomal Complex Nucleolus Nuclear Speck Nuclear Lumen U11/U12 SnRNP U2-type Prespliceosome U2-type Precatalytic Spliceosome Catalytic Step 2 Spliceosome B-WICH Complex	Nuclear Chromosome P-body Fibrillar Center Dense Fibrillar Component Male Germ Cell Nucleus Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Protein-DNA Complex Perikaryon
	Molecular Function	RNA Binding MRNA Binding Protein Binding Splicing Factor Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding Chromatin Binding Double-stranded DNA Binding Single-stranded DNA Binding RNA Binding DNA Topoisomerase Activity DNA Topoisomerase Type I (single Strand Cut, ATP-independent) Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding DNA Binding, Bending Isomerase Activity Protein Domain Specific Binding Chromatin DNA Binding Protein-containing Complex Binding Supercoiled DNA Binding
	Biological Process	Spliceosomal Complex Assembly RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome Chromatin Remodeling MRNA Processing RNA Splicing Positive Regulation Of Transcription By RNA Polymerase I Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase III U2-type Prespliceosome Assembly	DNA Replication DNA Topological Change Chromatin Remodeling Chromosome Segregation Circadian Rhythm Response To Temperature Stimulus RRNA Transcription Response To Xenobiotic Stimulus Response To Gamma Radiation Programmed Cell Death Peptidyl-serine Phosphorylation Animal Organ Regeneration Circadian Regulation Of Gene Expression Embryonic Cleavage Rhythmic Process Response To CAMP Cellular Response To Luteinizing Hormone Stimulus
Pathways		B-WICH complex positively regulates rRNA expression mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway	SUMOylation of DNA replication proteins
Drugs		H3B-8800	Irinotecan Dactinomycin Doxorubicin Topotecan Camptothecin Edotecarin Lucanthone Elsamitrucin 7-ethyl-10-hydroxycamptothecin Sodium stibogluconate Cositecan XMT-1001 Rubitecan 2,3-DIMETHOXY-12H-[1,3]DIOXOLO[5,6]INDENO[1,2-C]ISOQUINOLIN-6-IUM 4-(5,11-DIOXO-5H-INDENO[1,2-C]ISOQUINOLIN-6(11H)-YL)BUTANOATE Hexylresorcinol Sacituzumab govitecan Trastuzumab deruxtecan
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Major depressive disorder ( 27479909) Morning person ( 30696823) Schizophrenia ( 25056061 29483656 30285260) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Waist circumference adjusted for body mass index ( 34021172)	Accelerated cognitive decline after conversion of mild cognitive impairment to Alzheimer's disease (Alzhiemer's diagnosis trajectory interaction) ( 28560309) Antipsychotic drug-induced weight gain in schizophrenia ( 31447353) Brain morphology (MOSTest) ( 32665545) Cholesterol, total ( 24097068 20686565) Hemoglobin ( 32888494) Hip circumference adjusted for BMI ( 34021172) LDL cholesterol ( 20686565 24097068) LDL cholesterol levels ( 28334899) LDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Male-pattern baldness ( 28196072) Metabolite levels ( 23823483) PR interval ( 32439900) Red blood cell count ( 32888494) Refractive error ( 32231278) Total cholesterol levels ( 28334899) Urate levels ( 31578528) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		102 interacting genes: APBB1 C11orf58 CALM1 CLK1 CSNK2A1 DUX4 DYRK1A ERG H3C1 IL7R MECOM MELK MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I MYC NRIP1 NUDT21 PPP1R8 RBM17 RSPH1 SF1 SF3B3 SF3B6 SMAD1 SMAD5 SMAD9 SNIP1 SUMO2 TCERG1 TOP1 USP7 WBP4	59 interacting genes: APAF1 APP ATM BARD1 BRCA1 BRD2 BTBD1 BTBD2 BUB3 CASP3 CASP6 CDK8 CEBPA CKAP5 CSNK2A1 CSNK2A2 DDB2 ELK3 ERCC8 ERG FSHR GEMIN4 IL7R IRF4 IRF8 IRF9 JAK1 JUN LIG4 LSM4 MDM2 NCL NCOA6 PDE10A PIAS4 PPP2R2B PRB1 PYGM RBL1 RBL2 RCVRN SF3B1 SFPQ SNW1 SRPK2 SRSF1 SRSF11 SUMO1 SYMPK TARBP2 TDP1 TIAM1 TOPORS TP53 TRIM32 TUBD1 U2AF2 UBE2I XRCC5
Entrez ID		23451	7150
HPRD ID		09281	00535
Ensembl ID		ENSG00000115524	ENSG00000198900
Uniprot IDs		B4DGZ4 O75533	P11387 Q9BVT2
PDB IDs		2F9D 2F9J 2FHO 2PEH 3LQV 4OZ1 5IFE 5O9Z 5Z56 5Z57 5Z58 5ZYA 6AH0 6AHD 6EN4 6FF4 6FF7 6N3E 6QX9 6Y50 6Y53 6Y5Q 7ABG 7ABH 7ABI 7B0I 7B91 7B92 7B9C 7DVQ 7EVN 7EVO 7OMF 7ONB 7OPI 7Q3L 7Q4O 7Q4P 7QTT 7SN6 7VPX 8CH6 8H6E 8H6J 8H6K 8H6L 8HK1 8I0P 8I0R 8I0S 8I0T 8I0U 8I0V 8QO9 8QXD 8QZS 8R08 8R09 8R0A 8R0B 8RM5 8Y7E	1A31 1A35 1A36 1EJ9 1K4S 1K4T 1LPQ 1NH3 1R49 1RR8 1RRJ 1SC7 1SEU 1T8I 1TL8
Enriched GO Terms of Interacting Partners?		MiRNA-mediated Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Extracellular Vesicle Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Translation Regulation Of Macromolecule Metabolic Process MRNA Destabilization Regulation Of Metabolic Process RNA Destabilization Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Angiogenesis Negative Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Vasculature Development Regulation Of Angiogenesis Negative Regulation Of Cell Migration Regulation Of Vasculature Development Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Cytokine Production Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Regulation Of Translation Regulation Of MRNA Stability Negative Regulation Of Signal Transduction Negative Regulation Of Protein Metabolic Process Regulation Of RNA Stability Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Signaling Negative Regulation Of Cell Communication Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Developmental Process Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Endothelial Cell Migration Negative Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Endothelial Cell Migration	Nucleoplasm Nucleus DNA Damage Response Regulation Of Nucleobase-containing Compound Metabolic Process Nucleic Acid Metabolic Process Double-strand Break Repair Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Cellular Response To Stress Regulation Of RNA Metabolic Process Macromolecule Metabolic Process DNA Repair Response To Ionizing Radiation Response To Radiation Nucleobase-containing Compound Metabolic Process Response To Stress Cellular Response To Ionizing Radiation Positive Regulation Of Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Cycle Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of Apoptotic Process Regulation Of Macromolecule Biosynthetic Process Response To X-ray Regulation Of Programmed Cell Death Regulation Of Metabolic Process Chromatin Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Enzyme Binding MRNA Metabolic Process Cellular Response To Radiation Positive Regulation Of Neuron Apoptotic Process Intrinsic Apoptotic Signaling Pathway DNA Metabolic Process DNA Topoisomerase Binding Nuclear Speck Cellular Developmental Process Positive Regulation Of Apoptotic Process Transcription Cis-regulatory Region Binding Negative Regulation Of Cell Cycle Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Programmed Cell Death Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Protein-RNA Complex Assembly Protein Polyubiquitination
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